Characterisation of cell–substrate interactions between Schwann cells and three-dimensional fibrin hydrogels containing orientated nanofibre topographical cues
Dorothee Hodde, José Gerardo-Nava, Vanessa Wöhlk, Stefan Weinandy, Stefan Jockenhövel, Andreas Kriebel, Haktan Altinova, Harry W. M. Steinbusch, Martin Möller, Joachim Weis, Jörg Mey and Gary A. Brook
Article first published online: 18 AUG 2015 | DOI: 10.1111/ejn.13026
Schwann cells that were embedded in a matrix of a three-dimensional fibrin hydrogel with multiple layers of highly orientated electrospun nanofibres showed a strong tendency to migrate away from the fibrin hydrogel to align closely with the orientation of the nanofibres. The ability of this three-dimensional scaffold to support Schwann cell survival and direct process extension suggest it as an appropriate device design for the bridging of experimental lesions of the peripheral nervous system.