CYP2A6 metabolism in the development of smoking behaviors in young adults
Emily Olfson, Joseph Bloom, Sarah Bertelsen, John P Budde, Naomi Breslau, Andrew Brooks, Robert Culverhouse, Grace Chan, Li-Shiun Chen, David Chorlian, Danielle M Dick, Howard J Edenberg, Sarah Hartz, Dorothy Hatsukami, Victor M Hesselbrock, Eric O Johnson, John R Kramer, Samuel Kuperman, Jacquelyn L Meyers, John Nurnberger, Bernice Porjesz, Nancy L Saccone, Marc A Schuckit, Jerry Stitzel, Jay A Tischfield, John P Rice, Alison Goate and Laura J Bierut
Version of Record online: 29 DEC 2016 | DOI: 10.1111/adb.12477
This study links variation in a genome-wide significant gene, Cytochrome P450 2A6 (CYP2A6), with smoking behaviors in two independent young adult samples. The results demonstrate that a validated CYP2A6 metabolism metric is not associated with smoking initiation nor the development of daily use, but among young adult daily smokers, slow metabolism is associated with an elevated risk of nicotine dependence, which may be driven by time to first cigarette after waking. These findings elucidate the complex role of CYP2A6 variation in smoking behaviors.