Experimental Physiology

Cover image for Vol. 100 Issue 11

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Paul McLoughlin

Impact Factor: 2.669

ISI Journal Citation Reports © Ranking: 2014: 33/83 (Physiology)

Online ISSN: 1469-445X

Associated Title(s): The Journal of Physiology


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  1. Research Papers

    1. Cardiovascular control

      Characteristics of renal sympathetic nerve single units in rabbits with angiotensin-induced hypertension

      Sandra L. Burke, Elena V. Lukoshkova and Geoffrey A. Head

      Article first published online: 21 NOV 2015 | DOI: 10.1113/EP085472

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    2. Heart/Cardiac Muscle

      Regulation of B-type natriuretic peptide synthesis by insulin in obesity in male mice

      Haihua Zhang, Robrecht Thoonen, Vincent Yao, Emmanuel S. Buys, John Popovich, Yan Ru Su, Thomas J. Wang and Marielle Scherrer-Crosbie

      Article first published online: 18 NOV 2015 | DOI: 10.1113/EP085091

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  2. Cardiovascular control

    1. Determining the consequences of maternal obesity for offspring health

      Nashita Patel, Dharmintra Pasupathy and Lucilla Poston

      Article first published online: 17 NOV 2015 | DOI: 10.1113/EP085132

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      Professor Lucilla Poston is Head of the Division of Women's Health in the School of Medicine at Kings College London, and research lead in Women's Health for the King's Health Partners Academic Health Sciences Centre. She graduated in Physiology from University College London, and undertook her PhD at King's College London. Her research team focus on pre-eclampsia, obesity in pregnancy and the developmental origins of disease. Professor Poston is a Fellow ad eundem of the Royal College of Obstetricians and Gynaecologists, an NIHR Senior Investigator (UK) and Fellow of the Academy of Medical Sciences (UK). She has published more than 250 original research papers.

  3. Human, Environmental & Exercise

    1. Sex differences in fatigability of dynamic contractions

      Sandra K. Hunter

      Article first published online: 17 NOV 2015 | DOI: 10.1113/EP085370

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  4. Symposium Reports

    1. Human, Environmental & Exercise

      Revisiting dysanapsis: sex-based differences in airways and the mechanics of breathing during exercise

      A. William Sheel, Paolo B. Dominelli and Yannick Molgat-Seon

      Article first published online: 17 NOV 2015 | DOI: 10.1113/EP085366

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    2. Adaptations of skeletal muscle mitochondria to exercise training

      Carsten Lundby and Robert A. Jacobs

      Article first published online: 17 NOV 2015 | DOI: 10.1113/EP085319

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  5. Human, Environmental & Exercise

    1. Mild dehydration modifies the cerebrovascular response to the cold pressor test

      Blake G. Perry, Tracey L. K. Bear, Samuel J. E. Lucas and Toby Mündel

      Article first published online: 3 NOV 2015 | DOI: 10.1113/EP085449

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  6. Research Papers

    1. GI & Epithelial

      Sex-related differences in small intestinal transit and serotonin dynamics in high-fat-diet-induced obesity in mice

      Marion France, Emmalee Skorich, Mark Kadrofske, Greg M. Swain and James J. Galligan

      Article first published online: 28 OCT 2015 | DOI: 10.1113/EP085427

  7. Symposium Reports

    1. Cardiovascular control

      Is immune system-related hypertension associated with ovarian hormone deficiency?

      Kathryn Sandberg, Hong Ji, Gillian Einstein, April Au and Meredith Hay

      Article first published online: 20 OCT 2015 | DOI: 10.1113/EP085149

  8. G. L. Brown Prize Lecture

    1. Human, Environmental & Exercise

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  9. Symposium reports

    1. Human, Environmental & Exercise

      Skeletal muscle hypoxia-inducible factor-1 and exercise

      Malene E. Lindholm and Helene Rundqvist

      Article first published online: 15 OCT 2015 | DOI: 10.1113/EP085318

    2. Renal

      Gut microbiome in chronic kidney disease

      Maria R. Wing, Samir S. Patel, Ali Ramezani and Dominic S. Raj

      Article first published online: 2 OCT 2015 | DOI: 10.1113/EP085283

  10. Hot Topic Review

    1. Muscle

      Insights from physiology into myometrial function and dysfunction

      Susan Wray

      Article first published online: 13 SEP 2015 | DOI: 10.1113/EP085131

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      After training in physiology at UCL, I took up a lectureship in Liverpool in 1990 and am now getting my long-service award! I enjoy exploring myometrial physiology and its interaction with metabolism, as well as thinking about how our science may be of relevance to women in labour. I also spend time mentoring female physiologists and serve as Director of Athena SWAN for my university. I am proud to have co-edited The Physiological Society's book celebrating the centenary of women being elected to the Society, and to have been a Joan Mott lecturer.

  11. Symposium Reports

    1. Energy metabolism and the high-altitude environment

      Andrew J. Murray

      Article first published online: 13 SEP 2015 | DOI: 10.1113/EP085317

  12. Symposium reports

    1. Renal

      You have full text access to this OnlineOpen article
      Olfaction in the kidney: ‘smelling’ gut microbial metabolites

      Niranjana Natarajan and Jennifer L. Pluznick

      Article first published online: 27 AUG 2015 | DOI: 10.1113/EP085285

  13. Heart/Cardiac muscle

    1. Is there something fishy about the regulation of the ryanodine receptor in the fish heart?

      Holly A. Shiels and Rebecca Sitsapesan

      Article first published online: 16 AUG 2015 | DOI: 10.1113/EP085136

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      Holly Shiels was the 2012 recipient of the GSK Prize Lecture from the Physiological Society. This prize was ‘to encourage early-career physiologists and bring their work to general notice’. Exposure from the award led to invited talks, invited reviews and to new collaborations on the role of the cardiac sarcoplasmic reticulum, including one with her co-author, Professor Rebecca Sitsapesan. Rebecca's group investigates the biophysical properties of RyR and other ion channels on intracellular organelles that are involved in cardiac physiology and pathophysiology. The authors thank the Physiological Society for being interested in their work and for continuing to support comparative physiology.

  14. Cardiovascular control

    1. Sex differences and blood pressure regulation in humans

      Michael J. Joyner, B. Gunnar Wallin and Nisha Charkoudian

      Article first published online: 16 AUG 2015 | DOI: 10.1113/EP085146

  15. 2015 Joan Mott Prize Lecture

    1. 2015 Joan Mott Prize Lecture GI & Epithelial

      Taste and move: glucose and peptide transporters in the gastrointestinal tract

      Hannelore Daniel and Tamara Zietek

      Article first published online: 11 AUG 2015 | DOI: 10.1113/EP085029

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      Hannelore Daniel is Professor of Physiology of Human Nutrition and a Member of the German National Academy of Science Leopoldina. Hannelore received the 2015 Joan Mott Prize from the Physiological Society and various awards for distinguished contributions to teaching in science and recently also the State medal for achievements in science. Hannelore Daniel is recognized internationally for her research on nutrient transporters and their structure and functions and nutrigenomics approaches to better understand human nutrition. She received her Diploma and PhD degrees from the University of Giessen/Germany with postdoctoral work at the University of Glasgow/UK and the Medical School of the University of Pittsburgh/USA.

  16. Cardiovascular control

    1. Interactions between local dilator and sympathetic vasoconstrictor influences in skeletal muscle in acute and chronic hypoxia

      Janice M. Marshall

      Article first published online: 11 AUG 2015 | DOI: 10.1113/EP085139

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      Janice Marshall has a Personal Chair in Cardiovascular Science and is Bowman Professor of Physiology in the Centre for Cardiovascular Sciences, University of Birmingham. She gave the Joan Mott Lecture in 1998 and the Michael de Burgh Daly Lecture in 2002. From 2002 to 2008, she was Head of the Division of Medical Sciences, and when the University restructured in 2008, she was Director of Education in the College of Medical Sciences for 3 years. Her research interests lie in the interactions between sympathetic nerve activity and local mechanisms, particularly those regulating oxygen supply to skeletal muscle in health and disease.

  17. Hot Topic Reviews

    1. Cardiovascular control

      You have full text access to this OnlineOpen article
      Advances in genetic therapeutic strategies for Duchenne muscular dystrophy

      Simon Guiraud, Huijia Chen, David T. Burns and Kay E. Davies

      Article first published online: 4 AUG 2015 | DOI: 10.1113/EP085308

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      Professor Kay E. Davies: I gave the Joan Mott Lecture in 2010 on ‘High throughput screening for drugs in muscular dystrophy’. Since then we have made rapid progress in the identification of drugs that modulate expression of utrophin for the therapy of Duchenne muscular dystrophy, and one drug is being taken into a Phase 1b trial with Summit Therapeutics. Others have made progress with various approaches. I am Honorary Director of the MRC Functional Genomics Unit at the University of Oxford, where this research is based. I am also Deputy Chair of the Wellcome Trust and Associate Head of Division in the Medical Sciences Division at Oxford.

  18. Cardiovascular control

    1. The calcium-sensing receptor: one of a kind

      Irene Lopez-Fernandez, Martin Schepelmann, Sarah C. Brennan, Polina L. Yarova and Daniela Riccardi

      Article first published online: 26 JUL 2015 | DOI: 10.1113/EP085137

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      Daniela Riccardi has always been fascinated with how cells sense changes in their environment and their responses at the molecular and cellular through to whole-organism level. The extracellular calcium-sensing receptor (CaSR) has the unique ability to sample the extracellular milieu and to integrate multiple stimuli into one output, in a manner that is both cell and signal dependent. In most cases this feature is a boon, but it can become a bane when non-physiological CaSR activators hijack this receptor, leading to CaSR overactivation, hence pathology. Since receiving the Wellcome Trust Prize for Excellence in Physiology in 2000, Daniela Riccardi's work has focused on elucidating the physiological roles of the CaSR in non-calciotrophic tissues, on the identification of tissue-specific physiopathological stimuli and on the use of pharmacological modulators of the CaSR to manipulate receptor function in diseases such as vascular calcification and asthma.

  19. Genomic Physiology

    1. You have full text access to this OnlineOpen article
      Tracks through the genome to physiological events

      Diane Lipscombe, Jen Q. Pan and Stephanie Schorge

      Article first published online: 19 JUL 2015 | DOI: 10.1113/EP085129

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      Diane Lipscombe is Professor of Neuroscience and interim Director of the Brown Institute for Brain Science. Member-at-Large and Fellow of the American Association for the Advancement of Science, Diane received the 2012 Joan Mott Prize from the Physiological Society and the Harriet W. Sheridan Award for Distinguished Contribution to Teaching and Learning at Brown University. Diane Lipscombe is nationally recognized for her research on voltage-gated calcium ion channels from genes to behaviour, including cell-specific pre-mRNA processing. Diane Lipscombe obtained her BSc and PhD degrees in Pharmacology from University College London and completed her postdoctoral training in Physiology at Yale University and Stanford University Schools of Medicine.

  20. Hot Topic Reviews

    1. Vascular

      Interleukin-1 as a pharmacological target in acute brain injury

      David Brough, Nancy J. Rothwell and Stuart M. Allan

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085135

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      My Annual Prize Lecture in 1998 coincided with the award of an MRC Research professorship and me delivering the BBC Royal Institution Christmas Lectures. This was 20 years after my PhD on energy balance regulation at the University of London, from where I moved to the University of Manchester in 1987, to work on the role of inflammation in brain injury. I became Vice-President for Research at the newly formed University of Manchester in 2004, and President and Vice-Chancellor in 2010. I am still involved in research, including clinical trials of anti-inflammatory interventions in stroke, described in my lecture.

  21. Neuroendocrinology/Endocrinology

    1. Glucocorticoids as regulatory signals during intrauterine development

      Abigail L. Fowden and Alison J. Forhead

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085212

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      Abby Fowden is Professor of Perinatal Physiology in the Department of Physiology, Development and Neuroscience and Head Elect of the School of the Biological Sciences at the University of Cambridge. She was an undergraduate at Girton College and graduated with a first class degree in Physiology in 1975. She obtained her PhD from the University of Cambridge in 1979 and immediately joined the staff of the Department of Physiology as a demonstrator. Since then, she has held positions as a University Lecturer and Reader before being promoted to a personal chair in 2002. She obtained the ScD degree in 2001 and was awarded the Joan Mott Prize of the Physiological Society for her research in 2008. Her research interests are in the factors controlling feto-placental growth and development during late pregnancy in a range of species from mice to horses. The aims of her research are two fold: first, to determine how hormones and other environmental cues regulate feto-placental development; and, second, to establish how our experiences during early life alter the risk of degenerative diseases in adulthood.


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