Retinal lesions induce fast intrinsic cortical plasticity in adult mouse visual system
Katrien Smolders, Samme Vreysen, Marie-Eve Laramée, Annemie Cuyvers, Tjing-Tjing Hu, Leen Van Brussel, Ulf T. Eysel, Julie Nys and Lutgarde Arckens
Version of Record online: 13 JAN 2016 | DOI: 10.1111/ejn.13143
Induction of a monocular retinal lesion immediately influences neuronal activity in different lesion projection zones throughout adult mouse visual cortex. The speed of recovery of neuronal activity post injury mirrors retinotopic organization, cortical magnification factor and receptive field size. This vision impairment model can lead to a better understanding of brain region-, cell type-, and microcircuit-specific contributions to different forms of cortical neuronal plasticity in mammals.