Role of the satiety factor oleoylethanolamide in alcoholism
Ainhoa Bilbao, Antonia Serrano, Andrea Cippitelli, Francisco J. Pavón, Andrea Giuffrida, Juan Suárez, Nuria García-Marchena, Elena Baixeras, Raquel Gómez de Heras, Laura Orio, Francisco Alén, Roberto Ciccocioppo, Benjamin F. Cravatt, Loren H. Parsons, Daniele Piomelli and Fernando Rodríguez de Fonseca
Article first published online: 2 JUN 2015 | DOI: 10.1111/adb.12276
Oleoylethanolamide (OEA) is a satiety factor that binds to the peroxisome proliferator-activated receptor-alpha (PPARα). This bioactive lipid mediator also acts as a homeostatic signal that controls multiple aspects of the physiological adaptations to alcohol exposure. OEA production is triggered by alcohol administration, contributes to the regulation of alcohol consumption and the acute motivational response to alcohol, and reduces the severity of somatic withdrawal symptoms.