Cover image for Vol. 35 Issue 5

Edited By: Toru Iwaki

Impact Factor: 1.651

ISI Journal Citation Reports © Ranking: 2014: 48/76 (Pathology); 134/192 (Clinical Neurology); 195/252 (Neurosciences)

Online ISSN: 1440-1789

Author Guidelines

Latest information regarding submission
• Authors can submit to Neuropathology online at
• From 2014 Neuropathology has ceased publishing print copies and will be available to readers in electronic format 'online only'
• Accepted authors may choose to publish using Wiley's open access model, OnlineOpen
• Invited articles such as symposium articles are published as Free Access. Authors are advised not to choose Online Open for invited articles since they can already be read online for free.
• A Covering Letter and Disclosure Statement should be included in new submissions
Neuropathology has adopted CrossCheck plagiarism software.

Neuropathology is the international journal of the Japanese Society of Neuropathology and publishes original papers dealing with all aspects of human and experimental neuropathology, and related fields of research. The journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Neuropathology Education, Occasional Reviews, Editorials and Letters to the Editor.

The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Manuscripts are accepted whether or not the author is a member of the Japanese Society of Neuropathology and on the understanding that the content has not been published or accepted for publication elsewhere. All materials submitted for publication, including solicited articles, are subject to editorial review and revision. Each manuscript is reviewed by at least two reviewers. Authors may suggest the names of potential referees; the Editor-in-Chief will try to honor these requests. The Editorial Board reserves the right to refuse any material for publication and final acceptance or rejection rests with the Board.

Manuscripts should be written so that they are intelligible to the professional reader who is not a specialist in the particular field. Where contributions are judged as acceptable for publication on the basis of scientific content, the Editor or the Publisher reserve the right to modify typescripts to eliminate ambiguity and repetition and improve communication between author and reader. If extensive alterations are required, the manuscript will be returned to the author for revision.

All articles submitted to the journal must comply with these instructions. Failure to do so will result in return of the manuscript and possible delay in publication.

Publication Ethics: This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.


Accepted papers will be passed to Wiley’s production team for publication. The author identified as the formal corresponding author for the paper will receive an email prompting them to login into Wiley’s Author Services, where via the Wiley Author Licensing Service (WALS) they will be asked to complete an electronic license agreement on behalf of all authors on the paper.

Authors may to publish using the journal's standard copyright transfer agreement (CTA), or they may choose to publish 'Open Access' with a Creative Commone licence by using Wiley's OnlineOpen service.

Standard Copyright Transfer Agreement: FAQs about the terms and conditions of the standard CTA in place for the journal, including terms regarding archiving of the accepted version of the paper, are available at: CTA Terms and Conditions FAQs

OnlineOpen – Wiley's Open Access Option
OnlineOpen is available to authors of articles who wish to make their article freely available to all on Wiley Online Library under a Creative Commons licence. In addition, authors of OnlineOpen articles are permitted to post the final, published PDF of their article on a website, institutional repository or other free public server, immediately on publication. With OnlineOpen the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made open access, known as ‘gold road’ open access.

OnlineOpen licenses. Authors choosing OnlineOpen retain copyright in their article and have a choice of publishing under the following Creative Commons License terms: Creative Commons Attribution License (CC BY); Creative Commons Attribution Non-Commercial License (CC BY NC); Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY NC ND).

For more information about the OnlineOpen license terms and conditions click here.

Funder Open Access and Self-Archiving Compliance: Please click here for more information on Wiley’s compliance with specific Funder Open Access and Self Archiving Policies (including NIH and Wellcome Trust), and click here for more detailed information specially about Self-Archiving definitions and policies.


Covering letter

Please address the following items in your covering letter:

• Papers are accepted for publication in the journal on the understanding that the content has not been published or concurrently submitted for publication elsewhere. This must be stated in the covering letter.
• In keeping with the latest guidelines of the International Committee of Medical Journal Editors (, each author’s contribution to the paper is to be quantified.
• Authors should declare any financial support or relationships that may pose conflict of interest.

Ethical considerations

• Authors must state that the protocol for the research project has been approved by a suitably constituted Ethics Committee of the institution within which the work was undertaken and that it conforms to the provisions of the Declaration of Helsinki (as revised in Brazil 2013), available at
• All investigations on human subjects must include a statement that the subject gave informed consent and patient anonymity should be preserved.
• Any experiments involving animals must be demonstrated to be ethically acceptable and where relevant conform to the guidelines for the care and use of laboratory animals.
• In the case of research involving recombinant DNA, experiments should be carried out according to the guidelines issued by the authorized agency in the country in which the research was carried out.

Search Engine Optimization for your paper

Authors are encouraged to consult Wiley’s SEO Tips for Authors page ( in order to maximize online discoverability for your published research. Included are tips for making your title and abstract SEO-friendly, choosing appropriate keywords, and promoting your research through social media.

Pre-acceptance English-language editing
• Authors are responsible for the linguistic accuracy of their manuscripts. Ensure your paper is clearly written in standard, scientific English language appropriate to your discipline.
• Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. Visit to learn about the options. All services are paid for and arranged by the author. Please note using the Wiley English Language Editing Service does not guarantee that your paper will be accepted by this journal.


Authors are required to provide submit their manuscript electronically. Two files should be supplied: the covering letter and the manuscript (in Word or rich text format (.rtf)). Additional figures, tables and images should be supplied as separate files. Authors must supply an email address as all correspondence will be by email.


Spelling. The journal uses US spelling and authors should therefore follow the latest edition of the Merriam–Webster’s Collegiate Dictionary.
Measurements. All measurements must be given in SI units as outlined in the latest edition of Units, Symbols and Abbreviations: A Guide for Medical and Scientific Editors and Authors (Royal Society of Medicine Press, London). Statistics and measurements should always be given in figures, for example 10 mm, except where the number begins the sentence. When the number does not refer to a unit of measurement, it is spelt out, except where the number is greater than nine.
Abbreviations should be used sparingly and only where they ease the reader’s task by reducing repetition of long, technical terms. Initially use the word in full (unless this is a common abbreviation; please check the list at, followed by the abbreviation in parentheses. Thereafter use the abbreviation.
Drug and chemical names. At the first mention of a chemical substance, give the generic name only. Trade names should not be used. Drugs should be referred to by their generic names, rather than brand names
Footnotes to the text are not allowed and any such material should be incorporated into the text as parenthetical matter.

Parts of the manuscript

Original Articles should be presented in the following order: (i) title page, (ii) abstract and keywords, (iii) text (introduction, materials and methods, results, discussion), (iv) acknowledgments, (v) references, (vi) tables (each table complete with title and footnotes), (vii) figures and (viii) figure legends.
Case reports should be presented in the following order: (i) title page, (ii) abstract and keywords, (iii) text (introduction, clinical summary, pathological findings, discussion), (iv) acknowledgments including disclosure, (v) references, (vi) figure legends, (vii) tables and (viii) figures.
Neuropathology Education articles should be presented in the following order: (i) title page, (ii) text (clinical course, pathological findings, diagnosis, discussion), (iii) acknowledgments including disclosure, (iv) references, (v) figure legends, (vi) tables and (vii) figures.

Title page

The title page should contain (i) the complete title of the paper, (ii) the full names of the authors and (iii) the addresses of the institutions at which the work was carried out together with (iv) the full contact details of the author to whom correspondence about the manuscript, proofs and requests for offprints should be sent. The title should be short, informative and contain the major key words. A short running title (less than 40 characters, including spaces) should also be provided.

Abstract and key words

Articles must have an abstract that states in 300 words or fewer the purpose, basic procedures, main findings and principal conclusions of the study. The abstract should not contain references. Five key words (for the purposes of indexing) should be supplied below the abstract and should be taken from those recommended by the US National Library of Medicine’s Medical Subject Headings (MeSH) browser list (


Introduction: This section should include sufficient background information to set the work in context. The aims of the manuscript should be clearly stated.
Materials and Methods: This should be concise but provide sufficient detail to allow the work to be repeated by others. The source of material should be given in detail, where possible. Ethical considerations should be detailed.
Results: Results should be presented in a logical sequence in the text, tables and figures; repetitive presentation of the same data in different forms should be avoided. Discussion: This should consider the results in relation to any hypotheses advanced in the introduction and place the study in the context of other work.


• ICMJE Vancouver style. Manuscripts should follow the style of the Vancouver agreement detailed in the International Committee of Medical Journal Editors’ revised ‘Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication’ as presented at
• In the text, references should be cited using superscript Arabic numerals in the order in which they appear. If cited only in tables or figure legends, number them according to the first identification of the table or figure in the text.
• In the reference list, the references should be numbered and listed in order of appearance in the text.List all authors for each reference, unless there are seven or more, in which case only the first three followed by et al. should be given. Names of journals should be abbreviated in the style used in Index Medicus.
• Reference to unpublished data, papers submitted, and personal communications should appear in the text only. Authors should check that all references listed have been cited in the text and that no reference has been omitted from the list.

References should be listed in the following form:

Journal article
1 Mollenhauer J, Wiemann S, Scheurlen W et al.DMBT1,a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 1997; 17: 32–39.

Journal articles published ahead of issue (print or online)
2 Benz JP, Soll J, Bölter B. Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import. FEBS J 2009. doi: 10.1111/j.1742-4658.2009.06874.x

Non-English journal articles
3 Nokura K,Yamamoto H, Uchida M, Hashizume Y, Inagaki T.Automatic movements of extremities induced in primary massive brain lesion with apneic coma (in Japanese with English abstract). Rinsho Shinkeigaku 1997; 37: 198-207.

4 Ghadially FN. Ultrastructural Pathology of the Cell and Matrix, Vol 2, 3rd edn. London: Butterworths, 1988.

Chapter in a Book
5 Esiri MM, Hyman BT, Beyreuther K, Masters CL. Ageing and dementia. In: Graham DI, Lantos PL, eds. Greenfield’s Neuropathology,Vol 2, 6th edn. London: Arnold, 1997; 153–233.

Journal article on the Internet
6 Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs (serial online) 2002 [Cited 12 Aug 2002.]; 102. Available from URL:

7 Diabetes Australia. Prevalence of Diabetes in the Australian Population. [Cited 5 Jun 1996.] Available from URL:

Authorship and Acknowledgement

The editors of Neuropathology subscribe to the recommendations formulated by the ICMJE regarding criteria for authorship. Accordingly, each person listed as an author or co-author for all submitted manuscripts must meet all the following criteria. An author or co-author shall have:
1) substantial contributions to the conception or design of the work, or acquisition, analysis or interpretation of data for the work;
2) drafting the work or revising it critically for important intellectual content;
3) final approval of the version to be published; and
4) agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Meeting these criteria should provide each author with sufficient knowledge of and participation in the work so that he or she can accept public responsibility for the report.

Names of collaborators who have provided data or cooperated substantially to the research but do not meet the criteria as an author should be listed in the acknowledgment section.


All authors should declare any financial support or relationship(s) that may pose a conflict of interest in Acknowledgments section. Authors can download the form from If there are no competing interests, the author should state ‘None Declared’. An example of a filled out form is found at


Tables should be self-contained and complement, but not duplicate, information contained in the text. Tables should be numbered consecutively in Arabic numerals. Each table should be presented on a separate file with a comprehensive but concise legend above the table. Column headings should be brief, with units of measurement in parentheses; all abbreviations should be defined in footnotes. Footnote symbols: †, ‡, §, ¶, should be used (in that order) and *, **, *** should be reserved for P-values. The table and its legend/footnotes should be understandable without reference to the text.


All illustrations (line drawings and photographs) are classified as figures.
Figures should be cited in consecutive order in the text.
Figures should be sized to fit within the column (85 mm), intermediate (120 mm) or the full text width (180 mm).
• Do not embed figures in the Word document - they must be supplied in separate files.
• Please note that we cannot accept PowerPoint files. These files must be converted to one of the following file types: TIF/EPS/JPG (use maximum quality). Converting PowerPoint files frequently results in unexpected changes to the figures (e.g. missing or shifted text; shifted image elements). We recommend you not to create figures by PowerPoint. If you do try to convert from PowerPoint to one of these file types, be very careful to compare the final version to your original.
• Individual photographs forming a composite figure should be of equal contrast, and should be accurately squared. Photographs need to be cropped sufficiently to prevent the subject being recognized, or an eye bar used. Magnifications should be indicated using a scale bar on the illustration.
• Electronic graphics should be supplied as high-resolution files. Save line art such as charts, graphs and illustrations in EPS or PDF format. Save photographic images in TIFF format. Save figures containing a combination of photographic images and text (e.g. annotated photographic images with text labels) as EPS or PDF. All graphics and images supplied should have resolution of at least 300 ppi.
• Visit Wiley’s web page for digital graphics standards at

Color figures
Publishing color figures is free of charge.

Figure legends
Legends should be self-explanatory and supplied on a separate sheet. The legend should incorporate definitions of any symbols used and all abbreviations and units of measurement should be explained so that the figure and its legend are understandable without reference to the text. A letter stating copyright authorisation should be provided if figures have been reproduced from another source.


Manuscripts can be submitted online at

If there are any problems using the site or managing a manuscript, please contact ScholarOne Manuscripts technical support at

For authors unable to submit their manuscript online, please consult with Prof Toru Iwaki, Editor-in-Chief of Neuropathology:
Tel: +81 92 642 5536

Submission documents
When submitting you will be required to submit at least two files: the covering letter and the manuscript (in Word or rich text format (.rtf)). Additional figures, tables and images should also be supplied as separate files. Authors must supply an email address as all correspondence will be by email.


Author Services
Author Services enables authors to track their article, once it has been accepted, through the production process to publication online. Authors can check the status of their articles online and choose to receive automated emails at key stages of production so they do not need to contact the production editor to check on progress. Visit for more details on online production tracking and for a wealth of resources, including FAQs and tips on article preparation, submission and more.

Page charges
For articles of five typeset pages or less there are no page charges. Articles in excess of five pages are subject to a charge of ¥10 000 per extra typeset page.

It is essential that corresponding authors supply an email address to which correspondence can be emailed while their article is in production. Word files of edited articles will be sent for checking via email, and should be returned to the Publisher. It is essential that these files are checked carefully. Full instructions on how to correct and return the file will be attached to the email. Notification of the URL from where to download a PDF typeset page proof, associated forms and further instructions will be sent by email to the corresponding author. The purpose of the PDF proof is a final check of the layout, and of tables and figures. Alterations other than the essential correction of errors are unacceptable at PDF proof stage. The proof should be checked, and approval to publish the article should be emailed to the Publisher by the date indicated, otherwise, it may be signed off on by the Editor or held over to the next issue.

A minimum of 50 additional offprints will be provided upon request, at the author’s expense. These paper offprints may be ordered online. Please visit, fill in the necessary details and ensure that you type information in all of the required fields. If you have queries about offprints please email

Early View
Neuropathology offers rapid speed to publication using Wiley’s Early View service. Early View articles are complete full-text articles published online in advance of their publication in an issue. Articles are therefore available as soon as they are ready, rather than having to wait for the next scheduled issue. Early View articles are complete and final. They have been fully reviewed, revised and edited for publication and the authors’ final corrections have been incorporated. Because they are in final form, no changes can be made after online publication. The nature of Early View articles means that they do not yet have volume, issue or page numbers, so Early View articles cannot be cited in the traditional way. They are therefore given a Digital Object Identifier (DOI), which allows the article to be cited and tracked before it is allocated to an issue. After publication in an issue, the DOI remains valid and can continue to be used to cite and access the article. More information about DOIs can be found at