Experimental Physiology

Cover image for Vol. 100 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Paul McLoughlin

Impact Factor: 2.669

ISI Journal Citation Reports © Ranking: 2014: 33/83 (Physiology)

Online ISSN: 1469-445X

Associated Title(s): The Journal of Physiology


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  1. Research Papers

    1. Autonomic Neuroscience

    2. Neuroendocrinology/Endocrinology

      Involvement of central relaxin-3 signalling in sodium (salt) appetite

      Craig M. Smith, Lesley L. Walker, Berenice E. Chua, Michael J. McKinley, Andrew L. Gundlach, Derek A. Denton and Andrew J. Lawrence

      Article first published online: 27 JUL 2015 | DOI: 10.1113/EP085349

  2. Cardiovascular control

    1. You have free access to this content
      The calcium-sensing receptor: one of a kind

      Irene Lopez-Fernandez, Martin Schepelmann, Sarah C. Brennan, Polina L. Yarova and Daniela Riccardi

      Article first published online: 26 JUL 2015 | DOI: 10.1113/EP085137

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      Daniela Riccardi has always been fascinated with how cells sense changes in their environment and their responses at the molecular and cellular through to whole-organism level. The extracellular calcium-sensing receptor (CaSR) has the unique ability to sample the extracellular milieu and to integrate multiple stimuli into one output, in a manner that is both cell and signal dependent. In most cases this feature is a boon, but it can become a bane when non-physiological CaSR activators hijack this receptor, leading to CaSR overactivation, hence pathology. Since receiving the Wellcome Trust Prize for Excellence in Physiology in 2000, Daniela Riccardi's work has focused on elucidating the physiological roles of the CaSR in non-calciotrophic tissues, on the identification of tissue-specific physiopathological stimuli and on the use of pharmacological modulators of the CaSR to manipulate receptor function in diseases such as vascular calcification and asthma.

  3. Genomic Physiology

    1. You have full text access to this OnlineOpen article
      Tracks through the genome to physiological events

      Diane Lipscombe, Jen Q. Pan and Stephanie Schorge

      Article first published online: 19 JUL 2015 | DOI: 10.1113/EP085129

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      Diane Lipscombe is Professor of Neuroscience and interim Director of the Brown Institute for Brain Science. Member-at-Large and Fellow of the American Association for the Advancement of Science, Diane received the 2012 Joan Mott Prize from the Physiological Society and the Harriet W. Sheridan Award for Distinguished Contribution to Teaching and Learning at Brown University. Diane Lipscombe is nationally recognized for her research on voltage-gated calcium ion channels from genes to behaviour, including cell-specific pre-mRNA processing. Diane Lipscombe obtained her BSc and PhD degrees in Pharmacology from University College London and completed her postdoctoral training in Physiology at Yale University and Stanford University Schools of Medicine.

  4. Research Papers

    1. Neuroendocrinology/Endocrinology

      Neuromodulation of the luteal regression: presence of progesterone receptors in coeliac ganglion

      Federica Ghersa, Juan Burdisso, Sandra S. Vallcaneras, Federico Fuentes, Magalí de la Vega, Silvia M. Delgado, Carlos M. Telleria and Marilina Casais

      Article first published online: 15 JUL 2015 | DOI: 10.1113/EP085261

    2. Human, Environmental & Exercise

      Fluid restriction during exercise in the heat reduces tolerance to progressive central hypovolaemia

      Zachary J. Schlader, Daniel Gagnon, Eric Rivas, Victor A. Convertino and Craig G. Crandall

      Article first published online: 15 JUL 2015 | DOI: 10.1113/EP085280

    3. Postexercise orthostatic intolerance: influence of exercise intensity

      Toby Mündel, Blake G. Perry, Philip N. Ainslie, Kate N. Thomas, Elisabeth L. G. Sikken, James D. Cotter and Samuel J. E. Lucas

      Article first published online: 15 JUL 2015 | DOI: 10.1113/EP085143

  5. Research papers

    1. Respiratory

  6. Symposium reports

    1. Neuroendocrinology/Endocrinology

      Metabolic aspects of high-altitude adaptation in Tibetans

      Ri-Li Ge, Tatum S. Simonson, Victor Gordeuk, Josef T. Prchal and Donald A. McClain

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085292

  7. Hot Topic Reviews

    1. Vascular

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      Interleukin-1 as a pharmacological target in acute brain injury

      David Brough, Nancy J. Rothwell and Stuart M. Allan

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085135

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      My Annual Prize Lecture in 1998 coincided with the award of an MRC Research professorship and me delivering the BBC Royal Institution Christmas Lectures. This was 20 years after my PhD on energy balance regulation at the University of London, from where I moved to the University of Manchester in 1987, to work on the role of inflammation in brain injury. I became Vice-President for Research at the newly formed University of Manchester in 2004, and President and Vice-Chancellor in 2010. I am still involved in research, including clinical trials of anti-inflammatory interventions in stroke, described in my lecture.

  8. Neuroendocrinology/Endocrinology

    1. Glucocorticoids as regulatory signals during intrauterine development

      Abigail L. Fowden and Alison J. Forhead

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085212

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      Abby Fowden is Professor of Perinatal Physiology in the Department of Physiology, Development and Neuroscience and Head Elect of the School of the Biological Sciences at the University of Cambridge. She was an undergraduate at Girton College and graduated with a first class degree in Physiology in 1975. She obtained her PhD from the University of Cambridge in 1979 and immediately joined the staff of the Department of Physiology as a demonstrator. Since then, she has held positions as a University Lecturer and Reader before being promoted to a personal chair in 2002. She obtained the ScD degree in 2001 and was awarded the Joan Mott Prize of the Physiological Society for her research in 2008. Her research interests are in the factors controlling feto-placental growth and development during late pregnancy in a range of species from mice to horses. The aims of her research are two fold: first, to determine how hormones and other environmental cues regulate feto-placental development; and, second, to establish how our experiences during early life alter the risk of degenerative diseases in adulthood.

  9. Research papers

    1. GI & Epithelial

      Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats

      Soad Shaker Ali, Enas Ahmed Hamed, Nasra Naeim Ayuob, Ahmed Shaker Ali and Mansour Ibrahem Suliman

      Article first published online: 5 JUL 2015 | DOI: 10.1113/EP085015

  10. Research Papers

    1. Human, Environmental & Exercise

      Cerebral oxygenation in highlanders with and without high-altitude pulmonary hypertension

      M. Furian, T. D. Latshang, S. S. Aeschbacher, S. Ulrich, T. Sooronbaev, E. M. Mirrakhimov, A. Aldashev and K. E. Bloch

      Article first published online: 5 JUL 2015 | DOI: 10.1113/EP085200

  11. Vascular

    1. Perfusion pressure and blood flow determine microvascular apparent viscosity

      Ozlem Yalcin, Daniel Ortiz, Alexander T. Williams, Paul C. Johnson and Pedro Cabrales

      Article first published online: 28 JUN 2015 | DOI: 10.1113/EP085101

  12. Human, Environmental & Exercise

  13. Research papers

    1. Renal

      Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat

      Malwina Monika Roszkowska-Chojecka, Agnieszka Walkowska, Olga Gawryś, Iwona Baranowska, Małgorzata Kalisz, Anna Litwiniuk, Lidia Martyńska and Elżbieta Kompanowska-Jezierska

      Article first published online: 23 JUN 2015 | DOI: 10.1113/EP085325

  14. Human, Environmental & Exercise

  15. Respiratory


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