Diabetic Medicine

Cover image for Vol. 33 Issue 8

Early View (Online Version of Record published before inclusion in an issue)

Editor-in-Chief: Professor Richard I.G Holt, Southampton, UK

Impact Factor: 3.152

ISI Journal Citation Reports © Ranking: 2015: 56/131 (Endocrinology & Metabolism)

Online ISSN: 1464-5491


  1. 1 - 100
  2. 101 - 102
  1. Research: Epidemiology

    1. Insulin resistance and β-cell function in smokers: results from the EGIR-RISC European multicentre study

      M. Gottsäter, B. Balkau, M. Hatunic, R. Gabriel, C.-H. Anderwald, J. Dekker, N. Lalic and P. M. Nilsson

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/dme.13172

      What's new?

      • Smoking is not associated with insulin sensitivity or β-cell function in healthy participants, in this large study with insulin sensitivity measured using hyperinsulinaemic, euglycaemic clamps.
      • Smoking is associated with increased glycaemic and C-peptide responses during an oral glucose tolerance test.
  2. Research: Treatment

    1. You have full text access to this OnlineOpen article
      Efficacy and safety of once-daily insulin degludec/insulin aspart compared with once-daily insulin glargine in participants with Type 2 diabetes: a randomized, treat-to-target study

      S. Kumar, H. C. Jang, N. Guvener Demirağ, T. V. Skjøth, L. Endahl and B. Bode

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/dme.13125

      What's new?

      • After 26 weeks, treatment with insulin degludec/insulin aspart (IDegAsp) once daily effectively improved glycaemic control and was non-inferior to insulin glargine (IGlar) once daily in terms of lowering HbA1c in participants with Type 2 diabetes inadequately controlled on basal insulin.
      • Compared with IGlar, higher rates of overall hypoglycaemia were observed with IDegAsp, primarily in relation to the meal at which it was dosed (IDegAsp was administered once daily at the same fixed meal every day). The possibility of using IDegAsp once daily offers flexibility in the injection and provides both specific mealtime coverage and the benefits of full 24-h basal coverage in a single injection.
  3. Research: Complications

    1. Identifying the independent effect of HbA1c variability on adverse health outcomes in patients with Type 2 diabetes

      J. C. Prentice, S. D. Pizer and P. R. Conlin

      Version of Record online: 17 JUL 2016 | DOI: 10.1111/dme.13166

      What's new?

      • Glucose variability over time may contribute to microvascular and macrovascular complications. This retrospective cohort study uses data on US military veterans diagnosed with Type 2 diabetes (n = 50 861) to examine the relationship between HbA1c variability and health outcomes.
      • Greater HbA1c variability is associated with increased risk of mortality, hospitalization for ambulatory care-sensitive conditions and myocardial infarction or stroke.
      • The models controlled for mean HbA1c levels and the direction of change in HbA1c levels, emphasizing the independent effect HbA1c variability has on outcomes.
      • Limiting the range of HbA1c fluctuations over time may reduce adverse complications in patients with Type 2 diabetes.
  4. Research: Genetics

    1. Variants associated with autoimmune Type 1 diabetes in Japanese children: implications for age-specific effects of cis-regulatory haplotypes at 17q12-q21

      T. Ayabe, M. Fukami, T. Ogata, T. Kawamura, T. Urakami, N. Kikuchi, I. Yokota, K. Ihara, K. Takemoto, T. Mukai, A. Nishii, T. Kikuchi, T. Mori, N. Shimura, G. Sasaki, R. Kizu, N. Takubo, S. Soneda, T. Fujisawa, R. Takaya, Z. Kizaki, S. Kanzaki, K. Hanaki, N. Matsuura, Y. Kasahara, K. Kosaka, T. Takahashi, K. Minamitani, S. Matsuo, H. Mochizuki, K. Kobayashi, A. Koike, R. Horikawa, S. Teno, K. Tsubouchi, T. Mochizuki, Y. Igarashi, S. Amemiya, S. Sugihara and the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/dme.13175

      What's new?

      • Sequence variants including rs2290400 in GSDMB and polymorphisms in INS and CTLA4 are significantly associated with autoimmune Type 1 diabetes in Japanese children.
      • Our results imply that cis-regulatory haplotypes at 17q12-q21 encompassing rs2290400 determine the risk of autoimmune Type 1 diabetes predominantly in early childhood.
  5. Research: Educational and Psychological Aspects

    1. Correlates of psychological outcomes in people with diabetes: results from the second Diabetes Attitudes, Wishes and Needs (DAWN2) study

      A. Nicolucci, K. Kovacs Burns, R. I. G. Holt, G. Lucisano, S. E. Skovlund, A. Kokoszka, M. Massi Benedetti and M. Peyrot

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/dme.13178

      What's new?

      • The results of this study provide a comprehensive assessment of the risk and protective factors for psychological outcomes among adults with diabetes on a global scale.
      • Modifiable risk/protective factors mediate the impact of demographic and clinical factors on psychological outcomes.
      • Accounting for individual-level risk and protective factors reduces between-country disparities in psychological outcomes, but results show that risk/protective factors operate differently in different countries.
  6. Research: Epidemiology

    1. Baseline characteristics of participants in the Kerala Diabetes Prevention Program: a cluster randomized controlled trial of lifestyle intervention in Asian Indians

      T. Sathish, B. Oldenburg, R. J. Tapp, J. E. Shaw, R. Wolfe, B. Sajitha, F. D'Esposito, P. Absetz, E. Mathews, P. Z. Zimmet and K. R. Thankappan

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/dme.13165

      What's new?

      • Large-scale use of an oral glucose tolerance test (OGTT) as a prerequisite for entering a diabetes prevention programme is a major financial and practical barrier.
      • The Kerala Diabetes Prevention Program is the first diabetes prevention trial from a low- and middle-income country to use a simple and low-cost diabetes risk score as a screening tool to identify high-risk individuals.
      • Of 1209 screen positives, 202 (16.7%) had undiagnosed Type 2 diabetes mellitus on OGTT.
      • The trial will evaluate the effectiveness of lifestyle intervention in a population selected on the basis of a risk score, a large proportion of whom had prediabetes and there were high rates of cardiometabolic risk factors.
  7. Research: Care Delivery

    1. You have full text access to this OnlineOpen article
      A multicentre demonstration project to evaluate the effectiveness and acceptability of the web-based Joint Asia Diabetes Evaluation (JADE) programme with or without nurse support in Chinese patients with Type 2 diabetes

      G. E. Tutino, W. Y. Yang, X. Li, W. H. Li, Y. Y. Zhang, X. H. Guo, A. O. Luk, R. O. P. Yeung, J. M. Yin, R. Ozaki, W.Y. So, R. C. W. Ma, L. N. Ji, A. P. S. Kong, J. P. Weng, G. T. C. Ko, W. P. Jia, J. C. N. Chan and on behalf of the China JADE Study Group

      Version of Record online: 11 JUL 2016 | DOI: 10.1111/dme.13164

      What's new?

      • The value of quality improvement programmes in the management of chronic conditions has been established in a number of prospective studies and meta-analyses.
      • The effect of the Joint Asia Diabetes Evaluation (JADE) programme, an information technology-augmented integrated care model, on diabetes-related outcomes has been demonstrated in several studies within developed healthcare systems.
      • This study represents one of the few quality improvement initiatives undertaken in a developing country and is the first to answer the question of whether initiatives such as JADE are effective in enhancing quality of care in underfunded healthcare systems.
      • Given the increasing demand for healthcare resources in developing countries, quality improvement has the potential to improve chronic care without substantial additional costs.
  8. Short Report: Educational and Psychological Aspects

    1. An empirically derived short form of the Hypoglycaemia Fear Survey II

      J. Grabman, K. Vajda Bailey, K. Schmidt, B. Cariou, L. Vaur, S. Madani, D. Cox and L. Gonder-Frederick

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/dme.13162

      What's new?

      • Extensive research shows that fear of hypoglycaemia can negatively affect quality of life and diabetes management.
      • The Hypoglycaemia Fear Survey II (HFS-II) is the most studied and utilized instrument to measure fear of hypoglycaemia, but the length of the survey sometimes limits its utility.
      • This study is the first to generate and validate a short form of the HFS-II, which will enable expanded investigation of fear of hypoglycaemia and its associated outcomes in clinical and research settings.
  9. Research: Complications

    1. Distal lower limb strength is reduced in subjects with impaired glucose tolerance and is related to elevated intramuscular fat level and vitamin D deficiency

      M. M. Almurdhi, N. D. Reeves, F. L. Bowling, A.J.M. Boulton, M. Jeziorska and R. A. Malik

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/dme.13163

      What's new?

      • There are no studies on the structure and function of lower limb muscles in people with impaired glucose tolerance (IGT).
      • We believe such a study may provide insights into the early mechanisms of motor dysfunction in people with Type 2 diabetes.
      • People with IGT have a significant reduction in distal but not proximal leg muscle strength and no evidence of proximal or distal muscle atrophy.
      • Distal weakness was associated with increased distal intramuscular non-contractile tissue, small fibre neuropathy and vitamin D deficiency in subjects with IGT.
  10. Research: Educational and psychological Aspects

    1. Barriers to and motivators for physical activity among people with Type 2 diabetes: patients' perspectives

      L. P. Lidegaard, N. Schwennesen, I. Willaing and K. Færch

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/dme.13167

      What's new?

      • In overweight and obese European adults with dysregulated Type 2 diabetes, poor physical condition and lack of knowledge about how and where to exercise are substantial barriers to physical activity. Goal-setting, self-tracking of activities and improved health status are important motivators.
      • Fear of hypoglycaemic events does not seem to be an important barrier for engaging in physical activity among people with dysregulated Type 2 diabetes.
      • A high level of social interaction is important for maintaining adherence to physical activity.
      • Interventions should combine individually tailored exercise plans with the establishment of customized local exercise communities, offering enjoyment and support.
  11. Research: Treatment

    1. Effectiveness of intensification therapies in Danes with Type 2 diabetes who use basal insulin: a population-based study

      R. W. Thomsen, L. M. Baggesen, M. Søgaard, L. Pedersen, H. Nørrelund, E. S. Buhl, C. L. Haase and S. P. Johnsen

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/dme.13168

      What's new?

      • Among people with Type 2 diabetes treated in routine clinical practice, 22% attained a target HbA1c value of < 53 mmol/mol (< 7%) and 38% attained an HbA1c of < 58 mmol/mol (< 7.5%) 3–6 months after intensification of their basal insulin therapy.
      • Compared with intensification with premixed insulin, target attainment was similar with bolus insulin and higher with glucagon-like peptide-1 receptor agonists.
  12. Research: Complications

    1. Sleep biosignature of Type 2 diabetes: a case–control study

      A. Lecube, O. Romero, G. Sampol, O. Mestre, A. Ciudin, E. Sánchez, C. Hernández, A. Caixàs, L. Vigil and R. Simó

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/dme.13161

      What's new?

      • A complex cross-talk between glucose homeostasis and sleep integrity exist.
      • Type 2 diabetes shows a distinctive sleep architecture, with different effects according to rapid eye movement (REM) or non-REM sleep.
      • Type 2 diabetes favours intermittent hypoxia during REM sleep.
      • Type 2 diabetes increases sleep fragmentation through higher rates of microarousals during non-REM sleep.
  13. Research: Pathophysiology

    1. Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls

      D. Carmody, A. N. Pastore, K. A. Landmeier, L. R. Letourneau, R. Martin, J. L. Hwang, R. N. Naylor, S. J. Hunter, M. E. Msall, L. H. Philipson, M. N. Scott and S. A. W. Greeley

      Version of Record online: 22 JUN 2016 | DOI: 10.1111/dme.13159

      What's new?

      • The current series represents the largest and most comprehensive study of neuropsychological and behavioural dysfunction in individuals with KCNJ11-related diabetes, in whom such impairment is likely due to brain expression of mutated channels.
      • The study is the first to provide detailed information on sibling controls, which was essential for demonstrating significant differences on a range of assessments including IQ, measures of academic achievement and executive function, even in subjects without any history of global developmental delay.
      • KCNJ11 patients with global delay exhibited significant differences in behavioural symptoms, as well as significant deficits in all subdomains of daily living skills.
  14. Research: Treatment

    1. Different clinical prognostic factors are associated with improved glycaemic control: findings from MARCH randomized trial

      J. Han, H. Yu, Y. Tu, J. Pang, F. Liu, Y. Bao, W. Yang and W. Jia

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/dme.13154

      What's new?

      • Some clinical features and laboratory parameters have important prognostic factors for predicting drug responsiveness. Patients with higher body mass index and lower fasting blood glucose achieved good glycemic control when metformin was selected as the initial treatment. Acarbose was best for patients with higher phase I insulin secretion (I30/G30) and shorter duration of Type 2 diabetes.
  15. Research: Educational and Psychological Aspects

    1. Increasing patient involvement in the diabetic foot pathway: a pilot randomized controlled trial

      E. McBride, B. Hacking, R. O'Carroll, M. Young, J. Jahr, C. Borthwick, A. Callander and Z. Berrada

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/dme.13158

      What's new?

      • To our knowledge, this is the first study to test an intervention to facilitate shared decision-making in patients with a diabetic foot ulcer.
      • Despite the national push for shared decision-making in diabetes, this pilot study found no impact on patient confidence or adherence.
      • Participants were more conflicted about decisions after increased involvement in the care pathway.
      • Unexpectedly, we observed extremely high decisional confidence at baseline. This would appear to be in conflict with high morbidity and mortality rates.
      • This extremely high confidence may be indicative of little perceived need to engage in treatment pathways. This has important practice implications for future interventions.
  16. Systematic Review or Meta-analysis

  17. Research: Treatment

    1. Medication use and potentially high-risk prescribing in older patients hospitalized for diabetes: a missed opportunity to improve care?

      G. E. Caughey, J. D. Barratt, S. Shakib, A. Kemp-Casey and E. E. Roughead

      Version of Record online: 2 JUN 2016 | DOI: 10.1111/dme.13148

      What's new?

      • This nationwide prospective cohort study describes the real-life prescribing of guideline-recommended therapies, the appropriateness of medicine use and the potentially high-risk prescribing associated with comorbid conditions in older patients before and after a diabetes hospitalization in Australia.
      • Sub-optimum use of diabetic therapy and high-risk prescribing among older patients with diabetes, including 70% with hyper-polypharmacy, a third having at least one treatment conflict and almost 50% being dispensed a potentially inappropriate medicine, was observed before hospitalization.
      • After hospitalization, the use of diabetic medicines improved, but little change in high-risk prescribing was observed. This highlights where medicine-related care for older patients with diabetes needs to be improved.
  18. Research: Pregnancy

    1. Sleep duration and quality, and risk of gestational diabetes mellitus in pregnant Chinese women

      H. Wang, J. Leng, W. Li, L. Wang, C. Zhang, W. Li, H. Liu, S. Zhang, J. Chan, G. Hu, Z. Yu and X. Yang

      Version of Record online: 2 JUN 2016 | DOI: 10.1111/dme.13155

      What's new?

      • Sleep disturbances increase the risk of Type 2 diabetes mellitus but it is uncertain whether they also increase the risk of gestational diabetes mellitus.
      • Using a large prospective population-based study of Chinese pregnant women, this study is the first to report that suboptimum sleep quality as well as shorter and longer sleep duration during pregnancy were associated with increased risk of gestational diabetes, the latter being presented by an approximately J-shaped risk relationship.
  19. Research: Pathophysiology

    1. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults

      S. Arif, V. B. Gibson, V. Nguyen, P. J. Bingley, J. A. Todd, C. Guy, D. B. Dunger, C. M. Dayan, J. Powrie, A. Lorenc and M. Peakman

      Version of Record online: 30 MAY 2016 | DOI: 10.1111/dme.13153

      What's new?

      • Type 1 diabetes development in children appears more rapid and severe compared with that in adults. This paper shows that immune responses against β cells are more common and target more autoantigens in children compared with adults. In addition, the immune response in children is particularly focused on proinsulin and insulin as the main drivers of the autoimmune response.
      • The findings of this study suggest age-related immunological heterogeneity in Type 1 diabetes. This may be important in developing age-appropriate immune-intervention strategies.
  20. Research: Treatment

    1. Effect of basal insulin therapy on vascular endothelial function and adipokine profiles in people with Type 2 diabetes

      H. Makino, A. Tanaka, H. Hosoda, R. Koezuka, M. Tochiya, Y. Ohata, T. Tamanaha, Y. Miyamoto, K. Kangawa and I. Kishimoto

      Version of Record online: 30 MAY 2016 | DOI: 10.1111/dme.13151

      What's new?

      • The magnitude of the improvement in flow-mediated vasodilatation with glargine treatment was smaller than that obtained with detemir, suggesting that the two compounds might differ in terms of their effect on atherosclerosis progression.
      • Detemir treatment significantly decreased plasminogen activator inhibitor-1 level, whereas glargine treatment did not significantly change this. By contrast, glargine treatment significantly augmented leptin adiponectin ratio, whereas detemir treatment did not significantly change this.
      • This is the first study to report that fasting acyl ghrelin level was decreased by glargine treatment, while acyl ghrelin level was not affected by detemir treatment.
  21. Research: Epidemiology

    1. Examining factors associated with excess mortality in older people (age ≥ 70 years) with diabetes – a 10-year cohort study of older people with and without diabetes

      A. Forbes, T. Murrells and A. J. Sinclair

      Version of Record online: 28 MAY 2016 | DOI: 10.1111/dme.13132

      What's new?

      • Older people with diabetes experience excess mortality compared with those without diabetes.
      • Comorbidity and polypharmacy increase mortality risk for older people with diabetes, but they do not explain excess mortality.
      • Mortality hazard is significantly greater for younger older people (70–75 years) with longer disease duration.
      • Gender is important in mortality for older people with diabetes, although males experience higher levels of absolute mortality, the relative risk is much greater for females.
      • Heart failure is a standout risk factor for mortality risk in older people with diabetes.
  22. Short Report: Educational and Psychological Aspects

    1. Disclosure of Type 1 diabetes at work among Finnish workers

      P. Hakkarainen, L. Moilanen, V. Hänninen, K. Räsänen and F. Munir

      Version of Record online: 27 MAY 2016 | DOI: 10.1111/dme.13134

      What's new?

      • We examined disclosure of Type 1 diabetes to colleagues, line managers and occupational health personnel in a representative national sample.
      • Psychosocial factors had the biggest role in workplace disclosure. Social support and psychosocial work ability were associated with disclosure to colleagues, line managers and occupational health personnel. Quality of relationships at work was associated with disclosure to colleagues and to the line manager. Furthermore, opportunity to self-manage diabetes at work was associated with disclosure to colleagues.
      • Only half of respondents disclosed their Type 1 diabetes at work and further research is required to examine the reasons for not disclosing Type 1 diabetes.
  23. Research: Educational and Psychological Aspects

    1. Correlates of psychological outcomes among family members of people with diabetes in the second Diabetes Attitudes, Wishes and Needs (DAWN2) study

      K. Kovacs Burns, R. I. G. Holt, A. Nicolucci, G. Lucisano, S. E. Skovlund, M. Comaschi, M. Vallis and M. Peyrot

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/dme.13136

      What's new?

      • DAWN2, conducted in 17 countries across four continents, is the first study to identify key sociodemographic, treatment-related, psychosocial and behavioural factors associated with psychological outcomes for adult family members of adults with diabetes.
      • Older age, not working because of diabetes, lower education or lower levels of education, use of injectable medicine by the person with diabetes, worry about hypoglycaemia, high perceived severity of diabetes and experience of discrimination on the part of the person with diabetes were associated with worse psychological outcomes among adult family members of people with diabetes.
      • Family arguments about diabetes management, frustration with not knowing how best to help, and greater responsibility for diabetes management were associated with worse psychological outcomes for family members of people with diabetes.
      • Knowing good ways to support, providing more support for diabetes and having access to more people to talk to about diabetes challenges were associated with better psychological outcomes.
      • The study extends earlier evidence from the DAWN2 study highlighting the psychosocial impact of diabetes on family members and identifies globally important factors for psychological well-being of family members of adults with diabetes which need to be considered in future efforts to improve diabetes care.
  24. Short Report: Treatment

    1. Sodium-glucose co-transporter-2 inhibitors suppress atrial natriuretic peptide secretion in patients with newly diagnosed Type 2 diabetes

      Y. Wang, L. Xu, L. Yuan, D. Li, Y. Zhang, R. Zheng, C. Liu, X. Feng, Q. Li, Q. Li and J. Ma

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/dme.13107

      What's new?

      • The aim of this study was to evaluate the effects of sodium-glucose co-transporter-2 inhibitors on atrial natriuretic peptide levels in patients with Type 2 diabetes.
      • We found that treatment with a sodium-glucose co-transporter-2 inhibitor not only improved glucose homeostasis, but also led to lower atrial natriuretic peptide levels and elevated sodium levels compared with placebo.
      • These findings suggest a complex interplay between sodium-glucose co-transporter-2 and natriuretic peptides; further studies are required to elucidate the mechanisms that regulate this relationship.
  25. Short Report: Care Delivery

    1. Random non-fasting C–peptide: bringing robust assessment of endogenous insulin secretion to the clinic

      S. V. Hope, B. A. Knight, B. M. Shields, A. T. Hattersley, T. J. McDonald and A. G. Jones

      Version of Record online: 26 MAY 2016 | DOI: 10.1111/dme.13142

      What's new?

      • Measuring endogenous insulin secretion using C–peptide can assist diabetes management, but standard stimulation tests are impractical for clinical use.
      • This study assessed whether a random non-fasting C–peptide can be used to assess endogenous insulin secretion.
      • Random blood C–peptide and urine C–peptide creatinine ratio (UCPCR) were both highly correlated with mixed meal tolerance test C–peptide and were sensitive and specific measures for clinically useful mixed meal test thresholds.
      • A random non-fasting C–peptide taken when a patient is seen in clinic can be used to assess endogenous insulin secretion in clinical practice.
  26. Systematic Review or Meta-analysis

  27. Research: Complications

  28. Research: Treatment

    1. Sitagliptin plus pantoprazole can restore but not maintain insulin independence after clinical islet transplantation: results of a pilot study

      P. A. Senior, A. Koh, J. Yau, S. Imes, P. Dinyari, A. J. Malcolm, P. Light and A. M. J. Shapiro

      Version of Record online: 22 MAY 2016 | DOI: 10.1111/dme.13131

      What's new?

      • Declining graft function is common after islet transplant, but there are no treatments to reverse this. We tested a combination of sitagliptin and pantoprazole in islet recipients with early graft insufficiency because gut peptides can increase β–cell mass in rodents.
      • Islet function improved, and insulin independence re-established in 25%, but did not persist when treatment was withdrawn.
      • This is the first prospective study to evaluate the potential to promote preservation and/or regeneration of β–cells after clinical islet transplantation.
  29. Short Report: Epidemiology

    1. Brain natriuretic peptide and insulin resistance in older adults

      F. Kim, M. L. Biggs, J. R. Kizer, E. F. Brutsaert, C. de Filippi, A. B. Newman, R. A. Kronmal, R. P. Tracy, J. S. Gottdiener, L. Djoussé, I. H. de Boer, B. M. Psaty, D. S. Siscovick and K. J. Mukamal

      Version of Record online: 21 MAY 2016 | DOI: 10.1111/dme.13139

  30. Research: Complications

    1. Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus

      E. Hammer, E. Lilienthal, S. E. Hofer, S. Schulz, E. Bollow, R. W. Holl and for the DPV Initiative and the German BMBF Competence Network for Diabetes Mellitus

      Version of Record online: 21 MAY 2016 | DOI: 10.1111/dme.13138

  31. Short Report: Educational and Psychological Aspects

    1. You have full text access to this OnlineOpen article
      Psychiatric morbidity in children with KCNJ11 neonatal diabetes

      P. Bowman, E. Broadbridge, B. A. Knight, L. Pettit, S. E. Flanagan, M. Reville, J. Tonks, M. H. Shepherd, T. J. Ford and A. T. Hattersley

      Version of Record online: 21 MAY 2016 | DOI: 10.1111/dme.13135

      What's new?

      • This is the first study to systematically assess psychiatric morbidity in people with KCNJ11 mutations, using validated, standardized diagnostic tools.
      • The data show that KCNJ11 mutations, in addition to causing neonatal diabetes, also cause psychiatric disorders that are clinically unrecognized but have high impact on families.
      • This research highlights the need for early assessment and an integrated and collaborative approach to clinical care in people with KCNJ11 neonatal diabetes.
  32. Research: Pathophysiology

    1. Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study

      C. J. Stewart, A. Nelson, M. D. Campbell, M. Walker, E. J. Stevenson, J. A. Shaw, S. P. Cummings and D. J. West

      Version of Record online: 14 MAY 2016 | DOI: 10.1111/dme.13140

      What's new?

      1. This study is the first to explore the gut microbiota in patients with Type 1 diabetes, but who otherwise have good glycaemic control and high physical fitness.
      2. The gut microbiota from people with Type 1 diabetes and good glycaemic control and high physical fitness was comparable with that from matched healthy controls without diabetes.
  33. Research: Care Delivery

    1. Impact of a multifaceted strategy to improve perioperative diabetes care

      I. Hommel, H. Wollersheim, C. J. Tack, J. Mulder, P. J. van Gurp and M. E. J. L. Hulscher

      Version of Record online: 11 MAY 2016 | DOI: 10.1111/dme.13130

      What's new?

      • We present a multifaceted improvement strategy that targets barriers to optimal perioperative diabetes care in daily practice.
      • The impact on the quality of perioperative diabetes care was limited.
      • This study shows the complexity of improving perioperative diabetes care throughout the hospital care pathway, which is characterized by multiple care transitions and multiprofessional involvement.
  34. Short Report: Epidemiology

    1. Representation of people of South Asian origin in cardiovascular outcome trials of glucose-lowering therapies in Type 2 diabetes

      K. Khunti, S. Bellary, M. A. Karamat, K. Patel, V. Patel, A. Jones, J. Gray, P. Shepherd, W. Hanif and on behalf of the South Asian Health Foundation

      Version of Record online: 28 APR 2016 | DOI: 10.1111/dme.13103

  35. Research: Treatment

    1. Long-term outcome of insulin pump therapy: reduction of hypoglycaemia and impact on glycaemic control

      C. Quirós, M. Giménez, P. Ríos, M. Careaga, D. Roca, M. Vidal and I. Conget

      Version of Record online: 28 APR 2016 | DOI: 10.1111/dme.13094

  36. Systematic Review or Meta-analysis

  37. Research: Complications

    1. Glycaemic control and risk of incident urinary incontinence in women with Type 1 diabetes: results from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study

      S. M. Lenherr, J. Q. Clemens, B. H. Braffett, R. L. Dunn, P. A. Cleary, C. Kim, W. H. Herman, J. M. Hotaling, A. M. Jacobson, J. S. Brown, H. Wessells, A. V. Sarma and the DCCT/EDIC Research Group

      Version of Record online: 24 APR 2016 | DOI: 10.1111/dme.13126

      What's new?

      • Research to date has failed to show an association between glycaemic control and urinary incontinence (UI) in women with diabetes.
      • We examined the relationship between HbA1c and UI using longitudinal data from the Diabetes Control and Complications Trial (DCCT) and its observational follow-up, the Epidemiology of Diabetes Interventions and Complications (EDIC) study.
      • Our findings show that the odds of UI increase with poor glycaemic control in women with Type 1 diabetes, independently of other well-described predictors of UI.
  38. Systematic Review or Meta-analysis

  39. Research: Epidemiology

    1. Increased mortality in a Danish cohort of young people with Type 1 diabetes mellitus followed for 24 years

      K. Sandahl, L. B. Nielsen, J. Svensson, J. Johannesen, F. Pociot, H. B. Mortensen, P. Hougaard, R. Broe, M. L. Rasmussen, J. Grauslund, T. Peto and B. S. Olsen

      Version of Record online: 21 APR 2016 | DOI: 10.1111/dme.13124

      What's new?

      • We included 75% of all children and adolescents with Type 1 diabetes in Denmark in 1989 and followed them for 24 years using high-quality registries.
      • We confirmed that Type 1 diabetes is associated with a higher mortality than the general population, with an almost five times increased standardized mortality ratio.
      • Among our patients, HbA1c was the only significant covariate predicting death, with a 38% increase in risk of death for every 1% increase in HbA1c.
      • We observed that Type 1 diabetes with multiple complications was the most frequently reported cause of death in this cohort.
  40. Short Report: Epidemiology

    1. Glycaemic control modifies the haptoglobin 2 allele-conferred susceptibility to coronary artery disease in Type 1 diabetes

      T. Costacou, R. W. Evans and T. J. Orchard

      Version of Record online: 20 APR 2016 | DOI: 10.1111/dme.13127

      What's new?

      • The haptoglobin (Hp) 2 allele has been shown to increase the risk of coronary artery disease (CAD) among individuals with diabetes, while, in the absence of diabetes, an Hp 2 allele–CAD association was not apparent.
      • We assessed whether glycaemic control modifies the Hp genotype–CAD association in people with Type 1 diabetes.
      • We noted significant modification of the Hp effect by long-term glycaemic levels, such that the adverse Hp 2 allele effect was more pronounced in people with better glycaemic control.
      • Our results suggest that, although better glycaemic control may reduce CAD incidence in Type 1 diabetes, a residual risk associated with the Hp 2 allele remains.
  41. Short Report: Genetics

    1. Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes

      M. J. Redondo, S. F. A. Grant, A. Davis, C. Greenbaum and the T1D Exchange Biobank

      Version of Record online: 20 APR 2016 | DOI: 10.1111/dme.13123

      What's new?

      • Individuals with Type 1 diabetes who carry the Type 2 diabetes-associated TCF7L2 single-nucleotide polymorphism (SNP) genotype are less likely to carry human leukocyte antigen (HLA) genotypes that confer susceptibility to Type 1 diabetes.
      • These findings support our previous report that children with fewer markers of islet autoimmunity are more likely to have the Type 2 diabetes-associated TCF7L2 SNP genotype.
      • These results also support disease heterogeneity and possibly open new pathways for treatment and prevention.
  42. Research: Epidemiology

    1. Sex-specific incidence rates and risk factors of insulin resistance and β–cell dysfunction: a decade follow-up in a Middle Eastern population

      A. Derakhshan, M. Tohidi, M. A. Hajebrahimi, N. Saadat, F. Azizi and F. Hadaegh

      Version of Record online: 19 APR 2016 | DOI: 10.1111/dme.13117

      What's new?

      • This is the first study to assess the risk factors contributing to a 10–year incidence of insulin resistance and β–cell dysfunction, as defined by baseline upper and lower quartiles of HOMA–IR and HOMA–β, respectively, in the entire population.
      • Sex differences were detected regarding the relationship between some risk factors and the development of insulin resistance and β–cell dysfunction.
      • Modifiable risk factors, such as central obesity and dyslipidaemia, were related to incident insulin resistance and β–cell dysfunction in the reverse direction, which reflects their different pathophysiological roles in insulin and glucose metabolism.
  43. Research: Pregnancy

    1. Diagnostic value of haemoglobin A1c in post-partum screening of women with gestational diabetes mellitus

      K.-S. Kim, S.-K. Kim, Y.-W. Cho and S. W. Park

      Version of Record online: 16 APR 2016 | DOI: 10.1111/dme.13119

      What's new?

      • The usefulness of HbA1c for the reassessment of glycaemic status women with a history of GDM remains controversial because evaluations have been performed at various times from 6 weeks to 3 years post-partum in previous studies.
      • HbA1c may not be sensitive enough for an accurate diagnosis, but it is highly specific for diagnosing overt diabetes at 6–12 weeks post-partum in women with previous GDM.
      • Therefore, at 6–12 weeks post-partum, women with previous GDM who were HbA1c < 48 mmol/mol (6.5%) might not screen for persistent diabetes using the 75–g oral glucose tolerance test, which is inconvenient and time-consuming.
  44. Research: Health Economics

    1. You have full text access to this OnlineOpen article
      Estimating the impact of better management of glycaemic control in adults with Type 1 and Type 2 diabetes on the number of clinical complications and the associated financial benefit

      M. Baxter, R. Hudson, J. Mahon, C. Bartlett, Y. Samyshkin, D. Alexiou and N. Hex

      Version of Record online: 15 APR 2016 | DOI: 10.1111/dme.13062

      What's new?

      • This study provides estimates of the potential costs avoided as a consequence of reducing the incidence of complications by improving glycaemic control in the current UK adult population with diabetes.
      • By implementing modest and achievable reductions in HbA1c levels, a significant cost avoidance of ˜£340 m is apparent after 5 years. This increases to ˜£5.5bn after 25 years of sustained improvement in glycaemic control.
      • These results suggest that action taken now could produce demonstrable clinical and financial benefit within the next 5 years; sustained intervention will ensure this accrues for decades to come.
  45. Research: Pathophysiology

    1. Pancreas volume and fat fraction in children with Type 1 diabetes

      S. E. Regnell, P. Peterson, L. Trinh, P. Broberg, P. Leander, Å. Lernmark, S. Månsson and H. Elding Larsson

      Version of Record online: 15 APR 2016 | DOI: 10.1111/dme.13115

      What's new?

      • Children with Type 1 diabetes have smaller pancreases than controls, yet pancreas size is unrelated to diabetes duration.
      • Exogenous insulin administration may decelerate the decline in pancreas size in Type 1 diabetes.
      • We found no difference in fat fraction between children with Type 1 diabetes and controls.
  46. Systematic Review or Meta-analysis

  47. Research: Epidemiology

    1. Causes of death in childhood-onset Type 1 diabetes: long-term follow-up

      V. Gagnum, L.C. Stene, T. G. Jenssen, L. M. Berteussen, L. Sandvik, G. Joner, P. R. Njølstad and T. Skrivarhaug

      Version of Record online: 7 APR 2016 | DOI: 10.1111/dme.13114

      What's new?

      • This nationwide, population-based study is a long-term follow-up of two cohorts, diagnosed with childhood-onset Type 1 diabetes in 1973–1982 and 1989–2012 [mean (range) follow-up 16.8 (0–40.7) years].
      • The study addresses cause-specific mortality based on clinical information in addition to high-quality register data.
      • The leading cause of death before the age of 30 years was acute complications; after the age of 30 years cardiovascular death was predominant.
      • In spite of improved diabetes care during the study period we report no change in mortality attributable to acute complications.
      • Our results indicate a need to improve diabetes management and psychosocial care to prevent premature mortality.
  48. Research: Educational and Psychological Aspects

    1. Correlates of psychological care strategies for people with diabetes in the second Diabetes Attitudes, Wishes and Needs (DAWN2) study

      R. I. G. Holt, A. Nicolucci, K. Kovacs Burns, G. Lucisano, S. E. Skovlund, A. Forbes, S. Kalra, E. Menéndez Torre, N. Munro and M. Peyrot

      Version of Record online: 31 MAR 2016 | DOI: 10.1111/dme.13109

      What's new?

      • This study examined barriers and facilitators for healthcare professionals in the provision of person-centred psychological care and self-management support for people with diabetes.
      • Psychological care was positively associated with beliefs that patients need help with emotional issues and that clinical success depends on doing so.
      • There were differences in psychological care between disciplines and countries.
      • The provision of psychological care improved with training received and desired, multidisciplinary team membership, and resources for psychological care.
  49. Research: Epidemiology

    1. Exploring the non-linear association between BMI and mortality in adults with and without diabetes: the US National Health Interview Survey

      Z. Wang, B. Dong, J. Hu, O. Adegbija and L. W. Arnold

      Version of Record online: 30 MAR 2016 | DOI: 10.1111/dme.13111

      What's new?

      • A U-shaped association exists between BMI and mortality in adults with and without diabetes.
      • The BMI value associated with the lowest mortality risk is 29.1 kg/m2 for adults with diabetes and 26.7 kg/m2 for adults without diabetes.
      • Researchers should use BMI in either a large number of categories or as a continuous variable to explore the association between BMI and mortality.
  50. Short Report: Metabolism

    1. Association of aerobic fitness level with exercise-induced hypoglycaemia in Type 1 diabetes

      R. A. Al Khalifah, C. Suppère, A. Haidar, R. Rabasa-Lhoret, M. Ladouceur and L. Legault

      Version of Record online: 25 MAR 2016 | DOI: 10.1111/dme.13070

      What's new?

      • Patients with Type 1 diabetes who have a good fitness level are at more risk of developing exercise-associated hypoglycaemia.
      • Patients with good physical fitness levels may need to be more cautious when planning physical activity and implement hypoglycaemia prevention strategies early in the activity.
  51. Research: Complications

    1. Lower verbal intelligence is associated with diabetic complications and slower walking speed in people with Type 2 diabetes: the Maastricht Study

      P. J. J. Spauwen, R. J. H. Martens, C. D. A. Stehouwer, F. R. J. Verhey, M. T. Schram, S. J. S. Sep, C. J. H. van der Kallen, P. C. Dagnelie, R. M. A. Henry, N. C. Schaper and M. P. J. van Boxtel

      Version of Record online: 25 MAR 2016 | DOI: 10.1111/dme.13105

      What's new?

      1. This cohort study is the first to examine the associations of verbal intelligence with diabetic complications and walking speed in people with Type 2 diabetes.
      2. Lower verbal intelligence was associated with the presence of neuropathic pain and cardiovascular disease, and with slower walking speed, a measure of physical functioning.
      3. Educational level seemed to play an important role in these associations
      4. It is important for clinicians to be aware of the educational level of their patients with diabetes so as to tailor the information to a level that can be understood.
  52. Research: Pregnancy

    1. Insulin pump use compared with intravenous insulin during labour and delivery: the INSPIRED observational cohort study

      E. Drever, G. Tomlinson, A. D. Bai and D. S. Feig

      Version of Record online: 20 MAR 2016 | DOI: 10.1111/dme.13106

      What's new?

      • An increasing number of women are using continuous subcutaneous insulin infusion therapy (CSII) during their pregnancy, however, there are few data on the safety and efficacy of continuing this therapy during labour and delivery.
      • This is the first study to compare the use of CSII with an intravenous insulin infusion during labour and delivery.
      • This study demonstrates that the continuation of CSII in the labour and delivery period appears safe and efficacious, with similar glycaemic control in the CSII group compared with women using insulin infusion therapy during labour, with no serious adverse events. Moreover, women who choose to continue CSII during labour have better glucose control than those that choose to switch from CSII to intravenous insulin infusion, suggesting that it should be standard practice to allow women the option of continuing pump therapy during labour and delivery.
  53. Research: Epidemiology

    1. Conversion of gestational diabetes mellitus to future Type 2 diabetes mellitus and the predictive value of HbA1c in an Indian cohort

      Y. Gupta, D. Kapoor, A. Desai, D. Praveen, R. Joshi, R. Rozati, N. Bhatla, D. Prabhakaran, P. Reddy, A. Patel and N. Tandon

      Version of Record online: 17 MAR 2016 | DOI: 10.1111/dme.13102

      What's new?

      • This study provides new information pertaining to the risk of developing Type 2 diabetes among Indian women with a history of gestational diabetes mellitus.
      • Within 5 years of a gestational diabetes pregnancy, 32% women have progressed to Type 2 diabetes. Another 40% have prediabetes.
      • The prevalence of Type 2 diabetes rose from < 25% within 2 years to almost 50% after 2–4 years' follow-up.
      • The utility of HbA1c in postpartum screening has been evaluated for the first time from an Indian sample. HbA1c ≥ 48 mmol/mol (6.5%) had a sensitivity and specificity of 81 and 91%, respectively, for determining the presence of Type 2 diabetes postpartum.
      • A detailed analysis of factors associated with increased risk of dysglycaemia is provided.
  54. Short Report: Treatment

    1. Urinary C–peptide analysis in an intervention study: experience from the DEFEND–2 otelixizumab trial

      P. Ambery, J. Donaldson, J. Parkin and D. J. Austin

      Version of Record online: 9 MAR 2016 | DOI: 10.1111/dme.13095

      What's new?

      • Mixed meal testing can be unpleasant for patients with diabetes and resource-intensive for healthcare professionals with respect to the provision of blood sampling.
      • This is the first successful attempt to demonstrate that longitudinal sampling of urinary C–peptide in the context of an interventional clinical trial is feasible and could provide a viable alternative to mixed meal testing.
      • The results confirm that future intervention studies in Type 1 diabetes mellitus should build in urinary C–peptide analysis to their analysis plan.
  55. Research: Complications

    1. Association of hearing impairment with insulin resistance, β–cell dysfunction and impaired fasting glucose before onset of diabetes

      M. Seo, Y.-S. Lee and S.-S. Moon

      Version of Record online: 6 MAR 2016 | DOI: 10.1111/dme.13096

      What's new?

      • This is the first study to examine the association of insulin resistance, β–cell dysfunction and pre-diabetes with hearing impairment in a population before the onset of diabetes, using a representative sample of the general population
  56. Research: Treatment

    1. Lactic acidosis: relationship between metformin levels, lactate concentration and mortality

      D. Boucaud-Maitre, J. Ropers, B. Porokhov, J.-J. Altman, B. Bouhanick, J. Doucet, E. Girardin, E. Kaloustian, V. Lassmann Vague and J. Emmerich

      Version of Record online: 6 MAR 2016 | DOI: 10.1111/dme.13098

      What's new?

      • This paper examines the correlations observed between metformin, lactate plasma and mortality in the largest case series of lactic acidosis available (n = 727).
      • Significant differences are observed between surviving and deceased patients in terms of metformin plasma levels (25.2 vs. 37.4 mg/l, P = 0.002) and lactate concentrations (10.8 vs. 16.3 mmol/l, P < 0.001).
      • These findings contradict other publications on this matter and suggest that metformin accumulation might contribute to the pathogenesis and prognosis of lactic acidosis.
    2. You have full text access to this OnlineOpen article
      Insulin degludec/insulin aspart once daily in Type 2 diabetes: a comparison of simple or stepwise titration algorithms (BOOST®: SIMPLE USE)

      S. W. Park, W. M. W. Bebakar, P. G. Hernandez, S. Macura, M. L. Hersløv and R. de la Rosa

      Version of Record online: 6 MAR 2016 | DOI: 10.1111/dme.13069

      What's new?

      • The co-formulation, insulin degludec/insulin aspart (IDegAsp), provides basal and mealtime insulin coverage in a single injection.
      • IDegAsp may be titrated using two titration algorithms, Simple (titrated twice weekly) or Stepwise (titrated once weekly). Both algorithms effectively reduce HbA1c levels in participants with insulin-naïve Type 2 diabetes, with similar rates of nocturnal hypoglycaemia and no reported severe hypoglycaemic events. IDegAspStepwise leads to significantly lower rates of overall confirmed hypoglycaemia compared with IDegAspSimple.
      • Optimizing titration may facilitate better disease management by healthcare professionals and people with diabetes.
  57. Research: Epidemiology

    1. Incident Type 2 diabetes and the effect of early regression to normoglycaemia in a population with impaired glucose regulation

      D. H. Bodicoat, K. Khunti, B. T. Srinivasan, S. Mostafa, L. J. Gray, M. J. Davies and D. R. Webb

      Version of Record online: 3 MAR 2016 | DOI: 10.1111/dme.13091

      What's new?

      • We provide contemporary estimates of the natural history of impaired glucose regulation, which are vital for service planning.
      • Reductions in weight and waist circumference were associated with regression to normal glucose tolerance, which was in turn associated with a much lower subsequent risk of Type 2 diabetes.
      • These data are from a population-based UK cohort and so are more generalizable than existing data from randomized controlled trials.
      • A message for patients identified with intermediate hyperglycaemia could be that if they lose any weight in the year after diagnosis then they may be almost twice as likely to achieve normal glucose tolerance.
  58. Short Report: Metabolism

    1. Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study

      D. Preiss, N. Rankin, P. Welsh, R. R. Holman, A. J. Kangas, P. Soininen, P. Würtz, M. Ala-Korpela and N. Sattar

      Version of Record online: 3 MAR 2016 | DOI: 10.1111/dme.13097

      What's new?

      • Aromatic and branched-chain amino acids have been shown to predict both the development of diabetes and cardiovascular disease in several recent epidemiological studies.
      • Some studies have suggested that metformin may alter amino acid concentrations but these studies have been small with a short duration of follow-up, limiting the inferences that could be made about long-term treatment.
      • In the CAMERA trial of 173 individuals without diabetes, daily metformin therapy led to sustained reductions in phenylalanine and tyrosine and sustained increases in alanine and histidine concentrations over 18 months.
  59. Review Articles

    1. Guidelines for managing diabetes in Ramadan

      S. Ali, M. J. Davies, E. M. Brady, L. J. Gray, K. Khunti, S. A. Beshyah and W. Hanif

      Version of Record online: 25 FEB 2016 | DOI: 10.1111/dme.13080

    2. Enigma of painful diabetic neuropathy: can we use the basic science, research outcomes and real-world data to help improve patient care and outcomes?

      D. V. Coppini

      Version of Record online: 25 FEB 2016 | DOI: 10.1111/dme.13089

      What's new?

      • Basic pathogenesis helps give some insight into the complexity of painful diabetic neuropathy and explains overall poor drug treatment response.
      • Early recognition, reassurance and an individualized treatment plan is likely to prevent the development of chronic pain syndrome and improve patient outcomes.
      • A team approach with regular contact is important in ensuring continuity of care, with specialist referral where appropriate.
      • Treatment limitations highlight the importance of regular outcomes audit and a need for further research on both current and new therapies.
  60. Research: Epidemiology

    1. Young people with Type 1 diabetes of non-white ethnicity and lower socio-economic status have poorer glycaemic control in England and Wales

      A. R. Khanolkar, R. Amin, D. Taylor-Robinson, R. M. Viner, J. T. Warner and T. Stephenson

      Version of Record online: 23 FEB 2016 | DOI: 10.1111/dme.13079

      What's new?

      • This is the largest study in the UK to investigate associations between ethnicity, deprivation and glycaemic control using a large nationally representative sample of children with Type 1 diabetes, from all major ethnic groups.
      • Black and mixed ethnicity children had poorest glycaemic control. Greater deprivation was associated with worse glycaemic control in all ethnicities.
      • Ethnicity remained independently associated with glycaemic control even after accounting for deprivation and treatment type (insulin pump therapy vs. no insulin pump therapy).
  61. Research: Care Delivery

    1. Twin pregnancies complicated by gestational diabetes mellitus: a single centre cohort study

      G. K. Dinham, A. Henry, S. A. Lowe, N. Nassar, K. Lui, V. Spear and A. W. Shand

      Version of Record online: 22 FEB 2016 | DOI: 10.1111/dme.13076

      What's new?

      • Rates of gestational diabetes in twin pregnancy increased threefold from 4.4% to 14.7% with a change towards universal early pregnancy glucose-tolerance testing.
      • Adverse pregnancy outcomes in twin pregnancies did not change with increased screening and treatment of gestational diabetes, although there was a decrease in large for gestational age infants.
      • Nearly half of women with a twin pregnancy had risk factors for gestational diabetes, apart from twin pregnancy.
  62. Systematic Review or Meta-analysis

    1. Systematic review of treatments for diabetic peripheral neuropathy

      N. Çakici, T. M. Fakkel, J. W. van Neck, A. P. Verhagen and J. H. Coert

      Version of Record online: 21 FEB 2016 | DOI: 10.1111/dme.13083

      What's new?

      • In this systematic review we evaluated 19 treatment regimens for diabetic peripheral neuropathy in people with diabetes mellitus. Pharmacological, non-pharmacological and alternative treatments were found. Six studies investigated the effect of α-lipoic acid on diabetic peripheral neuropathy symptoms, and all showed significant improvement in the total symptom score. Significant beneficial effects were also found in trials investigating opioids, botulinum toxin A, mexidol, reflexology and Thai foot massage. Interventions such as micronutrients, neurotrophic peptide ORG 2677 and photon stimulation therapy resulted in a significant improvement in diabetic peripheral neuropathy symptoms in favour of their placebo group.
  63. Research: Complications

    1. QT interval, corrected for heart rate, is associated with HbA1c concentration and autonomic function in diabetes

      K. Stern, Y. H. Cho, P. Benitez-Aguirre, A. J. Jenkins, M. McGill, P. Mitchell, A. C. Keech and K. C. Donaghue

      Version of Record online: 21 FEB 2016 | DOI: 10.1111/dme.13085

      What's new?

      • Longer QT interval corrected for heart rate (QTc) is associated with higher HbA1c concentration, less exogenous insulin and a lower rate of significant hypoglycaemia in adolescents with Type 1 diabetes.
      • This is the first study to show significant associations between abnormal pupillometry, cardiac autonomic dysfunction and longer QTc interval in adolescents with Type 1 diabetes.
      • A threshold of QTc > 409 ms in adolescents with Type 1 diabetes differentiates those most at risk of autonomic dysfunction, in addition to being female, having higher HbA1c, BMI and total cholesterol.
      • Electrocardiogram screening to exclude long QTc syndromes and assess complication risk may be of value in routine complications assessment in young people with diabetes.
  64. Research: Treatment

    1. You have full text access to this OnlineOpen article
      Safety and efficacy of insulin degludec/insulin aspart with bolus mealtime insulin aspart compared with standard basal–bolus treatment in people with Type 1 diabetes: 1–year results from a randomized clinical trial (BOOST® T1)

      I. B. Hirsch, E. Franek, H. Mersebach, L. Bardtrum and K. Hermansen

      Version of Record online: 19 FEB 2016 | DOI: 10.1111/dme.13068

      What's new?

      • For people with Type 1 diabetes, modern-day basal–bolus regimens requiring separate daily injections of basal and prandial insulin are the standard of care.
      • To date, it has not been possible to combine basal and bolus insulin in a single injection (thereby reducing the injection number) without adversely affecting the glucose-lowering properties of both components.
      • Insulin degludec/insulin aspart (IDegAsp) is a combination of the basal insulin analogue, insulin degludec, and the rapid-acting insulin analogue, insulin aspart.
      • This Phase 3 trial presents the first long-term safety and efficacy data comparing IDegAsp with mealtime bolus with a standard basal–bolus regimen in Type 1 diabetes.
  65. Short Report: Epidemiology

    1. Factors associated with early insulin initiation in Type 2 diabetes: a Canadian cross-sectional study

      W. Abu-Ashour, L. Chibrikova, W. K. Midodzi, L. K. Twells and J.-M. Gamble

      Version of Record online: 14 FEB 2016 | DOI: 10.1111/dme.13082

      What's new?

      • In a cross-sectional study using a 2012 Canadian health survey, we evaluated the association between several patient characteristics and early use of insulin in patients with Type 2 diabetes.
      • We found that approximately one-third of Canadians with Type 2 diabetes who reported using insulin, initiated insulin within their first year of diagnosis.
      • Older age, smoking, geographical location, poor mental health and being overweight were strongly associated with early initiation of insulin, whereas current use of oral antidiabetic medication and regular alcohol consumption were associated with later use of insulin.
  66. Research: Care Delivery

    1. Diabetic ketoacidosis in an adolescent and young adult population in the UK in 2014: a national survey comparison of management in paediatric and adult settings

      J. A. Edge, I. Nunney and K. K. Dhatariya

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13065

      What's new?

      • Teenagers and young adults with diabetic ketoacidosis are treated largely according to national guidelines.
      • Monitoring during treatment is not always carried out according to guidelines, especially in young adults.
      • The incidence of hypoglycaemia is high in teenagers and young adults.
      • The incidence of hypokalaemia in young adults is high.
  67. Short Report: Epidemiology

    1. Impact of lifestyle intervention in primary prevention of Type 2 diabetes did not differ by baseline age and BMI among Asian-Indian people with impaired glucose tolerance

      A. Nanditha, C. Snehalatha, J. Ram, S. Selvam, L. Vijaya, S. A. Shetty, R. Arun and A. Ramachandran

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13071

      What's new?

      • In Western diabetes primary prevention programmes the effectiveness of lifestyle intervention has been shown to be influenced by baseline BMI and age.
      • The present study assessed the effectiveness of lifestyle intervention on the incidence of diabetes among Asian-Indian people with impaired glucose tolerance, stratified by age and BMI.
      • The results showed that the impact of lifestyle intervention was similar among non-obese and obese Asian-Indians with impaired glucose tolerance in different age categories
  68. Research: Epidemiology

    1. DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes

      N. Bansal, C. S. Hampe, L. Rodriguez, E. O'Brian Smith, J. Kushner, A. Balasubramanyam and M. J. Redondo

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13077

      What's new?

      • This is the first study to report the recognition of the DPD-defined glutamic acid decarboxylase 65 autoantibody (GAD65Ab) epitope in children with Type 1 diabetes.
      • Recognition of DPD-defined GAD65Ab epitope is directly correlated with β-cell function, BMI and age in children with newly diagnosed Type 1 diabetes.
      • Differential GAD65Ab epitope recognition may reflect immunological heterogeneity in Type 1 diabetes and perhaps explain the clinical heterogeneity of the disease.
  69. Research: Complications

    1. Functional hearing deficits in children with Type 1 diabetes

      G. Rance, D. Chisari, N. Edvall and F. Cameron

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13086

      What's new?

      • This study explores functional hearing deficits in children with Type 1 diabetes. As such, it differs from most work in this field, which has only considered the effect of diabetes on sound detection ability.
      • We demonstrate auditory pathway disorder in individuals with normal sound detection thresholds and consider the underlying mechanisms.
      • The findings highlight binaural processing deficits and their effect on speech processing in background noise.
      • Everyday listening ability is considered, as are potential developmental risks.
    2. Oestrogen activity of the serum in adolescents with Type 1 diabetes

      D. Martínez, A. Castro, P. M. Merino, P. López, M. C. Lardone, G. Iñiguez, F. Cassorla and E. Codner

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13078

      What's new?

      • Clinical evidence of hypoestrogenism has been found in women with Type 1 diabetes, but there have been no systematic studies evaluating oestrogen profile in such patients.
      • We studied the overall serum oestrogenic activity and oestrogenic profile in adolescents with Type 1 diabetes.
      • This study showed that adolescents with Type 1 diabetes have lower levels of serum oestrogen activity, and these levels were lower than expected based on measurement of their serum oestradiol levels.
      • We postulate that low serum oestrogenic activity levels may play a role in the pathophysiology of chronic complications in women with Type 1 diabetes.
  70. Short Report: Epidemiology

  71. Research: Epidemiology

    1. First report on the nationwide incidence and prevalence of Type 1 diabetes among children in Turkey

      E. Yeşilkaya, P. Cinaz, N. Andıran, A. Bideci, Ş. Hatun, E. Sarı, T. Türker, Ö. Akgül, M. Saldır, H. Kılıçaslan, C. Açıkel and M. E. Craig

      Version of Record online: 12 FEB 2016 | DOI: 10.1111/dme.13063

      What's new?

      • This is the first study to report the nationwide prevalence and incidence of childhood Type 1 diabetes in Turkey.
      • The study was given the award for best oral presentation at 35th Union of Middle-Eastern and Mediterranean Pediatric Societies (UMEMPS) Congress.
  72. Research: Care Delivery

    1. You have full text access to this OnlineOpen article
      Glucose test provenance recording in UK primary care: was that fasted or random?

      A. P. McGovern, H. Fieldhouse, Z. Tippu, S. Jones, N. Munro and S. de Lusignan

      Version of Record online: 11 FEB 2016 | DOI: 10.1111/dme.13067

      What's new?

      • It has previously been noted that the recording of provenance data with glucose results is poor, but lack of provenance data has not previously been quantified.
      • We found that 58% of glucose values tested in primary care were recorded without provenance information.
      • A single audit practice showed lack of provenance information lead to delays in diagnosis, unnecessary repeated testing, and wasted clinician time.
  73. Research: Treatment

    1. Optimum bolus wizard settings in insulin pumps in children with Type 1 diabetes

      A. J. B. Andersen, A. Ostenfeld, C. B. Pipper, B. S. Olsen, A. M. Hertz, L. K. Jørgensen, J. Høgsmose and J. Svensson

      Version of Record online: 5 FEB 2016 | DOI: 10.1111/dme.13064

      What's new?

      • We found age-related and insulin dose-dependent differences in optimum insulin pump settings.
      • Bolus wizard settings need to be individualized because standardized calculation factors are not constant for children.
      • The insulin to carbohydrate factor corresponding to the ‘500 rule’ and the insulin sensitivity factor corresponding to the ‘100 rule’ is not applicable in children.
      • Optimum pump settings at initiation of pump treatment and adjustment to these settings as children grow may increase treatment adherence.
      • Further prospective studies on calculation factors and metabolic control are needed.
  74. Short Report: Genetics

    1. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations

      T. Demir, H. Onay, D. B. Savage, E. Temeloglu, A. K. Uzum, P. Kadioglu, C. Altay, S. Ozen, L. Demir, U. Cavdar and B. Akinci

      Version of Record online: 5 FEB 2016 | DOI: 10.1111/dme.13061

      What's new?

      • In this study we compare the fat distribution and metabolic characteristics of subjects with familial partial lipodystrophy caused by a novel peroxisome proliferator activator receptor-γ (PPARG) mutation, H449L, with those of a cluster of patients with familial partial lipodystrophy caused by classic codon 482 Lamin A/C (LMNA) mutations.
      • PPARG H449L is associated with a slight fat loss that is limited to the extremities.
      • PPARG H449L mutation is associated with insulin resistance in affected subjects, but the severity is variable.
  75. Short Report: Pathophysiology

    1. Survivors of childhood leukaemia treated with haematopoietic stem cell transplantation and total body irradiation should undergo screening for diabetes by oral glucose tolerance tests

      C. Wei, R. Unsworth, N. Davis, R. Cox, K. Bradley, M. Stevens and E. Crowne

      Version of Record online: 5 FEB 2016 | DOI: 10.1111/dme.13060

      What's new?

      • Young adult survivors of childhood leukaemia treated with haematopoietic stem cell transplantation have a high risk of developing diabetes early in life but there is a lack of information on the optimal method of screening.
      • Thresholds of fasting glucose and HbA1c recommended for population screening are unreliable in identifying haematopoietic stem cell transplantation survivors of childhood cancer diagnosed with or at risk of diabetes.
  76. Short Report: Epidemiology

    1. Substantial proportion of MODY among multiplex families participating in a Type 1 diabetes prediction programme

      L. Petruzelkova, P. Dusatkova, O. Cinek, Z. Sumnik, S. Pruhova, O. Hradsky, J. Vcelakova, J. Lebl and S. Kolouskova

      Version of Record online: 16 JAN 2016 | DOI: 10.1111/dme.13043

      What's new?

      • Patients with maturity-onset diabetes of the young (MODY) might be over-represented among the relatives of children with Type 1 diabetes due to similar clinical outcomes.
      • To the best of our knowledge, this tiered investigation is the first to evaluate the prevalence of MODY in a Type 1 diabetes prediction project.
      • The results suggested that cases of MODY are hidden among multiplex families within Type 1 diabetes prediction projects and that the prevalence of these cases is not negligible.
      • Based on our results, a diagnosis of MODY should be considered and investigated within these programmes because patients clearly benefit from an accurate aetiological diagnosis that enables the optimization of therapy.
  77. Systematic Review or Meta-analysis

  78. Research: Epidemiology

    1. Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom

      J. W. Walsh, O. J. Hoffstad, M. O. Sullivan and D. J. Margolis

      Version of Record online: 10 JAN 2016 | DOI: 10.1111/dme.13054

      What's new?

      • This is the largest patient cohort study ever to study the association between diabetic foot ulcers and risk of death in adults with diabetes.
      • Our findings support the hypothesis that diabetic foot ulcers are a marker associated with a risk to patients’ longevity independent of other complications of diabetes.
  79. Research: Educational and Psychological Issues

    1. Prevalence of depression in Type 1 diabetes and the problem of over-diagnosis

      L. Fisher, D. M. Hessler, W. H. Polonsky, U. Masharani, A. L. Peters, I. Blumer and L. A. Strycker

      Version of Record online: 5 JAN 2016 | DOI: 10.1111/dme.12973

      What's new?

      • The prevalence of current depression in adults with Type 1 diabetes is far lower than commonly assumed, and is similar to rates reported in community populations.
      • There are high rates of false-positive results when comparing the eight-iterm Patient Health Questionnaire and structured diagnostic interviews to identify major depressive disorder.
      • The prevalence of significant diabetes distress is high among adults with Type 1 diabetes, ˜40%.
      • Much of what self-report depression scales, such as the Patient Health Questionnaire, assess is not psychopathology but, instead, is the emotional distress associated with managing a demanding chronic disease over time.
      • The findings of this study permit more targeted interventions directed at the emotional side of diabetes.
  80. Research: Complications

    1. Cochlear, auditory brainstem responses in Type 1 diabetes: relationship with metabolic variables and diabetic complications

      A. Lasagni, P. Giordano, M. Lacilla, A. Raviolo, M. Trento, E. Camussi, G. Grassi, L. Charrier, F. Cavallo, R. Albera, M. Porta and M. M. Zanone

      Version of Record online: 29 DEC 2015 | DOI: 10.1111/dme.13039

      What's new?

      • Auditory function involves the cochlea and neural transmission, making the ear a potential ‘window’ through which to evaluate microvascular and neurological abnormalities associated with chronic hyperglycaemia.
      • We tested the presence of auditory alterations in young adults with long-term Type 1 diabetes.
      • We detected a qualitative auditory dysfunction, reflecting cochlear dysfunction.
      • Otoacoustic emission alterations are associated with higher blood pressure, indicating a possible role for vascular mechanisms. A delay in acoustic nerve transmission and the presence of somatic or autonomic neuropathy are observed.
      • In young adults with Type 1 diabetes, abnormalities of auditory perception might reflect neuropathic and/or vascular alterations.
  81. Research: Treatment

    1. Saxagliptin co-therapy in C-peptide negative Type 1 diabetes does not improve counter-regulatory responses to hypoglycaemia

      P. S. George and R. J. McCrimmon

      Version of Record online: 28 DEC 2015 | DOI: 10.1111/dme.13046

      What's new?

      • This study tested the novel hypothesis that dipeptidyl peptidase-4 inhibitor co-therapy in Type 1 diabetes would act indirectly to improve symptom and hormonal responses to hypoglycaemia.
      • The hypothesis was rejected and no significant impact of dipeptidyl peptidase-4 inhibitor therapy was seen on measures of glucose variability, hypoglycaemia counter-regulation or glycaemic control.
      • These findings do not support the use of dipeptidyl peptidase-4 inhibitors in the management of C-peptide-negative Type 1 diabetes.
  82. Research: Epidemiology

    1. Pre-diabetes tsunami: incidence rates and risk factors of pre-diabetes and its different phenotypes over 9 years of follow-up

      F. Hadaegh, A. Derakhshan, N. Zafari, D. Khalili, M. Mirbolouk, N. Saadat and F. Azizi

      Version of Record online: 24 DEC 2015 | DOI: 10.1111/dme.13034

      What's new?

      • This is the first study to investigate the risk factors of combined impaired fasting glucose/impaired glucose tolerance, isolated impaired fasting glucose and isolated impaired glucose tolerance separately in men and women in a long-term population-based cohort.
      • A high annual incidence rate of pre-diabetes was observed, with over 4% of the population developing the disease each year, indicating a need for a stronger approach to the prevention of pre-diabetes.
      • The differences between the risk factors for different pre-diabetes phenotypes require specific intervention strategies.
  83. Short Report: Epidemiology

    1. Validation of administrative data case definitions for gestational diabetes mellitus

      S. L. Bowker, A. Savu, N. K. Lam, J. A. Johnson and P. Kaul

      Version of Record online: 24 DEC 2015 | DOI: 10.1111/dme.13030

      What's new?

      • Using population-based data, we examined the validity of two International Classification of Diseases (ICD)-based algorithms for identifying gestational diabetes mellitus using administrative data: 1) the current National Diabetes Surveillance System algorithm for excluding gestational diabetes cases; and 2) gestational diabetes-specific ICD codes in the delivery-related hospitalization.
      • We found that the National Diabetes Surveillance System algorithm significantly underestimates the number of gestational diabetes cases, whereas the gestational diabetes-specific ICD codes had a sensitivity of 86% and specificity of 99%.
      • These findings suggest that gestational diabetes-specific ICD codes in the delivery hospitalization are a more valid mechanism to identify gestational diabetes prevalence using health administrative data.
  84. Research: Epidemiology

    1. Prevalence and risk of diabetes based on family history in the Shanghai High-Risk Diabetic Screen (SHiDS) study

      Y. Zhang, H. Chen, H. Lu, Y. Shen, R. Chen, P. Fang, X. Du, Y. Bao, C. Wang and W. Jia

      Version of Record online: 12 DEC 2015 | DOI: 10.1111/dme.13013

      What's new?

      • This is the first study assessing different family histories of diabetes in a large Chinese population of subjects at high risk of developing diabetes.
      • Comparability across studies was ensured by application of the oral glucose tolerance test and a uniform definition of diabetes according to the WHO criteria.
      • Sibling history of diabetes represented the greatest risk of developing diabetes, even in high-risk subjects.
      • Results showed that insulin secretion was significantly lower in participants with normal glucose tolerance who had a sibling or maternal history of diabetes, but insulin sensitivity was not significantly different among the different disease inheritance groups.
  85. Research: Educational and Psychological Issues

    1. Predictors of low diabetes risk perception in a multi-ethnic cohort of women with gestational diabetes mellitus

      G. Mukerji, S. Kainth, C. Pendrith, J. Lowe, D. S. Feig, A. T. Banerjee, W. Wu and L. L. Lipscombe

      Version of Record online: 12 DEC 2015 | DOI: 10.1111/dme.13009

      What's new?

      • This study is among the first to report on risk perception for diabetes among pregnant women with gestational diabetes within a universal healthcare setting.
      • Findings demonstrate that among a large and diverse representative sample of pregnant women with gestational diabetes, almost half do not recognize their high future diabetes risk. This indicates a need to implement better strategies to translate risk of future Type 2 diabetes among pregnant women with gestational diabetes.
      • Women with gestational diabetes from non-Caucasian ethnic backgrounds were more likely to underestimate their risk perception for diabetes, even after adjusting for known factors predictive of Type 2 diabetes.
  86. Research: Education and Psychological Issues

    1. Suicidal ideation reported by adults with Type 1 or Type 2 diabetes: results from Diabetes MILES—Australia

      T. E. Handley, A. D. Ventura, J. L. Browne, J. Rich, J. R. Attia, P. Reddy, F. Pouwer and J. Speight

      Version of Record online: 8 DEC 2015 | DOI: 10.1111/dme.13022

      What's new?

      • People with diabetes experience considerable mental health issues, including elevated rates of depression and suicidal ideation (SI).
      • Contrary to previous assumptions, the increased prevalence of SI is not entirely accounted for by depressive symptoms, and may be the result of the burden of diabetes and physical comorbidities more generally.
      • Those with greater social support report lower levels of SI, indicating a protective effect. Strategies to improve social integration and support for people with diabetes should be included in diabetes care.
  87. Research: Epidemiology

    1. Quality of care in patients with diabetic kidney disease in Asia: The Joint Asia Diabetes Evaluation (JADE) Registry

      A. O. Luk, X. Li, Y. Zhang, X. Guo, W. Jia, W. Li, J. Weng, W. Yang, W. B. Chan, R. Ozaki, C. C. Tsang, M. Mukhopadhyay, A. K. Ojha, E. G. Hong, K. H. Yoon, L. Sobrepena, R. M. Toledo, M. Duran, W. Sheu, T. Q. Do, T. K. Nguyen, R. C. Ma, A. P. Kong, C. C. Chow, P. C. Tong, W. Y. So, J. C. Chan and for the JADE Study Group

      Version of Record online: 6 DEC 2015 | DOI: 10.1111/dme.13014

      What's new?

      • In this large multi-national Asia diabetes database, 15% of patients had diabetic kidney disease, over a quarter of whom had other concomitant micro- or macrovascular complications.
      • Despite their inherent high vascular risk, only one third of patients with diabetic kidney disease achieved pre-specified glycaemic and/or blood pressure targets and their use of organ-protective drugs such as renin–angiotensin system inhibitors and statins was suboptimal.
      • This article highlights a major treatment gap in Asian patients with diabetic kidney disease calling for greater quality improvement effort.
    2. The association between sociodemographic and clinical characteristics and poor glycaemic control: a longitudinal cohort study

      K. A. McBrien, B. J. Manns, B. R. Hemmelgarn, R. Weaver, A. L. Edwards, N. Ivers, D. Rabi, R. Lewanczuk, T. Braun, C. Naugler, D. Campbell, N. Saad and M. Tonelli

      Version of Record online: 6 DEC 2015 | DOI: 10.1111/dme.13023

      What's new?

      • We used linked laboratory and administrative data for a large geographically defined cohort of over 160 000 people with diabetes to determine the association between sociodemographic and clinical characteristics and poor glycaemic control, defined as sustained HbA1c ≥ 86 mmol/mol (10%). We used a longitudinal study design with up to 8 years of follow-up.
      • We found that younger age was the strongest predictor of poor glycaemic control. Other sociodemographic factors (First Nations status and low socio-economic status), psychiatric disorders and clinical factors including cardiovascular disease, albuminuria and dyslipidaemia were also associated with the outcome of poor glycaemic control.
    3. Temporal changes in the prevalence of diagnosed diabetes, undiagnosed diabetes and prediabetes: findings from the German Health Interview and Examination Surveys in 1997–1999 and 2008–2011

      C. Heidemann, Y. Du, R. Paprott, M. Haftenberger, W. Rathmann and C. Scheidt-Nave

      Version of Record online: 23 NOV 2015 | DOI: 10.1111/dme.13008

      What's new?

      • For the first time, this study provides recent, nationally representative prevalence estimates and temporal changes for diagnosed diabetes, as well as for undiagnosed diabetes and prediabetes in Germany by combining interview, medication and laboratory data from health surveys.
      • We observed opposing prevalence changes for diagnosed diabetes (that increased) and undiagnosed diabetes and prediabetes (that decreased) independent of changes in age structure, BMI, sport activity or education level over the last decade.
      • The decreased proportion of diabetes that is undiagnosed suggests a better health system responsiveness regarding diabetes diagnosis and care. However, Germany continues to have one of the largest burdens of diabetes within Europe.
    4. Rapidly rising incidence of Type 1 diabetes in children and adolescents aged 0–19 years in Zhejiang, China, 2007 to 2013

      H. B. Wu, J. M. Zhong, R. Y. Hu, H. Wang, W. W. Gong, J. Pan, F. R. Fei, M. Wang, L. H. Guo, L. Yang and M. Yu

      Version of Record online: 22 NOV 2015 | DOI: 10.1111/dme.13010

      What's new?

      • The incidence of Type 1 diabetes in children and adolescents aged 0–19 years was relatively low between 2007 and 2013 in Zhejiang, China, with a mean annual age-standardized incidence rate of 2.02/100 000 person-years. However, a rapidly increasing trend was observed over the same period, with an average annual increase of 12.0% per year.
      • The risk for Type 1 diabetes was estimated to be 1.25 times higher in girls than in boys.
      • The age at diagnosis of Type 1 diabetes in children and adolescents has become younger, and a steep rise in diabetes incidence in the under 5 years age group was observed.
    5. One-hour plasma glucose as a predictor of the development of Type 2 diabetes in Japanese adults

      R. Oka, T. Aizawa, S. Miyamoto, T. Yoneda and M. Yamagishi

      Version of Record online: 14 NOV 2015 | DOI: 10.1111/dme.12994

      What's new?

      • The study confirmed the superior predictive ability of 1-h plasma glucose to that of 2-h plasma glucose with regard to the development of diabetes and that this finding can be generalized to an Asian population.
      • The association between 1-h plasma glucose and the future development of diabetes was independent of indices of insulin secretion or action as assessed by insulinogenic index or disposition index.
      • The results of receiver-operating characteristic curve analysis showed that the predictive ability of indices of insulin secretion or action were not superior to that of sampling plasma glucose at 1 h.
  88. Research: Care Delivery

    1. Performance of three glomerular filtration rate estimation equations in a population of sub-Saharan Africans with Type 2 diabetes

      D. D. Agoons, E. V. Balti, F. F. Kaze, M. Azabji-Kenfack, G. Ashuntantang, A. P. Kengne, E. Sobngwi and J. C. Mbanya

      Version of Record online: 14 NOV 2015 | DOI: 10.1111/dme.12996

      What's new?

      • Glomerular filtration rate (GFR) equations for estimating kidney function are routinely used in sub-Saharan Africa. There is, however, a paucity of data on the performance of these equations in patients with diabetes mellitus who are, for the most part, undiagnosed and unaware of their condition.
      • We investigated the performance of the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Cockcroft–Gault (CG) equations in patients with Type 2 diabetes.
      • Our results suggest that the lowest bias is observed with the MDRD formula compared with the CKD-EPI and CG equations. However, all three equations performed similarly in predicting altered kidney function based on low GFR.
  89. Research: Epidemiology

    1. Does First Nations ancestry modify the association between gestational diabetes and subsequent diabetes: a historical prospective cohort study among women in Manitoba, Canada

      G. X. Shen, L. A. Shafer, P. J. Martens, E. Sellers, A. A. Torshizi, S. Ludwig, W. Phillips-Beck, M. Heaman, H. J. Prior, J. McGavock, M. Morris, A. B. Dart, R. Campbell and H. J. Dean

      Version of Record online: 3 NOV 2015 | DOI: 10.1111/dme.12962

      What's new?

      • This historical cohort study examined the impact of gestational diabetes after excluding pre-existing diabetes in mothers who delivered between 1981 and 2011 in Manitoba, Canada.
      • First Nations (FN) women had two times more gestational diabetes and were three times more likely to develop post-partum diabetes than non-FN women.
      • Post-partum diabetes in both FN and non-FN mothers was affected by gestational diabetes, lower family income and rural residence.
      • The relative risk of developing post-partum diabetes in non-FN women was higher than in FN women.
      • The findings suggest that reductions in gestational diabetes and socio-economic inequities are required to prevent post-partum diabetes in FN and non-FN women.
  90. Short Report: Epidemiology

    1. Smoking affects the oral glucose tolerance test profile and the relationship between glucose and HbA1c in gestational diabetes mellitus

      A. Aulinas, C. Colom, A. García Patterson, J. Ubeda, M. A. María, I. Orellana, J. M. Adelantado, A. de Leiva and R. Corcoy

      Version of Record online: 27 OCT 2015 | DOI: 10.1111/dme.12966

      What's new?

      • Women with gestational diabetes mellitus who smoke at the beginning of pregnancy had an oral glucose tolerance test consistent with accelerated glucose absorption and a disproportionately higher HbA1c.
      • In these women, 1 h plasma glucose and HbA1c overestimate glucose exposure.
  91. Research: Educational and Psychological Aspects

    1. Effect of a structured diabetes education programme in primary care on hospitalizations and emergency department visits among people with Type 2 diabetes mellitus: results from the Patient Empowerment Programme

      C. K. H. Wong, W. C. W. Wong, Y. F. Wan, A. K. C. Chan, F. W. K. Chan and C. L. K. Lam

      Version of Record online: 27 OCT 2015 | DOI: 10.1111/dme.12969

      What's new?

      • Hospital service utilization, with respect to hospital admission and emergency department visits, was significantly reduced among patients who participated in the Patient Empowerment Programme in a ‘real-world’ primary care setting.
      • Our population-based cohort study showed that a structured diabetes education programme led to the benefits of substantial delaying of an initial hospitalization event and reductions in the frequency of hospital service utilization and the associated direct medical costs.
  92. Research: Educational and Psychological Issues

    1. A checklist that enhances the provision of education during insulin initiation simulation: a randomized controlled trial

      C. G. Taylor Jr, K. Bynoe, A. Worme, I. Hambleton, A. Atherley, A. Husbands and N. Unwin

      Version of Record online: 16 OCT 2015 | DOI: 10.1111/dme.12956

      What's new?

      • The provision of education by healthcare professionals to people with diabetes during insulin initiation is a potentially complex task given the extent of education required.
      • Checklists have proven to be beneficial in a number of areas within healthcare, but there are no published studies on their value during insulin initiation by doctors.
      • This paper presents a randomized control trial that shows significantly increased education imparted by doctors utilizing a checklist during simulated insulin initiation.
      • The checklist is applicable to insulin administration with a syringe or pen.


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