Development, Growth & Differentiation

Cover image for Vol. 57 Issue 8

Edited By: Harukazu Nakamura

Impact Factor: 2.42

ISI Journal Citation Reports © Ranking: 2014: 26/41 (Developmental Biology); 124/184 (Cell Biology)

Online ISSN: 1440-169X

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  1. You have full text access to this OnlineOpen article
    Timing by rhythms: Daily clocks and developmental rulers

    Alexis B. Webb and Andrew C. Oates

    Article first published online: 6 NOV 2015 | DOI: 10.1111/dgd.12242

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    We compare and contrast two biological "clocks". The circadian clock is used by organisms to regulate their behaviour in time with the 24 hour daily planetary cycle, whereas the segmentation clock appears to be an oscillatory ruler that is used briefly during development to subdivide the body axis into morphological segments.

  2. Application of local gene induction by infrared laser-mediated microscope and temperature stimulator to amphibian regeneration study

    Aiko Kawasumi-Kita, Toshinori Hayashi, Takuya Kobayashi, Chikashi Nagayama, Shinichi Hayashi, Yasuhiro Kamei, Yoshihiro Morishita, Takashi Takeuchi, Koji Tamura and Hitoshi Yokoyama

    Article first published online: 29 OCT 2015 | DOI: 10.1111/dgd.12241

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    A local heat shock by infrared laser irradiation (IR-LEGO) is applicable to amphibians to induce gene expression only at the target cells. A local heat shock by a temperature-controlled metal probe (temperature stimulator) is also applicable to an amphibian to induce wider gene expression at the target tissue. These techniques enable us to do a rigorous cell lineage trace as well as to analyze gene function in a target region or cells in study of amphibian regeneration.

  3. You have full text access to this OnlineOpen article
    Expansion of the neck reconstituted the shoulder–diaphragm in amniote evolution

    Tatsuya Hirasawa, Satoko Fujimoto and Shigeru Kuratani

    Article first published online: 29 OCT 2015 | DOI: 10.1111/dgd.12243

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    Analyses of the lateral plate mesoderm at cranial somite levels revealed that the deep part of the lateral body wall is moved concomitant with the caudal transposition of the heart, resulting in the infolding of the expanded cervical lateral body wall into the thorax in amniote embryos. In amniote evolution, this infolding process provided a basis for the evolution of diverse shoulder structures, which deviate from those in the anamniote grade, and the diaphragm represents the most distinct example.

  4. You have full text access to this OnlineOpen article
    Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development (pages 570–580)

    Saneela Anwar, Rashid Minhas, Shahid Ali, Nicholas Lambert, Yasuhiko Kawakami, Greg Elgar, Syed Sikandar Azam and Amir Ali Abbasi

    Article first published online: 14 OCT 2015 | DOI: 10.1111/dgd.12239

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    In this study we report novel enhancers regulating human GLI3 expression in the developing limb and neural tube. We employ transgenic zebrafish and human cell culture based assy.

  5. Cellular retinoic acid binding protein 2 inhibits osteogenic differentiation by modulating LIMK1 in C2C12 cells (pages 581–589)

    Rui Wang, Qingyuan Yang, Weifan Xiao, Ruirui Si, Fenyong Sun and Qiuhui Pan

    Article first published online: 9 OCT 2015 | DOI: 10.1111/dgd.12240

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    CRABP2 regulates actin remodelling and osteogenic differentiation via LIMK1 in C2C12 cells, presenting a possible molecular target for promoting the osteogenic differentiation in bone degenerative diseases.