M. J. Abla and A. K. Banga
The constant bombardment of UV rays on the skin depletes the antioxidants present in the skin over time. In order to protect the skin from oxidative stress, tocopherol the most active, lipid soluble, membrane bound antioxidant; should be supplemented topically to replenish the antioxidant in the upper layers of the skin. Recently, nanocarriers have emerged as a promising drug delivery system offering several advantages over conventional passive delivery. Hence, we formulated tocopherol as nanocarriers (nanostructured lipid carriers and nanoemulsion). The obtained results confirmed that nanostructured lipid carriers were better nanocarriers than nanoemulsions with comparatively high drug release profile and retention of higher amount of tocopherol in the epidermis. Also, as seen in the graph above nanostructured lipid carriers were categorized as a non-irritant formulation.