Development, Growth & Differentiation

Cover image for Vol. 58 Issue 4

Edited By: Harukazu Nakamura

Impact Factor: 2.42

ISI Journal Citation Reports © Ranking: 2014: 26/41 (Developmental Biology); 124/184 (Cell Biology)

Online ISSN: 1440-169X

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  1. Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice

    Hiroshi Yajima and Kiyoshi Kawakami

    Version of Record online: 25 MAY 2016 | DOI: 10.1111/dgd.12290

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    We used the mdx mice to investigate the function of Six4 and Six5 in muscle regeneration and demonstrated that low dosage of these genes in mdx mice was associated with improved dystrophic phenotypes and prolonged life span, probably due to enhanced skeletal muscle regeneration. This finding suggests that Six4 and Six5 are involved in the regulation of regeneration capacity and that these two transcription factors are potentially useful de novo targets in therapeutic applications against muscle disorders, such as DMD.

  2. In vivo recombination efficiency of two site-specific recombination systems, VCre/VloxP and SCre/SloxP, in medaka (Oryzias latipes)

    Kenta Kishimoto, Manabu Nakayama and Masato Kinoshita

    Version of Record online: 25 MAY 2016 | DOI: 10.1111/dgd.12289

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    The present study delineates the in vivo efficiency of two site-specific recombination systems, VCre/VloxP and SCre/SloxP, in medaka (Oryzias latipes). These findings provide two novel alternative recombination systems in vivo in addition to the existing Cre/loxP and Flp/FRT systems, thus enabling sophisticated gene expression in model organisms.

  3. Adenosine Triphosphate stimulates differentiation and mineralization in human osteoblast-like Saos-2 cells (pages 400–408)

    Alessandro Cutarelli, Mario Marini, Virginia Tancredi, Giovanna D'Arcangelo, Michela Murdocca, Claudio Frank and Umberto Tarantino

    Version of Record online: 18 MAY 2016 | DOI: 10.1111/dgd.12288

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    In osteoblasts ATP can regulate several activities like cell proliferation, cell death, cell differentiation and matrix mineralization. ATP can increase alkaline phosphatase (ALP) activity in a dose dependent manner as well as it can reduce cell proliferation in human osteoblast-like Saos-2 cells. ATP can affect mineralization in a biphasic manner inducing an increase of Calcium deposits at lower concentrations and a reduction of mineral deposition at higher concentrations.

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    ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects (pages 409–421)

    Yudai Tokumasu, Atsuo Iida, Zi Wang, Satoshi Ansai, Masato Kinoshita and Atsuko Sehara-Fujisawa

    Version of Record online: 16 MAY 2016 | DOI: 10.1111/dgd.12286

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    ADAM12 is a membrane-bound metalloprotease involved to obesity in mammals. We generated adam12-KO zebrafish using CRISPR/Cas9 system, and analyzed its phenotypes. The adam12-KO zebrafish exhibited a retardation body growth at the juvenile stage without developmental defects.

  5. Regulation of the neural niche by the soluble molecule Akhirin

    Uzzal Kumar Acharjee, Athary Abdulhaleem Felemban, Asrafuzzaman M. Riyadh and Kunimasa Ohta

    Version of Record online: 1 MAY 2016 | DOI: 10.1111/dgd.12284

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    Akhirin is a soluble molecule and is expressed in the neural niche of the eye and spinal cord. In this review, we focus on the role of Akhirin as a niche molecule that regulates the proliferation and differentiation of neural stem/progenitor cells.

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