Development, Growth & Differentiation

Cover image for Vol. 59 Issue 7

Edited By: Harukazu Nakamura

Impact Factor: 2.145

ISI Journal Citation Reports © Ranking: 2016: 25/41 (Developmental Biology); 141/189 (Cell Biology)

Online ISSN: 1440-169X

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  • Current Issue:September 2017

    Volume 59, Issue 7

  • August 2017

    Volume 59, Issue 6

  • June 2017

    Volume 59, Issue 5

    Special Issue: MATHEMATICS, PHYSICS AND ENGINEERIN...

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    Volume 59, Issue 4

    Special Issue: VERTEBRATE BRAINS: EVOLUTION, STRUC...

  • April 2017

    Volume 59, Issue 3

Recently Published Articles

  1. BMP signaling regulates the skeletal and connective tissue differentiation during caudal fin regeneration in sailfin molly (Poecilia latipinna)

    Shailja Rajaram, Sonam Patel, Gowri Kumari Uggini, Isha Desai and Suresh Balakrishnan

    Version of Record online: 12 SEP 2017 | DOI: 10.1111/dgd.12392

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    In this study, we investigated the effects of BMP inhibition by LDN193189 on skeletal and connective tissues formation, at 5 days post amputation in the caudal fin of Poecilia latipinna. We observed that BMP inhibition leads to compromised growth of fin regenerate. Histological analysis supports the findings, as stunted progression of skeletal elements and below par formation of collagen. Biochemical analysis of collagen and subsequent transcript level analysis of genes that regulate the formation of skeletal elements reaffirm these observations. Overall, our results highlight the significance of BMP signaling in directing the blastemal cells for proper skeletal and connective tissue differentiation during caudal fin regeneration.

  2. Reduction of nitric oxide level results in maturation promoting factor destabilization during spontaneous meiotic exit from diplotene arrest in rat cumulus oocytes complexes cultured in vitro (pages 615–625)

    Meenakshi Tiwari and Shail K. Chaube

    Version of Record online: 24 AUG 2017 | DOI: 10.1111/dgd.12390

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    The reduced level of NO through iNOS-mediated pathway resulted in transient decrease of intraoocyte cGMP as well as cAMP levels. The reduced level of cAMP resulted in decreased Cdc25B level. The reduced Cdc25B level was associated with accumulation of Thr14/Tyr15 phosphorylated Cdk1 level and decreased Thr161 phosphorylated Cdk1 as well as cyclin B1 levels that finally destabilized MPF. The destabilized MPF triggered EDA.

  3. Emerging mechanisms regulating mitotic synchrony during animal embryogenesis (pages 565–579)

    Yosuke Ogura and Yasunori Sasakura

    Version of Record online: 22 AUG 2017 | DOI: 10.1111/dgd.12391

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    Synchronous mitosis is commonly observed in the earliest stages of animal embryogenesis. Subsequent reduction of mitotic synchrony and the emergence of asynchronous mitotic patterns are crucial for creating an embryo with the appropriate cell number and morphology. In this article, we review three key mechanisms for achieving and breaking the synchrony of mitosis in the early animal embryogenesis.

  4. Early segregation of the adrenal cortex and gonad in chicken embryos (pages 593–602)

    Daisuke Saito, Koji Tamura and Yoshiko Takahashi

    Version of Record online: 16 AUG 2017 | DOI: 10.1111/dgd.12389

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    We found that early medial coelomic epithelium (CE) consists of a two-cell layer-thick band of epithelial-like cells, the outer and inner CEs. Lineage tracing experiments suggested that the adrenocortex derives from the inner CE but not from the outer CE, from which the gonad derives. This is the first demonstration of early segregation of adrenocortex and gonad in the CE upon the opening of the coelomic cavity.

  5. Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson (pages 580–592)

    Edward M. De Robertis, Yuki Moriyama and Gabriele Colozza

    Version of Record online: 16 AUG 2017 | DOI: 10.1111/dgd.12388

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    We present experiments in which the form of the Xenopus embryo is modified by depleting the chordinase Tolloid or its inhibitor Sizzled specifically in ventral cells. This changes body form in ways reminiscent of D'Arcy Thompson's proposals in his 1917 book “On Growth and Form”.

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