Diseases of the Esophagus

Cover image for Vol. 29 Issue 8

Edited By: John Pandolfino and Giovanni Zaninotto

Impact Factor: 2.146

ISI Journal Citation Reports © Ranking: 2015: 52/79 (Gastroenterology & Hepatology)

Online ISSN: 1442-2050

Author Guidelines

Diseases of the Esophagus is the official journal of the International Society for Diseases of the Esophagus (ISDE) and the European Society of Disease of the Esophagus (ESDE)

The Journal is devoted to esophageal physiology and esophageal and covers all aspects of their etiology, diagnosis and both medical and surgical treatment. All manuscripts submitted to Disease of the Esophagus must be original, i.e. not published elsewhere, except than in an abstract form, and should not under consideration in another journal. Manuscript must be prepared according the instructions below. Manuscripts not following this format will be sent back for revision to the Authors before being submitted to the reviewers. Editors in Chief invite submission of manuscripts in the following categories:

• Original Research at the highest level, including randomized controlled clinical studies, prospective case-controlled studies, retrospective case-controlled studies, substantive retrospective series.
• In depth clinical reviews and meta-analysis
• Papers focused on esophageal physiology and pathogenesis
• Technology papers, describing new technologies and their evaluation
• Practice Guidelines
• Leading articles (by invitation only)
• Short Editorials (by invitation only)
• Letters to the Editors

Basic sciences articles will no longer be considered for publication. Exceptions may be made if they possess a strong translational component and the Editors will contact authors directly with a decision of whether or not the paper will be reviewed.
Disease of the Esophagus does not accept Case Reports.

The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. All manuscripts are subject to peer review by at least two experts in the field, the Associate Editor and the Editors-in-Chief. Final acceptance or rejection rests with the Editorial Board. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence, as material cannot be returned. The Editors-in-Chief strongly suggest that for those Authors of not English speaking countries a revision of the English should be provided by a professional mother tongue English speaking scientific writer. In case you would like to receive language editing, Wiley recommends Wiley Editing Services. For more information and price quotation please contact The Editors in Chief take the right to send back to the Authors every manuscript with poor English for proper editing before sending it to the reviewers. Reviewers are the most important asset of the Journal and their time should not be wasted!

Effective with the 2012 volume, this journal will be published in an online-only format.

Edited by: John Pandolfino and Giovanni Zaninotto
Online ISSN: 1442-2050
Frequency: Eight times a year
Current volume: 28
ISI Journal Citation Reports® Ranking: 2013: 46/75 Gastroenterology & Hepatology
2013 Impact Factor: 2.057
Editorial Office: Zach DeBoer – DES@jjeditorial.com

Peer review and editing

Upon submission, the manuscript is checked for compliance with these author instructions. If the submission is complete, the Editors-in-Chief assesses the manuscript for suitability. A small percentage of manuscripts are rejected without peer review--for example, if the article type is inappropriate (DE rarely publishes case reports or guidelines), if the subject matter is unsuitable for the DE readership, or if the scientific and/or surgical merit of the paper is flawed (not ethical). All other articles are allocated to a specialist Editor, who either selects relevant referees for single-blind peer review (the referees know the identity of the authors, but the authors do not know the identity of the referees) or consults with at least one other Editor before rejecting the manuscript without peer review (for the reasons outlined above).

This “triage” system of rejecting a small percentage of manuscripts without peer review serves two purposes. First, quick decisions on papers unsuitable for DE facilitate submission to another journal in a timely fashion and, second, the Journal’s most valuable asset – the referees – are not overloaded with manuscripts that will not be accepted for publication.

Two or three referees are usually invited to comment on each submission. If the first two referee reports are in agreement, a decision is made on the basis of two reports, hopefully saving the third referee valuable time. When the opinions of the referees differ significantly, the manuscript is discussed at the Editors’ meeting. When a decision has been reached, this is communicated to the author. Articles not subjected to peer review include solicited Leading Articles (in which case the topic and structure of the article is largely designed by the Editor-in-Chief in collaboration with the author), the Correspondence section, and Book Reviews. These are all managed with the highest standards by the Diseases of the Esophagus Editors.

The Editors’ decision is final unless there is a proven error in the process of manuscript evaluation or peer review. If you believe that there has been an error of process in the handling of your manuscript, please address your concerns to the Editor-in-Chief and include the manuscript submission number.

Authorship and Scientific Responsibility

Only those individuals who made direct contributions to the intellectual content of the paper may be listed as authors. Persons designated as authors should meet all of the following criteria:

  1. Made substantial contributions to conception and design, and/or acquisition of data, and/or analysis and interpretation of data.

  2. Participated in drafting the article or revising it critically for important intellectual content

  3. Gave final approval of the version to be submitted and any revised version to be published

Within the Introduction Letter, the authors should describe the role of the study’s sponsors in the following areas:

  1. Designing the study

  2. Collecting, analyzing, and interpreting the data

  3. Writing the report

  4. Making the decision to submit for publication

After a manuscript is accepted for publication, no author can be removed from or added to the author list, nor can the order of the authors be changed without the written permission of all of the manuscript authors.

Informed Consent

The Journal adheres to the principles set forth in the Helsinki Declaration (http://www.wma.net/e/policy/b3.htm) and holds that all reported research conducted with human participants should be conducted in accordance with such principles. Reports describing data obtained from research conducted in human participants must contain a statement in the Methods section indicating approval by the institutional review board and affirmation that informed consent was obtained from each participant. If patients are identifiable from illustrations, photographs, case reports, or other study data, release forms (or copies of the figures with the appropriate release statement) giving permission for publication must be submitted with the manuscript.

Consort Statement

All authors engaged in studies based on randomized trials are asked to adhere to the principles outlined in the CONSORT statement (http://www.consort-statement.org/), an important research tool that takes evidence-based approach to improve the quality of reports of randomized trials. Manuscripts reporting results of randomized controlled trials (RCTs) should include the CONSORT flow diaphragm showing the progress of patients through the trial (http://www.consort-statement.org). The CONSORT checklist should also be completed and submitted with the manuscript.

Consultant Statistician and Statistical Methods

All manuscripts with statistical analysis are required to undergo biostatistical review to ensure adequate and appropriate study design, analysis, interpretation, and reporting. The Journal requires that a biostatistician review these manuscripts prior to submission. The most appropriate way to involve a biostatistician is a consultant or coauthor from the investigators’ home institution or collaborative group. The individual must review the Statistical Methods statement and complete and sign the Statistical Collaboration/Review Release Statement, available online at our manuscript submission site. Manuscripts may undergo further biostatistical review by the Journal after submission. Additional information on statistical methods can be found in “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” (www.icmje.org/index.html).

Registration of Clinical Trials

In 2004, the International Committee of Medical Journal Editors (ICMJE) recommended that clinical trials be registered in a public database as a prerequisite for subsequent publication (see De Angelis C, Drazen JM, Frizelle FA, et al. Clinical trials registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med 2004;351:1250-1).Joining with the Surgical Journal Editors Group (SJEG), DE has agreed to adopt this registration standard. The Editor now requires the pre-registration of all prospective clinical trials that have a control group, as well as any commercially-sponsored clinical trial, including Phase I and II trials. Registration for retrospective reviews or summaries of standard clinical treatment is not required. Clinical trials that meet the above requirement and commenced after April 1, 2007 must be registered prior to enrollment of the first patient. Relevant trials that began before this date must be unique study number assigned at www.clinicaltrials.gov, the principle site of registration sponsored by the National Library of Medicine (NLM). Detailed directions and a tutorial for registering a trial are available at http://prsinfo.clinicaltrials.gov (see Consensus statement on mandatory registration of clinical trials. J Thorac Cardiovasc Surg 2007;133:859-60).


  • Original articles should not exceed 4500 words, which includes all words submitted regardless of location within the manuscript. The counted words include title page, abstract, text, acknowledgments, disclosures, tables, figure legends and references. The combined total of illustrations and tables should not exceed 10 and the number of references should not exceed 40. At the discretion of the editor, supplementary material may be submitted for publication.

  • Review Articles are limited to 6500 words, and all words are counted regardless of location within tables, figure legends and all references.The total number of references should not exceed 80. The editor is willing to discuss more specific guidelines about the subject matter and content of review articles by e-mail or telephone.

  • New Technology articles are limited to 2500 words including title page, abstract, text, acknowledgments, disclosures, tables figure legends and references. The number of tables should not exceed three; the number of illustrations should not exceed six if tables are included; eight, if there are no tables. The number of references should not exceed 10. All New Technology papers require an Acknowledgment, which discloses funding sources and includes a freedom of investigation statement.

  • Case reports are not published unless they represent very original information. Authors of case reports that don't meet these requirements are encouraged to submit to Wiley’s open access journal Clinical Case Reports (www.clinicalcasesjournal.com), which aims to directly improve health outcomes by identifying and disseminating examples of best clinical practice.

  • Editorials usually provide solicited commentary and analysis concerning an article in the issue of the Journal in which they appear. They may include one figure or table. Editorials are limited to 900 words, with up to 10 references.

  • Leading Articles are commissioned by the Editors on “hot topics” of esophageal physiology or disease. They should not exceed 2000 words with up to 20 references.

  • Correspondence (Letters to the Editor) The Editors welcome topical correspondence from readers relating to articles published in the Journal. Selected letters must be no more than 250 words in length, including no more than five references. Original data will not be published in the Correspondence section. When selected these opinions will be sent to the authors of the related articles to be published with their response.

  • Book Reviews are generally solicited. We are willing to consider proposals for book reviews, but please contact the Editorial Office before submitting a review.

Author Checklist

IMPORTANT NOTES: Failure to respect the specification for each of the following item will result in automatic rejection. Case Reports will be considered only if they are unique and of exceptional interest to the readership. Language: Manuscripts must be written in English. Spelling can be British or American, but consistent throughout.

 Item Original Article Review New Technology Images Letter to Editor
 Cover Letter YesYes Yes Yes  Yes
 Title Page YesYes  YesYes  Yes
Abstract (500 Words)
Keywords (3-5)
 YesNo Yes Yes No
 Maximum Text Words (on Title page)  45006500 2500  300 250
 Acknowledgements YesYes  YesYes  Yes
 References Yes
 Figure Legends YesYes YesYes  No
 Tables YesYesYes No No
 Figures* YesYes Yes Yes No

* Figures and graphics should be supplied as high-resolution files saved as .eps or .tif format.


Diseases of the Esophagus prefers to receive all manuscript submissions electronically. To submit a manuscript, please follow the instructions below.

Getting Started

1. Launch your web browser (Internet Explorer 5 or higher or Netscape 7 or higher) and go to the Diseases of the Esophagus Manuscript Central homepage (http://mc.manuscriptcentral.com/des).

2. Log-in or click the “Create Account” option if you are a first-time user of Manuscript Central.

3. If you are creating a new account:

  • After clicking on “Create Account”, enter your name and e-mail information and click “Next”. Your e-mail information is very important.

  • Enter your institution and address information as appropriate, and then click “Next.”

  • Enter a user ID and password of your choice (we recommend using your e-mail address as your user ID), and then select your area of expertise.

  • Click “Finish”.

4. Log-in and select “Author Center.”

5. After you have logged in, click the “Submit a Manuscript” link in the menu bar.

6. Enter data and answer questions as appropriate.

7. Click the “Next” button on each screen to save your work and advance to the next screen.

8. You are required to upload your files.

  • Click on the “Browse” button and locate the file on your computer.

  • Select the designation of each file in the drop down next to the Browse button.

  • When you have selected all files you wish to upload , click the “Upload Files” button.

9. Review your submission (in both PDF and HTML formats) before sending to the Journal. Click the “Submit” button when you are finished reviewing.

You may suspend a submission at any phase before clicking the “Submit” button and save it to submit later. After submission, you will receive a confirmation e-mail. You can also access Manuscript Central any time to check the status of your manuscript. The Journal will inform you by e-mail once a decision has been made.

Conditions of Publication
All articles submitted to the Journal must comply with the following instructions. Failure to do so will result in return of the manuscript and possible delay in publication. Manuscripts should be written so that they are intelligible to the professional reader who is not a specialist in the particular field. Where contributions are judged as acceptable for publication on the basis of scientific content, the Editor or the Publisher reserves the right to modify typescripts to eliminate ambiguity and repetition and improve communication between author and reader. If extensive alterations are required, the manuscript will be returned to the author for revision.

Manuscript Preparation
Submissions should be doubled-spaced in Microsoft Word using US letter (8.5 by 11 inch) sizing. The top, bottom and side margins should be 30 mm. All pages should be numbered consecutively in the top right-hand corner, beginning with the title page. Indent new paragraphs. Turn the hyphenation option off, including only those hyphens that are essential to the meaning. The font should be 12 point.

Manuscripts should follow the style of the Vancouver agreement detailed in the International Committee of Medical Journal Editors revised 'Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication', as presented at http://www.ICMJE.org/.

The Journal uses US spelling and authors should therefore follow the latest edition of the Merriam-Webster's Collegiate Dictionary.

All measurements must be given in SI units as outlined in the latest edition of Units, Symbols and Abbreviations: A Guide for Medical and Scientific Editors and Authors (Royal Society of Medicine Press, London).

Abbreviations should be used sparingly and only where they ease the reader’s task by reducing repetition of long, technical terms. Initially use the word in full, followed by the abbreviation in parentheses. Thereafter use the abbreviation. At the first mention of a chemical substance, give the generic name only. Trade names should not be used. Drugs should be referred to by their generic names, rather than brand names.

Parts of the manuscript
Manuscripts should be presented in the following order: (i) title page, (ii) abstract and key words, (iii) text, (iv) acknowledgments, (v) references, (vi) figure legends, (vii) tables (each table complete with title and footnotes) and (viii) figures. Footnotes to the text are not allowed and any such material should be incorporated into the text as parenthetical matter.

Title page
The title page should contain (i) the title of the paper, (ii) the full names of the authors and (iii) the addresses of the institutions at which the work was carried out together with (iv) the full postal and email address, plus facsimile and telephone numbers, of the author to whom correspondence about the manuscript, proofs and requests for offprints should be sent.

In keeping with the latest guidelines of the International Committee of Medical Journal Editors, each author’s contribution to the paper is to be quantified.

The title should be short, informative and contain the major key words. A short running title (fewer than 40 characters, including spaces) should also be provided.

Abstract and key words
Articles must have an abstract that states in 500 words or fewer the purpose, basic procedures, main findings and principal conclusions of the study. The abstract should not contain abbreviations or references. Up to five key words should be supplied below the abstract and should be taken from those recommended by the Index Medicus Medical Subject Heading (MeSH) browser list (http://www.nlm.nih.gov/mesh/meshhome.html).

Authors should use subheadings to divide the sections of their manuscript: Introduction, Materials and methods, Results, Discussion, Acknowledgments, References.

The source of financial grants and other funding should be acknowledged, including a frank declaration of the authors’ industrial links and affiliations. The contribution of colleagues or institutions should also be acknowledged. Thanks to anonymous reviewers are not appropriate.

The Vancouver system of referencing should be used. In the text, references should be cited using superscript Arabic numerals in the order in which they appear. If cited only in tables or figure legends, number them according to the first identification of the table or figure in the text. In the reference list, the references should be numbered and listed in order of appearance in the text. Cite the names of all authors when there are six or fewer; when seven or more list the first three followed by et al. Names of journals should be abbreviated in the style used in Index Medicus. Reference to unpublished data and personal communications should appear in the text only.

References should be listed in the following form:

Journal article
Soter NA, Wasserman SI, Austen KF. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med 1976; 294: 687-90.

HE, Baron BA, McDonald MB, Waltman SR (eds). The Cornea. New York: Churchill Livingstone, 1988.

Chapter in a Book
McEwen WK, Goodner IK. Secretion of tears and blinking. In: Davson H (ed.) The Eye, Vol. 3, 2nd edn. New York: Academic Press, 1969; 34-78.

Tables should be self-contained and complement, but not duplicate, information contained in the text. Tables should be numbered consecutively in Arabic numerals. Each table should be presented on a separate sheet of A4 paper with a comprehensive but concise legend above the table. Tables should be double-spaced and vertical lines should not be used to separate columns. Column headings should be brief, with units of measurement in parentheses; all abbreviations should be defined in footnotes. Footnote symbols: †, ‡, §, ¶, should be used (in that order) and *, **, *** should be reserved for P-values. The table and its legend/footnotes should be understandable without reference to the text.

Figures should be submitted as publication-quality figures in TIFF or EPS file format. JPEG or GIF files are not permitted. Figure legends Legends should be self-explanatory and listed separately sheet. The legend should incorporate definitions of any symbols used and all abbreviations and units of measurement should be explained so that the figure and its legend are understandable without reference to the text. (Provide a letter stating copyright authorization if figures have been reproduced from another source.)

Online Guidelines
If possible, authors should visit the Wiley-Blackwell websites for authors at http://authorservices.wiley.com/bauthor/journal.asp and http://authorservices.wiley.com/ which detail further information on the preparation and submission of articles and figures.

Note: Image files submitted during the peer review process must be in digital format, not a format for publication. If your manuscript is accepted, you may be requested to submit higher quality images in to the journal.

Rapid Review
Diseases of the Esophagus now offers a rapid review of manuscripts previously submitted to another journal.

As stated in the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication” ( http://www.icmje.org ; Updated February 2006): “ If the manuscript has been submitted previously to another journal, it is helpful to include the previous editor’s and reviewers’ comments with the submitted manuscript, along with the authors’ responses to those comments. Editors encourage authors to submit these previous communications and doing so may expedite the review process.”

For manuscripts previously submitted to other journals with impact factor more than 5 , if authors upload previous editor’s and reviewers’ comments along with their responses to their electronic submission, Diseases of the Esophagus will guarantee a rapid (within 2 business days) in-house assessment once the manuscript has been processed (after the completion of the submission checklist), with three possible outcomes:

a. Acceptance or acceptance with minor changes (no additional external reviews needed);
b. Rejection;
c. Additional external review needed; in this case the authors will have the possibility of accepting the additional external review or withdrawing the manuscript.

If you can comply with the above requirements, check the box that states, “I have previously submitted this paper to another journal with Impact Factor of 5 or higher, and I would like it to be considered under the Rapid Review policy.” This checkbox is located in Step 5 of the submission process.

Cover letter
Papers are accepted for publication in the Journal on the understanding that the content has not been published or submitted for publication elsewhere. This must be stated in the covering letter. Authors must also state that the protocol for the research project has been approved by a suitably constituted Ethics Committee of the institution within which the work was undertaken and that it conforms to the provisions of the Declaration of Helsinki in 1995 (as revised in Edinburgh 2000). All investigations on human subjects must include a statement that the subject gave informed consent and patient anonymity should be preserved. Authors should declare any financial support or relationships that may pose conflict of interest.

Proofs will be sent via email as an Acrobat PDF (Portable Document Format) file and should be returned within 3 days of receipt. Alterations to the text and figures (other than the essential correction of errors) are unacceptable at proof stage and authors may be charged for excessive alterations. Acrobat Reader will be required in order to read the PDF. This software can be downloaded (free of charge) from the following: www.adobe.com/products/acrobat/readstep2.html.

This will enable the file to be opened, read on screen, and printed out in order for any corrections to be added. Further instructions will be sent with the proof.

Authors should therefore supply an email address to which proofs can be emailed. Proofs will be sent by courier if no email address is available. If absent, authors should arrange for a colleague to access their email, retrieve the PDF proof and check and return it to the Publisher on their behalf.

Papers accepted for publication become copyright of the International Society for Diseases of the Esophagus (ISDE) and authors will be asked to sign a transfer of copyright form. In signing the transfer of copyright it is assumed that authors have obtained permission to use any copyrighted or previously published material. All authors must read and agree to the conditions outlined in the Copyright Assignment Form, and must sign the Form or agree that the corresponding author can sign on their behalf. Articles cannot be published until a signed Copyright Assignment Form has been received.

Ordering Reprints
A minimum of 50 offprints will be provided upon request, at the author's expense. An Offprint Order Form outlining the cost of offprints will be sent to the corresponding author with the page proofs. Offprints will be provided only if a completed Offprint Order Form is returned to the Publisher by the specified date.

Journal Contact Information
Stephanie Norie Theng – stephanie.norie.theng.chum@ssss.gouv.qc.ca

Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see www.wiley.com/go/nihmandate.

IMPORTANT NOTES: Failure to respect the specification for each of the following item will result in automatic rejection. Case Reports will be considered only if they are unique and of exceptional interest to the readership. Language: Manuscripts must be written in English. Spelling can be British or American, but consistent throughout.