Development, Growth & Differentiation

Cover image for Vol. 57 Issue 6

Edited By: Harukazu Nakamura

Impact Factor: 2.42

ISI Journal Citation Reports © Ranking: 2014: 26/41 (Developmental Biology); 124/184 (Cell Biology)

Online ISSN: 1440-169X

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  1. RAC1 regulate tumor necrosis factor-α-mediated impaired osteogenic differentiation of dental pulp stem cells

    Guijuan Feng, Qijie Shen, Min Lian, Zhifeng Gu, Jing Xing, Xiaohui Lu, Dan Huang, Liren Li, Shen Huang, Yi Wang, Jinlong Zhang, Jiahai Shi, Dongmei Zhang and Xingmei Feng

    Article first published online: 28 JUL 2015 | DOI: 10.1111/dgd.12233

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    TNF-α could suppress the osteogenic differentiation of DPSCs via increasing the expression of RAC1, which could activate the Wnt/β-catenin signaling pathway and liberate β-catenin to translocate into the nucleus. Genetic silencing of RAC1 expression using siRNA restored osteogenic differentiation of DPSCs.

  2. Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α

    Luan Wen and Yun-Bo Shi

    Article first published online: 28 JUL 2015 | DOI: 10.1111/dgd.12231

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    Recent genetic studies by using TALEN have demonstrated an important role of thyroid hormone receptor TRα in regulating the timing of anuran metamorphosis. They have also revealed a novel function of the receptor in controlling premetamorphic tadpole growth rate.

  3. Identification of β integrin-like- and fibronectin-like proteins in the bivalve mollusk Mytilus trossulus

    Vyacheslav A. Dyachuk, Maria A. Maiorova and Nelly A. Odintsova

    Article first published online: 16 JUL 2015 | DOI: 10.1111/dgd.12234

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    The main result of our study is the discovery of the fact that β integrin-like protein expression correlates with the development and differentiation of the digestive system in mollusk larvae. Despite the β integrin- and fibronectin-like proteins were expressed in different cell types of mussel larvae, we do not exclude the possibility of direct interaction between these two proteins during M. trossulus development or in adult tissues. These novel results should accelerate interest in studying the integrin/ligand variations and functions in non-model marine organisms.

  4. You have full text access to this OnlineOpen article
    Identification of tool use acquisition-associated genes in the primate neocortex (pages 484–495)

    Eiji Matsunaga, Sanae Nambu, Mariko Oka, Michio Tanaka, Miki Taoka and Atsushi Iriki

    Article first published online: 14 JUL 2015 | DOI: 10.1111/dgd.12227

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    The macaque brain induced plastic changes by tool use training. In this study, by microarray screening, we identified three genes as tool use acquisition-associated genes.

  5. Nepro is localized in the nucleolus and essential for preimplantation development in mice

    Masakazu Hashimoto, Tatsuya Sato, Yuko Muroyama, Lisa Fujimura, Masahiko Hatano and Tetsuichiro Saito

    Article first published online: 14 JUL 2015 | DOI: 10.1111/dgd.12232

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    The nucleolus-associated protein Nepro is indispensable for preimplantation development in mice. Nepro is involved in the nucleolar formation and ribosome biogenesis.