Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task
Liam J Nestor, Anna Murphy, John McGonigle, Csaba Orban, Laurence Reed, Eleanor Taylor, Remy Flechais, Louise M Paterson, Dana Smith, Edward T Bullmore, Karen D Ersche, John Suckling, Roger Tait, Rebecca Elliott, Bill Deakin, Ilan Rabiner, Anne Lingford-Hughes, David J Nutt, Barbara Sahakian, Trevor W Robbins and ICCAM Consortium
Version of Record online: 6 SEP 2016 | DOI: 10.1111/adb.12444
Opioid disturbances within dopamine fronto-striatal reward circuitry may confer an ongoing risk for relapse to drug rewards if there is a diminished incentive value of, and motivation to procure, non-drug rewards. Here, we show that acute naltrexone treatment does not remediate disturbances in fronto-striatal regions during non-drug reward anticipation in long-term abstinent alcoholic and polysubstance-dependent groups.