A regenerative microchannel device for recording multiple single-unit action potentials in awake, ambulatory animals
Akhil Srinivasan, John Tipton, Mayank Tahilramani, Adel Kharbouch, Eric Gaupp, Chao Song, Poornima Venkataraman, Jessica Falcone, Stéphanie P. Lacour, Garrett B. Stanley, Arthur W. English and Ravi V. Bellamkonda
Article first published online: 28 OCT 2015 | DOI: 10.1111/ejn.13080
We report on the development of a fully integrated regenerative microchannel interface, the GT-RE, with large numbers microelectrodes and signal extraction capabilities enabling evaluation in an awake and freely moving rat animal model. In vivo, the GT-RE was successfully utilized for high-throughput recordings of single unit action potentials through 63% of the 30 integrated microelectrodes at the early time point of 3 weeks marking a significant advancement in microchannel interfacing.