Development, Growth & Differentiation

Cover image for Vol. 57 Issue 4

Edited By: Harukazu Nakamura

Impact Factor: 2.178

ISI Journal Citation Reports © Ranking: 2013: 29/41 (Developmental Biology); 134/185 (Cell Biology)

Online ISSN: 1440-169X

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Read Special Issue free online, featuring key research and review articles on Genome Editing, edited by T. Yamamoto and H. Nakamura.

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Recently Published Articles

  1. Gene expression kinetics in individual plasmodial cells reveal alternative programs of differential regulation during commitment and differentiation

    Viktoria Rätzel and Wolfgang Marwan

    Article first published online: 26 MAY 2015 | DOI: 10.1111/dgd.12220

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    By repeatedly taking samples of the same plasmodial cell at successive time points after the induction to sporulation we show that individual cells take different trajectories leading to cell fate decision and differentiation. Pair-wise correlated gene expression kinetics revealed qualitatively different patterns of co-regulation, indicating that alternative programs of differential regulation are operational in individual plasmodial cells. The results support the concept of a Waddington-type quasipotential landscape for the regulatory control of cell differentiation and the impact of mutations on the topology of the landscape.

  2. Early development of circadian rhythmicity in the suprachiamatic nuclei and pineal gland of teleost, flounder (Paralichthys olivaeus), embryos

    Makoto Mogi, Susumu Uji, Hayato Yokoi and Tohru Suzuki

    Article first published online: 26 MAY 2015 | DOI: 10.1111/dgd.12222

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    We report the development of circadian rhythmicity in the SCN and PG. per2 expression rhythmicity in flounder SCN is regulated by a molecular clock. LL and DD conditions deeply affect the development of circadian rhythmicity in the SCN and PG.

  3. SP1 promotes the odontoblastic differentiation of dental papilla cells

    Jie Zhang, Heng Lin, Huan Liu, Lu Zhang, Guohua Yuan and Zhi Chen

    Article first published online: 24 MAY 2015 | DOI: 10.1111/dgd.12221

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    We observed that the expression of SP1 progressively upregulated during the odontoblastic differentiation both in vivo and in vitro. Overexpression and knock-down of SP1 forced and suppressed the odontoblastic differentiation of the mDPC6T cells, respectively. In conclusion, SP1 promotes the odontoblastic differentiation of dental papilla cells.

  4. Mechanisms of cell height changes that mediate epithelial invagination (pages 313–323)

    Takefumi Kondo and Shigeo Hayashi

    Article first published online: 19 MAY 2015 | DOI: 10.1111/dgd.12224

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    Invagination is the core process of the three-dimensional morphogenesis of epithelial organs driven by shape change of each epithelial cells. Recent progress in this field is reviewed here with special emphasis on cell height control.

  5. Asymmetrical allocation of JAK1 mRNA during spermatogonial stem cell division in Xenopus laevis

    Keiichiro Hyakutake, Toshihiro Kawasaki, JiDong Zhang, Hiroshi Kubota, Sin-Ichi Abe and Kazufumi Takamune

    Article first published online: 19 MAY 2015 | DOI: 10.1111/dgd.12219

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    Xenopus spermatogonial stem cells (SSCs) at telophase. Primary spermatogonium destined to differentiate and SSC are thought to arise from areas in which JAK1 mRNA (blue signals in the middle and right column) is present (arrowheads) and absent (double arrowheads), respectively.

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