BJU International

Cover image for Vol. 116 Issue 1

Edited By: Prokar Dasgupta

Impact Factor: 3.533

ISI Journal Citation Reports © Ranking: 2014: 13/76 (Urology & Nephrology)

Online ISSN: 1464-410X

Virtual Issues

List of BJUI Virtual Issues

Best of British 2015

Best of British 2015
We hope you will enjoy the BJUI Editor-in-Chief’s selection of the best of recent British papers published as a BJUI Virtual Issue to coincide with BAUS 2015. This year’s articles include clinical research, basic science and reviews and cover a wide range of urological topics.

Indications, results and safety profile of transperineal sector biopsies (tpsb) of the prostate: a single centre experience of 634 cases
Lona Vyas, Peter Acher, Janette Kinsella, Ben Challacombe, Richard T.M. Chang, Paul Sturch, Declan Cahill, Ashish Chand Ra And Richard Popert

Perioperative outcomes of 6042 nephrectomies in 2012: surgeon-reported results in the uk from the British Association Of Urological Surgeons (BAUS) nephrectomy database
John M. Henderson, Sarah Fowler, Adrian Joyce, Andrew Dickinson, Francis X. Keeley And On Behalf Of Baus

Percutaneous nephrolithotomy in england: practice and outcomes described in the hospital episode statistics database
James N. Armitage, John Withington, Jan van der Meulen, David A. Cromwell, Jonathan Glass, William G. Finch, Stuart O. Irving and Neil A. Burgess

Does prostate histoscanning (tm) play a role in detecting prostate cancer in routine clinical practice? Results from three independent studies
Saqib Javed, Eliot Chadwick, Albert A. Edwards, Sabeena Beveridge, Robert Laing, Simon Bott, Christopher Eden and Stephen Langley

Learning curves for urological procedures: a systematic review
Hamid Abboudi, Mohammed Shamim Khan, Khurshid A. Guru, Saied Froghi, Gunter de Win, Hendrik Van Poppel, Prokar Dasgupta and Kamran Ahmed

Implementation of the exeter enhanced recovery programme for patients undergoing radical cystectomy
Thomas J. Dutton, Mark O. Daugherty, Robert G. Mason and John S. McGrath

Is there an antiandrogen withdrawal syndrome with Enzalutamide?
Alejo Rodriguez-Vida, Diletta Bianchini, Mieke Van Hemelrijck, Simon Hughes, Zafar Malik, Thomas Powles, Amit Bahl, Sarah Rudman, Heather Payne, Johann de Bono and Simon Chowdhury

Meta-analysis of robot-assisted vs conventional laparoscopic and open pyeloplasty in children
Thomas P. Cundy,, Leanne Harling, Archie Hughes-Hallett, Erik K. Mayer, Azad S. Najmaldin, Thanos Athanasiou, Guang-Zhong Yang and Ara Darzi

Stage, grade and pathological characteristics of bladder cancer in the UK:British Association of Urological Surgeons (BAUS) urological tumour registry
Gregory B. Boustead, Sarah Fowler, Rajiv Swamy, Roger Kocklebergh, Luke Hounsome and on behalf of the Section of Oncology, BAUS

An assessment of the physical impact of complex surgical tasks on surgeon errors and discomfort: a comparison between robot-assisted, laparoscopic and open approaches
Oussama Elhage,, Ben Challacombe, Adam Shortland and Prokar Dasgupta

Superiority of Fesoterodine 8 mg vs 4 mg in reducing urgency urinary incontinence episodes in patients with overactive bladder: results of the randomised, double-blind, placebo-controlled eight trial
Christopher Chapple, Tim Schneider, François Haab, Franklin Sun, Laurence Whelan, David Scholfield, Erika Dragon and Erin Mangan

Virtual Issue: The Best of Australia and New Zealand 2015


BJUI is proud of its long-standing association with USANZ and present in this Virtual Issue the Best of Australia and New Zealand in recognition of their Annual Meeting.

The Melbourne Consensus Statement on the early detection of prostate cancer
Declan G. Murphy, Thomas Ahlering, William J. Catalona, Helen Crowe, Jane Crowe, Noel Clarke0, Matthew Cooperberg, David Gillatt, Martin Gleave, Stacy Loeb, Monique Roobol, Oliver Sartor, Tom Pickles, Addie Wootten, Patrick C. Walsh And Anthony J. Costello

Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials
M. Diana Van Die, Kerry M. Bone, Scott G. Williams, And Marie V. Pirotta

Positive surgical margins: rate, contributing factors and impact on further treatment: findings from the Prostate Cancer Registry
Sue M. Evans, Jeremy L. Millar, Mark Frydenberg, Declan G. Murphy, Ian D. Davis, Tim Spelman, Damien M. Bolton, Graham G. Giles9, Joanne Dean, Anthony J. Costello, Albert G. Frauman, Paul A. Kearns, Laura Day, Christopher Daniels and John J. McNeill

Outcomes of artificial urinary sphincter implantation in the irradiated patient
Niranjan J. Sathianathen, Sean M. McGuigan and Daniel A. Moon

Multicentre prospective crossover study of the ‘prostatic urethral lift’ for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia
Anthony L. Cantwell, William K. Bogache, Steven F. Richardson, Ronald F. Tutrone, Jack Barkin, James E. Fagelson, Peter T. Chin and Henry H. Woo

Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy: a randomised controlled trial
Prue Cormie, Daniel A. Galvão, Nigel Spry, David Joseph, Raphael Chee, Dennis R. Taaffe, Suzanne K. Chambers and Robert U. Newton

Altered Significance of D'Amico Risk Classification in Prostate Cancer Patients linked to a Familial Breast Cancer (kConFab) cohort
Damien Bolton,, Yuan Cheng, Amber J. Willems-Jones, Jason Li, Eveline Niedermeyr, Gillian Mitchell, David Clouston, Nathan Lawrentschuk, Ania Sliwinski, Stephen Fox and Heather Thorne

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy
Joseph Ischia, Oneel Patel, Kapil Sethi, Marianne S. Nordlund, Damien Bolton, Arthur Shulkes and Graham S. Baldwin

The Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group – a new co-operative cancer trials group in genitourinary oncology
Shomik Sengupta, Peter Grimison, Dickon Hayne, Scott Williams, Suzanne Chambers, Paul DeSouza,, Martin Stockler, Margaret McJannett, Guy Toner, and Ian D. Davis

Effects of bariatric surgery on untreated lower urinary tract symptoms: a prospective multicentre cohort study
Serge Luke, Ben Addison, Katherine Broughton, Jonathan Masters, Richard Stubbs and Andrew Kennedy-Smith

Combination of multi-parametric magnetic resonance imaging (mp-MRI) and transperineal template-guided mapping biopsy (TTMB) of the prostate to identify candidates for hemi-ablative focal therapy
Minh Tran,, James Thompson,, Maret Böhm, Marley Pulbrook, Daniel Moses, Ron Shnier6, Phillip Brenner,, Warick Delprado, Anne-Maree Haynes, Richard Savdie and Phillip D Stricker

Virtual Issue: Paediatrics

This online Virtual Issue includes some of the important paediatrics publications from BJUI over last two years.

In the realm of paediatric minimally invasive surgery (MIS), robotic application is slowly increasing to complex procedures with safe and critical selection, as described in the review article by Orvieto et al, leading to the next step to reduce surgical morbidity. Authors from Los Angeles have compared different approaches (Open/Robotic and LESS) to nephrectomy and it seems to have the benefits of reduced analgesia and hospitalization, compared to an open approach. The robotic approach requires more time compared to others and probably a steeper learning curve with available instrumentation (Kim et al). The population based study in the USA for pyeloplasty has not shown this widespread adoption of MIS, perhaps due to the study period being 2004-2008. The use of robotic technology became more common after 2008, and the other reason could be that a laparoscopic pyeloplasty has a long learning curve (Knoedler et al).
Hypospadias remains a challenging topic for geneticists and paediatric urologists, as it is difficult to pinpoint the cause, association and how can it be prevented (Iris et al).
The passion to improve the functional outcomes by understanding the anatomy in bladder exstrophy remains a quest, as described by Anusionwu et al, because the long-term sexual satisfaction is suboptimal for males as reported in the present study by Gupta et al. The reconstructions were performed 20 years ago in these patients, and the surgical principles have evolved over these years, and hopefully we will see better outcomes in the next 20 years.
There is a mammoth task to undertake: to streamline and have a structured follow-up for data collection, with respect to urological outcomes in closed spinal dysrahisim and neurogenic bladder patients, as supported by the article by Veenboer et al. Establishing adolescent urology units with a dedicated team may be an answer to this problem (Wood et al).
Pediatric stone management – PNL has shown comparable outcomes and complications with adults as reported by CROES study (Guven et al). ESWL has still to show long-term safety in regards to development of HT, DM and renal growth (El Nahas et al).

Mohan S Gundeti MD MCh FEBU FRCS (Urol) FEAPU
BJUI Consulting Editor, Associate Professor

Early comparison of nephrectomy options in children (open, transperitoneal laparoscopic, laparo-endoscopic single site (LESS), and robotic surgery)
Kim, Ph; Patil, Mb; Kim, Ss; Dorey, F; De Filippo, Re; Chang, Ay; Hardy, Be; Gill, Is; Desai, Mm; Koh, Cj

Robotic paediatric urology
Orvieto, Ma; Large, M; Gundeti, Ms

Risk factors for different phenotypes of hypospadias: results from a Dutch case–control study
Iris A.L.M. van Rooij, Loes F.M. van der Zand en, Marijn M. Brouwers, Nine V.A.M. Knoers, Wout F.J. Feitz and Nel Roeleveld

Comparison of musculoskeletal anatomic relationships, determined by magnetic resonance imaging, in postpubertal female patients with and without classic bladder exstrophy
Ifeanyi Anusionwu, Aylin Tekes, Andrew A. Stec, John P. Gearhart and E. James Wright

Nomogram and scoring system for predicting stone-free status after extracorporeal shock wave lithotripsy in children with urolithiasis
Onal, B; Tansu, N; Demirkesen, O; Yalcin, V; Huang, L; Nguyen, HT; Cilento, BG; Erozenci, A

Percutaneous nephrolithotomy in children in different age groups: data from the Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy Global Study
Guven, S; Frattini, A; Onal, B; Desai, M; Montanari, E; Kums, J; Garofalo, M; de la Rosette, J

Paucity of evidence for urinary tract outcomes in closed spinal dysraphism: a systematic review
Paul W. Veenboer, J.L.H. Ruud Bosch, Floris W.A. van Asbeck and Laetitia M.O. de Kort

Population-based comparison of laparoscopic and open pyeloplasty in paediatric pelvi-ureretic junction obstruction
Knoedler, J; Han, L; Granberg, C; Kramer, S; Chow, G; Gettman, M; Kimball, B; Moriarty, J; Kim, S; Husmann, D

Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients?
El-Nahas, AR; Awad, BA; El-Assmy, AM; Abou El-Ghar, ME; Eraky, I; El-Kenawy, MR; Sheir, KZ

Examining long-term outcomes of bladder exstrophy: a 20-year follow-up
Angela D. Gupta, Sameer K. Goel, Christopher R.J. Woodhouse and Dan Wood

Virtual Issue: Articles of the Month 2014

Articles of the Month 2014

Every issue the BJUI Editor-in-Chief selects a paper he thinks is the most important, interesting or clinically useful as the Article of the Month. Here we collect all of the 2014 Articles of the Month into one Virtual Issue making them free to all our readers

Male Circumcision Wound Healing in HIV-negative and HIV-positive men in Rakai, Uganda
Godfrey Kigozi, Richard Musoke, Nehemiah Kighoma, Stephen Watya, David Serwadda, Fred Nalugoda, Noah Kiwanuka, James Nkale, Fred Wabwire-Mangen, Frederick Makumbi, Nelson K. Sewankambo, Ronald H. Gray And Maria J. Wawer

The Melbourne Consensus Statement on the early detection of prostate cancer
Declan G. Murphy, Thomas Ahlering, William J. Catalona, Helen Crowe, Jane Crowe, Noel Clarke, Matthew Cooperberg, David Gillatt, Martin Gleave, Stacy Loeb, Monique Roobol, Oliver Sartor, Tom Pickles, Addie Wootten, Patrick C. Walsh And Anthony J. Costello

The transcriptional programme of the androgen receptor (AR) in prostate cancer
Alastair D. Lamb, Charlie E. Massie and David E. Neal

The Surgical Spectacle: A Survey of Urologists Viewing Live Case Demonstrations
Sammy E. Elsamra, Mathew Fakhoury, Hector Motato, Justin I. Friedlander, Daniel M. Moreira, Joel Hillelsohn, Brian Duty, Zeph Okeke and Arthur D. Smith

Prospective comparison of Quality of life assessment between ileal conduit and orthotopic neobladder following radical cystectomy: A statistical model
Vishwajeet Singh, Rahul Yadav, Rahul Janak Sinha and Dheeraj Kumar Gupta

Role of multiparametric 3.0-Tesla magnetic resonance imaging in patients with prostate cancer eligible for active surveillance
Bong H. Park, Hwang G. Jeon, Seol H. Choo, Byong C. Jeong, Seong I. Seo, Seong S. Jeon, Han Y. Choi and Hyun M. Lee

Penile vibratory stimulation in the recovery of urinary continence and erectile function after nerve sparing radical prostatectomy: A randomized, controlled trial
Mikkel Fode, Michael Borre, Dana A. Ohl, Jonas Lichtbach and Jens Sønksen1

Validation of the pre-treatment neutrophil-lymphocyte ratio as prognostic factor in a European cohort of patients with upper tract urothelial carcinoma
Orietta Dalpiaz, Georg C. Ehrlich, Sebastian Mannweiler, Jessica M.Martín Hernández, Armin Gerger, Tatjana Stojakovic, Karl Pummer, Richard Zigeuner, Martin Pichler and Georg C. Hutterer

Meta analysis of robot-assisted versus conventional laparoscopic and open pyeloplasty in children
Thomas P. Cundy, Leanne Harling, Archie Hughes-Hallett, Erik K. Mayer, Azad S. Najmaldin, Thanos Athanasiou, Guang-Zhong Yang and Ara Darzi

One-stop clinic for ketamine-associated uropathy: report on service delivery model, patients’ characteristics and non-invasive investigations at baseline by a cross-sectional study in a prospective cohort of 318 teenagers and young adults
Yuk-Him Tam, Chi-Fai Ng, Kristine Kit-Yi Pang, Chi-Hang Yee, Winnie Chiu-Wing Chu, Vivian Yee-Fong Leung, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan and Paul Bo-San Lai

Health related quality of life from a prospective randomized clinical trial of robotic assisted laparoscopic versus open radical cystectomy
Jamie C. Messer, Sanoj Punnen, John Fitzgerald, Robert Svatek and Dipen J. Parekh

Best of India 2015

With USICON 2015 fast approaching, BJUI once again presents the Best of India, a free Virtual Issue. You can find out more about USICON 2015 in this Blogs@BJUI post.

Single-stage preputial skin flap urethroplasty for long-segment urethral strictures: evaluation and determinants of success
Raj Kumar Mathur, Milesh Nagar, Rahul Mathur, Fareed Khan, Chaitanya Deshmukh And Nilesh Guru

Robotic kidney transplantation with intraoperative regional hypothermia
Ronney Abaza, Khurshid R. Ghani, Akshay Sood, Rajesh Ahlawat, Ramesh K. Kumar, Wooju Jeong, Mahendra Bhand Ari, Vijay Kher And Mani Menon

Prospective comparison of quality-of-life outcomes between ileal conduit urinary diversion and orthotopic neobladder reconstruction after radical cystectomy: a statistical model
Vishwajeet Singh, Rahul Yadav, Rahul Janak Sinha and Dheeraj Kumar Gupta

A critical appraisal of complications of percutaneous nephrolithotomy in paediatric patients using adult instruments
Neeraj Kumar Goyal, Apul Goel, Satya Narayan Sankhwar, Vishwajeet Singh, Bhupendra Pal Singh, Rahul Janak Sinha, Divakar Dalela and Rahul Yadav

Astaxanthin modulates osteopontin and transforming growth factor β1 expression levels in a rat model of nephrolithiasis: a comparison with citrate administration
Manju Alex, M.V. Sauganth Paul, M. Abhilash, Varghese V. Mathews, T.V. Anilkumar and R. Harikumaran Nair

Evolution of shockwave lithotripsy (SWL) technique: a 25-year single centre experience of >5000 patients
Jitendra Jagtap, Shashikant Mishra, Amit Bhattu, Arvind Ganpule, Ravindra Sabnis and Mahesh Desai

Best of China 2014

Best of China 2014
Recent years have witnessed the boom of Chinese urology. An increasing amount of high-quality research is carried out in China, which is reflected in increasing numbers of articles being accepted by prestigious journals like BJUI. As the president of the Chinese Urological Association, I believe that it is necessary to select provocative articles – focusing on better solutions to widely discussed clinical issues as well as latest achievements from Chinese laboratories – for readers in China and abroad. This BJUI Virtual Issue – Best of China 2014 includes 12 studies from Chinese urologists, covering a wide range from basic research, translational medicine to clinical concerns. Many of the selected studies are aimed to assess the safety and efficacy of a certain urological surgery, such as remote ischaemic preconditioning during laparoscopic partial nephrectomy (by Prof. Yiran Huang), tubeless percutaneous nephrolithotomy (by Prof. Qing Jiang) and photoselective vaporization of the prostate (by Prof. Danfeng Xu), which are hot issues in the clinic. Also, the articles on functional molecules in the progress of urinary disorders (by Prof. Benkang Shi) and urological pathology and epidemiology (by Prof. Liqun Zhou) are well worth reading. I hope that this collection can provide interest and value, and that this Virtual Issue can help to build a solid connection between Chinese urologists and the peers of the world. Many thanks to all of those who contribute to the development of Chinese urology as a cause.

Yinghao Sun MD, PhD
President, Second Military Medical University (SMMU)
Director & Professor, Department of Urology, Shanghai Hospital, SMMU
President, Chinese Urological Association (CUA)


近年来,中国泌尿外科事业发展迅猛,涌现出越来越多高质量的科研成果。在BJUI等权威杂志上中国学者的文章日益增多就是很好的说明。作为CUA的主任委员,我认为将那些具有启发性的中国泌尿外科学者的文章加以整理,以飨读者是很有意义的。这些文章或是有关临床问题的解决方案,或是有关实验室的最新进展。这部精选合集就选择了12篇中国泌尿外科学者近期在BJUI发表的文章,内容涵盖基础医学、转化医学和临床医学。有些文章侧重评估当前热议的一些泌尿外科术式的安全性和有效性,比如肾部分切中远端缺血预处理技术(黄翼然) 、无造瘘管的经皮肾镜术(重医二附院 姜庆)和绿激光前列腺汽化术(徐丹枫)。另外,有关功能性分子在泌尿外科疾病进展中的作用(史本康)及泌尿外科病理学和流行病学的文章(周利群)也值得一读。我希望这本合集能为读者带来兴趣和启发,希望这本精选集有助于建立中国泌尿外科学者和其他国家的同道之间紧密的联系。感谢那些为中国泌尿外科事业做出贡献的人们!

Yinghao Sun MD, PhD
President, Second Military Medical University (SMMU)
Director & Professor, Department of Urology, Shanghai Hospital, SMMU
President, Chinese Urological Association (CUA)

Photoselective vaporization with the green light laser vs transurethral resection of the prostate for treating benign prostate hyperplasia: a systematic review and meta-analysis
Jingfei Teng, Dongxu Zhang, Yao Li, Lei Yin, Kai Wang, Xingang Cui, Danfeng Xu

Tubeless vs standard percutaneous nephrolithotomy: a meta-analysis
Jiawu Wang, Chunlei Zhao, Chengyao Zhang, Xiaodong Fan, Yanjun Lin, Qing Jiang

A comparative study of thulium laser resection of the prostate and bipolar transurethral plasmakinetic prostatectomy for treating benign prostatic hyperplasia
Bo Peng, Guang-chun Wang, Jun-hua Zheng, Sheng-qiang Xia, Jiang Geng, Jian-ping Che, Yang Yan, Jian-hua Huang, Yun-Fei Xu, Bin Yang

Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials
Hui Ding, Junqiang Tian, Wan Du, Liyuan Zhang, Hanzhang Wang, Zhiping Wang

The correlation between size of renal cell carcinoma and its histopathological characteristics: a single center study of 1867 renal cell carcinoma cases
Cuijian Zhang, Xuesong Li, Han Hao, Wei Yu, Zhisong He, Liqun Zhou

Expression and electrophysiological characteristics of P2X3 receptors in interstitial cells of Cajal in rats with partial bladder outlet obstruction
Li, Yuxin, Xue, Li, Miao, Qing, Mao, Fengfeng, Yao, Liping, Yuan, Jianlin, Qin, Weijun, Zhao, Yufeng, Sun, Hang, Liu, Fei, Wang, He

Urinary tract stone raises subsequent risk for urinary tract cancer: a population-based cohort study
Sun, Li-Min, Lin, Cheng-Li, Chang, Yen-Jung, Liang, Ji-An, Liu, Shu-Hui, Sung, Fung-Chang, Kao, Chia-Hung

Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model
Li, Yan, Sun, Yan, Zhang, Zhaocun, Feng, Xiaodi, Meng, Hui, Li, Shun, Zhu, Yaofeng, Chen, Shouzhen, Wang, Yang, Wang, Jun, Zhang, Deqing, Jiang, Xuewen, Li, Ning, Shi, Benkang

Male circumcision decreases penile sensitivity as measured in a large cohort
Wang, Kunjie, Tian, Ye, Wazir, Romel

Percutaneous nephrolithotomy guided solely by ultrasonography: a 5-year study of >700 cases
Yan, Song, Xiang, Fei, Yongsheng, Song

Congenital completely buried penis in boys: anatomical basis and surgical technique
Liu, Xing, He, Da-wei, Hua, Yi, Zhang, De-ying, Wei, Guang-hui

Effect of remote ischaemic preconditioning on renal protection in patients undergoing laparoscopic partial nephrectomy: a ‘blinded’ randomised controlled trial
Huang, Jiwei, Chen, YongHui, Dong, Baijun, Kong, Wen, Zhang, Jin, Xue, Wei, Liu, DongMing, Huang, Yiran

Joint Virtual Issue: BJUI and JSM - Best Papers in Sexual Medicine

BJU InternationalJournal of Sexual Medicine

We have the greatest pleasure in presenting this virtual issue of some of the best papers on Sexual Medicine in the BJUI and JSM. The articles are a selection of the highest quality basic, translational and the clinical research in this exciting and evolving field. They encompass both male and female sexual disorders.
This issue showcases a unique collaboration between two journals, bringing together some of our best papers in one place for your reading pleasure. Even better, it is free to all our global readers. Please enjoy them and send us your feedback.

Irwin Goldstein
Ian Eardley
Prokar Dasgupta

Male circumcision wound healing in human immunodeficiency virus (HIV)-negative and HIV- positive men in Rakai, Uganda
Godfrey Kigozi, Richard Musoke, Nehemiah Kighoma, Stephen Watya, David Serwadda, Fred Nalugoda, Noah Kiwanuka, James Nkale, Fred Wabwire-Mangen, Frederick Makumbi, Nelson K. Sewankambo, Ronald H. Gray and Maria J. Wawer
BJU International. Volume 113, Issue 1, January 2014, Pages: 127–132

Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.
Hannan JL, Kutlu O, Stopak BL, Liu X, Castiglione F, Hedlund P, Burnett AL, and Bivalacqua TJ.
J Sex Med 2014;11:1442–1451.

Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies
Darius A. Paduch, Alexander Bolyakov, Paula K. Polzer and Steven D. Watts
BJU International. Volume 111, Issue 2, February 2013, Pages: 334–343

Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis.
Musicki B, Bivalacqua TJ, Champion HC, and Burnett AL.
J Sex Med 2014;11:424–430.

Penile Doppler sonographic and clinical characteristics in Peyronie's disease and/or erectile dysfunction: an analysis of 1500 men with male sexual dysfunction
Eric Chung, Hanmu Yan, Ling De Young and Gerald B. Brock
BJU International. Volume 110, Issue 8, October 2012, Pages: 1201–1205

Current opinions on alternative reservoir placement for inflatable penile prosthesis among members of the Sexual Medicine Society of North America.
Karpman E, Sadeghi-Nejad H, Henry G, Khera M, and Morey AF.
J Sex Med 2013;10:2115–2120.

Sexual function with localized prostate cancer: active surveillance vs radical therapy
Roderick C.N. van den Bergh, Ida J. Korfage, Monique J. Roobol, Chris H. Bangma, Harry J. de Koning, Ewout W. Steyerberg and Marie-Louise Essink-Bot
BJU International. Volume 110, Issue 7, October 2012, Pages: 1032–1039

Testosterone improves antidepressant-emergent loss of libido in women: Findings from a randomized, doubleblind, placebo-controlled trial.
Fooladi E, Bell RJ, Jane F, Robinson PJ, Kulkarni J, and Davis SR.
J Sex Med 2014;11:831–839.

Outcomes of clomiphene citrate treatment in young hypogonadal men
Darren J. Katz, Omar Nabulsi, Raanan Tal and John P. Mulhall
BJU International. Volume 110, Issue 4, August 2012, Pages: 573–578

Inhibition of phosphodiesterase 4 enhances clitoral and vaginal blood flow responses to dorsal clitoral nerve stimulation or PGE1 in anesthetized female rats.
Castiglione F, Bergamini A, Russo A, La Croce G, Castagna G, Colciago G, Salonia A, Rigatti P, Montorsi F, and Hedlund P.
J Sex Med 2013;10:939–950.

Virtual Issue: Diabetes, Obesity & Metabolic SyndromeVirtual Issue: Diabetes, Obesity & Metabolic Syndrome

BJUI presents a FREE Virtual Issue bringing together the best recent papers on Diabetes, Obesity and Metabolic Syndrome in Urology, selected by our Editor-in-Chief, Prokar Dasgupta

Introduction: Dr Jonathan Rees, GP, Backwell & Nailsea Medical Group with interest in Men’s Health & Urology

May 2014

The concept of ‘men’s health’ was for many years taken to consist of the male-specific urological conditions such as prostate disease and erectile dysfunction. However, despite the importance of these conditions, particularly in terms of quality of life, it is cardiovascular disease and the components of the metabolic syndrome (hypertension, type 2 diabetes, dyslipidaemia) which have the biggest impact on the shorter life expectancy (and healthy life expectancy) seen in men. This collection of articles reflects the increased interest and awareness of these issues amongst Urologists, and demonstrates a number of important themes that have been seen in the wider urological literature over recent years:

1. Obesity and other components of the metabolic syndrome are seen to significantly increase the risk of developing a number of urological conditions. Insulin resistance, the driving force behind many components of metabolic syndrome also appears to be implicated in the pathogenesis of erectile dysfunction, benign prostatic hyperplasia, prostate cancer, hypogonadism, nephrolithiasis and overactive bladder.

2. The presence of visceral obesity and the metabolic syndrome may influence biological outcomes in many conditions with, for instance, men with high waist circumference (a fundamental component of metabolic syndrome) seen to have more severe lower urinary tract symptoms, whilst those with prostate cancer shown to have more aggressive disease at diagnosis and worse outcomes after radical prostatectomy.

3. Central obesity in particular, and high body mass index in general, increases surgical complexity (with consequent risks to patient safety) and operating times, and is therefore an important factor in predicting surgical outcomes. As understanding of these associations grows within the specialty of Urology, it allows Urologists to act as true advocates for overall men’s health. Just as we have become familiar with looking for undiagnosed diabetes and future cardiovascular risk in men with erectile dysfunction, the evidence increasingly points to the importance of consideration of these issues in many other urological disease processes. Identification of central obesity, hypertension, dyslipidaemia, diabetes or ‘pre-diabetes’ and other components of the metabolic syndrome offers the potential for lifestyle intervention and primary prevention strategies. Urologists may wish to arrange these tests themselves or more likely, liaise with colleagues in primary care with more expertise in the management of these conditions.

Central obesity as measured by waist circumference is predictive of severity of lower urinary tract symptoms
Lee, Richard K.; Chung, Doreen; Chughtai, Bilal; Te, Alexis E.; Kaplan, Steven A.

Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy: results from the SEARCH database
Keto, Christopher J.; Aronson, William J.; Terris, Martha K.; Presti, Joseph C.; Kane, Christopher J.; Amling, Christopher L.; Freedland, Stephen J.

Association between obesity and alteration of sperm DNA integrity and mitochondrial activity
Fariello, Roberta M.; Pariz, Juliana R.; Spaine, Deborah M.; Cedenho, Agnaldo P.; Bertolla, Ricardo P.; Fraietta, Renato

Visceral obesity is a strong predictor of perioperative outcome in patients undergoing laparoscopic radical nephrectomy
Hagiwara, Masayuki; Miyajima, Akira; Hasegawa, Masanori; Jinzaki, Masahiro; Kikuchi, Eiji; Nakagawa, Ken; Oya, Mototsugu

Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-beta 1 therapies in inducible nitric oxide synthase-deficient mice
Ferrini, Monica G.; Moon, Joanne; Rivera, Steve; Rajfer, Jacob; Gonzalez-Cadavid, Nestor F.

Safety and efficacy of ureteroscopic lithotripsy for stone disease in obese patients: a systematic review of the literature
Aboumarzouk, Omar M.; Somani, Bhaskar; Monga, Manoj

Obesity is associated with worse oncological outcomes in patients treated with radical cystectomy
Chromecki, Thomas F.; Cha, Eugene K.; Fajkovic, Harun; Rink, Michael; Ehdaie, Behfar; Svatek, Robert S.; Karakiewicz, Pierre I.; Lotan, Yair; Tilki, Derya; Bastian, Patrick J.; Daneshmand, Siamak; Kassouf, Wassim; Durand, Matthieu; Novara, Giacomo; Fritsche, Hans-Martin; Burger, Maximilian; Izawa, Jonathan I.; Brisuda, Antonin; Babjuk, Marek; Pummer, Karl; Shariat, Shahrokh F

Metabolic syndrome increases the risk of aggressive prostate cancer detection
Morote, Juan; Ropero, Jordi; Planas, Jacques; Bastaros, Juan M.; Delgado, Gueisy; Placer, Jose; Celma, Anna; de Torres, Ines M.; Carles, Joan; Reventos, Jaume; Doll, Andreas

Special ASM IssueSpecial ASM Issue: The USANZ Collection

Welcome to this special on-line only edition of the BJUI USANZ Supplement! It is a collection of carefully selected past papers, which I hope members will enjoy reading.

It is the last edition of the Supplement with Prof David Nicol as Editor. Associate Professor Nathan Lawrentschuk takes over as the new Supplement Editor from the next issue and I have no doubt, Nathan will take up the challenge of continuing the great work by David Nicol. David has left a lasting legacy as inaugural editor and members will no doubt join with me enthusiastically in recognising his outstanding contribution to USANZ research and academia.

Nathan has the drive and enthusiasm to ensure the Journal’s quality and depth of publications are maintained. Could I sound a friendly warning that members, and especially SAG leaders will be gently coaxed by Nathan to produce papers for publication. This important period of USANZ history cannot be underestimated in its quest for justified recognition on the very crowded world stage of urology. Australian and New Zealand urologists have for too long been hiding their talents under a bushel. Please support Nathan as vigorously as you can and wish him well as he continues to display his many talents.

The Journal will continue to be available in hardcopy, on-line and via the USANZ website. In time, the paper version will be phased out as members adjust to the world communicating solely electronically!

I personally congratulate those members who have already stepped up to the plate by conducting research and writing papers that have been published. Enjoy your success and please encourage others to emulate your dedication and hard work. May USANZ’ torch shine brightly.

Steve Ruthven, President

Virtual Supplement

Non-steroidal anti-inflammatory drugs for lower urinary tract symptoms in benign prostatic hyperplasia: systematic review and meta-analysis of randomized controlled trials
Arman Kahokehr, Ryash Vather, Anthony Nixon and Andrew G. Hill

Intravesical chemotherapy plus bacille Calmette-Guérin in non-muscle invasive bladder cancer: a systematic review with meta-analysis
Baerin B. Houghton, Venu Chalasani, Dickon Hayne, Peter Grimison, Christopher S. B. Brown, Manish I. Patel, Ian D. Davis and Martin R. Stockler

Factors associated with treatment received by men diagnosed with prostate cancer in Queensland, Australia
Peter D. Baade, Danny R. Youlden, Robert A. Gardiner, Megan Ferguson, Joanne F. Aitken, John Yaxley and Suzanne K. Chambers

A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma
Shankar Siva, Daniel Pham, Suki Gill, Niall M. Corcoran and Farshad Foroudi

High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer
Amber Willems-Jones, Liam Kavanagh, David Clouston, Damien Bolton, kConFab Investigators, Stephen Fox and Heather Thorne

The Prostate Cancer Registry: monitoring patterns and quality of care for men diagnosed with prostate cancer
Sue M. Evans, Jeremy L. Millar, Julie M. Wood, Ian D. Davis, Damien Bolton, Graham G. Giles, Mark Frydenberg, Albert Frauman, Antony Costello and John J. McNeil

A novel technique to limit renal warm ischaemia time during laparoscopic partial nephrectomy
Nikhil Sapre, Niall M. Corcoran, Anthony J. Costello and Dinesh Agarwal

Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease
Niall M. Corcoran, Chris M. Hovens, Charles Metcalfe, Matthew K.H. Hong, John Pedersen, Rowan G. Casey, Justin Peters, Laurence Harewood, S. Larry Goldenberg, Anthony J. Costello and Martin E. Gleave

Conversion rates of abstracts presented at the Urological Society of Australia and New Zealand (USANZ) Annual Scientific Meeting into full-text journal articles
Peter D. Yoon, Venu Chalasani and Henry H. Woo

Greenlight hps™ 120-w laser vaporization vs transurethral resection of the prostate (60 ml): a 2-year randomized double-blind prospective urodynamic investigation

Henry H. Woo and James L. Symons

Trends in the use of of nephron-sparing surgery (NSS) at an Australian tertiary referral centre: an analysis of surgical decision-making using the R.E.N.A.L. nephrometry scoring system
Prassannah Satasivam, Nieroshan Rajarubendra, Ping Han Chia, Aasheen Munshey, Shomik Sengupta and Damien Bolton