Development, Growth & Differentiation

Cover image for Vol. 57 Issue 7

Edited By: Harukazu Nakamura

Impact Factor: 2.42

ISI Journal Citation Reports © Ranking: 2014: 26/41 (Developmental Biology); 124/184 (Cell Biology)

Online ISSN: 1440-169X

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Recently Published Articles

  1. Cellular retinoic acid binding protein 2 inhibits osteogenic differentiation by modulating LIMK1 in C2C12 cells

    Rui Wang, Qingyuan Yang, Weifan Xiao, Ruirui Si, Fenyong Sun and Qiuhui Pan

    Article first published online: 9 OCT 2015 | DOI: 10.1111/dgd.12240

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    CRABP2 regulates actin remodelling and osteogenic differentiation via LIMK1 in C2C12 cells, presenting a possible molecular target for promoting the osteogenic differentiation in bone degenerative diseases.

  2. You have full text access to this OnlineOpen article
    Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos

    Yoshikazu Hirate, Shino Hirahara, Ken-ichi Inoue, Hiroshi Kiyonari, Hiroshi Niwa and Hiroshi Sasaki

    Article first published online: 9 OCT 2015 | DOI: 10.1111/dgd.12235

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    In 16-cell stage mouse embryos, cell polarity regulated by the Par-aPKC system inhibits asymmetric cell division, thereby regulating the number of inner cells. In contrast to 32-cell stage embryos, effects of the Par-aPKC system on Yap activity and Cdx2 expression is limited at the 16-cell stage.

  3. Development of the pancreas in medaka, Oryzias latipes, from embryo to adult

    Takayoshi Otsuka, Tatsuya Tsukahara and Hiroyuki Takeda

    Article first published online: 5 OCT 2015 | DOI: 10.1111/dgd.12237

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    This article is the endocrine component of principal and secondary islets. Insulin-producing cells and Somatostatin-producing cells are located in the central of islets and glucagon-producing cells are in the periphery.

  4. Tangential cell migration during layer formation of chick optic tectum

    Yuji Watanabe and Hiroyuki Yaginuma

    Article first published online: 30 SEP 2015 | DOI: 10.1111/dgd.12238

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    The laminated structure of the optic tectum is formed by radial and tangential cell migration during development. Studies of developing chick optic tectum have revealed two streams of tangential cell migration. We will review the process of the two types of tangential migrations, in order to elucidate their roles in the formation of the optic tectum layers.

  5. RAC1 regulate tumor necrosis factor-α-mediated impaired osteogenic differentiation of dental pulp stem cells (pages 497–506)

    Guijuan Feng, Qijie Shen, Min Lian, Zhifeng Gu, Jing Xing, Xiaohui Lu, Dan Huang, Liren Li, Shen Huang, Yi Wang, Jinlong Zhang, Jiahai Shi, Dongmei Zhang and Xingmei Feng

    Article first published online: 28 JUL 2015 | DOI: 10.1111/dgd.12233

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    TNF-α could suppress the osteogenic differentiation of DPSCs via increasing the expression of RAC1, which could activate the Wnt/β-catenin signaling pathway and liberate β-catenin to translocate into the nucleus. Genetic silencing of RAC1 expression using siRNA restored osteogenic differentiation of DPSCs.