Amine neurotransmitters, inflammation and epithelial sodium transport
Patrício Soares-da-Silva, José Miguel Cabral, Diogo Magalhães, Sónia Fraga and Fernando Magro
Article first published online: 14 DEC 2015 | DOI: 10.1113/EP085284
What is the topic of this review?
The present work reviews the roles of renal and intestinal dopamine and 5-HT in the maintenance of fluid and electrolyte homeostasis. The role of inflammatory agents at the intestinal level that affect fluid and electrolyte homeostasis is also addressed.
What advances does it highlight?
General mechanisms of epithelial cell ion transport in the gastrointestinal tract and kidney share considerable similarities, particularly with regard to basolateral Na+,K+-ATPase as a driving force for the movement of numerous substrates across the cell membrane.