Three-dimensional morphometric analysis of microglial changes in a mouse model of virus encephalitis: age and environmental influences
Aline A. de Sousa, Renata R. dos Reis, Camila M. de Lima, Marcus A. de Oliveira, Taiany N. Fernandes, Giovanni F. Gomes, Daniel G. Diniz, Nara M. Magalhães, Cristovam G. Diniz, Marcia C. K. Sosthenes, João Bento-Torres, José Antonio P. Diniz Jr, Pedro F. da C. Vasconcelos and Cristovam Wanderley P. Diniz
Article first published online: 26 JUN 2015 | DOI: 10.1111/ejn.12951
We measured the influences of aging and environment on behavioral and microglial changes in a mice model of virus sublethal encephalitis. We found that aged infected mice, showed permanent behavioral impairments and this was associated with smaller morphological changes in CA3 microglia. Young infected mice showed significant CA3 microglial changes with transitory or absent behavioral impairments. Reduced inflammatory response in immunosenescent individuals may aggravate encephalitis outcomes.