European Journal of Neuroscience

Cover image for Vol. 41 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: John Foxe and Paul Bolam

Impact Factor: 3.669

ISI Journal Citation Reports © Ranking: 2013: 85/252 (Neurosciences)

Online ISSN: 1460-9568

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  1. Research Reports

    1. In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model

      Shinji Matsumura, Wataru Taniguchi, Kazuhiko Nishida, Terumasa Nakatsuka and Seiji Ito

      Article first published online: 29 JAN 2015 | DOI: 10.1111/ejn.12837

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      The present study first demonstrates that structural synaptic plasticity occurred in the spinal dorsal horn in inflammatory pain by in vivo two-photon microscopy imaging and transgenic mice expressing fluorescent protein specific to the nervous system. Furthermore, acute inflammation-associated structural changes in the spinal dorsal horn were shown to be mediated by glutamate receptor activation.

    2. Activation of the mouse odorant receptor 37 subsystem coincides with a reduction of novel environment-induced activity within the paraventricular nucleus of the hypothalamus

      Bettina Klein, Verena Bautze, Anna-Maria Maier, Jan Deussing, Heinz Breer and Jörg Strotmann

      Article first published online: 24 JAN 2015 | DOI: 10.1111/ejn.12838

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      Secretions from conspecifics modulate the novel environment (NE) induced activity of CRH-producing neurons in the paraventricular nucleus of the mouse hypothalamus. This stress-reducing effect can also be elicited by identified chemical compounds that are detected by a special subfamily of odorant receptors (OR37) in the main olfactory epithelium. These data indicate that the OR37 system may play a role in mediating a phenomenon called social buffering.

    3. Exploration of the dynamics between brain regions associated with the default-mode network and frontostriatal pathway with regards to task familiarity

      Jean-Sebastien Provost and Oury Monchi

      Article first published online: 24 JAN 2015 | DOI: 10.1111/ejn.12821

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      The default-mode network is known to be deactivated when a goal-directed task is being performed. Using functional magnetic resonance imaging, we observed an anticorrelation between the frontostriatal pathway and the regions associated with the default-mode network while performing a set-shifting task. More importantly, a significant increase of activity of the default-mode network was observed as the number of trials executing the same rule increased suggesting a specific contribution of the default-mode network with the level of familiarity of a goal-directed task.

    4. Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice

      A. U. Joshi, C. Orset, B. Engelhardt, E. Baumgart-Vogt, T. Gerriets, D. Vivien and S. M. Kanse

      Article first published online: 23 JAN 2015 | DOI: 10.1111/ejn.12830

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      Mice lacking endogenous Factor VII activating protease (FSAP) had a poorer outcome after a transient ischaemic stroke compared to wild type mice. This was associated with enhanced leukocyte infiltration and apoptosis. At a cellular level, FSAP increased cell survival and decreased apoptosis in primary cortical neurons and astrocytes. These in vivo data indicate that FSAP is a novel endogenous cytoprotective factor which could be relevant for the treatment of stroke.

    5. Effects of defeat stress on behavioral flexibility in males and females: modulation by the mu-opioid receptor

      Sarah A. Laredo, Michael Q. Steinman, Cindee F. Robles, Emilio Ferrer, Benjamin J. Ragen and Brian C. Trainor

      Article first published online: 23 JAN 2015 | DOI: 10.1111/ejn.12824

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      The current study aimed to bridge independent lines of research discussing the role of psychosocial stress and the mu-opioid receptor (MOR) in mediating behavioral flexibility. We have shown that social defeat reduces flexibility and MOR density in males whereas females remain resilient to these deficits. Behavioral deficits were reproduced via MOR antagonism in naïve males, and ameliorated by MOR agonism in defeated males. This is discussed in the context of coping strategies and mood disorders.

    6. Diurnal and stress-induced intra-hippocampal corticosterone rise attenuated in 11β-HSD1-deficient mice: a microdialysis study in young and aged mice

      Joyce L. W. Yau, June Noble, Christopher J. Kenyon, Mike Ludwig and Jonathan R. Seckl

      Article first published online: 23 JAN 2015 | DOI: 10.1111/ejn.12836

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      The diurnal rise in intra-hippocampal corticosterone (CORT) levels in wildtype mice increased with ageing but was greatly diminished in 11β-HSD1−/− mice. A short swim stress induced a greater rise in intra-hippocampal CORT levels in wildtype than 11β-HSD1−/− mice; effects were more pronounced with ageing. These data indicate that 11β-HSD1 activity contributes substantially to diurnal and stress-induced increases in hippocampal CORT levels.

    7. Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy

      Ayako Shima, Naoki Nitta, Fumio Suzuki, Anne-Marie Laharie, Kazuhiko Nozaki and Antoine Depaulis

      Article first published online: 21 JAN 2015 | DOI: 10.1111/ejn.12835

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      In the mouse model of mesial temporal lobe epilepsy induced by intrahippocampal kainate, the mTOR signaling pathway is continuously activated. Its inhibition by rapamycine suppresses granule cell dispersion and sprouting but not focal seizures, BDNF overexpression nor GAD67 reduction. mTOR activation is reversed by midazolam which reduces neuronal activity and seizures. Our data suggest that mTOR signalling pathway contributes to morphological changes of MTLE but does not block epileptogenesis.

    8. Early-life stress induces anxiety-like behaviors and activity imbalances in the medial prefrontal cortex and amygdala in adult rats

      Junko Ishikawa, Ryoichi Nishimura and Akinori Ishikawa

      Article first published online: 10 JAN 2015 | DOI: 10.1111/ejn.12825

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      Early-life stress induces anxiety-like behaviors, and hypoactivity of medial prefrontal cortex (mPFC) and hyperactibvity of basolateral nucleus of amygdala (BLA) in right hemisphere during anxiety-like state in the rats. Early-lifestress increases excitatory latencies of mPFC neurons to amygdalar stimulation in right hemisphere. These data suggest that early-life stress impairs the mPFC–amygdala circuit development, resulting in imbalanced mPFC and amygdala activities and anxiety-like behaviors.

    9. Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain

      H. Beaudry, L. Gendron and J. A. Morón

      Article first published online: 9 JAN 2015 | DOI: 10.1111/ejn.12829

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      We investigated the role of DOP during the development of morphine-tolerance in an animal model of chronic inflammatory pain. Interestingly, naltriben, (DOP2 selective antagonist) but not BNTX (DOP1 selective antagonist) was able to attenuate the development of morphine analgesic tolerance in inflamed rats. Altogether, our results suggest that the blocking DOP2 provides a valuable strategy to attenuate morphine analgesic tolerance in the setting of chronic inflammatory pain.

    10. Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area

      Tsuyoshi Yamaguchi, Jia Qi, Hui-Ling Wang, Shiliang Zhang and Marisela Morales

      Article first published online: 9 JAN 2015 | DOI: 10.1111/ejn.12818

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      Unlike the A10 area of the rat, the mouse A10 area contains a group of TH and VGluT2/TH neurons that do not seem to synthesize dopamine in the adult under normal conditions, as they lack detectable levels of TH protein. By double immunofluorescence, we found mesohabenular fibers expressing mCherry under the TH promoter contain high levels of mCherry signal, but lack detectable levels of TH protein, indicating that the lateral habenula is targeted by TH mRNA(+)/TH protein(−) neurons. In contrast, the A10 innervations to the nucleus accumbens containing mCherry also contained TH-protein.

    11. Identification of a direct GABAergic pallidocortical pathway in rodents

      Michael C. Chen, Loris Ferrari, Matthew D. Sacchet, Lara C. Foland-Ross, Mei-Hong Qiu, Ian H. Gotlib, Patrick M. Fuller, Elda Arrigoni and Jun Lu

      Article first published online: 8 JAN 2015 | DOI: 10.1111/ejn.12822

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      The globus pallidus externa (GPe) projects directly to the cortex. Tracing and in vivo electrophysiology experiments reveal a direct projection from GABAergic GPe neurons to the premotor frontal cortex.

    12. Non-classical mechanism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor channel block by fluoxetine

      Oleg I. Barygin, Margarita S. Komarova, Tatiana B. Tikhonova and Denis B. Tikhonov

      Article first published online: 31 DEC 2014 | DOI: 10.1111/ejn.12817

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      In the present work, we demonstrated that: (i) Ca2+-permeable AMPARs are among the targets for fluoxetine, and (ii) that mechanism of voltage-dependent fluoxetine action on AMPARs does not coincide with action of classical channel blockers like IEM-1460 and philanthotoxins. Molecular modeling suggests the binding of fluoxetine in the subunit interface; analogous binding is proposed for local anesthetics in the closed sodium channels and benzothiazepines in calcium channels.

    13. Differential contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex – a double dissociation

      Krista A. Mitchnick, Samantha Creighton, Matthew O'Hara, Bettina E. Kalisch and Boyer D. Winters

      Article first published online: 30 DEC 2014 | DOI: 10.1111/ejn.12819

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      This study has demonstrated, for the first time, the involvement of DNA methyltransferase enzymes in perirhinal cortex-mediated memory. Furthermore, we reveal a functional double dissociation between the maintenance and de novo DNA methyltransferase families in perirhinal cortex- and hippocampus-mediated object memory, respectively. We hypothesize that these enzymes differentially regulate memory consolidation in these regions for two distinct forms of memory.

    14. Binding body and self in visuo-vestibular conflicts

      Gianluca Macauda, Giovanni Bertolini, Antonella Palla, Dominik Straumann, Peter Brugger and Bigna Lenggenhager

      Article first published online: 30 DEC 2014 | DOI: 10.1111/ejn.12809

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      Vestibular signaling and its multisensory integration are crucial for the sense of a bodily self. Here we showed that moving on a motion platform congruently with a mannequin seen from a first person perspective cools down skin temperature. This suggests that conflicting visuo-vestibular input alters thermoregulation as an implicit measure of body ownership.

    15. Type 2 wide-field amacrine cells in TH::GFP mice show a homogenous synapse distribution and contact small ganglion cells

      Bianca Brüggen, Arndt Meyer, Franziska Boven, Reto Weiler and Karin Dedek

      Article first published online: 29 DEC 2014 | DOI: 10.1111/ejn.12813

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      In the retina of tyrosine hydroxylase (TH)::GFP mice, GFP-expressing type 2 amacrine cells (TH2) are characterized by short and long radial processes, stratifying in the middle of the inner plexiform layer. Here, we show that electrical, excitatory and inhibitory synapses are uniformly distributed along TH2 cell dendrites. We reveal that TH2 cells provide postsynaptic inhibition to several types of ganglion cells; one of them is the W3 cell, a ganglion cell sensitive to object motion.

    16. Interests shape how adolescents pay attention: the interaction of motivation and top-down attentional processes in biasing sensory activations to anticipated events

      Snigdha Banerjee, Hans-Peter Frey, Sophie Molholm and John J. Foxe

      Article first published online: 26 DEC 2014 | DOI: 10.1111/ejn.12810

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      This work examined the influence of level of interest in anticipated stimuli on established ERP indices of spatial attention in adolescents. Results showed significantly greater accuracy in target detection for high versus low interest stimuli, as well as enhanced amplitude in parieto-occipital processes related to anticipatory spatial attention. This provides a foundation for future work with developmentally disabled populations using level of interest in stimuli as incentive to potentially regulate atypical attentional processes.

    17. You have full text access to this OnlineOpen article
      Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates

      Stanislaw Glazewski and Alison L. Barth

      Article first published online: 26 DEC 2014 | DOI: 10.1111/ejn.12805

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      Experience-dependent plasticity in primary somatosensory cortex, induced by removal of all but one whisker, is most pronounced in layer 2/3 neurons for responses to very small whisker deflections, a finding that was not anticipated by prior studies that focused only on relatively high-intensity stimuli. At low stimulus intensities, there was an overall increase in the proportion of neurons that responded to the whisker deflection, indicating a reduction in sparseness.

    18. Chronic alcohol intake abolishes the relationship between dopamine synthesis capacity and learning signals in the ventral striatum

      Lorenz Deserno, Anne Beck, Quentin J. M. Huys, Robert C. Lorenz, Ralph Buchert, Hans-Georg Buchholz, Michail Plotkin, Yoshitaka Kumakara, Paul Cumming, Hans-Jochen Heinze, Anthony A. Grace, Michael A. Rapp, Florian Schlagenhauf and Andreas Heinz

      Article first published online: 26 DEC 2014 | DOI: 10.1111/ejn.12802

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      In alcohol dependence, ‘hijacked’ dopamine signals may impair flexible learning from non-drug rewards. Using fMRI during reversal learning and FDOPA PET, this study suggests that dopaminergic modulation of ventral striatal learning signals is disrupted in alcohol dependence in proportion to long-term alcohol intake of patients. Alcohol intake may perpetuate itself by interfering with dopaminergic modulation of neural learning signals, thus increasing craving for habitual drug intake.

    19. Selective processing of buildings and faces during working memory: the role of the ventral striatum

      Alexa Haeger, Hweeling Lee, Juergen Fell and Nikolai Axmacher

      Article first published online: 22 DEC 2014 | DOI: 10.1111/ejn.12808

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      While being in a 3T MRI scanner, eighteen healthy human subjects performed a modified Sternberg working memory task consisting of faces and buildings which either had to be maintained as low or high memory load or maintained in the context of distraction. Striatum is activated when irrelevant information needs to be suppressed while relevant information needs to be maintained. Striatum reduces gating to category-specific regions (fusiform face area, FFA, and parahippocampal place area, PPA) via attenuation of interregional connectivity.

    20. Intracortical modulation, and not spinal inhibition, mediates placebo analgesia

      M. Martini, M. C. H. Lee, E. Valentini and G. D. Iannetti

      Article first published online: 19 DEC 2014 | DOI: 10.1111/ejn.12807

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      After successful conditioning the placebo analgesia group was associated with a significant reduction of the amplitude of the late laser evoked potentials (LEPs). In contrast, the early component (N1), was only affected by stimulus energy. This selective suppression of late LEPs indicates that placebo analgesia is mediated by direct intracortical modulation and not by an inhibition of the nociceptive input at spinal level, which would have led to a modulation of all LEPs.

    21. Placebo-induced decrease in fatigue: evidence for a central action on the preparatory phase of movement

      Alessandro Piedimonte, Fabrizio Benedetti and Elisa Carlino

      Article first published online: 19 DEC 2014 | DOI: 10.1111/ejn.12806

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      The study of the placebo effect has moved from the clinical to the physical performance setting, whereby placebos boost performance. In the present study we investigated the correlation between the placebo-induced decrease in fatigue and the motor preparation phase, measured through the readiness potential. Our results suggest that placebos reduce fatigue by acting during the anticipatory phase of movement, thus emphasizing the key role of the central nervous system in the generation of fatigue.

    22. A transcranial magnetic stimulation study on response activation and selection in spatial conflict

      Lara Bardi, Sami Schiff, Demis Basso and Daniela Mapelli

      Article first published online: 12 DEC 2014 | DOI: 10.1111/ejn.12803

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      We investigated the role of dorsal premotor cortex (PMd) in response activation and selection during spatial conflict. Single-pulse transcranial magnetic stimulation (TMS) was applied to the PMd during the execution of a Simon task, at different timing after the onset of the visual stimulus. When TMS was applied in an early timing, we observed a delay of responses in corresponding trials. When TMS was applied in a late timing, we observed a delay of non-corresponding responses. This outcome revealed that PMd is involved both in the activation of the spatially triggered response and in response selection during spatial conflict.

    23. Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses

      Christian Vogl, Shota Tanifuji, Benedicte Danis, Veronique Daniels, Patrik Foerch, Christian Wolff, Benjamin J. Whalley, Sumiko Mochida and Gary J. Stephens

      Article first published online: 8 DEC 2014 | DOI: 10.1111/ejn.12799

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      Synaptic vesicle glycoprotein-2A (SV2A) has a controversial role in neurotransmitter release and function is yet to described in peripheral synapses. SV2A knockdown is shown to affect synaptic vesicle release, refilling kinetics and, for the first time, voltage-dependent Ca2+ channel current density. SV2A is an important regulator of presynaptic function in peripheral synapses with a secretory and calcium channel phenotype.

    24. You have full text access to this OnlineOpen article
      Parallel pathways from motor and somatosensory cortex for controlling whisker movements in mice

      Varun Sreenivasan, Kajari Karmakar, Filippo M. Rijli and Carl C. H. Petersen

      Article first published online: 5 DEC 2014 | DOI: 10.1111/ejn.12800

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      Neurons in whisker motor cortex (wM1) project to the reticular formation (Rt) in the brain stem innervating premotor neurons for intrinsic muscles, which drive whisker protraction through motor neurons in the facial nucleus (FN). Neurons in whisker somatosensory cortex (wS1) project to spinal trigeminal (Sp5) brain stem nuclei innervating premotor neurons for extrinsic muscles, which drive whisker retraction through motor neurons in the facial nucleus (FN).

    25. Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area

      Rochelle Herrington, Maxime Lévesque and Massimo Avoli

      Article first published online: 4 DEC 2014 | DOI: 10.1111/ejn.12797

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      Application of 0.1, 1 or 5 μm THDOC to 4AP-treated slices caused a dose-dependent decrease in the duration of the fast events and increase in the occurrence of ripples but not fast ripples; in contrast, the duration of slow interictal events increased. THDOC potentiated the slow events that were recorded during pharmacological blockade of glutamatergic transmission, but had no effect on interictal discharges occurring during GABAA receptor antagonism. The potentiation of GABAA receptor mediated signalling by THDOC differentially affects slow and fast interictal discharges.

    26. Encoding of point of view during action observation in the local field potentials of macaque area F5

      Vittorio Caggiano, Martin Giese, Peter Thier and Antonino Casile

      Article first published online: 1 DEC 2014 | DOI: 10.1111/ejn.12793

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      We analysed the Local Field Potentials (LFPs) in monkey area F5 during the obsevation of actions from two different points of view – the subjective and the frontal view. We found that LFPs were strongly modulated by the point of view. The subjective point of view produced LFPs more similar to those produced by action execution compared to the frontal view. These results suggest that, depending on the point of view, action observation might activate different processes in monkey area F5.

    27. RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions

      Andrew R. Chandna, Manoj Nair, Christine Chang, Paul R. Pennington, Yasuhiko Yamamoto, Darrell D. Mousseau and Verónica A. Campanucci

      Article first published online: 28 NOV 2014 | DOI: 10.1111/ejn.12795

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      Our article demonstrates that RAGE signaling is required to induce oxidative stress and autonomic malfunction during high glucose conditions in cultured sympathetic neurons. This work strongly suggest a pivotal role of RAGE in triggering autonomic complications in diabetes, and proposes RAGE as a potential therapeutic target in the treatment of diabetic autonomic neuropathy.

    28. Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons

      Vivien Zell, Pierre-Éric Juif, Ulrike Hanesch, Pierrick Poisbeau, Fernand Anton and Pascal Darbon

      Article first published online: 26 NOV 2014 | DOI: 10.1111/ejn.12796

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      Corticosterone is spinally reduced in the neuroactive metabolite THDOC that enhances spinal GABAergic synaptic transmission. In turn, we observed a reduction of dorsal spinal network excitability reflecting a selective decrease in processing of C-fibers nociceptive inputs. The depressed neuronal activity at the spinal level leads to a weaker nociceptive message transmission to supraspinal structures and hence to an alleviation of pain.

    29. Preferential assembly of heteromeric small conductance calcium-activated potassium channels

      Timothy W. Church, Kate L. Weatherall, Sonia A. L. Corrêa, David L. Prole, Jon T. Brown and Neil V. Marrion

      Article first published online: 25 NOV 2014 | DOI: 10.1111/ejn.12789

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      Co-expression of a combination of rat and human SK1 and SK2 channel subunits shows that heteromeric channel formation is preferred, but only if species are identical. Viral-mediated expression of a mutant rat SK1 subunit in organotypic hippocampal slices shows that a preference to form heteromeric channels in neurons.

    30. Inhibition in the lateral septum increases sucrose intake and decreases anorectic effects of stress

      Arojit Mitra, Christophe Lenglos and Elena Timofeeva

      Article first published online: 24 NOV 2014 | DOI: 10.1111/ejn.12798

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      The development of sucrose overeating by repeated weekly cycles of food restriction was accompanied by (1) a decrease in the anorectic effects of stress and stress-induced c-fos expression in the lateral septum (LS), (2) an increase in expression of GAD67 in the LS, and (3) an increase in the percentage of LS neurons inhibited at the start of sucrose licking. Direct inhibition of the LS by baclofen decreased the anorectic effects of stress and increased sucrose intake.

    31. A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction

      Kalicharan Patra, David J. Lyons, Pavol Bauer, Markus M. Hilscher, Swati Sharma, Richardson N. Leão and Klas Kullander

      Article first published online: 20 NOV 2014 | DOI: 10.1111/ejn.12790

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      Here, we demonstrate a novel and potentially important role for SLC10A4 (or VAAT) in maintaining the structural integrity and transmission efficiency at the neuromuscular junction (NMJ). VaatKO NMJs display fragmented endplates and reduced synaptic plasticity but elevated levels of cholinergic receptor transcripts. Further studies on VAAT may provide a better understanding of synaptic physiology and treatment of neuromuscular diseases.

    32. Perineuronal nets affect parvalbumin expression in GABAergic neurons of the mouse hippocampus

      J. Yamada, T. Ohgomori and S. Jinno

      Article first published online: 20 NOV 2014 | DOI: 10.1111/ejn.12792

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      High-PV GABAergic neurons in the hippocampus are enwrapped with PNNs, while low-PV neurons lack PNNs. Digestion of PNNs by chondroitinase ABC causes reduction in expression level of PV.

    33. Synapse formation changes the rules for desensitization of PKC translocation in Aplysia

      Carole A. Farah, Faisal Naqib, Daniel B. Weatherill, Christopher C. Pack and Wayne S. Sossin

      Article first published online: 17 NOV 2014 | DOI: 10.1111/ejn.12794

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      We had previously shown that PKC translocation desensitizes differently during spaced and massed applications of serotonin in the cell body of isolated sensory neurons. In this study, we show that synapse formation changes desensitization dynamics of PKC translocation. Using mathematical modeling, we show that these changes could be explained by changes in the targets of translational control and differential PKA targets at the synapse and the cell body.

    34. Neural correlates of object size and object location during grasping actions

      Simona Monaco, Anna Sedda, Cristiana Cavina-Pratesi and Jody C. Culham

      Article first published online: 15 NOV 2014 | DOI: 10.1111/ejn.12786

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      We found coding of object size for grasping movements in the anterior intraparietal sulcus (aIPS), while coding of both object size and location was observed in the superior parietal occipital sulcus (SPOC), primary somatosensory and motor area (S1/M1), Precuneus, dorsal premotor cortex (PMd), and supplementary motor area (SMA). We suggest that area aIPS processes intrinsic object attributes for the execution of an efficient grasp. On the other hand, SPOC, S1/M1, Precuneus, PMd, and SMA integrate object size and location in order to process the digit positioning of the fingers on the object to allow a stable grasp.

    35. Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner

      Andrzej Bialowas, Sylvain Rama, Mickaël Zbili, Vincenzo Marra, Laure Fronzaroli-Molinieres, Norbert Ankri, Edmond Carlier and Dominique Debanne

      Article first published online: 13 NOV 2014 | DOI: 10.1111/ejn.12787

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      The context in which the presynaptic action potential is elicited determines the neuronal output. We show here that spike-evoked transmission at CA3-CA3 synapses can be modulated by analog subthreshold depolarization of the presynaptic neuron. Using a combination of electrophysiological, computational and imaging techniques, we show that axonal Kv1.1 channels determine glutamate release in CA3 neurons in a time-dependent manner through the control of presynaptic spike waveform.

    36. Age-related changes in neural gap detection thresholds in the rat auditory cortex

      Yin Zhao, Xiaoxiao Xu, Juan He, Jinghong Xu and Jiping Zhang

      Article first published online: 12 NOV 2014 | DOI: 10.1111/ejn.12791

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      We measured the neural gap detection thresholds (GDTs) in the primary auditory cortex of juvenile rats (P20-30) and adult rats (Adult I: 8–10 weeks; Adult II: 28–30 weeks), and found that the neural GDTs of juvenile rats were higher than that of adult rats. In addition, auditory cortex neurons generally showed lower GDTs at higher sound levels than at lower sound levels. These results provided evidences for neural correlates of age-related changes in behavioral gap detection ability.

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