Neuropathology and Applied Neurobiology

Virtual Issues

11th European Congress of Neuropathology, July 2016

Neuropathology and Applied Neurobiology is proud to sponsor the 11th European Congress of Neuropathology to be held in Bordeaux 6th – 9th July 2016. Together with the British Neuropathological Society the Journal will sponsor a plenary lecture entitled ‘Auto-immune synaptic diseases’ to be delivered by Dr Josep Dalmau, ICREA Senior Investigator, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Spain.

The meeting covers all aspects of neuropathology and this new Virtual Issue presents a selection of papers to reflect the programme content.

Autoimmune disease and neuroinflammation:

Carbonic anhydrase- related protein VIII antibodies and paraneoplastic cerebellar degeneration
R. Höftberger, L. Sabater, F. Velasco, R. Ciordia, J. Dalmau and F. Graus

Natalizumab analogon therapy is effective in a B cell-dependent multiple sclerosis model
D. Häusler, S. Nessler, N. Kruse, W. Brück and I. Metz

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space
O. W. Howell, E. K. Schulz-Trieglaff, D. Carassiti, S. M. Gentleman, R. Nicholas, F. Roncaroli and R. Reynolds

Tumours of the central nervous system:

Diagnostic, prognostic and predictive relevance of molecular markers in gliomas
S. Brandner and A. von Deimling

Landscape of chromosomal copy number aberrations in gangliogliomas and dysembryoplastic neuroepithelial tumours
A. S. Prabowo, H. F. van Thuijl, I. Scheinin, D. Sie, H. F. van Essen, A. M. Iyer, W. G. Spliet, C. H. Ferrier, P. C. van Rijen, T. J. Veersema, M. Thom, A. Y. Schouten-van Meeteren, J. C. Reijneveld, B. Ylstra, P. Wesseling and E. Aronica

K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant transformation extends the histopathological spectrum of the histone H3 oncogenic pathway
N. Joyon, A. Tauziède-Espariat, A. Alentorn, M. Giry, D. Castel, L. Capelle, M. Zanello, P. Varlet and F. Bielle

Vascular disease:

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases
L. Craggs, J. Taylor, J. Y. Slade, A. Chen, C. Hagel, G. Kuhlenbaeumer, A. Borjesson-Hanson, M. Viitanen, H. Kalimo, V. Deramecourt, A. E. Oakley and R. N. Kalaria

Synaptic protein levels altered in vascular dementia
L. I. Sinclair, H. M. Tayler and S. Love

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort
C. J. Garwood, J. E. Simpson, S. Al Mashhadi, C. Axe, S. Wilson, P. R. Heath, P. J. Shaw, F. E. Matthews, C. Brayne, P. G. Ince, S. B. Wharton and on behalf of the MRC Cognitive Function and Ageing Study

Prion disease:

Identification of clinical target areas in the brainstem of prion-infected mice
I. Mirabile, P. S. Jat, S. Brandner and J. Collinge

Subtype and regional regulation of prion biomarkers in sporadic Creutzfeldt-Jakob disease
F. Llorens, S. Zafar, B. Ansoleaga, M. Shafiq, R. Blanco, M. Carmona, O. Grau-Rivera, C. Nos, E. Gelpí, J. A. Del Río, I. Zerr and I. Ferrer

Alzheimer’s disease:

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)- 3β
J. Amin, C. Paquet, A. Baker, A. A. Asuni, S. Love, C. Holmes, J. Hugon, J. A. Nicoll and D. Boche

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic
S. Dujardin, M. Colin and L. Buée

Muscle disease:

Review: Polycomb group genes in the regeneration of the healthy and pathological skeletal muscle
S. Marino and V. Di Foggia

Invited review: Stem cells and muscle diseases: advances in cell therapy strategies
E. Negroni, T. Gidaro, A. Bigot, G. S. Butler-Browne, V. Mouly and C. Trollet

Neurodevelopment:

Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate
J. J. Hutsler and M. F. Casanova

Review: Neuropathological features of unexplained sudden unexpected death in infancy: current evidence and controversies
S. M. Paine, T. S. Jacques and N. J. Sebire

Brain weight in sudden unexpected death in infancy: experience from a large single-centre cohort
A. R. Bamber, S. M. Paine, D. A. Ridout, J. W. Pryce, T. S. Jacques, N. J. Sebire

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Tauopathy: neuropathology and models, March 2016

The symposium entitled Tau Pathobiology and Tau Disorders chaired by Professor Johannes Attems, University of Newcastle, Newcastle, UK and Professor Steve M. Gentleman, Imperial College, London, UK at the 2016 annual meeting of the British Neuropathological Society provides an ideal opportunity to highlight recent publications in Neuropathology and Applied Neurobiology in the field of tau biology. The first paper provides a comprehensive review of frontotemporal lobar degenerations, including tauopathies. Subsequent papers cover neuropathological studies and experimental models extending our understanding of the role of tau in neurodegenerative diseases.

All papers included in this Virtual Issue have been made free-to-access until the end of April 2016.

Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations
Tammaryn Lashley, Jonathan D. Rohrer, Simon Mead and Tamas Revesz

Phosphorylation of tau protein at sites Ser396–404 is one of the earliest events in Alzheimer's disease and Down syndrome
S. Mondragón-Rodríguez, G. Perry, J. Luna-Muñoz, M. C. Acevedo-Aquino and S. Williams

Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β
Jay Amin, Claire Paquet, Alex Baker, Ayodeji A. Asuni, Seth Love, Clive Holmes, Jacques Hugon, James A. R. Nicoll and Delphine Boche

The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments
T. Nishikawa, T. Takahashi, M. Nakamori, N. Hosomi, H. Maruyama, Y. Miyazaki, Y. Izumi and M. Matsumoto

Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice
Hong Xu, Thomas W. Rösler, Thomas Carlsson, Anderson de Andrade, Julius Bruch, Matthias Höllerhage, Wolfgang H. Oertel and Günter U. Höglinger

Early-onset axonal pathology in a novel P301S-Tau transgenic mouse model of frontotemporal lobar degeneration
Janet van Eersel, Claire H. Stevens, Magdalena Przybyla, Amadeus Gladbach, Kristie Stefanoska, Chesed Kai-Xin Chan, Wei-Yi Ong, John R. Hodges, Greg T. Sutherland, Jillian J. Kril, Dorothee Abramowski, Matthias Staufenbiel, Glenda M. Halliday and Lars M. Ittner

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Multiple Sclerosis, December 2015

Neuropathological research in the field of multiple sclerosis continues to provide important insights into the disease pathogenesis. This new virtual issue highlights recently published research in this exciting area.

All papers included in this Virtual Issue have been made free-to-access until the end of June 2016.

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space
Owain W. Howell, Elena Katharina Schulz-Trieglaff, Daniele Carassiti, Steven M. Gentleman, Richard Nicholas, Federico Roncaroli and Richard Reynolds

Natalizumab analogon therapy is effective in a B cell-dependent multiple sclerosis model
Darius Häusler, Stefan Nessler, Niels Kruse, Wolfgang Brück and Imke Metz

The influence of HLA-DRB1*15 on motor cortical pathology in multiple sclerosis
Richard L. Yates, Margaret M. Esiri, Jacqueline Palace, Arunesh Mittal and Gabriele C. DeLuca

Biopsy findings of symptomatic cerebral X-linked adrenoleucodystrophy and histological differentiation from multiple sclerosis
Sabine Pfeifenbring, Louisa von Baumgarten, Ulrich Schüller, Hendrik Rosewich, Dietmar Rudolf Thal, Christian Rainer Wirtz, Martin Hecht, Nicole Angela Terpolilli and Wolfgang Brück

Axonal expression of sodium channels and neuropathology of the plaques in multiple sclerosis
Adel Bouafia, Jean-Louis Golmard, Valerie Thuries, Veronique Sazdovitch, Jean Jacques Hauw, Betrand Fontaine and Danielle Seilhean

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Vascular Pathology, June 2015

Vascular disease is an important area of neuropathology with broad clinical implications. This new virtual issue of Neuropathology and Applied Neurobiology highlights recent publications in the field to complement the British Neuropathological Summer School entitled ‘Cerebrovascular Diseases: Genetics and Pathophysiology’ which takes place in July 2015.

All papers included in this Virtual Issue have been made free-to-access until the end of September 2015.

Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases
Lucinda Craggs, Julie Taylor, Janet Y. Slade, Aiqing Chen, Christian Hagel, Gregor Kuhlenbaeumer, Anne Borjesson-Hanson, Matti Viitanen, Hannu Kalimo, Vincent Deramecourt, Arthur E. Oakley and Raj N. Kalaria

The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy
Mieke de Jager, Max V. Boot, John G.J.M. Bol, John J.P. Brevé, Cornelis A.M. Jongenelen, Benjamin Drukarch and Micha M.M. Wilhelmus

Patterns of cerebral amyloid angiopathy define histopathological phenotypes in Alzheimer's disease
N. Allen, A. C. Robinson, J. Snowden, Y. S. Davidson and D. M. A. Mann

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy
R. O. Carare, C. A. Hawkes, M. Jeffrey, R. N. Kalaria and R. O. Weller

The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease
E. Kövari, F. R. Herrmann, P. R. Hof and C. Bouras

Immunolocalization of platelet-derived growth factor receptor-β (PDGFR-β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Lucinda J.L. Craggs, Richard Fenwick, Arthur E. Oakley, Masafumi Ihara and Raj N. Kalaria

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke
Emma L. Bailey, Martin W. McBride, Wendy Beattie, John D. McClure, Delyth Graham, Anna F. Dominiczak, Cathie L.M. Sudlow, Colin Smith and Joanna M. Wardlaw

Review: environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation physical activity to enhance experience-dependent plasticity
A. J. Hannan

Review: Could neurotransmitters influence neurogenesis and neurorepair after stroke?
E. Sánchez-Mendoza, V. Bellver-Landete, J. J. Merino, M. P. González, R. Martínez-Murillo and M. J. Oset-Gasque

White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
Lucinda J. L. Craggs, Yumi Yamamoto, Masafumi Ihara, Richard Fenwick, Matthew Burke, Arthur E. Oakley, Sigrun Roeber, Marco Duering, Hans Kretzschmar and Raj N. Kalaria

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds
B. M. Janaway, J. E. Simpson, N. Hoggard, J. R. Highley, G. Forster, D. Drew, O. H. Gebril, F. E. Matthews, C. Brayne, S. B. Wharton, P. G. Ince and on behalf of the MRC Cognitive Function and Ageing Neuropathology Study

Synaptic protein levels altered in vascular dementia
Lindsey I. Sinclair, Hannah M. Tayler and Seth Love

Hippocampus and cerebral cortex present a different autophagic response after oxygen and glucose deprivation in an ex vivo rat brain slice model
Diego Pérez-Rodríguez, Berta Anuncibay-Soto, Irene L. Llorente, Carlos C. Pérez-García and Arsenio Fernández-López

Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling
Magdalena Wadowska, Julie Woods, Magdalena Rogozinska and Teresita L. Briones

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia
Emma L. Ashby, James S. Miners, Sathish Kumar, Jochen Walter, Seth Love and Patrick G. Kehoe

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Pathology of Skeletal Muscle, February 2015

This new virtual issue for Neuropathology and Applied Neurobiology provides a selection of recent papers in the field of skeletal muscle pathology. This collection is issued to coincide with the 116th meeting of the British Neuropathological Society to be held at the Institute of Child Health, London, UK, 4-6th March 2015. The meeting symposium, entitled ‘Recent Advances in Muscle Disease’ will include presentations by experts in the field and will culminate with the Alfred Meyer Memorial Lecture, ‘Advances in Mitochondrial Disease and New Therapies’, to be given by Professor Doug Turnbull. The papers selected for this virtual issue complement the lectures to be presented at the symposium.
Janice Holton, Editor-in-Chief

Stem cells and muscle diseases: advances in cell therapy strategies
E. Negroni, T. Gidaro, A. Bigot, GS. Butler-Browne, V. Mouly and C. Trollet

Review: Immune-mediated necrotizing myopathies – a heterogeneous group of diseases with specific myopathological features
W. Stenzel, H.-H. Goebel and E. Aronica

Mitochondrial and inflammatory changes in sporadic Inclusion Body Myositis
Karolina A. Rygiel, James Miller, John P. Grady, Mariana C. Rocha, Robert W. Taylor and Doug M. Turnbull

Overexpression of autophagic proteins in the skeletal muscle of sporadic inclusion body myositis
M. Strippoli, C. Coppola, D. Virgintino, L. Roncali, A. Toscano, L. Serlenga and M. Trojano

Chaperone-mediated autophagy components are upregulated in sporadic inclusion-body myositis muscle fibres
M. Cacciottolo, A. Nogalska, C. D'Agostino, W. K. Engel and V. Askanas

Accumulation of STIM1 is associated with the degenerative muscle fibre phenotype in ALS and other neurogenic atrophies
A. Goswami, CM. Jesse, A. Chandrasekar, E. Bushuven, JT. Vollrath, A. Dreser, I. Katona, C. Beyer, S. Johann, AC. Feller, M. Grond, S. Wagner, S. Nikolin, D. Troost and J. Weis

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Frontotemporal lobar degeneration, August 2014

Welcome to a new virtual issue presenting a selection of papers recently published in Neuropathology and Applied Neurobiology. There have been rapid advances in understanding the neuropathology underlying frontotemporal lobar degeneration and the papers selected for this virtual issue represent the breadth of work in this exciting field.
Janice Holton, Editor-in Chief

A pathogenic progranulin mutation and C9orf72 repeat expansion in a family with frontotemporal dementia
Lashley T, Rohrer JD, Mahoney C et al.

TARDBP mutation p.Ile383Val associated with semantic dementia and complex proteinopathy
Gelpi E, van der Zee J, Turon Estrada A et al.

Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting
Armstrong RA, Hamilton RL, Mackenzie IR et al.

A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)
Armstrong RA, Carter D, Cairns NJ

Frontotemporal lobar degeneration in a very young patient is associated with fused in sarcoma (FUS) pathological changes
Baborie A, Jaros E, Griffiths TD et al.

Transportin 1 colocalization with Fused in Sarcoma (FUS) inclusions is not characteristic for amyotrophic lateral sclerosis- FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from frontotemporal lobar degeneration with FUS inclusions
Troakes C, Hortobágyi T, Vance C et al.

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium
Kovacs GG, Rozemuller AJ, van Swieten JC et al.

Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype
Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z et al.

Memory Deficits Correlate with Tau and Spine Pathology in P301S MAPT Transgenic Mice
Xu H, Rösler TW, Carlsson T, de Andrade A et al.

von Economo neurones are selectively targeted in frontotemporal dementia
Santillo AF, Nilsson C, Englund E