Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21
T. Ayabe, M. Fukami, T. Ogata, T. Kawamura, T. Urakami, N. Kikuchi, I. Yokota, K. Ihara, K. Takemoto, T. Mukai, A. Nishii, T. Kikuchi, T. Mori, N. Shimura, G. Sasaki, R. Kizu, N. Takubo, S. Soneda, T. Fujisawa, R. Takaya, Z. Kizaki, S. Kanzaki, K. Hanaki, N. Matsuura, Y. Kasahara, K. Kosaka, T. Takahashi, K. Minamitani, S. Matsuo, H. Mochizuki, K. Kobayashi, A. Koike, R. Horikawa, S. Teno, K. Tsubouchi, T. Mochizuki, Y. Igarashi, S. Amemiya, S. Sugihara and the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Version of Record online: 15 JUL 2016 | DOI: 10.1111/dme.13175
- Sequence variants including rs2290400 in GSDMB and polymorphisms in INS and CTLA4 are significantly associated with autoimmune Type 1 diabetes in Japanese children.
- Our results imply that cis-regulatory haplotypes at 17q12-q21 encompassing rs2290400 determine the risk of autoimmune Type 1 diabetes predominantly in early childhood.