Experimental Physiology

Cover image for Vol. 100 Issue 9

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Paul McLoughlin

Impact Factor: 2.669

ISI Journal Citation Reports © Ranking: 2014: 33/83 (Physiology)

Online ISSN: 1469-445X

Associated Title(s): The Journal of Physiology


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  1. Research Papers

    1. Renal

      The chloride–bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat

      Crystal A. West, Jill W. Verlander, Susan M. Wall and Chris Baylis

      Article first published online: 2 SEP 2015 | DOI: 10.1113/EP085396

  2. Symposium reports

    1. Renal

      You have full text access to this OnlineOpen article
      Olfaction in the kidney: ‘smelling’ gut microbial metabolites

      Niranjana Natarajan and Jennifer L. Pluznick

      Article first published online: 27 AUG 2015 | DOI: 10.1113/EP085285

  3. Research papers

    1. Cardiovascular control

  4. Heart/Cardiac muscle

    1. Is there something fishy about the regulation of the ryanodine receptor in the fish heart?

      Holly A. Shiels and Rebecca Sitsapesan

      Article first published online: 16 AUG 2015 | DOI: 10.1113/EP085136

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      Holly Shiels was the 2012 recipient of the GSK Prize Lecture from the Physiological Society. This prize was ‘to encourage early-career physiologists and bring their work to general notice’. Exposure from the award led to invited talks, invited reviews and to new collaborations on the role of the cardiac sarcoplasmic reticulum, including one with her co-author, Professor Rebecca Sitsapesan. Rebecca's group investigates the biophysical properties of RyR and other ion channels on intracellular organelles that are involved in cardiac physiology and pathophysiology. The authors thank the Physiological Society for being interested in their work and for continuing to support comparative physiology.

  5. Cardiovascular control

    1. Sex differences and blood pressure regulation in humans

      Michael J. Joyner, B. Gunnar Wallin and Nisha Charkoudian

      Article first published online: 16 AUG 2015 | DOI: 10.1113/EP085146

  6. 2015 Joan Mott Prize Lecture

    1. 2015 Joan Mott Prize Lecture GI & Epithelial

      Taste and move: glucose and peptide transporters in the gastrointestinal tract

      Hannelore Daniel and Tamara Zietek

      Article first published online: 11 AUG 2015 | DOI: 10.1113/EP085029

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      Hannelore Daniel is Professor of Physiology of Human Nutrition and a Member of the German National Academy of Science Leopoldina. Hannelore received the 2015 Joan Mott Prize from the Physiological Society and various awards for distinguished contributions to teaching in science and recently also the State medal for achievements in science. Hannelore Daniel is recognized internationally for her research on nutrient transporters and their structure and functions and nutrigenomics approaches to better understand human nutrition. She received her Diploma and PhD degrees from the University of Giessen/Germany with postdoctoral work at the University of Glasgow/UK and the Medical School of the University of Pittsburgh/USA.

  7. Cardiovascular control

    1. Interactions between local dilator and sympathetic vasoconstrictor influences in skeletal muscle in acute and chronic hypoxia

      Janice M. Marshall

      Article first published online: 11 AUG 2015 | DOI: 10.1113/EP085139

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      Janice Marshall has a Personal Chair in Cardiovascular Science and is Bowman Professor of Physiology in the Centre for Cardiovascular Sciences, University of Birmingham. She gave the Joan Mott Lecture in 1998 and the Michael de Burgh Daly Lecture in 2002. From 2002 to 2008, she was Head of the Division of Medical Sciences, and when the University restructured in 2008, she was Director of Education in the College of Medical Sciences for 3 years. Her research interests lie in the interactions between sympathetic nerve activity and local mechanisms, particularly those regulating oxygen supply to skeletal muscle in health and disease.

  8. Hot Topic Reviews

    1. Cardiovascular control

      You have full text access to this OnlineOpen article
      Advances in genetic therapeutic strategies for Duchenne muscular dystrophy

      Simon Guiraud, Huijia Chen, David T. Burns and Kay E. Davies

      Article first published online: 4 AUG 2015 | DOI: 10.1113/EP085308

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      Professor Kay E. Davies: I gave the Joan Mott Lecture in 2010 on ‘High throughput screening for drugs in muscular dystrophy’. Since then we have made rapid progress in the identification of drugs that modulate expression of utrophin for the therapy of Duchenne muscular dystrophy, and one drug is being taken into a Phase 1b trial with Summit Therapeutics. Others have made progress with various approaches. I am Honorary Director of the MRC Functional Genomics Unit at the University of Oxford, where this research is based. I am also Deputy Chair of the Wellcome Trust and Associate Head of Division in the Medical Sciences Division at Oxford.

  9. Cardiovascular control

    1. The calcium-sensing receptor: one of a kind

      Irene Lopez-Fernandez, Martin Schepelmann, Sarah C. Brennan, Polina L. Yarova and Daniela Riccardi

      Article first published online: 26 JUL 2015 | DOI: 10.1113/EP085137

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      Daniela Riccardi has always been fascinated with how cells sense changes in their environment and their responses at the molecular and cellular through to whole-organism level. The extracellular calcium-sensing receptor (CaSR) has the unique ability to sample the extracellular milieu and to integrate multiple stimuli into one output, in a manner that is both cell and signal dependent. In most cases this feature is a boon, but it can become a bane when non-physiological CaSR activators hijack this receptor, leading to CaSR overactivation, hence pathology. Since receiving the Wellcome Trust Prize for Excellence in Physiology in 2000, Daniela Riccardi's work has focused on elucidating the physiological roles of the CaSR in non-calciotrophic tissues, on the identification of tissue-specific physiopathological stimuli and on the use of pharmacological modulators of the CaSR to manipulate receptor function in diseases such as vascular calcification and asthma.

  10. Genomic Physiology

    1. You have full text access to this OnlineOpen article
      Tracks through the genome to physiological events

      Diane Lipscombe, Jen Q. Pan and Stephanie Schorge

      Article first published online: 19 JUL 2015 | DOI: 10.1113/EP085129

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      Diane Lipscombe is Professor of Neuroscience and interim Director of the Brown Institute for Brain Science. Member-at-Large and Fellow of the American Association for the Advancement of Science, Diane received the 2012 Joan Mott Prize from the Physiological Society and the Harriet W. Sheridan Award for Distinguished Contribution to Teaching and Learning at Brown University. Diane Lipscombe is nationally recognized for her research on voltage-gated calcium ion channels from genes to behaviour, including cell-specific pre-mRNA processing. Diane Lipscombe obtained her BSc and PhD degrees in Pharmacology from University College London and completed her postdoctoral training in Physiology at Yale University and Stanford University Schools of Medicine.

  11. Symposium reports

    1. Neuroendocrinology/Endocrinology

      Metabolic aspects of high-altitude adaptation in Tibetans

      Ri-Li Ge, Tatum S. Simonson, Victor Gordeuk, Josef T. Prchal and Donald A. McClain

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085292

  12. Hot Topic Reviews

    1. Vascular

      Interleukin-1 as a pharmacological target in acute brain injury

      David Brough, Nancy J. Rothwell and Stuart M. Allan

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085135

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      My Annual Prize Lecture in 1998 coincided with the award of an MRC Research professorship and me delivering the BBC Royal Institution Christmas Lectures. This was 20 years after my PhD on energy balance regulation at the University of London, from where I moved to the University of Manchester in 1987, to work on the role of inflammation in brain injury. I became Vice-President for Research at the newly formed University of Manchester in 2004, and President and Vice-Chancellor in 2010. I am still involved in research, including clinical trials of anti-inflammatory interventions in stroke, described in my lecture.

  13. Neuroendocrinology/Endocrinology

    1. Glucocorticoids as regulatory signals during intrauterine development

      Abigail L. Fowden and Alison J. Forhead

      Article first published online: 14 JUL 2015 | DOI: 10.1113/EP085212

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      Abby Fowden is Professor of Perinatal Physiology in the Department of Physiology, Development and Neuroscience and Head Elect of the School of the Biological Sciences at the University of Cambridge. She was an undergraduate at Girton College and graduated with a first class degree in Physiology in 1975. She obtained her PhD from the University of Cambridge in 1979 and immediately joined the staff of the Department of Physiology as a demonstrator. Since then, she has held positions as a University Lecturer and Reader before being promoted to a personal chair in 2002. She obtained the ScD degree in 2001 and was awarded the Joan Mott Prize of the Physiological Society for her research in 2008. Her research interests are in the factors controlling feto-placental growth and development during late pregnancy in a range of species from mice to horses. The aims of her research are two fold: first, to determine how hormones and other environmental cues regulate feto-placental development; and, second, to establish how our experiences during early life alter the risk of degenerative diseases in adulthood.

  14. Human, Environmental & Exercise

  15. Respiratory


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