Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation
Pierre-Eric Juif, Chiara Salio, Vivien Zell, Meggane Melchior, Adrien Lacaud, Nathalie Petit-Demouliere, Francesco Ferrini, Pascal Darbon, Ulrike Hanesch, Fernand Anton, Adalberto Merighi, Vincent Lelièvre and Pierrick Poisbeau
Version of Record online: 29 JUN 2016 | DOI: 10.1111/ejn.13294
Noxious events occurring early after birth are now well recognize to give rise to hyperexcitable circuits in the nociceptive system at later age. Here, we show that neonatal maternal deprivation (NMD) in rats produces a similar consequence: young adult animals exhibit low nociceptive thresholds and hyperexcitable C-type nociceptors displaying high levels of Nav1.8 gene transcripts. Interestingly, NMD-associated hypernociceptive state is preceded an alteration in the establishment of C-type sensorispinal transmission which is characterized by (i) impaired expression of NGF and DGNF, (ii) hypoexcitable C-type sensory neurons due to excessive K2P channel expression, and (iii) increased inhibition in the superficial layers of the spinal cord.