Neuropathology and Applied Neurobiology

Cover image for Vol. 41 Issue 7

Edited By: Prof Janice Holton

Impact Factor: 3.927

ISI Journal Citation Reports © Ranking: 2014: 11/76 (Pathology); 34/192 (Clinical Neurology); 69/252 (Neurosciences)

Online ISSN: 1365-2990

Virtual Issues

Vascular Pathology, June 2015

Vascular disease is an important area of neuropathology with broad clinical implications. This new virtual issue of Neuropathology and Applied Neurobiology highlights recent publications in the field to complement the British Neuropathological Summer School entitled ‘Cerebrovascular Diseases: Genetics and Pathophysiology’ which takes place in July 2015.

All papers included in this Virtual Issue have been made free-to-access until the end of September 2015.

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases
Lucinda Craggs, Julie Taylor, Janet Y. Slade, Aiqing Chen, Christian Hagel, Gregor Kuhlenbaeumer, Anne Borjesson-Hanson, Matti Viitanen, Hannu Kalimo, Vincent Deramecourt, Arthur E. Oakley and Raj N. Kalaria

The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy
Mieke de Jager, Max V. Boot, John G.J.M. Bol, John J.P. Brevé, Cornelis A.M. Jongenelen, Benjamin Drukarch and Micha M.M. Wilhelmus

Patterns of cerebral amyloid angiopathy define histopathological phenotypes in Alzheimer's disease
N. Allen, A. C. Robinson, J. Snowden, Y. S. Davidson and D. M. A. Mann

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy
R. O. Carare, C. A. Hawkes, M. Jeffrey, R. N. Kalaria and R. O. Weller

The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease
E. Kövari, F. R. Herrmann, P. R. Hof and C. Bouras

Immunolocalization of platelet-derived growth factor receptor-β (PDGFR-β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Lucinda J.L. Craggs, Richard Fenwick, Arthur E. Oakley, Masafumi Ihara and Raj N. Kalaria

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke
Emma L. Bailey, Martin W. McBride, Wendy Beattie, John D. McClure, Delyth Graham, Anna F. Dominiczak, Cathie L.M. Sudlow, Colin Smith and Joanna M. Wardlaw

Review: environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation physical activity to enhance experience-dependent plasticity
A. J. Hannan

Review: Could neurotransmitters influence neurogenesis and neurorepair after stroke?
E. Sánchez-Mendoza, V. Bellver-Landete, J. J. Merino, M. P. González, R. Martínez-Murillo and M. J. Oset-Gasque

White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Lucinda J. L. Craggs, Yumi Yamamoto, Masafumi Ihara, Richard Fenwick, Matthew Burke, Arthur E. Oakley, Sigrun Roeber, Marco Duering, Hans Kretzschmar and Raj N. Kalaria

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds
B. M. Janaway, J. E. Simpson, N. Hoggard, J. R. Highley, G. Forster, D. Drew, O. H. Gebril, F. E. Matthews, C. Brayne, S. B. Wharton, P. G. Ince and on behalf of the MRC Cognitive Function and Ageing Neuropathology Study

Synaptic protein levels altered in vascular dementia
Lindsey I. Sinclair, Hannah M. Tayler and Seth Love

Hippocampus and cerebral cortex present a different autophagic response after oxygen and glucose deprivation in an ex vivo rat brain slice model
Diego Pérez-Rodríguez, Berta Anuncibay-Soto, Irene L. Llorente, Carlos C. Pérez-García and Arsenio Fernández-López

Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling
Magdalena Wadowska, Julie Woods, Magdalena Rogozinska and Teresita L. Briones

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia
Emma L. Ashby, James S. Miners, Sathish Kumar, Jochen Walter, Seth Love and Patrick G. Kehoe

Skeletal Muscle VI

Pathology of Skeletal Muscle, February 2015

This new virtual issue for Neuropathology and Applied Neurobiology provides a selection of recent papers in the field of skeletal muscle pathology. This collection is issued to coincide with the 116th meeting of the British Neuropathological Society to be held at the Institute of Child Health, London, UK, 4-6th March 2015. The meeting symposium, entitled ‘Recent Advances in Muscle Disease’ will include presentations by experts in the field and will culminate with the Alfred Meyer Memorial Lecture, ‘Advances in Mitochondrial Disease and New Therapies’, to be given by Professor Doug Turnbull. The papers selected for this virtual issue complement the lectures to be presented at the symposium.
Janice Holton, Editor-in-Chief

Stem cells and muscle diseases: advances in cell therapy strategies
E. Negroni, T. Gidaro, A. Bigot, GS. Butler-Browne, V. Mouly and C. Trollet

Review: Immune-mediated necrotizing myopathies – a heterogeneous group of diseases with specific myopathological features
W. Stenzel, H.-H. Goebel and E. Aronica

Mitochondrial and inflammatory changes in sporadic Inclusion Body Myositis
Karolina A. Rygiel, James Miller, John P. Grady, Mariana C. Rocha, Robert W. Taylor and Doug M. Turnbull

Overexpression of autophagic proteins in the skeletal muscle of sporadic inclusion body myositis
M. Strippoli, C. Coppola, D. Virgintino, L. Roncali, A. Toscano, L. Serlenga and M. Trojano

Chaperone-mediated autophagy components are upregulated in sporadic inclusion-body myositis muscle fibres
M. Cacciottolo, A. Nogalska, C. D'Agostino, W. K. Engel and V. Askanas

Accumulation of STIM1 is associated with the degenerative muscle fibre phenotype in ALS and other neurogenic atrophies
A. Goswami, CM. Jesse, A. Chandrasekar, E. Bushuven, JT. Vollrath, A. Dreser, I. Katona, C. Beyer, S. Johann, AC. Feller, M. Grond, S. Wagner, S. Nikolin, D. Troost and J. Weis

Frontotemporal VI

Frontotemporal lobar degeneration, August 2014

Welcome to a new virtual issue presenting a selection of papers recently published in Neuropathology and Applied Neurobiology. There have been rapid advances in understanding the neuropathology underlying frontotemporal lobar degeneration and the papers selected for this virtual issue represent the breadth of work in this exciting field.
Janice Holton, Editor-in Chief

A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia
Lashley T, Rohrer JD, Mahoney C et al.

TARDBP mutation p.Ile383Val associated with semantic dementia and complex proteinopathy
Gelpi E, van der Zee J, Turon Estrada A et al.

Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting
Armstrong RA, Hamilton RL, Mackenzie IR et al.

A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
Armstrong RA, Carter D, Cairns NJ

Frontotemporal lobar degeneration in a very young patient is associated with fused in sarcoma (FUS) pathological changes
Baborie A, Jaros E, Griffiths TD et al.

Transportin 1 colocalization with Fused in Sarcoma (FUS) inclusions is not characteristic for amyotrophic lateral sclerosis- FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from frontotemporal lobar degeneration with FUS inclusions
Troakes C, Hortobágyi T, Vance C et al.

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium
Kovacs GG, Rozemuller AJ, van Swieten JC et al.

Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype
Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z et al.

Memory Deficits Correlate with Tau and Spine Pathology in P301S MAPT Transgenic Mice
Xu H, Rösler TW, Carlsson T, de Andrade A et al.

von Economo neurones are selectively targeted in frontotemporal dementia
Santillo AF, Nilsson C, Englund E