Development, Growth & Differentiation

Cover image for Vol. 57 Issue 6

Edited By: Harukazu Nakamura

Impact Factor: 2.42

ISI Journal Citation Reports © Ranking: 2014: 26/41 (Developmental Biology); 124/184 (Cell Biology)

Online ISSN: 1440-169X

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  1. Identification of β integrin-like- and fibronectin-like proteins in the bivalve mollusk Mytilus trossulus

    Vyacheslav A. Dyachuk, Maria A. Maiorova and Nelly A. Odintsova

    Article first published online: 16 JUL 2015 | DOI: 10.1111/dgd.12234

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    The main result of our study is the discovery of the fact that β integrin-like protein expression correlates with the development and differentiation of the digestive system in mollusk larvae. Despite the β integrin- and fibronectin-like proteins were expressed in different cell types of mussel larvae, we do not exclude the possibility of direct interaction between these two proteins during M. trossulus development or in adult tissues. These novel results should accelerate interest in studying the integrin/ligand variations and functions in non-model marine organisms.

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    Identification of tool use acquisition-associated genes in the primate neocortex (pages 484–495)

    Eiji Matsunaga, Sanae Nambu, Mariko Oka, Michio Tanaka, Miki Taoka and Atsushi Iriki

    Article first published online: 14 JUL 2015 | DOI: 10.1111/dgd.12227

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    The macaque brain induced plastic changes by tool use training. In this study, by microarray screening, we identified three genes as tool use acquisition-associated genes.

  3. Nepro is localized in the nucleolus and essential for preimplantation development in mice

    Masakazu Hashimoto, Tatsuya Sato, Yuko Muroyama, Lisa Fujimura, Masahiko Hatano and Tetsuichiro Saito

    Article first published online: 14 JUL 2015 | DOI: 10.1111/dgd.12232

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    The nucleolus-associated protein Nepro is indispensable for preimplantation development in mice. Nepro is involved in the nucleolar formation and ribosome biogenesis.

  4. Lgr5 positive stem cells sorted from small intestines of diabetic mice differentiate into higher proportion of absorptive cells and Paneth cells in vitro (pages 453–465)

    Xian-Yang Zhong, Tao Yu, Wa Zhong, Jie-Yao Li, Zhong-Sheng Xia, Yu-Hong Yuan, Zhong Yu and Qi-Kui Chen

    Article first published online: 30 JUN 2015 | DOI: 10.1111/dgd.12226

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    We characterized the expression of Lgr5 in the small intestine of diabetic mice, and sorted Lgr5 positive Intestinal epithelial stem cells (IESCs) for investigating their differentiation in vitro. We proved that the quantity of Lgr5 positive IESCs was significantly increased in the small intestines of diabetic mice. IESCs sorted from the diabetic mice can differentiate into higher proportion of absorptive cells and Paneth cells in vitro.

  5. Regeneration inducers in limb regeneration (pages 421–429)

    Akira Satoh, Kazumasa Mitogawa and Aki Makanae

    Article first published online: 23 JUN 2015 | DOI: 10.1111/dgd.12230

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    The defined molecules (BMP7 (or2)+FGF2+FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.