Psychiatry and Clinical Neurosciences

Cover image for Vol. 70 Issue 7

Edited By: Shigenobu Kanba and Tadafumi Kato

Impact Factor: 2.025

ISI Journal Citation Reports © Ranking: 2015: 78/140 (Psychiatry); 111/192 (Clinical Neurology); 177/256 (Neurosciences)

Online ISSN: 1440-1819

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Magnetoencephalography in the study of children with autism spectrum disorder
Mitsuru Kikuchi, Yuko Yoshimura, et al.
Volume 70 Issue 2 - February 2016

Promising evidence and remaining issues regarding the clinical application of oxytocin in autism spectrum disorders
Hidenori Yamasue
Volume 70 Issue 2 - February 2016

Multidimensional anatomy of ‘modern type depression’ in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5
Takahiro A. Kato, Ryota Hashimoto, et al.
Volume 70 Issue 1 - January 2016

Tobacco smoking: From ‘glamour’ to ‘stigma’. A comprehensive review
João Mauricio Castaldelli-Maia, Antonio Ventriglio, et al.
Volume 70 Issue 1 - January 2016

Generalized social anxiety disorder: A still-neglected anxiety disorder 3 decades since Liebowitz's review
Toshihiko Nagata, Futoshi Suzuki, et al.
Volume 69 Issue 12 - December 2015

Schizophrenia in 2020: Trends in diagnosis and therapy
Wolfgang Gaebel and Jürgen Zielasek
Volume 69 Issue 11 - November 2015

Practical pharmacotherapy for acute schizophrenia patients
Kotaro Hatta
Volume 69 Issue 11 - November 2015

Biochemical markers subtyping major depressive disorder
Hiroshi Kunugi, Hiroaki Hori, et al.
Volume 69 Issue 10 - October 2015

Statistical aspects of psychiatric inpatient care in Japan: Based on a comprehensive nationwide survey of psychiatric hospitals conducted from 1996 to 2012
Hisateru Tachimori, Tadashi Takeshima, et al.
Volume 69 Issue 9 - September 2015

Glia-related genes and their contribution to schizophrenia
Chenyao Wang, Branko Aleksic, et al.
Volume 69 Issue 8 - August 2015

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Cutting Edge Neuroimaging Research (July 2016)

Focusing on Mental Health (September 2015)

Cutting Edge of Anxiety and Obsessive Compulsive Disorder Research (July 2015)

Targets in Schizophrenia (May 2015)

Recent Findings of Neurodevelopmental Disorders in Japan (March 2015)

Conquering depression (January 2015) Free Online

Featured Articles - Free Online Access


Magnetoencephalographic recording of auditory mismatch negativity in response to duration and frequency deviants in a single session in patients with schizophrenia
Motomu Suga, Yukika Nishimura, et al.
Volume 70 Issue 7 - July 2016
This paper reports the potential usefulness of mismatch negativity by using magnetoencephalography (MMNm) as a biomarker for schizophrenia in real-world clinical psychiatry settings. Two types of MMNm were examined, and power of duration-variant MMNm was reduced in patients with schizophrenia regardless of illness duration, while that of frequency- deviant MMNm was not. This report is valuable because two types of MMNm were simultaneously recorded with significantly large number of subjects compared to previous studies.

Biological aspects and candidate biomarkers for psychotic bipolar disorder: A systematic review
Massimiliano Buoli, Alice Caldiroli, et al.
Volume 70 Issue 6 - June 2016

Post-traumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage
Hirokazu Yoshida, Natsuko Kobayashi, et al.
Volume 70 Issue 5 - May 2016

Correlation between neurochemical metabolism and memory function in adolescent patients with depression: A multi-voxel 1H magnetic resonance spectroscopy study
Ning Mao, Junfang Fang, et al.
Volume 70 Issue 4 - April 2016
This study examined biochemical abnormalities of the brain in patients with depression using proton magnetic resonance (MR) spectroscopy. It is superior in terms of using multi-voxel MR spectroscopy to detect localized abnormalities. We found characteristic abnormalities in the prefrontal white matter of untreated adolescent patients with depression, and a decreased N-acetylaspartate to creatine ratio in the bilateral prefrontal white matter was associated with an impaired memory function.

Diffuse neurofibrillary tangles with calcification (Kosaka–Shibayama disease) in Japan
Katsuyuki Ukai and Kenji Kosaka
Volume 70 Issue 3 - March 2016
In this ambitious article, the authors propose clinical diagnostic criteria for “diffuse neurofibrillary tangles with calcification (DNTC),” which has, to date, been primarily reported by neuropathologists in Japan. In future, opportunities for diagnosing patients with DNTC worldwide are anticipated. Genetic research of idiopathic basal ganglia calcification (IBGC) has made remarkable progress in recent years (refer to the editorial of this issue), and the possibility that patients with DNTC could be hidden among those with IBCG accompanied by dementia should be carefully examined.

Autobiographical memory dysfunctions in depressive disorders
Monika Talarowska, Michael Berk, et al.
Volume 70 Issue 2 - February 2016
The present study broadly reviewed the literature examining autobiographical memory dysfunction in depressive disorders. Autobiographic memory (AM) includes two elements, episodic and semantic ones, and plays both interpersonal and intrapsychic roles. The authors considered recurrent depressive disorders as a systematic condition that neuroanatomically included the function of hippocampus, frontal lobes, amygdale nucleus, and hypothalamic-pituitary-adrenal axis, and suggested that AM dysfunctions could be a cause and consequence of depression symptoms. The present hypotheses of a circle of AM dysfunctions may be helpful for further research and treatment for depression.

Baseline symptom severity predicts serotonin transporter change during psychotherapy in patients with major depression
Mikko Joensuu, Pasi Ahola, et al.
Volume 70 Issue 1 - January 2016
This study examined association between the availability of serotonin transporter (SERT) and effects of dynamic psychotherapy in patients with depression over 12–18 months. The availability of SERT was measured using single-photon emission computed tomography imaging before and after the therapy. We found that the severity of depressive symptoms before therapy could predict the changes in the availability of SERT in the midbrain during the therapy. The study has some limitations; the number of subjects is not enough to evaluate its efficacy and standardization of the protocol of dynamic psychotherapy is difficult.
Nevertheless, this report is valuable because there are few other reports describing the neural basis of dynamic psychotherapy.

Clinical impact of 11C-Pittsburgh compound-B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cognitive impairment
Yoshie Omachi, Kimiteru Ito, et al.
Volume 69 Issue 12 - December 2015
This study investigated a degree of consistency in clinical and research diagnostic criteria of Alzheimer's disease, and the influences of PiB PET on such degree. The evaluation was performed under the present circumstances in Japan, that MRI is used for structural imaging and cerebral blood flow SPECT is used for functional imaging.

Longitudinal association between habitual physical activity and depressive symptoms in older people
Yuko Yoshida, Hajime Iwasa, et al.
Volume 69 Issue 11 - November 2015
This is a cohort study investigating the relationship between physical activity and depression symptoms among 950 community-dwelling older people. A state of physical activity and depression of the subjects during a 2-year period from 2002 to 2003 was examined, and 270 subjects who had depression symptoms in 2003 were excluded. The state of depression in 2006 in the remaining 680 subjects was examined, using the Geriatric Depression Scale. The results showed significantly lower rates of depression among subjects who had continued physical activities in 2002 and 2003, compared to the subjects who had not. With regards to the correlation between physical activity and depression, it was difficult to confirm the causality between these two parameters. However, this cohort study demonstrated very interesting results suggesting that physical activity may prevent depression.

Evaluation of resting state gamma power as a response marker in schizophrenia
Sayantanava Mitra, S. Haque Nizamie, et al.
Volume 69 Issue 10 - October 2015

Comparison of treatment selections by Japanese and US psychiatrists for major depressive disorder: A case vignette study
Atsuo Nakagawa, Aya Williams, et al.
Volume 69 Issue 9 - September 2015
This study investigated a gap between the treatment algorithm and the clinical practices for depression performed by early-career psychiatrists in Japan and the USA. The gap was greater in Japanese psychiatrists. Even though the small sample size is a limitation, this study is valuable due to its social relevance and creativity.

Rare heterozygous truncating variations and risk of autism spectrum disorder: Whole-exome sequencing of a multiplex family and follow-up study in a Japanese population
Emiko Inoue, Yuichiro Watanabe, et al.
Volume 69 Issue 8 - August 2015
A genome-wide analysis was performed for autism spectrum disorders in multiplex families, and two rare heterozygous truncating mutations (RPS24 Q191X and CD300LF P261fsX266) were identified. However, the same mutation was not found in another study including 667 individuals in the control group and 243 individuals in the autism spectrum disorder group. The results of the present study indicate that these two heterozygous truncating mutations are risk candidates for autism spectrum disorders. Our results may shed light on the genetic background of autism spectrum disorders in future.

Biological heterogeneity of obsessive–compulsive disorder: A voxel-based morphometric study based on dimensional assessment
Kayo Okada, Tomohiro Nakao, et al.
Volume 69 Issue 7 - July 2015
Abnormal orbitofrontal cortical–striatal–thalamic circuit is a well-known feature of obsessive-compulsive disorder (OCD). This study examined brain anatomy in OCD, and reported extensively reduced gray matter. Further, it was revealed that the part of the brain involved varied depending on the symptoms, suggesting that the neural basis of OCD differs depending on the symptoms.

White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study
Miho Ota, Takamasa Noda, et al.
Volume 69 Issue 6 - June 2015
This valuable study examined the structural changes in white matter using diffusion tensor imaging to clarify the neurobiological basis of major depressive disorder presenting with atypical features differing from the clinical manifestations, course, and drug reaction of melancholic depression.

Role of cortisol in patients at risk for psychosis mental state and psychopathological correlates: A systematic review
Evangelos Karanikas and Giorgos Garyfallos
Volume 69 Issue 5 - May 2015
Many studies to date have examined the role of cortisol, a stress hormone, in schizophrenia. This paper comprises a systematic review of 16 articles related to the role of cortisol in the pathology of the prodromal phase of schizophrenia, which has garnered particular attention recently.



Folia awards were established with aims to pursue the development of psychiatric research. One outstanding article per year is selected. Click on the title links to read these awarded articles for FREE

Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography
Hirotoshi Hiraishi et al.
Volume 69 Issue 3 - March 2015

Effects of maternal depressive symptomatology during pregnancy and the postpartum period on infant–mother attachment
Harue Ohoka et al.
Volume 68 Issue 8 - August 2014

To access previously awarded articles, click here