Addiction Biology

Cover image for Vol. 20 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Rainer Spanagel, Editor for North America: Markus Heilig

Impact Factor: 5.929

ISI Journal Citation Reports © Ranking: 2013: 1/18 (Substance Abuse); 37/291 (Biochemistry & Molecular Biology)

Online ISSN: 1369-1600

Associated Title(s): Addiction


  1. 1 - 93
  1. Original Articles

    1. From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence

      Simone Kühn, Charlotte Witt, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Christian Büchel, Patricia J. Conrod, Herta Flor, Hugh Garavan, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Tomas Paus, Marcella Rietschel, Michael N. Smolka, Andreas Ströhle, Rüdiger Brühl, Gunter Schumann, Andreas Heinz, Jürgen Gallinat and The IMAGEN Consortium

      Article first published online: 24 APR 2015 | DOI: 10.1111/adb.12240

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      Adolescence is a common time for initiation of alcohol. The neuroanatomical foundation for later alcohol-related problems may already manifest prenatally, particularly due to alcohol consumption during pregnancy. The present data support the idea that alcohol consumption during pregnancy mediates the development of neuroanatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in adolescence. The results stress the importance of prenatal alcohol exposure for later increases in alcohol-use-related problems, mediated by structural brain characteristics.

    2. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function

      Francis Joseph McClernon, Brett Froeliger, Jed E. Rose, Rachel V. Kozink, Merideth A. Addicott, Maggie M. Sweitzer, Eric C. Westman and Dana M. Van Wert

      Article first published online: 22 APR 2015 | DOI: 10.1111/adb.12253

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      We investigated the differential influence of nicotine and non-nicotine smoking factors on working memory and brain function. Smokers were scanned 24-h after wearing a nicotine vs. placebo patch, while smoking either very low nicotine content cigarettes or remaining abstinent. Following placebo (vs. nicotine) administration, accuracy on the N-back working memory task was significantly worse and task-related BOLD signal lower in dorsomedial frontal cortex, irrespective of smoking condition. These data provide novel evidence on the cause of withdrawal-induced changes in neurocognition.

  2. Invited Reviews

    1. Effects of drugs of abuse on the central neuropeptide Y system

      Joana Gonçalves, João Martins, Sofia Baptista, António Francisco Ambrósio and Ana Paula Silva

      Article first published online: 22 APR 2015 | DOI: 10.1111/adb.12250

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      Neuropeptide Y (NPY) is involved in several neuropathologies including addiction. Here we comprehensively and systematically review alterations on the central NPY system induced by several drugs. Overall, expression and function of NPY and its receptors are changed under conditions of drug exposure. Further, manipulation of the NPY system seems to be a potential target to counteract neural alterations, addiction-related behaviors and cognitive deficits induced by these drugs.

  3. Original Articles

    1. White matter connectivity and Internet gaming disorder

      Bum Seok Jeong, Doug Hyun Han, Sun Mi Kim, Sang Won Lee and Perry F. Renshaw

      Article first published online: 20 APR 2015 | DOI: 10.1111/adb.12246

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      Subjects with internet gaming disorder (IGD) had increased Fractional FA values within forceps minor, right anterior thalamic radiation, right corticospinal tract, right inferior longitudinal fasciculus (ILF), right cingulum to hippocampus, and right inferior front-occipital fasciculus (IFOF) as well as parallel decreases in RD value within forceps minor, right anterior thalamic radiation, and IFOF, relative to healthy control subjects. increased myelination (increased FA and decreased RD values) in right-sided frontal fiber tracts may be the result of extended game play.

    2. Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats

      Robyn Mary Brown, Andrezza K. Kim, Shaun Yon-Seng Khoo, Jee Hyun Kim, Bianca Jupp and Andrew John Lawrence

      Article first published online: 20 APR 2015 | DOI: 10.1111/adb.12251

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      We used the orexin-1 (OX1) receptor antagonist SB-334867 to examine the role of prelimbic cortex and ventral tegmental area OX1 receptors in cue-induced reinstatement of ethanol-seeking. SB-334867 infused into the prelimbic cortex attenuated cue-induced reinstatement of ethanol-seeking, but not sucrose-seeking. OX1 antagonism in the ventral tegmental area also attenuated cue-induced reinstatement of ethanol-seeking. These findings suggest that OX1 receptors located in the prelimbic cortex and ventral tegmental area are part of a circuit driving cue-mediated ethanol-seeking behavior.

    3. Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder

      Jin-Tao Zhang, Yuan-Wei Yao, Chiang-Shan R. Li, Yu-Feng Zang, Zi-Jiao Shen, Lu Liu, Ling-Jiao Wang, Ben Liu and Xiao-Yi Fang

      Article first published online: 20 APR 2015 | DOI: 10.1111/adb.12247

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      In comparison to health controls, Internet Gaming Disorder subjects (IGDs) exhibited enhanced resting-state functional connectivity (rsFC) between the anterior insula and anterior cingulate cortex, putamen, angular gyrus, and precuneous, which are involved in salience, craving, self-monitoring, and attention. IGDs also demonstrated significantly stronger rsFC between the posterior insula and postcentral gyrus, precentral gyrus, and supplemental motor area, which are involved in interoception and movement control. These findings highlighted the importance to examine functional abnormalities of the anterior and posterior insula separately in IGDs.

  4. Commentary

  5. Original Articles

    1. Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex

      Betina González, Celeste Rivero-Echeto, Javier A. Muñiz, Jean Lud Cadet, Edgar García-Rill, Francisco J. Urbano and Verónica Bisagno

      Article first published online: 14 APR 2015 | DOI: 10.1111/adb.12249

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      Repeated exposure to methamphetamine (METH) can alter medial prefrontal cortex (mPFC) dependent functions. Here, we show that METH withdrawal depressed voltage-dependent calcium currents (ICa), increased IH amplitude and the paired-pulse ratio of evoked EPSCs in pyramidal mPFC neurons. These effects were blocked by the D1/D5 receptor antagonist SCH23390. In vitro bath-applied METH was able to emulate its systemic effects. We also found that METH altered mRNA expression of voltage-gated calcium channels, Hcn1, Hcn2 and glutamate receptors subunits in mPFC.

    2. Pharmacological reduction of adult hippocampal neurogenesis modifies functional brain circuits in mice exposed to a cocaine conditioned place preference paradigm

      Estela Castilla-Ortega, Eduardo Blanco, Antonia Serrano, David Ladrón de Guevara-Miranda, María Pedraz, Guillermo Estivill-Torrús, Francisco Javier Pavón, Fernando Rodríguez de Fonseca and Luis J. Santín

      Article first published online: 14 APR 2015 | DOI: 10.1111/adb.12248

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      We investigated the role of adult hippocampal neurogenesis in the cocaine-induced conditioned place preference (CPP) paradigm and the functional brain circuitry involved. The neurogenesis-reduced mice showed normal CPP acquisition but engaged an alternate brain network where the functional connectivity of the dentate gyrus was decreased. Moreover, neurogenesis reduction delayed extinction of CPP behaviour and enhanced its cocaine-primed reinstatement. The results show that adult hippocampal neurogenesis sculpts the addiction-related functional brain circuits, and reduction of the adult-born hippocampal neurons increases cocaine-seeking.

    3. Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort

      Toni-Kim Clarke, Andrew H. Smith, Joel Gelernter, Henry R. Kranzler, Lindsay A. Farrer, Lynsey S. Hall, Ana M. Fernandez-Pujals, Donald J. MacIntyre, Blair H. Smith, Lynne J. Hocking, Sandosh Padmanabhan, Caroline Hayward, Pippa A. Thomson, David J. Porteous, Ian J. Deary and Andrew M. McIntosh

      Article first published online: 10 APR 2015 | DOI: 10.1111/adb.12245

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      Two independent polygenic profile scores for alcohol dependence were tested for association with alcohol consumption and measures of cognitive ability in 9863 members Generation Scotland, recruited from the general population. Polygenic profile scores were positively associated with alcohol consumption and negatively associated with several measures of cognitive ability, including verbal fluency, Mill Hill vocabulary and digit symbol coding. Individuals who carried more alcohol dependence risk alleles consumed more alcohol and performed worse on tests of cognitive ability, however the effect sizes were small.

    4. Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?

      Amy B. Hart, Kevin G. Lynch, Lindsay Farrer, Joel Gelernter and Henry R. Kranzler

      Article first published online: 1 APR 2015 | DOI: 10.1111/adb.12244

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      In this study, we sought to test whether specific alcohol dependence criteria contributed to associations between ADH1B gene variants and alcohol use disorders. The largest contributions came from criteria that reflect neuroadaptation, with tolerance being most significant for the association with rs2066702 in AAs and withdrawal being the most significant contributor to the association with rs1229984 in EAs. We replicated the findings for rs2066702 and tolerance in an independent sample. ADH1B appears to influence the neuroadaptation to heavy drinking.

    5. Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence

      Maria Garbusow, Daniel J. Schad, Miriam Sebold, Eva Friedel, Nadine Bernhardt, Stefan P. Koch, Bruno Steinacher, Norbert Kathmann, Dirk E. M. Geurts, Christian Sommer, Dirk K. Müller, Stephan Nebe, Sören Paul, Hans-Ulrich Wittchen, Ulrich S. Zimmermann, Henrik Walter, Michael N. Smolka, Philipp Sterzer, Michael A. Rapp, Quentin J. M. Huys, Florian Schlagenhauf and Andreas Heinz

      Article first published online: 1 APR 2015 | DOI: 10.1111/adb.12243

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      To date mechanisms by which contextual stimuli promote relapse in detoxified alcohol-dependent patients have not been elucidated. One hypothesis is that contextual stimuli stimulate the motivation to drink (Pavlovian-to-Instrumental-Transfer; PIT) via associated brain regions like the ventral striatum and thus promote relapse. Using a PIT paradigm during fMRI, we observed that PIT-related Nucleus Accumbens activation was associated with and predictive of relapse during a three months follow up period in detoxified alcohol-dependent patients.

    6. Increased corticolimbic connectivity in cocaine dependence versus pathological gambling is associated with drug severity and emotion-related impulsivity

      Oren Contreras-Rodríguez, Natalia Albein-Urios, Raquel Vilar-López, Jose C. Perales, Jose M. Martínez-Gonzalez, Maria J. Fernández-Serrano, Oscar Lozano-Rojas, Luke Clark and Antonio Verdejo-García

      Article first published online: 29 MAR 2015 | DOI: 10.1111/adb.12242

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      Global and seed-based functional connectivity analyses were applied to contrast corticolimbic reward networks in individuals with cocaine dependence (CD) versus pathological gamblers (PG). CD exhibited increased global connectivity in a large-scale ventral corticostriatal network relative to PG. CD also displayed increased seed-based connectivity between the orbitofrontal cortex and the subgenual cingulate cortex, and between the caudate nucleus and the lateral prefrontal cortex relative to PG. Orbitofrontal-subgenual cingulate cortical connectivity correlated with impulsivity and caudate-amygdala connectivity correlated with cocaine severity.

    7. Effect of dehydroepiandrosterone add-on therapy on mood, decision making and subsequent relapse of polydrug users

      David Ohana, Rachel Maayan, Yael Delayahu, Paola Roska, Alexander M. Ponizovsky, Abraham Weizman, Gal Yadid and Eldad Yechiam

      Article first published online: 26 MAR 2015 | DOI: 10.1111/adb.12241

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      We examined the effect of dehydroepiandrosterone (DHEA) on relapse to drug usage in adult poly-drug users taking part in a detoxification program. Top pane: In a 16 months follow-up, we found that re-use rates in the DHEA condition were about a third compared to placebo (12% versus 38%). Bottom pane: Compared to their counter-parts, individuals who re-used drugs, had lower levels of DHEA-S following 1 month of treatment (t(34) = 2.34, p =.03). Error terms denote standard errors.

    8. Increased ventral-striatal activity during monetary decision making is a marker of problem poker gambling severity

      Damien Brevers, Xavier Noël, Qinghua He, James A. Melrose and Antoine Bechara

      Article first published online: 17 MAR 2015 | DOI: 10.1111/adb.12239

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      During monetary decision-making, and as compared with controls, poker players exhibited higher ventral striatal connectivity in the left posterior cingulate cortex (pathway-a.), the occipital fusiform gyrus (pathway-b.), and the middle/superior temporal gyrus (pathway-c.). In poker players, scores of problem gambling severity were positively associated with connectivity between the ventral striatal seed and the occipital fusiform and middle temporal gyri. Hence, the more severe an individual's gambling problem is, the more monetary decision-making is underlined by bottom-up reward-salient processes.

    9. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines

      Joachim D. Uys, Natalie S. McGuier, Justin T. Gass, William C. Griffin III, Lauren E. Ball and Patrick J. Mulholland

      Article first published online: 17 MAR 2015 | DOI: 10.1111/adb.12238

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      Alcoholism is a chronic relapsing brain disease characterized by neuropathological changes and the inability to limit drinking, yet the underlying neural mechanisms remain unknown. Using multiplexed quantitative proteomics, we found that chronic intermittent ethanol (CIE) exposure dysregulated proteins expressed at tetrapartite synapses that critically regulate cellular morphology. We also found that CIE exposure altered dendrite diameter and dendritic spine density and morphology. These experiments identified novel PSD proteins that drive maladaptive structural plasticity of NAc neurons in ethanol dependent mice.

    10. Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference

      Sui-Jun Guo, Yu Cui, Zhen-Zhen Huang, Huan Liu, Xue-Qin Zhang, Jin-Xiang Jiang and Wen-Jun Xin

      Article first published online: 10 MAR 2015 | DOI: 10.1111/adb.12236

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      In this study, we investigated the dynamic adaptation of orexin A released from the LHA projecting neurons into the DG in the DG and its functional significance in the acquisition, expression, maintenance of and relapse to rewarding behavior induced by morphine. Meanwhile, the significant increase of the phosphorylation of AKT in the DG was associated with preference for the morphine-paired chamber in rats, which was reversed by the local administration of an OXR1 antagonist.

    11. Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit/hyperactivity disorder

      Annabeth P. Groenman, Corina U. Greven, Marjolein M. J. van Donkelaar, Arnt Schellekens, Kimm J. E. van Hulzen, Nanda Rommelse, Catharina A. Hartman, Pieter J. Hoekstra, Marjolein Luman, Barbara Franke, Stephen V. Faraone, Jaap Oosterlaan and Jan K. Buitelaar

      Article first published online: 6 MAR 2015 | DOI: 10.1111/adb.12230

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      Several neurobiological pathways have been implicated in both ADHD and SUDs, including dopamine and serotonin pathways. We hypothesized that variations in dopamine and serotonin neurotransmission genes were involved in the genetic liability to develop SUDs/nicotine dependence in ADHD. The serotonin genetic risk score significantly predicted alcohol use severity in ADHD. While the focus of the literature so far has been mostly on dopamine, our study suggests that serotonin may also play a role in the relationship between these disorders.

    12. Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene

      Jacob T. Beckley, Patrick K. Randall, Rachel J. Smith, Benjamin A. Hughes, Peter W. Kalivas and John J. Woodward

      Article first published online: 6 MAR 2015 | DOI: 10.1111/adb.12235

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      We report that toluene, a volatile solvent intentionally inhaled for its intoxicating effects, differentially alters glutamatergic synaptic transmission on medium spiny neurons (MSN) in the rat nucleus accumbens (NAc). Using partial least squares discriminative analysis to classify neurons by their electrophysiological properties, we show that toluene induces an endocannbinoid-mediated long-term depression of AMPA-mediated currents in only one subtype of NAc MSN neurons. Using immunohistochemistry, we verify that these neurons are the indirect pathway dopamine D2 receptor MSNs.

    13. White matter integrity in young smokers: a tract-based spatial statistics study

      Dahua Yu, Kai Yuan, Baohua Zhang, Jixin Liu, Minghao Dong, Chenwang Jin, Lin Luo, Jinquan Zhai, Ling Zhao, Ying Zhao, Yu Gu, Ting Xue, Xin Liu, Xiaoqi Lu, Wei Qin and Jie Tian

      Article first published online: 5 MAR 2015 | DOI: 10.1111/adb.12237

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      Tract-based spatial statistics (TBSS) was employed to investigate the WM microstructure in young smokers by integrating multiple indices. Compared with healthy non-smoking controls, young smokers showed significantly increased fractional anisotropy (FA) with increased axial diffusivity (AD) and decreased radial diffusivity (RD) in the right posterior limb of the internal capsule (PLIC), the right external capsule (EC) and the right superior corona radiata (SCR). It may be the biomarker as the cumulative effect and severity of nicotine dependence.

    14. Abnormal white matter structural networks characterize heroin-dependent individuals: a network analysis

      Ruibin Zhang, Guihua Jiang, Junzhang Tian, Yingwei Qiu, Xue Wen, Andrew Zalesky, Meng Li, Xiaofen Ma, Junjing Wang, Shumei Li, Tianyue Wang, Changhong Li and Ruiwang Huang

      Article first published online: 4 MAR 2015 | DOI: 10.1111/adb.12234

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      To examine the alterations of brain white matter (WM) connectivity in heroin dependent individuals (HDIs), we constructed brain white matter structural networks for 20 HDIs and 18 healthy controls, and analyzed the topological properties according to graph theory. The HDIs showed increased global integration (increased Eglob and Sp, decreased Lp), accompany with increased WM connections in the orbital frontal cortex, prefrontal cortex, and anterior cingulate gyrus. These results may suggest the disruption of brain WM structural network in HDIs.

    15. mGluR5 in the nucleus accumbens shell regulates morphine-associated contextual memory through reactive oxygen species signaling

      Chong Qi, Xinjuan Wang, Feifei Ge, Yijing Li, Fang Shen, Junkai Wang and Cailian Cui

      Article first published online: 3 MAR 2015 | DOI: 10.1111/adb.12222

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      Working model for the signal transduction pathway involved in the retrieval of morphine-associated contextual memory in the nucleus accumbens (NAc) shell. When rats were exposed to the morphine-associated contextual cues, an abnormally high amount of glutamate was released into the NAc shell. This resulted in enhanced activation of metabotropic glutamate receptor 5 (mGluR5), leading to inositol-1,4,5-trisphosphate (IP3)-mediated Ca2+ release and production of reactive oxygen species (ROS). Moreover, the protein kinases, might be implicated in the further ROS-related synaptic plasticity.

    16. Abnormal gray matter volume and resting-state functional connectivity in former heroin-dependent individuals abstinent for multiple years

      Lubin Wang, Feng Zou, Tianye Zhai, Yu Lei, Shuwen Tan, Xiao Jin, Enmao Ye, Yongcong Shao, Yihong Yang and Zheng Yang

      Article first published online: 26 FEB 2015 | DOI: 10.1111/adb.12228

    17. ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers

      Yan Sun, Li-Yan Zhao, Gui-Bin Wang, Wei-Hua Yue, Yong He, Ni Shu, Qi-Xiang Lin, Fan Wang, Jia-Li Li, Na Chen, Hui-Min Wang, Thomas R. Kosten, Jia-Jia Feng, Jun Wang, Yu-De Tang, Shu-Xue Liu, Gui-Fa Deng, Gan-Huan Diao, Yun-Long Tan, Hong-Bin Han, Lu Lin and Jie Shi

      Article first published online: 24 FEB 2015 | DOI: 10.1111/adb.12233

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      We assessed the association between psychosis risk variants in ZNF804A and heroin addiction in 1,035 heroin abusers and 2,887 controls. The genetic effects on neurocognitive performance and gray matter volume were also studied in the subgroups. Our findings revealed several ZNF804A intronic variants were significantly associated with the risk of heroin addiction, and these variants affected decision making and gray matter volume in heroin abusers.

    18. Functional consequences of cocaine expectation: findings in a non-human primate model of cocaine self-administration

      Linda J. Porrino, Thomas J. R. Beveridge, Hilary R. Smith and Michael A. Nader

      Article first published online: 15 FEB 2015 | DOI: 10.1111/adb.12231

  6. Special Issue

    1. Diffusion tensor imaging reveals adolescent binge ethanol-induced brain structural integrity alterations in adult rats that correlate with behavioral dysfunction

      Ryan P. Vetreno, Richard Yaxley, Beatriz Paniagua and Fulton T. Crews

      Article first published online: 11 FEB 2015 | DOI: 10.1111/adb.12232

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      Binge drinking is common during adolescence and can have deleterious effects on brain maturation. Using diffusion tensor imaging (DTI), we discovered that adolescent rats exposed to the adolescent intermittent ethanol (AIE) model of human binge drinking alters adult brain structural integrity in the cerebellum, corpus callosum, hippocampus, and neocortex. AIE increased anxiety-like behavior and impaired object recognition memory, which was correlated with DTI. Thus, AIE treatment caused long-term changes to brain structural integrity that could contribute to cognitive dysfunction.

  7. Original Articles

    1. The impact of cognitive impairment and impulsivity on relapse of alcohol-dependent patients: implications for psychotherapeutic treatment

      Marta Czapla, Joe J. Simon, Barbara Richter, Matthias Kluge, Hans-Christoph Friederich, Stephan Herpertz, Karl Mann, Sabine C. Herpertz and Sabine Loeber

      Article first published online: 11 FEB 2015 | DOI: 10.1111/adb.12229

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      The present study demonstrated that alcohol dependent patients showed poorer performance in response initiation, response inhibition, complex sustained attention and executive functions compared to healthy controls. The strongest predictor for relapse was the interaction between the number of previous detoxifications and response inhibition deficits. Patients with many previous detoxifications and large deficits in response inhibition showed the highest relapse risk. These findings emphasise the importance of more specific interventions addressing inhibition control.

    2. You have full text access to this OnlineOpen article
      Reflection impulsivity in binge drinking: behavioural and volumetric correlates

      Paula Banca, Iris Lange, Yulia Worbe, Nicholas A. Howell, Michael Irvine, Neil A. Harrison, Michael Moutoussis and Valerie Voon

      Article first published online: 11 FEB 2015 | DOI: 10.1111/adb.12227

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      This study investigates decision impulsivity in binge drinking using the Beads task, the Information Sampling Task (IST) and a delay discounting task. Greater impulsivity in the Beads task is associated with smaller dorsolateral prefrontal and inferior parietal volumes whereas in the IST is associated with greater dorsal cingulate and precuneus volumes. Binge drinking is characterized by impaired reflection impulsivity suggesting deficits in deciding on the basis of future outcomes that are more difficult to represent.

    3. The cerebellum on cocaine: plasticity and metaplasticity

      Dolores Vazquez-Sanroman, Ketty Leto, Miguel Cerezo-Garcia, María Carbo-Gas, Carla Sanchis-Segura, Daniela Carulli, Ferdinando Rossi and Marta Miquel

      Article first published online: 26 JAN 2015 | DOI: 10.1111/adb.12223

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      The present study demonstrated that a repeated regimen with cocaine that was able to induce motor sensitization in 60% of the cocaine-treated mice produced dramatic modifications in cerebellar neuroplasticity. Overall, cocaine-dependent effects lead to an inhibitory Purkinje function impairment and lower probability of remodelling in Purkinje synapses due to an up-regulation of extracellular matrix components in the perineuronal nets surrounding medial nuclear neurons.

    4. Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: a multi-channel near-infrared spectroscopy study

      Naohiro Okada, Katsuyoshi Takahashi, Yukika Nishimura, Shinsuke Koike, Ayaka Ishii-Takahashi, Eisuke Sakakibara, Yoshihiro Satomura, Akihide Kinoshita, Ryu Takizawa, Shingo Kawasaki, Mayumi Nakakita, Toshiyuki Ohtani, Yuji Okazaki and Kiyoto Kasai

      Article first published online: 26 JAN 2015 | DOI: 10.1111/adb.12224

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      Few studies have characterized brain dysfunction associated with methamphetamine-associated psychosis (MAP). We compared prefrontal cortical activity associated with stop-signal inhibitory task in patients with MAP, patients with schizophrenia and healthy controls, using near-infrared spectroscopy (NIRS). Both the MAP and schizophrenia groups showed significantly reduced activation in the bilateral ventrolateral prefrontal cortex compared to controls; however, only the MAP group showed reduced activation in the frontopolar cortex. These findings characterize similarities and differences in prefrontal cortical dysfunction between MAP and schizophrenia.

    5. Adenosine 2A receptors modulate reward behaviours for methamphetamine

      Rose Chesworth, Robyn M. Brown, Jee Hyun Kim, Catherine Ledent and Andrew J. Lawrence

      Article first published online: 22 JAN 2015 | DOI: 10.1111/adb.12225

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      Methamphetamine (METH) conditioned place preference was absent in adenosine A2A KO mice compared to wildtype littermates (WT). Intravenous self-administration of METH was intact in A2A KO mice; however, the motivation to self-administer was reduced in A2A KO mice compared to WT. Sucrose self-administration was also reduced in A2A KO mice, but only at higher schedules of reinforcement. These data suggest A2A signalling is critically required to integrate rewarding and motivational strength of drug and natural rewards.

  8. Invited Reviews

    1. Common single nucleotide variants underlying drug addiction: more than a decade of research

      Kora-Mareen Bühler, Elena Giné, Victor Echeverry-Alzate, Javier Calleja-Conde, Fernando Rodriguez de Fonseca and Jose Antonio López-Moreno

      Article first published online: 21 JAN 2015 | DOI: 10.1111/adb.12204

  9. Original Articles

    1. Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients

      Corinde E. Wiers, Vera U. Ludwig, Thomas E. Gladwin, Soyoung Q. Park, Andreas Heinz, Reinout W. Wiers, Mike Rinck, Johannes Lindenmeyer, Henrik Walter and Felix Bermpohl

      Article first published online: 13 JAN 2015 | DOI: 10.1111/adb.12221

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      To investigate neural effects of Cognitive Bias Modification (CBM), 26 male alcohol-dependent patients performed either 3 weeks of CBM (N=13; 90% alcohol push) or placebo training (N=13; 50% alcohol push). After training, patients in the CBM group showed stronger reductions in medial prefrontal cortex activation while approaching versus avoiding alcohol cues compared with the placebo group, which correlated with reductions in behavioral approach tendencies. Reductions in medial prefrontal cortex activation may be important for the clinical effectiveness of CBM.

    2. You have full text access to this OnlineOpen article
      Heritability of compulsive Internet use in adolescents

      Jacqueline M. Vink, Toos C. E. M. van Beijsterveldt, Charlotte Huppertz, Meike Bartels and Dorret I. Boomsma

      Article first published online: 13 JAN 2015 | DOI: 10.1111/adb.12218

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      A life without internet is almost impossible nowadays so it is important to explore the determinants of compulsive internet use (CIU). The time spent on specific internet activities differed between sexes: adolescent boys spent more time on gaming (especially if high CIU-score) while girls spent more time on social network sites. The heritability estimates for CIU were the same for boys and girls: 48%. The remaining variance was due to unique environmental factors. No contribution of shared (family) environment was observed.

    3. Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration

      Daniele Caprioli, Tamara Zeric, Eric B. Thorndike and Marco Venniro

      Article first published online: 12 JAN 2015 | DOI: 10.1111/adb.12220

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      The majority of male rats given a choice between cocaine and palatable food prefer the non-drug reward. We used a discrete choice procedure to determine palatable food versus methamphetamine preference in rats with a history of methamphetamine self-administration. Independent of the daily drug access conditions and withdrawal period, the rats strongly preferred the palatable food over methamphetamine, even after a priming injections or a satiation manipulation. Escalated methamphetamine intake or the progressive-ratio responding for the drug did not predict preference.

  10. Reviews

  11. Original Articles

    1. Nicotine produces chronic behavioral sensitization with changes in accumbal neurotransmission and increased sensitivity to re-exposure

      Julia Morud, Louise Adermark, Marta Perez-Alcazar, Mia Ericson and Bo Söderpalm

      Article first published online: 8 JAN 2015 | DOI: 10.1111/adb.12219

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      Tobacco use is often associated with long-term addiction as well as high risk of relapse. This is suggestive of persistent neural adaptations. In order to investigate the long-term effects of nicotine exposure rats were treated for three weeks with nicotine, and the duration of behavioral and neurophysiological adaptations were evaluated seven months later. We found that drug-induced locomotion persisted seven months after drug exposure together with altered synaptic activity and in vitro response to quinpirole.

    2. Glutamatergic and neurometabolic alterations in chronic cocaine users measured with 1H-magnetic resonance spectroscopy

      Lea M. Hulka, Milan Scheidegger, Matthias Vonmoos, Katrin H. Preller, Markus R. Baumgartner, Marcus Herdener, Erich Seifritz, Anke Henning and Boris B. Quednow

      Article first published online: 30 DEC 2014 | DOI: 10.1111/adb.12217

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      Glutamate and glutamine levels in the pgACC and the rDLPFC measured with 1H-MRS did not differ between cocaine users and controls but higher weekly cocaine use and cocaine hair concentrations were associated with lower glutamine/creatine in the pgACC. Cocaine users exhibited higher glucose/creatine than controls in the pgACC and higher choline/creatine in the pgACC and rDLPFC. Thus, cocaine use is associated with altered glucose metabolism and membrane turnover and appears to decrease glutamine levels indicating changes in glutamate cycling.

    3. Correlation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol

      Vincent Didone, Sébastien Masson, Caroline Quoilin, Vincent Seutin and Etienne Quertemont

      Article first published online: 24 DEC 2014 | DOI: 10.1111/adb.12216

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      The present study tested whether in vivo ethanol locomotor sensitization correlates with changes in either basal or ethanol-evoked firing rates of dopamine neurons in vitro in mice. Higher spontaneous basal firing rates of dopamine neurons were observed in ethanol sensitized mice relative to control mice, but without correlations with the behavioral effects. Ethanol-evoked firing rates of dopamine neurons were of higher magnitude in ethanol sensitized mice. Furthermore, this sensitization of dopamine neuron activity was significantly correlated with ethanol behavioral sensitization.

    4. Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal

      Daniel García-Pérez, Cristina Núñez, M. Luisa Laorden and M. Victoria Milanés

      Article first published online: 17 DEC 2014 | DOI: 10.1111/adb.12209

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      Dopamine is thought to represent a teaching signal and has been implicated in the induction of addictive behaviours. Increased Nurr1 and/or Pitx3 levels during morphine dependence and in morphine-withdrawn rats were associated to an increase of DAT, VMAT2 and DRD2, indicating that morphine dependence and withdrawal induced consistent alterations of most of the dopaminergic markers. Thus, Nurr1 and Pitx3 regulation might be associated with controlling adaptation to morphine dependence-induced alterations of DA neurons activity in the mesolimbic pathway.

    5. Differential regulation of mGlu5R and ΜOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice

      Polymnia Georgiou, Panos Zanos, Mazdak Ehteramyan, Susanna Hourani, Ian Kitchen, Rafael Maldonado and Alexis Bailey

      Article first published online: 17 DEC 2014 | DOI: 10.1111/adb.12208

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      This study assessed the modulation of metabotropic glutamate receptor 5 (mGlu5R) and μ-opioid receptors (MOPr) in a mouse model of cue- and priming-induced reinstatement of cocaine-seeking. We showed that priming- but not cue-induced reinstatement upregulates mGlu5R and MOPr binding in the nucleus accumbens and basolateral amygdala respectively, whilst cue- but not priming-induced reinstatement downregulates MOPr binding in caudate putamen and nucleus accumbens. We provide direct evidence of reinstatement-induced receptor alterations that are likely to contribute to the neurobiology of relapse.

    6. Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking

      Henry R. Kranzler, Stephen Armeli, Reagan Wetherill, Richard Feinn, Howard Tennen, Joel Gelernter, Jonathan Covault and Timothy Pond

      Article first published online: 15 DEC 2014 | DOI: 10.1111/adb.12207

    7. Linear pharmacokinetics of 3,4-methylenedioxypyrovalerone (MDPV) and its metabolites in the rat: relationship to pharmacodynamic effects

      Sebastien Anizan, Marta Concheiro, Kurt R. Lehner, Mohammad O. Bukhari, Masaki Suzuki, Kenner C. Rice, Michael H. Baumann and Marilyn A. Huestis

      Article first published online: 5 DEC 2014 | DOI: 10.1111/adb.12201

    8. Brain function during cognitive flexibility and white matter integrity in alcohol-dependent patients, problematic drinkers and healthy controls

      Jochem M. Jansen, Ruth J. van Holst, Wim van den Brink, Dick J. Veltman, Matthan W. A. Caan and Anna E. Goudriaan

      Article first published online: 5 DEC 2014 | DOI: 10.1111/adb.12199

    9. You have full text access to this OnlineOpen article
      The role of ghrelin signalling for sexual behaviour in male mice

      Emil Egecioglu, Luna Prieto-Garcia, Erik Studer, Lars Westberg and Elisabet Jerlhag

      Article first published online: 4 DEC 2014 | DOI: 10.1111/adb.12202

  12. Reviews

    1. Recent updates on incubation of drug craving: a mini-review

      Xuan Li, Daniele Caprioli and Nathan J. Marchant

      Article first published online: 1 DEC 2014 | DOI: 10.1111/adb.12205

  13. Original Articles

    1. Reduced striatal dopamine transporter density associated with working memory deficits in opioid-dependent male subjects: a SPECT study

      Chih-Sung Liang, Pei-Shen Ho, Che-Hung Yen, Yi-Wei Yeh, Shin-Chang Kuo, Chang-Chih Huang, Chun-Yen Chen, Mei-Chen Shih, Kuo-Hsing Ma and San-Yuan Huang

      Article first published online: 1 DEC 2014 | DOI: 10.1111/adb.12203

    2. Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization

      Bethania Mongi-Bragato, Emiliano Zamponi, Constanza García-Keller, María Amparo Assis, Miriam B. Virgolini, Daniel H. Mascó, Andreas Zimmer and Liliana M. Cancela

      Article first published online: 27 NOV 2014 | DOI: 10.1111/adb.12200

    3. Adolescent pre-treatment with oxytocin protects against adult methamphetamine-seeking behavior in female rats

      Callum Hicks, Jennifer L. Cornish, Sarah J. Baracz, Anastasia Suraev and Iain S. McGregor

      Article first published online: 17 NOV 2014 | DOI: 10.1111/adb.12197

    4. Oxytocin in the nucleus accumbens core reduces reinstatement of methamphetamine-seeking behaviour in rats

      Sarah J. Baracz, Nicholas A. Everett, Iain S. McGregor and Jennifer L. Cornish

      Article first published online: 16 NOV 2014 | DOI: 10.1111/adb.12198

    5. Methamphetamine induces a rapid increase of intracellular Ca++ levels in neurons overexpressing GCaMP5

      Seong-Jin Yu, Kou-Jen Wu, Eun K. Bae, Man-Jung Hsu, Christopher T. Richie, Brandon K. Harvey and Yun Wang

      Article first published online: 6 NOV 2014 | DOI: 10.1111/adb.12193

    6. Biobehavioral mechanisms of topiramate's effects on alcohol use: an investigation pairing laboratory and ecological momentary assessments

      Robert Miranda Jr., James MacKillop, Hayley Treloar, Alexander Blanchard, Jennifer W. Tidey, Robert M. Swift, Thomas Chun, Damaris J. Rohsenow and Peter M. Monti

      Article first published online: 29 OCT 2014 | DOI: 10.1111/adb.12192

    7. Dissociation of μ-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice

      Lara S. Hwa, Akiko Shimamoto, Tala Kayyali, Kevin J. Norman, Rita J. Valentino, Joseph F. DeBold and Klaus A. Miczek

      Article first published online: 28 SEP 2014 | DOI: 10.1111/adb.12189

    8. Abuse potential and adverse cognitive effects of mitragynine (kratom)

      Nurul H. M. Yusoff, Farah W. Suhaimi, Raja K. Vadivelu, Zurina Hassan, Anne Rümler, Andrea Rotter, Davide Amato, Hans C. Dringenberg, Sharif M. Mansor, Visweswaran Navaratnam and Christian P. Müller

      Article first published online: 28 SEP 2014 | DOI: 10.1111/adb.12185

    9. Social defeat in adolescent mice increases vulnerability to alcohol consumption

      Marta Rodriguez-Arias, Francisco Navarrete, Maria Carmen Blanco-Gandia, Maria Carmen Arenas, Adrián Bartoll-Andrés, Maria A. Aguilar, Gabriel Rubio, José Miñarro and Jorge Manzanares

      Article first published online: 14 SEP 2014 | DOI: 10.1111/adb.12184

    10. Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study

      Qiang Li, Wei Li, Hanyue Wang, Yarong Wang, Yi Zhang, Jia Zhu, Ying Zheng, Dongsheng Zhang, Lina Wang, Yongbin Li, Xuejiao Yan, Haifeng Chang, Min Fan, Zhe Li, Jie Tian, Mark S. Gold, Wei Wang and Yijun Liu

      Article first published online: 11 SEP 2014 | DOI: 10.1111/adb.12182

    11. Molecular basis of reduced birth weight in smoking pregnant women: mitochondrial dysfunction and apoptosis

      Glòria Garrabou, Ana-Sandra Hernàndez, Marc Catalán García, Constanza Morén, Ester Tobías, Sarai Córdoba, Marta López, Francesc Figueras, Josep M. Grau and Francesc Cardellach

      Article first published online: 3 SEP 2014 | DOI: 10.1111/adb.12183

    12. Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging

      Mateusz Dudek, Usama Abo-Ramadan, Derik Hermann, Matthew Brown, Santiago Canals, Wolfgang H. Sommer and Petri Hyytiä

      Article first published online: 22 AUG 2014 | DOI: 10.1111/adb.12179

    13. Memantine reduces alcohol drinking but not relapse in alcohol-dependent rats

      Stéphanie Alaux-Cantin, Romain Buttolo, Hakim Houchi, Jérôme Jeanblanc and Mickaël Naassila

      Article first published online: 20 AUG 2014 | DOI: 10.1111/adb.12177

    14. Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood

      Matthew O. Parker, Alexandra M-D. Evans, Alistair J. Brock, Fraser J. Combe, Muy-Teck Teh and Caroline H. Brennan

      Article first published online: 19 AUG 2014 | DOI: 10.1111/adb.12176

    15. Elevated dopamine in the medial prefrontal cortex suppresses cocaine seeking via D1 receptor overstimulation

      Paola Devoto, Liana Fattore, Silvia Antinori, Pierluigi Saba, Roberto Frau, Walter Fratta and Gian Luigi Gessa

      Article first published online: 19 AUG 2014 | DOI: 10.1111/adb.12178

    16. Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens

      Meriem Gaval-Cruz, Richard B. Goertz, Daniel J. Puttick, Dawn E. Bowles, Rebecca C. Meyer, Randy A. Hall, Daijin Ko, Carlos A. Paladini and David Weinshenker

      Article first published online: 13 AUG 2014 | DOI: 10.1111/adb.12174

    17. Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers

      Colleen A. Hanlon, Max M. Owens, Jane E. Joseph, Xun Zhu, Mark S. George, Kathleen T Brady and Karen J. Hartwell

      Article first published online: 13 AUG 2014 | DOI: 10.1111/adb.12171

    18. High-dose alcohol intoxication differentially modulates cognitive subprocesses involved in response inhibition

      Ann-Kathrin Stock, Tom Schulz, Martin Lenhardt, Meinolf Blaszkewicz and Christian Beste

      Article first published online: 6 AUG 2014 | DOI: 10.1111/adb.12170

    19. Inflated reward value in early opiate withdrawal

      Kate M. Wassum, Venuz Y. Greenfield, Kay E. Linker, Nigel T. Maidment and Sean B. Ostlund

      Article first published online: 31 JUL 2014 | DOI: 10.1111/adb.12172

    20. Involvement of μ- and δ-opioid receptor function in the rewarding effect of (±)-pentazocine

      Tomohisa Mori, Toshimasa Itoh, Kazumi Yoshizawa, Yuya Ise, Keisuke Mizuo, Tomoya Saeki, Sachiko Komiya, Daiki Masukawa, Masahiro Shibasaki and Tsutomu Suzuki

      Article first published online: 27 JUL 2014 | DOI: 10.1111/adb.12169

    21. Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history

      Yu-Wei Chen, Kimberly A. Fiscella, Samuel Z. Bacharach, Gianluigi Tanda, Yavin Shaham and Donna J. Calu

      Article first published online: 27 JUL 2014 | DOI: 10.1111/adb.12164

    22. Nicotine enhances modulation of food-cue reactivity by leptin and ghrelin in the ventromedial prefrontal cortex

      Nils B. Kroemer, Franziska Wuttig, Martin Bidlingmaier, Ulrich S. Zimmermann and Michael N. Smolka

      Article first published online: 24 JUL 2014 | DOI: 10.1111/adb.12167

    23. Abuse potential of intranasal buprenorphine versus buprenorphine/naloxone in buprenorphine-maintained heroin users

      Jermaine D. Jones, Maria A. Sullivan, Suzanne K. Vosburg, Jeanne M. Manubay, Shanthi Mogali, Verena Metz and Sandra D. Comer

      Article first published online: 24 JUL 2014 | DOI: 10.1111/adb.12163

    24. Subchronic administration of atomoxetine causes an enduring reduction in context-induced relapse to cocaine seeking without affecting impulsive decision making

      Nienke Broos, Rhianne Loonstra, Yvar van Mourik, Dustin Schetters, Anton N. M. Schoffelmeer, Tommy Pattij and Taco J. De Vries

      Article first published online: 23 JUL 2014 | DOI: 10.1111/adb.12168

    25. The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex

      Yvonne E. Ogbonmwan, Natale R. Sciolino, Jessica L. Groves-Chapman, Kimberly G. Freeman, Jason P. Schroeder, Gaylen L. Edwards, Philip V. Holmes and David Weinshenker

      Article first published online: 23 JUL 2014 | DOI: 10.1111/adb.12166

    26. The histone deacetylase inhibitor sodium butyrate decreases excessive ethanol intake in dependent animals

      Emmanuelle Simon-O'Brien, Stéphanie Alaux-Cantin, Vincent Warnault, Romain Buttolo, Mickaël Naassila and Catherine Vilpoux

      Article first published online: 8 JUL 2014 | DOI: 10.1111/adb.12161

    27. The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects

      Amaia M. Erdozain, Marina Rubio, Elsa M. Valdizan, Angel Pazos, J Javier Meana, Javier Fernández-Ruiz, Stephen P. H. Alexander and Luis F. Callado

      Article first published online: 8 JUL 2014 | DOI: 10.1111/adb.12160

    28. Involvement of reactive oxygen species in cocaine-taking behaviors in rats

      Eun Young Jang, Yeon-Hee Ryu, Bong Hyo Lee, Su-Chan Chang, Mi Jin Yeo, Sang Hyun Kim, Ryan J. Folsom, Nathan D. Schilaty, Kwang Joong Kim, Chae Ha Yang, Scott C. Steffensen and Hee Young Kim

      Article first published online: 26 JUN 2014 | DOI: 10.1111/adb.12159

    29. Altered brain functional networks in heavy smokers

      Fuchun Lin, Guangyao Wu, Ling Zhu and Hao Lei

      Article first published online: 24 JUN 2014 | DOI: 10.1111/adb.12155

    30. MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats

      Giordano de Guglielmo, Rémi Martin-Fardon, Koji Teshima, Roberto Ciccocioppo and Friedbert Weiss

      Article first published online: 16 JUN 2014 | DOI: 10.1111/adb.12157

    31. Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure

      Ji-Wei Tan, Ting-Ting Duan, Qi-Xin Zhou, Ze-Yang Ding, Liang Jing, Jun Cao, Li-Ping Wang, Rong-Rong Mao and Lin Xu

      Article first published online: 5 JUN 2014 | DOI: 10.1111/adb.12158

    32. Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity

      Pedro Araos, María Pedraz, Antonia Serrano, Miguel Lucena, Vicente Barrios, Nuria García-Marchena, Rafael Campos-Cloute, Juan J. Ruiz, Pablo Romero, Juan Suárez, Elena Baixeras, Rafael de la Torre, Jorge Montesinos, Consuelo Guerri, Marta Rodríguez-Arias, José Miñarro, Roser Martínez-Riera, Marta Torrens, Julie A. Chowen, Jesús Argente, Barbara J. Mason, Francisco J. Pavón and Fernando Rodríguez de Fonseca

      Article first published online: 22 MAY 2014 | DOI: 10.1111/adb.12156

    33. Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes

      Laura E. Kwako, Melanie L. Schwandt, Joanna R. Sells, Vijay A. Ramchandani, Daniel W. Hommer, David T. George, Rajita Sinha and Markus Heilig

      Article first published online: 7 MAY 2014 | DOI: 10.1111/adb.12150

    34. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse

      Segev Barak, Jun Wang, Somayeh Ahmadiantehrani, Sami Ben Hamida, Adrian P. Kells, John Forsayeth, Krystof S. Bankiewicz and Dorit Ron

      Article first published online: 6 MAY 2014 | DOI: 10.1111/adb.12152

    35. Sleep changes in smokers before, during and 3 months after nicotine withdrawal

      Andreas Jaehne, Thomas Unbehaun, Bernd Feige, Stefan Cohrs, Andrea Rodenbeck and Dieter Riemann

      Article first published online: 4 MAY 2014 | DOI: 10.1111/adb.12151


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