From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits
Angela Heinrich, Frauke Nees, Anbarasu Lourdusamy, Jelka Tzschoppe, Sandra Meier, Sabine Vollstädt-Klein, Mira Fauth-Bühler, Sabina Steiner, Christiane Bach, Luise Poustka, Tobias Banaschewski, Gareth J. Barker, Christian Büchel, Patricia J. Conrod, Hugh Garavan, Jürgen Gallinat, Andreas Heinz, Bernd Ittermann, Eva Loth, Karl Mann, Eric Artiges, Tomáš Paus, Claire Lawrence, Zdenka Pausova, Michael N. Smolka, Andreas Ströhle, Maren Struve, Stephanie H. Witt, Gunter Schumann, Herta Flor and Marcella Rietschel, The IMAGEN consortium
Article first published online: 1 APR 2013 | DOI: 10.1111/ejn.12201
We analysed the effects of the schizophrenia-associated risk variant in AMBRA1 (rs11819869) on impulsivity-related traits on a behavioral, temperament, and neural level in a large sample of healthy adolescents. Our findings support the hypothesis that rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral- as well as an imaging genetics level.