European Journal of Neuroscience

Cover image for Vol. 43 Issue 9

Edited By: John Foxe and Paul Bolam

Impact Factor: 3.181

ISI Journal Citation Reports © Ranking: 2014: 108/252 (Neurosciences)

Online ISSN: 1460-9568

Virtual Issue: Disorders of the Nervous System

This virtual issue of EJN on “Disorders of the Nervous System”, freely available for download [until 30 April 2013] from the journal’s website, is a compilation of articles describing clinical and translational neuroscience research published in 2012 (EJN volumes 35-36). This virtual issue highlights the superb quality and range of research on disease processes published by EJN. This issue also confirms the journals commitment to cover experimental, clinical, and theoretical research on disorders of the nervous system. Jean-Marc Fritschy and Martin Sarter
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Parkinson's disease / Movement disorders
Other neurodegenerative disorders
Chronic pain
Stress and mood disorders
Schizophrenia / autism-spectrum disorders

European Journal of Neuroscience


Disorders of the Nervous System
Jean-Marc Fritschy and Martin Sarter

Parkinson's disease / Movement disorders

Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat
Lalitha Madhavan, Brian F. Daley, Caryl E. Sortwell, Timothy J. Collier

Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model
Zacharias Kohl, Beate Winner, Kiren Ubhi, Edward Rockenstein, Michael Mante, Martina Münch, Carolee Barlow, Todd Carter, Eliezer Masliah, Jürgen Winkler

Striatal NTS1, dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release – a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat
Luca Ferraro, William T. O’Connor, Sarah Beggiato, Maria C. Tomasini, Kjell Fuxe, Sergio Tanganelli, Tiziana Antonelli

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress
Claus Rieker, Andreas Schober, Ainhoa Bilbao, Günther Schütz, Jan Rodriguez Parkitna

Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease
Iddo Magen, Sheila M. Fleming, Chunni Zhu, Eddie C. Garcia, Katherine M. Cardiff, Diana Dinh, Krystal De La Rosa, Maria Sanchez, Eileen Ruth Torres, Eliezer Masliah, J. David Jentsch, Marie-Françoise Chesselet

Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space
M. J. Lelos, D. J. Harrison, S. B. Dunnett

Levodopa influences striatal activity but does not affect cortical hyper-activity in Parkinson’s disease
K. Martinu, C. Degroot, C. Madjar, A. P. Strafella, O. Monchi

Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats
Christopher Bishop, Jessica A. George, William Buchta, Adam A. Goldenberg, Mohamed Mohamed, Sando O. Dickinson, Satie Eissa, Karen L. Eskow Jaunarajs

Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson’s disease: role of NMDA vs. 5-HT1A receptors
Melanie A. Paquette, Alex A. Martinez, Teresa Macheda, Charles K. Meshul, Steven W. Johnson, S. Paul Berger, Andrea Giuffrida

Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects
Jonathan E. Rubin, Cameron C. McIntyre, Robert S. Turner, Thomas Wichmann

Long-range temporal correlations in the subthalamic nucleus of patients with Parkinson’s disease
F. U. Hohlefeld, J. Huebl, C. Huchzermeyer, G.-H. Schneider, T. Schönecker, A. A. Kühn, G. Curio, V. V. Nikulin

Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement
Daniel Weiss, Sorin Breit, Julia Hoppe, Ann-Kathrin Hauser, Dirk Freudenstein, Rejko Krüger, Paul Sauseng, Rathinaswamy B. Govindan, Christian Gerloff

Effect of intermittent theta-burst stimulation on akinesia and sensorimotor integration in patients with Parkinson’s disease
Adrian Degardin, David Devos, Luc Defebvre, Alain Destée, Lucie Plomhause, Philippe Derambure, Hervé Devanne

The habenula couples the dopaminergic and the serotonergic systems: application to depression in Parkinson’s disease
Daphna Sourani, Renana Eitan, Noam Gordon, Gadi Goelman

Cognitive dysfunction and depression in Parkinson’s disease: what can be learned from rodent models?
Hanna S. Lindgren, Stephen B. Dunnett

Characterization of a rat model of Huntington’s disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors
Sanaz Gabery, Muhammad U. Sajjad, Sofia Hult1, Rana Soylu, Deniz Kirik, Åsa Petersén

Plasticity of cortical inhibition in dystonia is impaired after motor learning and paired-associative stimulation
Sabine Meunier, Heike Russmann, Ejaz Shamim, Jean-Charles Lamy, Mark Hallett

The differential modulation of the ventral premotor–motor interaction during movement initiation is deficient in patients with focal hand dystonia
Elise Houdayer, Sandra Beck, Anke Karabanov, Brach Poston, Mark Hallett

Other neurodegenerative disorders

Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation
Viswanath Das, John H. Miller

Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI
Fu-Hua Wang, Paulina Appelkvist, Tomas Klason, Olle Gissberg, Anna Bogstedt, Kristina Eliason, Stefan Martinsson, Sveinn Briem, Anders Andersson, Sandra A. G. Visser, Magnus Ivarsson, Mattias Lindberg, Karin Agerman, Johan Sandin

Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer’s disease [amyloid precursor protein/presenilin 1 (PS1)]
Noemí Esteras, Fernando Bartolomé, Carolina Alquézar, Desireé Antequera, Úrsula Muñoz, Eva Carro, Ángeles Martín-Requero

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease
Pedro M. Pimentel-Coelho, Serge Rivest

Extrusion of misfolded and aggregated proteins – a protective strategy of aging neurons?
Jana Doehner, Christel Genoud, Claudine Imhof, Dimitrije Krstic, Irene Knuesel

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis
Kimmy G. Su, Costanza Savino, Gail Marracci, Priya Chaudhary, Xiaolin Yu, Brooke Morris, Danielle Galipeau, Marco Giorgio, Michael Forte, Dennis Bourdette

An integrated approach to design novel therapeutic interventions for demyelinating disorders
Oscar G. Vidaurre, Jia Liu, Jeffery Haines, Juan Sandoval, Richard Nowakowski, Patrizia Casaccia

Mitochondrial sirtuins – a new therapeutic target for repair and protection in multiple sclerosis
C. M. Rice, M. Sun, K. Kemp, E. Gray, A. Wilkins, N. J. Scolding

Motor endplate disease affects neuromuscular junction maturation
Ghislaine Caillol, Hélène Vacher, Magali Musarella, Sarah Bellouze, Bénédicte Dargent, Amapola Autillo-Touati

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis
T. Prell, J. Lautenschläger, O. W. Witte, M. T. Carri, J. Grosskreutz

Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense
Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Anglister

Transplantation of human central nervous system stem cells – neuroprotection in retinal degeneration
Trevor J. McGill, Benjamin Cottam, Bin Lu, Shaomei Wang, Sergej Girman, Chunyu Tian, Stephen L. Huhn, Ray D. Lund, Alexandra Capela

Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration
M. J. Seiler, B. W. Jones, R. B. Aramant, P. B. Yang, H. S. Keirstead, R. E. Marc


Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus
Mirjam Sibbe, Ute Häussler, Sandra Dieni, Daniel Althof, Carola A. Haas, Michael Frotscher

Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences
Michael Bazelot, Jean Simonnet, Céline Dinocourt, Elodie Bruel-Jungerman, Richard Miles, Desdemona Fricker, Fiona Francis

The extracellular matrix and diffusion barriers in focal cortical dysplasias
Josef Zamecnik, Ales Homola, Michal Cicanic, Klara Kuncova, Petr Marusic, Pavel Krsek, Eva Sykova, Lydia Vargova

Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations
Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth, Merab Kokaia

Modelling the role of tissue heterogeneity in epileptic rhythms
Marc Goodfellow, Peter Neal Taylor, Yujiang Wang, Daniel James Garry, Gerold Baier

Persistent decrease in multiple components of the perineuronal net following status epilepticus
Paulette A. McRae, Esther Baranov, Stephanie L. Rogers, Brenda E. Porter

Interictal spikes, fast ripples and seizures in partial epilepsies – combining multi-level computational models with experimental data
Fabrice Wendling, Fabrice Bartolomei, Faten Mina, Clémént Huneau, Pascal Benquet

Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette
Kevin E. Chapman, Yogendra H. Raol, Amy Brooks-Kayal

Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy
Marta Rattka, Claudia Brandt, Wolfgang Löscher

N w-Propyl-l-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses
Edward Beamer, Jakub Otahal, Graeme J. Sills, Thimmasettappa Thippeswamy

The dynamic evolution of focal-onset epilepsies – combining theoretical and clinical observations
Alex Blenkinsop, Antonio Valentin, Mark P. Richardson, John R. Terry


Doxycycline treatment in a neonatal rat model of hypoxia–ischemia reduces cerebral tissue and white matter injury: a longitudinal magnetic resonance imaging study
Marius Widerøe, Marianne B Havnes, Tora Sund Morken, Jon Skranes, Pål-Erik Goa, Ann-Mari Brubakk

Disruption of raphé serotonergic neural projections to the cortex: a potential pathway contributing to remote loss of brainstem neurons following neonatal hypoxic–ischemic brain injury
Hanna E. Reinebrant, Julie A. Wixey, Kathryn M. Buller

Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance
Elisabetta Gerace, Tania Scartabelli, Laura Formentini, Elisa Landucci, Flavio Moroni, Alberto Chiarugi, Domenico E. Pellegrini-Giampietro

Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways
Fabrício Simão, Aline Matté, Aline S. Pagnussat, Carlos A. Netto, Christianne G. Salbego

Experience-dependent brain plasticity after stroke: effect of ibuprofen and poststroke delay
Jan A. Jablonka, Malgorzata Kossut, Otto W. Witte, Monika Liguz-Lecznar

Astrocyte activation and wound healing in intact-skull mouse after focal brain injury
Takayuki Suzuki, Honami Sakata, Chiaki Kato, John A. Connor, Mitsuhiro Morita

Influence of constraint-induced movement therapy upon evoked potentials in rats with cerebral infarction
Hyung W. Joo, Jung K. Hyun, Tae U. Kim, Sang H. Chae, Young I. Lee, Seong J. Lee

Chronic pain

Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats
Li-Hua Hang, Jian-Ping Yang, Wei Yin, Li-Na Wang, Feng Guo, Fu-Hai Ji, Dong-Hua Shao, Qi-Nian Xu, Xiu-Yun Wang, Jian-Ling Zuo

Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain
Shenglan Wang, Yi Dai, Kimiko Kobayashi, Wanjun Zhu, Yoko Kogure, Hiroki Yamanaka, You Wan, Wensheng Zhang, Koichi Noguchi

Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation
Leonor Gonçalves, Anthony H. Dickenson


Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission
Alessandra Lintas, Ning Chi, Nicole M. Lauzon, Stephanie F. Bishop, Ninglei Sun, Huibing Tan, Steven R. Laviolette

Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell
Ryan T. LaLumiere, Kyle C. Smith, Peter W. Kalivas

Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats
YueQiang Xue, Jeffery D. Steketee, WenLin Sun

Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking
Rachel J. Smith, Gary Aston-Jones

Regulation of the ventral tegmental area by the bed nucleus of the stria terminalis is required for expression of cocaine preference
Gregory C. Sartor, Gary Aston-Jones

Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose
Courtney M. Cameron, Regina M. Carelli

Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice
Lisa. A. Briand, Francis S. Lee, Julie A. Blendy, R. Christopher Pierce

Raclopride or high-frequency stimulation of the subthalamic nucleus stops cocaine-induced motor stereotypy and restores related alterations in prefrontal basal ganglia circuits
Verena Aliane, Sylvie Pérez, Jean-Michel Deniau, Marie-Louise Kemel

Impact of contextual cues in the expression of the memory associated with diazepam withdrawal: involvement of hippocampal PKMζin vivo, and Arc expression and LTP in vitro
Maria C. Monti, Laura A. Gabach, Mariela F. Perez, Oscar A. Ramírez

Structural and behavioral correlates of abnormal encoding of money value in the sensorimotor striatum in cocaine addiction
Anna B. Konova, Scott J. Moeller, Dardo Tomasi, Muhammad A. Parvaz, Nelly Alia-Klein, Nora D. Volkow, Rita Z. Goldstein

Stress and mood disorders

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism
Alana Knapman, Sebastian F. Kaltwasser, Daniel Martins-de-Souza, Florian Holsboer, Rainer Landgraf, Christoph W. Turck, Michael Czisch, Chadi Touma

Antidepressants are neuroprotective against nutrient deprivation stress in rat hippocampal neurons
David Yang, Michael Chen, Amelia Russo-Neustadt

Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system modulating emotional circuitry in adult rats
Shuhei Ishikawa, Yasuhiro Saito, Yoshiki Yanagawa, Satoru Otani, Sachiko Hiraide, Kei-ichi Shimamura, Machiko Matsumoto, Hiroko Togashi

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1
Xiao-Dong Wang, Christiana Labermaier, Florian Holsboer, Wolfgang Wurst, Jan M. Deussing, Marianne B. Müller, Mathias V. Schmidt

Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure
Ornella Valenti, Kathryn M. Gill, Anthony A. Grace

Identification of chronic stress-activated regions reveals a potential recruited circuit in rat brain
Jonathan N. Flak, Matia B. Solomon, Ryan Jankord, Eric G. Krause, James P. Herman

Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference
Robert R. Rozeske, Andre Der-Avakian, Linda R. Watkins, Steven F. Maier

Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei
Maria A. Esparza, Flavia Bollati, Constanza Garcia-Keller, Miriam B. Virgolini, Lidia M. Lopez, Alicia Brusco, Hao-Wei Shen, Peter W. Kalivas, Liliana M. Cancela

Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode
Ana P. Ventura-Silva, José M. Pêgo, João C. Sousa, Ana R. Marques, Ana J. Rodrigues, Fernanda Marques, João J. Cerqueira, Osborne F. X. Almeida, Nuno Sousa

Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze
Alice Pulga, Chiara Ruzza, Anna Rizzi, Remo Guerrini, Girolamo Calo

Schizophrenia and autism-spectrum disorders

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory
Qian Chen, Jeffrey H. Kogan, Adam K. Gross, Yuan Zhou, Noah M. Walton, Rick Shin, Carrie L. Heusner, Shinichi Miyake, Katsunori Tajinda, Kouichi Tamura, Mitsuyuki Matsumoto

Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes
P. Leon Brown, Paul D. Shepard, Greg I. Elmer, Sara Stockman, Rebecca McFarland, Cheryl L. Mayo, Jean Lud Cadet, Irina N. Krasnova, Martin Greenwald, Carrie Schoonover, Michael W. Vogel

Dopamine and gamma band synchrony in schizophrenia – insights from computational and empirical studies
Kübra Kömek, G. Bard Ermentrout, Christopher P. Walker, Raymond Y. Cho

Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia
Patricio O’Donnell

Cortical circuit dysfunction and cognitive deficits in schizophrenia – implications for preemptive interventions
David A. Lewis

Abnormal modulation of corticospinal excitability in adults with Asperger’s syndrome
Lindsay Oberman, Mark Eldaief, Shirley Fecteau, Fritz Ifert-Miller, Jose Maria Tormos, Alvaro Pascual-Leone

Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing
Sofya P. Kulikova, Elena A. Tolmacheva, Paul Anderson, Julien Gaudias, Brendan E. Adams, Thomas Zheng, Didier Pinault