Experimental Physiology

Cover image for Vol. 99 Issue 11

Edited By: Paul McLoughlin

Impact Factor: 2.871

ISI Journal Citation Reports © Ranking: 2013: 28/81 (Physiology)

Online ISSN: 1469-445X

Associated Title(s): The Journal of Physiology

EP Editor's Choice 2012

Online Virtual Issue

EP Editor's Choice 2012

All articles are FREE to access

Published online: 11 April 2012

Published by Experimental Physiology

Papers selected by Paul McLoughlin

Table of Contents


Since its inception Experimental Physiology has been committed to the publication of leading edge discoveries in integrative physiology addressing mechanistic questions in the whole organism.

Recent advances in genome sequencing, bioinformatics analysis, in vivo genetic manipulation including optogenetics, and advanced imaging technologies have provided powerful new tools with which physiologists can explore these fundamental questions and opens a whole new era in physiological and pathophysiological research.

The papers in this virtual issue have been selected as examples of the integrative and translational research recently published in Experimental Physiology. These papers reflect the enhanced scope of Experimental Physiology which takes on the challenge of publishing research that addresses major questions in physiology by using novel approaches and techniques. A particular additional focus is translational research that seeks to elucidate the role of disturbances of reflex, endocrine and neurohumeral control systems in the development and progression of human diseases and points the way towards how manipulations of these physiological mechanisms could bring therapeutic benefit.

The current editorial board comprises internationally recognized scientists spanning a wide range of expertise positioned to reflect current trends in physiology.

Experimental Physiology has been publishing high-quality physiological research since 1908 and the freely accessible archive contains landmark papers by world-class physiologists providing an important resource to the research community.

This is an exciting time in physiology when we are capitalizing on the major advances made by molecular biology and the resultant techniques to explore fundamental questions in vivo. Experimental Physiology is well placed to communicate these advances to a wide audience.

For more information about Experimental Physiology, visit our homepage and Information for Authors.

Paul McLoughlin

Table of Contents

Cardiovascular control


Angiotensin AT1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats
Ai-Dong Chen, Shu-Juan Zhang, Ning Yuan, Yao Xu, Wei De, Xing-Ya Gao, and Guo-Qing Zhu
Experimental Physiology, 96, 94-103


Autonomic mechanisms underpinning the stress response in borderline hypertensive rats
Olivera Šarenac, Maja Lozić, Srdja Drakulić, Dragana Bajić, Julian F. Paton, David Murphy, and Nina Japundžić-Žigon
Experimental Physiology, 96, 574-589


Lentivirus-mediated overexpression of angiotensin-(1–7) attenuated ischaemia-induced cardiac pathophysiology
YanFei Qi, Vinayak Shenoy, Fong Wong, Hongwei Li, Aqeela Afzal, J. Mocco, Colin Sumners, Mohan K. Raizada, and Michael J. Katovich
Experimental Physiology, 96, 863-874

Genomic Physiology


The transcriptome of the medullary area postrema: the thirsty rat, the hungry rat and the hypertensive rats
Charles C. T. Hindmarch, Mark Fry, Pauline M. Smith, Song T. Yao, Georgina G. J. Hazell, Stephen J. Lolait, Julian F. R. Paton, Alastair V. Ferguson, and David Murphy
Experimental Physiology, 96, 495-504

Heart/Cardiac Muscle


Effects of graded heat stress on global left ventricular function and twist mechanics at rest and during exercise in healthy humans
Eric J. Stöhr, José González-Alonso, James Pearson, David A. Low, Leena Ali, Horace Barker, and Rob Shave
Experimental Physiology, 96, 114-124


Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart
F. C. Howarth, M. A. Qureshi, Z. Hassan, L. T. Al Kury, D. Isaev, K. Parekh, S. R. K. D. Yammahi, M. Oz, T. E. Adrian, and E. Adeghate
Experimental Physiology, 96, 325-337


Ageing-dependent remodelling of ion channel and Ca2+ clock genes underlying sino-atrial node pacemaking
James O. Tellez, Michal Mączewski, Joseph Yanni, Pavel Sutyagin, Urszula Mackiewicz, Andrew Atkinson, Shin Inada, Andrzej Beresewicz, Rudi Billeter, Halina Dobrzynski, and M. R. Boyett
Experimental Physiology, 96, 1163-1178

Exercise Physiology


Exercise and vascular adaptation in asymptomatic humans
Daniel J. Green, Angela Spence, John R. Halliwill, N. Timothy Cable, and Dick H. J. Thijssen
Experimental Physiology, 96, 57-70


Cardiovascular strain impairs prolonged self-paced exercise in the heat
Julien D. Périard, Matthew N. Cramer, Phillip G. Chapman, Corinne Caillaud, and Martin W. Thompson
Experimental Physiology, 96, 134-144


Spinal opioid receptor-sensitive muscle afferents contribute to the fatigue-induced increase in intracortical inhibition in healthy humans
Lea Hilty, Kai Lutz, Konrad Maurer, Tobias Rodenkirch, Christina M. Spengler, Urs Boutellier, Lutz Jäncke, and Markus Amann
Experimental Physiology, 96, 505-517

Muscle Physiology


Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
Balindiwe Sishi, Benjamin Loos, Beverly Ellis, Wayne Smith, Eugene F. du Toit, and Anna-Mart Engelbrecht
Experimental Physiology, 96, 179-193


Progress in therapy for Duchenne muscular dystrophy
Rebecca J. Fairclough, Akshay Bareja, and Kay E. Davies
Experimental Physiology, 96, 1101-1113 LECTURE



Protein restriction in the pregnant mouse modifies fetal growth and pulmonary development: role of fetal exposure to β-hydroxybutyrate
Simon C. Langley-Evans, Zoe C. Daniel, Cathy A. Wells, Kevin J. P. Ryan, Richard Plant, and Simon J. M. Welham
Experimental Physiology, 96, 203-215


Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia
Rodrigo Rorato, Wagner Luis Reis, José Antunes-Rodrigues, and Lucila Leico Kagohara Elias
Experimental Physiology, 96, 439-450

Respiratory Physiology


Astrocyte chemoreceptors: mechanisms of H+ sensing by astrocytes in the retrotrapezoid nucleus and their possible contribution to respiratory drive
Daniel K. Mulkey and Ian C. Wenker
Experimental Physiology, 96, 400-406 (Symposium Report)

Autonomic Neuroscience


Neuron–glia metabolic coupling and plasticity
Pierre J. Magistretti
Experimental Physiology, 96, 407-410 (Symposium Report)


Astrocytes as brain interoceptors
Alexander V. Gourine1 and Sergey Kasparov
Experimental Physiology, 96, 411-416 (Symposium Report)

Optogenetics Themed


A user's guide to channelrhodopsin variants: features, limitations and future developments
John Y Lin
Experimental Physiology, 96, 19-25


Channelrhodopsin as a tool to investigate synaptic transmission and plasticity
Philipp Schoenenberger, Yan-Ping Zhang Schärer, and Thomas G. Oertner
Experimental Physiology, 96, 34-39

Vascular Physiology


Cerebroprotection by angiotensin-(1–7) in endothelin-1-induced ischaemic stroke
Adam P. Mecca, Robert W. Regenhardt, Timothy E. O'Connor, Jason P. Joseph, Mohan K. Raizada, Michael J. Katovich, and Colin Sumners
Experimental Physiology, 96, 1084-1096


Bidirectional control of arteriole diameter by astrocytes
Gordon Grant R. J.
Experimental Physiology, 96, 393-399