Biochemical analysis of the living human vitreous
Jan Kokavec, San H Min, Mei H Tan, Jagjit S Gilhotra, Henry S Newland, Shane R Durkin, John Grigg and Robert J Casson
Version of Record online: 19 APR 2016 | DOI: 10.1111/ceo.12732
Key point summary
- The concentration of solutes within the vitreous of living human eyes is largely unknown.
- The study provides the physiological concentrations of the following vitreous analytes in humans: sodium, potassium, chloride, calcium, magnesium, copper, zinc, selenium, iron, glucose, lactate, ferritin, transferrin, osmolality and β-hydroxybutyrate.
- These findings significantly differed from previous estimates using animal models.
- There were no significant gender differences, but differences in certain analytes between diabetic and non-diabetic participants were noted.