Granger causality reveals a dominant role of memory circuit in chronic opioid dependence
Yi Zhang, Qiang Li, Xiaotong Wen, Weiwei Cai, Guanya Li, Jie Tian, Yi Edi Zhang, Jixin Liu, Kai Yuan, Jizheng Zhao, Wei Wang, Zhenyu Zhou, Mingzhou Ding, Mark S. Gold, Yijun Liu and Gene-Jack Wang
Version of Record online: 14 MAR 2016 | DOI: 10.1111/adb.12390
The results revealed stronger effective connectivity between the hippocampus and amygdala implicated in mediating learning-memory, and anterior cingulate cortex involved in mediating inhibitory control while putamen mediated the learned habit, suggesting that the hippocampus and anterior cingulate cortex may propel the memory circuit to override the control circuit and drive the learned habit in heroin-dependent individuals during methadone treatment. The results implicate that the learning-memory and inhibitory control may contribute jointly and form a basis for relapse risk.