Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
Clemens Schroeder, Min Tae M. Park, Jürgen Germann, M. Mallar Chakravarty, Lars Michels, Spyros Kollias, Sara L. Kroll, Alfred Buck, Valerie Treyer, Egemen Savaskan, Paul G. Unschuld, Roger M. Nitsch, Andrea M. Kälin, Christoph Hock, Anton F. Gietl and Sandra E. Leh
Version of Record online: 11 OCT 2016 | DOI: 10.1111/ejn.13408
The authors of this study report a significant association between left hippocampal shape and amyloid deposition measured by PiB-PET in this region in a sample of cognitively healthy elderly individuals. This result was paralleled by a negative association between cortical amyloid burden and thickness of the entorhinal cortex, which is part of the cortical signature of AD. The results of this study show that measurements of entorhinal cortical thickness and hippocampal shape are capable to identify early structural brain changes that occur in association with regional or cortical amyloid deposition in presymptomatic AD.