Transplant International

Cover image for Vol. 29 Issue 5

Edited By: Thomas Wekerle and Rainer Oberbauer

Impact Factor: 2.599

ISI Journal Citation Reports © Ranking: 2014: 13/25 (Transplantation); 50/198 (Surgery)

Online ISSN: 1432-2277

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  • Complement inhibition as potential new therapy for antibody-mediated rejection

    Complement inhibition as potential new therapy for antibody-mediated rejection

    Schematic illustration of classical complement activation and therapeutic strategies targeting complement. In a first step of the classical cascade, antibodies bound to HLA expressed on donor endothelial cells interact with C1q and stabilize the formation of the C1 complex (Ca2+ dependent). Active C1 subunit C1s cleaves factor C4 into C4a and C4b, the latter providing a binding site for C2 facilitating its cleavage by C1s into C2a and C2b. Under the control of complement-regulatory proteins and Factor I, surface-bound C4b is degraded to C4d. Capillary C4d staining has proven to be a useful diagnostic marker. If strong activation overwhelms these control mechanisms, surface-bound C4b2a becomes a stable, active C3 convertase that cleaves C3 into the anaphylatoxin C3a and C3b which again covalently binds to the surface. The combination of C4b2a with C3b forms the active C5 convertase (C4b2a3b) that can now cleave C5 into the anaphylatoxin C5a and C5b. C5b is responsible for the assembly of the membrane attack complex (MAC) which is inserted in the cell membrane. By stably binding to C5 in a 0.5:1 molar ratio of antibody to C5, eculizumab hinders its cleavage.

  • Clinical consequences of circulating CD28-negative T cells for solid organ transplantation

    Clinical consequences of circulating CD28-negative T cells for solid organ transplantation

    CD28-positive (CD28pos) memory T cells may become CD28 negative (CD28neg) under the influence of repetitive cell proliferation and cytomegalovirus (CMV) infection, which is further promoted by an inflammatory milieu and tumor necrosis factor-alpha (TNF-alpha). The defining characteristics of the CD4 and CD8 CD28neg T cells are shown on the right side. The CD8 CD28neg T cells contain suppressor cells (Tsup). NKR: natural killer receptor.

  • Impact of de novo donor-specific anti-HLA antibodies on grafts outcomes in simultaneous pancreas–kidney transplantation

    Impact of de novo donor-specific anti-HLA antibodies on grafts outcomes in simultaneous pancreas–kidney transplantation

    Death-censored pancreas graft survival in patients with de novo donor-specific anti-HLA antibodies (DSA+, n = 22) and those without (DSA−, n = 128).

  • Eight-year results of the Spiesser study, a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation

    Eight-year results of the Spiesser study, a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation

    Patient, death-censored, and graft survival were similar in sirolimus and cyclosporine groups (ITT analysis). Estimated patient survival (a), death-censored graft survival (b), and graft survival (c) in sirolimus (bold black lines, n = 71) and cyclosporine groups (dashed lines, n = 74).

  • Complement inhibition as potential new therapy for antibody-mediated rejection
  • Clinical consequences of circulating CD28-negative T cells for solid organ transplantation
  • Impact of de novo donor-specific anti-HLA antibodies on grafts outcomes in simultaneous pancreas–kidney transplantation
  • Eight-year results of the Spiesser study, a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation

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Video interview with the winner of the rising star session of the ESOT Congress Brussels 2015, Karl Hillebrandt.

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Dr. Pietro Cippà interviews the winner of the rising star session of the ESOT Congress Brussels 2015, Karl Hillebrandt. Karl presents his work on the topic of 'Optimized decellularization of rat livers byarterial and portal venous perfusion underoscillating pressure conditions'.

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