The Journal of Physiology

Cover image for Vol. 594 Issue 9

Edited By: Kim Barrett

Impact Factor: 5.037

ISI Journal Citation Reports © Ranking: 2014: 5/83 (Physiology); 41/252 (Neurosciences)

Online ISSN: 1469-7793

Associated Title(s): Experimental Physiology

Virtual Issue IUPS 2013


The Journal of Physiology IUPS Virtual Issue Cover

The Journal of Physiology publishes important advances in our knowledge of physiology that increase our understanding of how our bodies function in health and disease.

We are pleased to offer you free access to the below top-quality articles published in The Journal of Physiology over the last 12 months. These articles are from each of the key research areas that The Journal covers and show the breath of topics The Journal publishes. They have been selected by our Senior Editors are free for you to download until the 31 August 2013.

Reasons to publish in The Journal of Physiology:
• The most highly-cited Physiology journal (>47,500 total cites)
• Cited half-life over 10 years
• Over 5 million full text downloads made in 2012
• Sustained excellence: Authors include 37 Nobel Prize winners in Physiology or Medicine and 5 Nobel Prize winners in Chemistry
• World-class Editorial Board, including three Nobel Prize winners
• No page or submission charges
• No page or figure limits
• Two reviewer reports and first decision in <4 weeks
• Immediate ‘In Press’ publication upon acceptance
• Articles published ahead of issue publication in <6 weeks
• Every issue made free after 12 months
• Impact Factor®: 4.380
• 5 year Impact Factor: 4.834

We hope you enjoy reading these articles, and we look forward to receiving your submissions.

Best wishes,
David Paterson

Table of Contents


Ursodeoxycholic acid attenuates colonic epithelial secretory function
Orlaith B. Kelly, Magdalena S. Mroz, Joseph B. J. Ward, Carolina Colliva, Michael Scharl, Roberto Pellicciari, John F. Gilmer, Padraic G. Fallon, Alan F. Hofmann, Aldo Roda, Frank E. Murray and Stephen J. Keely
J. Physiol. 591, 2307-2318

Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity
Lina Roosen, Werend Boesmans, Marjan Dondeyne, Inge Depoortere, Jan Tack, and Pieter Vanden Berghe
J. Physiol. 590, 4321-4333

Purinergic neuromuscular transmission is absent in the colon of P2Y1 knocked out mice
Diana Gallego, Víctor Gil, Míriam Martínez-Cutillas, Noemí Mañé, Maria Teresa Martín, and Marcel Jiménez
J. Physiol. 590, 1943-1956

P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit
Sung Jin Hwang, Peter J. Blair, Leonie Durnin, Violeta Mutafova-Yambolieva, Kenton M. Sanders, and Sean M. Ward
J. Physiol. 590, 1957-1972

Hedgehog signalling in gut development, physiology and cancer
Juanita L. Merchant
J. Physiol. 590, 421-432

The role of fructose transporters in diseases linked to excessive fructose intake
Veronique Douard, and Ronaldo P. Ferraris
J. Physiol. 591, 401-414

Molecular and cellular

Ion channels in genetic and acquired forms of epilepsy
Holger Lerche, Mala Shah, Heinz Beck, Jeff Noebels, Dan Johnston, and Angela Vincent
J. Physiol. 591, 753-764

Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems
Ming-Yi Lin, Joyce G. Rohan, Haijiang Cai, Kerstin Reim, Chien-Ping Ko, and Robert H. Chow
J. Physiol. 591, 2463-2473

Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel
Kristal Tucker, Sukhee Cho, Nicolas Thiebaud, Michael X. Henderson, and Debra Ann Fadool
J. Physiol. 591, 2541-2561

Single KATP channel opening in response to stimulation of AMPA/kainate receptors is mediated by Na accumulation and submembrane ATP and ADP changes
R. Mollajew, J. Toloe, and S. L. Mironov
J. Physiol. 591, 2593-2609

Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder
Luiz O. Leiria, Carolina Sollon, Fernando R. Báu, Fabíola Z. Mónica, Carlos L. D'Ancona, Gilberto De Nucci, Andrew D. Grant, Gabriel F. Anhê, and Edson Antunes
J. Physiol. 591, 2259-2273

ATP secretion in the male reproductive tract: essential role of CFTR
Ye Chun Ruan, Winnie W. C. Shum, Clémence Belleannée, Nicolas Da Silva, and Sylvie Breton
J. Physiol. 590, 4209-4222

The role of endogenous molecules in modulating pain through TRPV1
Sara L Morales-Lázaro, Sidney A Simon and Tamara Rosenbaum
J. Physiol. 591

Computational Physiology

Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit
Johan Hake, Andrew G. Edwards, Zeyun Yu, Peter M. Kekenes-Huskey, Anushka P. Michailova, J. Andrew McCammon, Michael J. Holst, Masahiko Hoshijima, Andrew D. McCulloch
J. Physiol. 590, 4403-4422

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation – insights from modelling
Sanjay Kharche, Ismail Adeniran, Jonathan Stott, Phillip Law, Mark R. Boyett, Jules C. Hancox and Henggui Zhang
J. Physiol. 590, 4501-4514

At the heart of computational modelling
S. A. Niederer and N. P. Smith
J Physiol. 590, 1331-1338

A new conceptual paradigm for the haemodynamics of salt-sensitive hypertension: a mathematical modelling approach
Viktoria A. Averina, Hans G. Othmer, Gregory D. Fink and John W. Osborn
J Physiol. 590, 5975-5992

Skeletal muscle

Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans
Y. Hellsten, M. Nyberg and S. P. Mortensen
J Physiol. 590, 5015-5023

Partial opening and subconductance gating of mechanosensitive ion channels in dystrophic skeletal muscle
Ivan Vasquez, Nhi Tan, Mark Boonyasampant, Kari A. Koppitch and Jeffry B. Lansman
J Physiol. 590, 6167-6185

Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle
Carlo Manno, Monika Sztretye, Lourdes Figueroa, Paul D. Allen and Eduardo Ríos
J Physiol. 591, 423-442

Dietary nitrate increases tetanic [Ca2 ]i and contractile force in mouse fast-twitch muscle
Andrés Hernández, Tomas A. Schiffer, Niklas Ivarsson, Arthur J. Cheng, Joseph D. Bruton, Jon O. Lundberg, Eddie Weitzberg and Håkan Westerblad
J Physiol. 590, 3575-3583

In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle-tendon units
Herbert RD, Clarke J, Kwah LK, Diong J, Martin J, Clarke EC, Bilston LE & Gandevia SC.
J Physiol 589, 5257-5267


Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
Peter J. Ratcliffe
J Physiol. 591, 2027-2042

Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors
Emma C. Hart, Michael J. Joyner, B. Gunnar Wallin and Nisha Charkoudian
J Physiol. 590, 2069-2079

Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice
Melissa L. Borg, Simin Fallah Omran, Jacquelyn Weir, Peter J. Meikle and Matthew J. Watt
J Physiol. 590, 4377-4389

Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand
Darren P. Casey and Michael J. Joyner
J Physiol. 590, 6321-6326

The role of α-adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man
Fairfax ST, Holwerda SW, Credeur DP, Zuidema MY, Medley JH, Dyke PC, Wray DW, Davis MJ, Fadel PJ.
J Physiol. 591

Cardiovascular and respiratory

Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles
Erika B. Westcott, Erica L. Goodwin, Steven S. Segal and William F. Jackson
J Physiol. 590, 1849-1869

Spreading vasodilatation in the murine microcirculation: attenuation by oxidative stress-induced change in electromechanical coupling
Lauren Howitt, Daniel J. Chaston, Shaun L. Sandow, Klaus I. Matthaei, Frank R. Edwards and Caryl E. Hill
J Physiol. 591 2157-2173

Transient outward K current reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes
A. J. Workman, G. E. Marshall, A. C. Rankin, G. L. Smith and J. Dempster
J Physiol. 590, 4289-305

Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat
Ana P. Abdala, Fiona D. McBryde, Nephtali Marina, Emma B. Hendy, Zoar J. Engelman, Marat Fudim, Paul A. Sobotka, Alexander V. Gourine and Julian F. R. Paton
J Physiol. 590, 4269-4277

Distribution of electrical activation to the external intercostal muscles during high frequency spinal cord stimulation in dogs
Anthony F. DiMarco and Krzysztof E. Kowalski
J Physiol. 589, 1383-1395

Expanding role of ATP as a versatile messenger at carotid and aortic body chemoreceptors
Nikol A. Piskuric and Colin A. Nurse
J Physiol. 591, 415-422

Neuroscience: cellular/molecular

Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release
Dongdong Li, Karine Hérault, Ehud Y. Isacoff, Martin Oheim and Nicole Ropert
J Physiol. 590, 855-873

Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBötzinger complex)
S. L. Mironov
J Physiol. 591, 1613-1630

Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity
Michael T. Craig, Elizabeth W. Mayne, Bernhard Bettler, Ole Paulsen,and Chris J. McBain
J Physiol. 591, 835-843

Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation
David M. MacLean and Derek Bowie
J Physiol. 589, 5383-5390

Neuroscience: behavioural/systems/cognitive

Activity-dependent depression of the recurrent discharge of human motoneurones after maximal voluntary contractions
Serajul I. Khan, Sabine Giesebrecht, Simon C. Gandevia and Janet L. Taylor
J Physiol. 590, 4957-4969

Sound-evoked network calcium transients in mouse auditory cortex in vivo
Christine Grienberger, Helmuth Adelsberger, Albrecht Stroh, Ruxandra-Iulia Milos, Olga Garaschuk, Anja Schierloh, Israel Nelken and Arthur Konnerth
J Physiol. 590, 899-918

Neuroscience: development/plasticity/repair

Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice
Mei-Feng Chen, Tung-Yi Huang, Yu-Min Kuo, Lung Yu, Hsiun-ing Chen and Chauying J. Jen
J Physiol. 591, 985-1000

Neuroscience: neurobiology of disease

Selective mitochondrial Ca2 uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis
Andrea Fuchs, Sylvie Kutterer, Tobias Mühling, Johanna Duda, Burkhard Schütz, Birgit Liss, Bernhard U. Keller and Jochen Roeper
J Physiol. 591, 2723-2745