Developmental Medicine & Child Neurology

Cover image for Vol. 59 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Bernard Dan and Peter Rosenbaum

Impact Factor: 3.615

ISI Journal Citation Reports © Ranking: 2015: 9/120 (Pediatrics); 43/193 (Clinical Neurology)

Online ISSN: 1469-8749

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  1. 1 - 46
  1. Original Articles

    1. Genotype–phenotype relationship in mucopolysaccharidosis II: predictive power of IDS variants for the neuronopathic phenotype

      Audrey A M Vollebregt, Marianne Hoogeveen-Westerveld, Marian A Kroos, Esmee Oussoren, Iris Plug, George J Ruijter, Ans T van der Ploeg and W W M Pim Pijnappel

      Version of Record online: 25 MAY 2017 | DOI: 10.1111/dmcn.13467

      What this paper adds

      • Central nervous system phenotypes of eight iduronate-2-sulphatase gene (IDS) variants are reported.
      • Expression studies of nine IDS gene variants are reported.
      • The molecular effects of IDS variants do not distinguish between mucopolysaccharidosis (MPS) II phenotypes.
      • The IDS genotype is a good predictor of the neuronopathic and non-neuronopathic MPS II phenotype.
    2. Phenotype and natural history of variant late infantile ceroid-lipofuscinosis 5

      Alessandro Simonati, Ruth E Williams, Nardo Nardocci, Minna Laine, Roberta Battini, Angela Schulz, Barbara Garavaglia, Francesca Moro, Francesco Pezzini and Filippo M Santorelli

      Version of Record online: 25 MAY 2017 | DOI: 10.1111/dmcn.13473

      What this paper adds

      • Disease onset is at preschool age (mean age 4y).
      • Behavioural manifestations and impaired language are early clinical symptoms.
      • Seizures and vision impairment occur 3 to 4 years after disease onset.
      • The predicted survival is about 15 to 20 years after disease start.
      • More rapid neurological decline is related to severity of CLN5 mutations.
  2. Commentary

    1. Preterm sucking behaviour and later neurodevelopment

      Justine Slattery

      Version of Record online: 25 MAY 2017 | DOI: 10.1111/dmcn.13470

      This commentary is on the original article by Wolthuis-Stigter et al.

  3. Original Articles

    1. Motor function domains in alternating hemiplegia of childhood

      Melanie Masoud, Kelly Gordon, Amanda Hall, Joan Jasien, Kara Lardinois, Julie Uchitel, Melissa Mclean, Lyndsey Prange, Jeffrey Wuchich and Mohamad A Mikati

      Version of Record online: 25 MAY 2017 | DOI: 10.1111/dmcn.13443

      What this paper adds

      • Motor function was not worse in older patients with alternating hemiplegia of childhood.
      • Motor speech was the most affected function.
      • Gross motor and upper extremity motor functions were less impaired.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  4. Invited Reviews

    1. Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease

      Nathalie H P Claessens, Christopher J Kelly, Serena J Counsell and Manon J N L Benders

      Version of Record online: 19 MAY 2017 | DOI: 10.1111/dmcn.13461

      What this paper adds

      • Infants with congenital heart disease show functional deficits in childhood and adolescence.
      • Neonatal brain dysmaturation and acquired brain injury can contribute to neurodevelopmental impairments.
  5. Systematic Reviews

    1. Use of active video gaming in children with neuromotor dysfunction: a systematic review

      Robbin Hickman, Lisa Popescu, Robert Manzanares, Brendan Morris, Szu-Ping Lee and Janet S Dufek

      Version of Record online: 19 MAY 2017 | DOI: 10.1111/dmcn.13464

      What this paper adds

      • Gaming is used more frequently for intervention than for data collection in cerebral palsy, developmental coordination disorder, and Down syndrome.
      • Active video gaming (AVG) demonstrates potential to improve impairments and outcomes in these populations.
      • AVG was more beneficial as an intervention when used with direct clinical supervision.
      • Choosing specific games was the most frequent method for individualizing tasks or difficulty levels.
      • Limitations generally focused on threats to internal validity of research, not on problems with AVG technology.
  6. Original Articles

    1. You have full text access to this OnlineOpen article
      Mental health outcomes of developmental coordination disorder in late adolescence

      Ian Harrowell, Linda Hollén, Raghu Lingam and Alan Emond

      Version of Record online: 16 MAY 2017 | DOI: 10.1111/dmcn.13469

      What this paper adds

      • Mental health difficulties in developmental coordination disorder persist into late adolescence.
      • Adolescent females with developmental coordination disorder may have greater risk of mental health difficulties.
      • Social communication difficulties mediate the relationship between developmental coordination disorder and mental health.
    2. Variations in Duchenne muscular dystrophy course in a multi-ethnic UK population: potential influence of socio-economic factors

      Margaret Hufton and Helen Roper

      Version of Record online: 16 MAY 2017 | DOI: 10.1111/dmcn.13460

      What this paper adds

      • Males of South Asian heritage with Duchenne muscular dystrophy (DMD) stop walking earlier than those of white British heritage.
      • The most deprived children with DMD lose ambulation earlier than the least deprived.
      • Children from South Asian backgrounds are more likely to decline or stop steroids.
    3. Assessments of pain in children and adolescents with cerebral palsy: a retrospective population-based registry study

      Lena Westbom, Amanda Rimstedt and Eva Nordmark

      Version of Record online: 16 MAY 2017 | DOI: 10.1111/dmcn.13459

      What this paper adds

      • Under-recognition of chronic pain in clinical care of children with cerebral palsy (CP) continues.
      • Validity of simple screening questions to capture information about pain.
      • Impact on pain of different interventions in CP can be explored, using the roughly 40 000 collected assessments in 3800 children in CPUP Sweden.
  7. Systematic Reviews

    1. A systematic review of scales to measure dystonia and choreoathetosis in children with dyskinetic cerebral palsy

      Kirsty Stewart, Adrienne Harvey and Leanne M Johnston

      Version of Record online: 9 MAY 2017 | DOI: 10.1111/dmcn.13452

      What this paper adds

      • Six scales report to measure dystonia and/or choreoathetosis in children with cerebral palsy (CP).
      • The Barry–Albright Dystonia Scale (BADS) and Burke–Fahn–Marsden Dystonia Rating Scale are the most reported measures.
      • The BADS and Dyskinesia Impairment Scale are the only measures developed specifically for CP.
      • Further examination of psychometrics is required for all tools.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  8. Original Articles

    1. Psychological well-being and independent living of young adults with childhood-onset craniopharyngioma

      Rodica Mia Memmesheimer, Karin Lange, Michael Dölle, Sabine Heger and Iris Mueller

      Version of Record online: 9 MAY 2017 | DOI: 10.1111/dmcn.13444

      What this paper adds

      • Young adults with childhood-onset craniopharyngioma have higher depression and anxiety rates.
      • They feel less socially integrated compared to typically developing population and young adults with type 1 diabetes.
      • Body mass index and negative life events are predictive factors for depression and anxiety.
      • Young adults with childhood-onset craniopharyngioma have limited independance.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  9. Commentary

    1. Understanding cerebral palsy: the power of population-based surveillance

      Kim Van Naarden Braun

      Version of Record online: 9 MAY 2017 | DOI: 10.1111/dmcn.13462

      This commentary is on the original article by Delobel-Ayoub et al.

    2. The impact of workplace violence on health care workers' quality of life

      Behdin Nowrouzi-Kia

      Version of Record online: 2 MAY 2017 | DOI: 10.1111/dmcn.13466

      This commentary is on the original article by Rousseau et al.

    3. Measuring trunk control in cerebral palsy: what's next?

      Sandra Saavedra

      Version of Record online: 2 MAY 2017 | DOI: 10.1111/dmcn.13450

      This commentary is on the original article by Marsico et al.

    4. The challenges of research in children with visual impairment

      Carey A Matsuba

      Version of Record online: 2 MAY 2017 | DOI: 10.1111/dmcn.13458

      This commentary is on the original article by Dale et al.

    5. Employment as a measure of participation in adults with cerebral palsy

      Susan I Michelsen

      Version of Record online: 28 APR 2017 | DOI: 10.1111/dmcn.13445

      This commentary is on the original article by Benner et al.

    6. In vivo muscle behaviour in cerebral palsy with an equinus gait: are we on track?

      Simon-Henri Schless, Kaat Desloovere and Lynn Bar-On

      Version of Record online: 28 APR 2017 | DOI: 10.1111/dmcn.13447

      This commentary is on the original article by Barber et al.

  10. Systematic Reviews

    1. Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases

      Margherita Nosadini, Shekeeb S Mohammad, Francesco Corazza, Ezia Maria Ruga, Kavitha Kothur, Giorgio Perilongo, Anna Chiara Frigo, Irene Toldo, Russell C Dale and Stefano Sartori

      Version of Record online: 25 APR 2017 | DOI: 10.1111/dmcn.13448

      What this paper adds

      • Movement disorder is characteristic of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis but not of herpes simplex virus (HSV) encephalitis.
      • Despite immune therapy for HSV-induced anti-NMDAR encephalitis, none of the patients had recurrence of HSV encephalitis.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  11. Commentary

    1. Māori gene and epigenetics hypotheses: the temptation of population genetics

      Armand Ngaketcha Njafang and Jean-Noël Missa

      Version of Record online: 25 APR 2017 | DOI: 10.1111/dmcn.13463

      This commentary is on the original article by Jones et al.

  12. Original Articles

    1. Prevalence and characteristics of autism spectrum disorders in children with cerebral palsy

      Malika Delobel-Ayoub, Dana Klapouszczak, Marit Maria Elisabeth van Bakel, Karen Horridge, Solveig Sigurdardottir, Kate Himmelmann and Catherine Arnaud

      Version of Record online: 25 APR 2017 | DOI: 10.1111/dmcn.13436

      What this paper adds

      • Among the children with cerebral palsy, 8.7% had a co-occurring autism spectrum disorder (ASD) diagnosis.
      • Variations between geographical areas: 4.0% to 16.7%.
      • Factors associated with ASD were male sex, epilepsy, intellectual disability, and less severe motor impairment.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    2. Functional vision and cognition in infants with congenital disorders of the peripheral visual system

      Naomi Dale, Elena Sakkalou, Michelle O'Reilly, Clare Springall, Michelle De Haan and Alison Salt

      Version of Record online: 25 APR 2017 | DOI: 10.1111/dmcn.13429

      What this paper adds

      • At 1 year, near-detection vision is strongly associated with cognitive outcome.
      • Infants with visual impairment have difficulty acquiring early manipulative abilities and object concepts, particularly if they have no vision.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    3. Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-Methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae

      Kavitha Kothur, Deepak Gill, Melanie Wong, Shekeeb S Mohammad, Sushil Bandodkar, Susan Arbunckle, Louise Wienholt and Russell C Dale

      Version of Record online: 25 APR 2017 | DOI: 10.1111/dmcn.13431

      What this paper adds

      • Inflammatory response is higher in anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis if is it preceded by herpes simplex encephalitis (HSE).
      • Aggressive immune treatment in acute post-HSE anti-NMDAR illness improves the chances of a good outcome.
      • Children with previous HSE and ongoing neurological symptoms may have persistent immune activation and chronic encephalitis.
      • Persistent cerebrospinal fluid upregulation of cyto-/chemokines may be modifiable with immune therapy.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    4. Longitudinal physical activity and sedentary behaviour in preschool-aged children with cerebral palsy across all functional levels

      Piyapa Keawutan, Kristie L Bell, Stina Oftedal, Robert S Ware, Richard D Stevenson, Peter S W Davies and Roslyn N Boyd

      Version of Record online: 22 APR 2017 | DOI: 10.1111/dmcn.13439

      What this paper adds

      • Physical activity in preschool-aged children with cerebral palsy (CP) decreases from 4 years of age.
      • Sedentary time in children with CP significantly increases from 3 years of age.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    5. Functional status and amount of hip displacement independently affect acetabular dysplasia in cerebral palsy

      Myung Ki Chung, Arif Zulkarnain, Jae Bong Lee, Byung Chae Cho, Chin Youb Chung, Kyoung Min Lee, Ki Hyuk Sung and Moon Seok Park

      Version of Record online: 22 APR 2017 | DOI: 10.1111/dmcn.13437

      What this paper adds

      • Acetabular dysplasia is independently aggravated according to increased migration percentage and Gross Motor Function Classification System (GMFCS) level.
      • Three-dimensional evaluation should be considered when deciding the pelvic osteotomy in patients with cerebral palsy.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    6. Sucking behaviour in infants born preterm and developmental outcomes at primary school age

      Mechteld I Wolthuis-Stigter, Saakje P Da Costa, Arend F Bos, Wim P Krijnen, Cees P Van Der Schans and Margreet R Luinge

      Version of Record online: 22 APR 2017 | DOI: 10.1111/dmcn.13438

      What this paper adds

      • Sucking behaviour before 40 weeks postmenstrual age is not associated with developmental outcomes at 5 years.
      • Persistently abnormal sucking behaviour is associated with balance, IQ, and language at 5 years.
      • Sucking behaviour is not associated with behaviour or memory at 5 years.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    7. Multimodal neurophysiological monitoring in healthy infants born at term: normative continuous somatosensory evoked potentials data

      Silvia Lori, Simonetta Gabbanini, Maria Bastianelli, Giovanna Bertini, Iuri Corsini and Carlo Dani

      Version of Record online: 22 APR 2017 | DOI: 10.1111/dmcn.13430

      What this paper adds

      • Standardized simultaneous recording of video- and amplitude-electroencephalography/continuous somatosensory evoked potentials (SEP) is feasible and safe in neonates born at term.
      • Continuous SEP is always present in all healthy newborn infants in the first 2 days of life.
      • SEP modulation responses could serve as prognostic indicator of brain integrity.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    8. Impact of caring for patients with severe and complex disabilities on health care workers’ quality of life: determinants and specificities

      Marie-Christine Rousseau, Karine Baumstarck, Tanguy Leroy, Cherazad Khaldi-Cherif, Catherine Brisse, Laurent Boyer, Noémie Resseguier, Claire Morando, Thierry Billette De Villemeur and Pascal Auquier

      Version of Record online: 22 APR 2017 | DOI: 10.1111/dmcn.13428

      What the paper adds

      • Quality of life (QoL) of health care workers caring for individuals with severe and complex disabilities.
      • Determinants of QoL for health care workers include age, financial difficulties, nature of coping strategy, and burn-out.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  13. Book Reviews

  14. Commentary

    1. Cost-effectiveness of web-based therapy: what's it worth?

      Claire Kerr

      Version of Record online: 11 APR 2017 | DOI: 10.1111/dmcn.13441

      This commentary is on the original article by Comans et al.

  15. Original Articles

    1. Clinical and metabolic correlates of cerebral calcifications in Sturge–Weber syndrome

      Vinod K Pilli, Michael E Behen, Jiani Hu, Yang Xuan, James Janisse, Harry T Chugani and Csaba Juhász

      Version of Record online: 11 APR 2017 | DOI: 10.1111/dmcn.13433

      What this paper adds
      • Brain calcifications progress faster in children with Sturge–Weber syndrome (SWS) and early-onset epilepsy.
      • Hypometabolism often extends beyond calcified brain regions.
      • Calcified brain volume may be an imaging biomarker for cognitive outcome in SWS.
    2. Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression

      Ori Scott, Diya Shi, Diana Andriashek, Brenda Clark and Helly R Goez

      Version of Record online: 6 APR 2017 | DOI: 10.1111/dmcn.13432

      What this paper adds

      • Familial autoimmunity is more prevalent in autistic regression variant compared with autism spectrum disorders (ASDs).
      • A higher rate of familial type 1 diabetes and autoimmune thyroid disease is seen in autistic regression variant than in ASDs.
      • Incidence of febrile illness preceding symptom onset is higher in autistic regression variant than in ASDs.
      • We suggest immune activation as a possible aetiology of autistic regression.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

    3. The Trunk Control Measurement Scale: reliability and discriminative validity in children and young people with neuromotor disorders

      Petra Marsico, Elena Mitteregger, Julia Balzer and Hubertus J A van Hedel

      Version of Record online: 4 APR 2017 | DOI: 10.1111/dmcn.13425

      What this paper adds

      • The Trunk Control Measurement Scale (TCMS) is highly reliable in children with various neuromotor disorders.
      • The TCMS is reliable in children aged 5 years and older.
      • Measurement errors of TCMS total and subscores allow for the interpretation of longitudinal changes.
      • The TCMS subscores are relevant concerning daily life, mobility, and self-care.
  16. Systematic Reviews

    1. You have full text access to this OnlineOpen article
      Evidence for increasing physical activity in children with physical disabilities: a systematic review

      Manon Bloemen, Leontien Van Wely, Jurgen Mollema, Annet Dallmeijer and Janke de Groot

      Version of Record online: 4 APR 2017 | DOI: 10.1111/dmcn.13422

      What this paper adds

      • Physical training alone does not increase physical activity in young people with cerebral palsy.
      • Behavioural interventions show conflicting evidence directly after the intervention.
      • Behavioural interventions show no increase in physical activity at follow-up.
  17. Original Articles

    1. Medial gastrocnemius and soleus muscle-tendon unit, fascicle, and tendon interaction during walking in children with cerebral palsy

      Lee Barber, Chris Carty, Luca Modenese, John Walsh, Roslyn Boyd and Glen Lichtwark

      Version of Record online: 1 APR 2017 | DOI: 10.1111/dmcn.13427

      What this paper adds

      • Medial gastrocnemius fascicles in children with cerebral palsy (CP) contract eccentrically during mid-stance phase.
      • Soleus fascicles in CP and typical development function similarly during stance.
      • The Achilles tendon contributes significantly to the stretch and shorten of the muscle-tendon unit in CP and typical development.
      • Reduced ankle power and work in CP may be attributed to reduced medial gastrocnemius fascicle shortening.

      This article's abstract has been translated into Spanish and Portuguese.

      Follow the links from the abstract to view the translations.

  18. Commentary

    1. Multidisciplinary care of children and young people with ataxia-telangiectasia

      William P Whitehouse

      Version of Record online: 24 MAR 2017 | DOI: 10.1111/dmcn.13426

      This commentary is on the original article by van Os et al.

  19. Original Articles

    1. Anti-N-methyl-d-aspartate receptor encephalitis in Māori and Pacific Island children in New Zealand

      Hannah F Jones, Shekeeb S Mohammad, Peter W Reed, Paul P J Dunn, Richard H Steele, Russell C Dale and Cynthia Sharpe

      Version of Record online: 22 MAR 2017 | DOI: 10.1111/dmcn.13420

      What this paper adds

      • Māori and Pacific Island children are at increased risk of anti-N-methyl-d-aspartate (NMDA) receptor encephalitis (3.4 and 10.0 per million children per year respectively).
      • One third of Māori and Pacific Island children with anti-NMDA receptor encephalitis have a poor outcome.
  20. Systematic Reviews

    1. You have free access to this content
      The efficacy of interventions to increase physical activity participation of children with cerebral palsy: a systematic review and meta-analysis

      Sarah Reedman, Roslyn N Boyd and Leanne Sakzewski

      Version of Record online: 20 MAR 2017 | DOI: 10.1111/dmcn.13413

      What this paper adds

      • Meta-analysis reveals therapy and behaviour change interventions have a modest but clinically insignificant effect on habitual physical activity.
      • Interventions targeting physical activity are generally not goal-directed or participation-focused.
      • There is no significant effect on intensity/frequency of participation in physical and skill-based activities.
  21. Reviews

    1. Ataxia-telangiectasia: recommendations for multidisciplinary treatment

      Nienke J H van Os, Charlotte A Haaxma, Michiel van der Flier, Peter J F M Merkus, Marcel van Deuren, Imelda J M de Groot, Jan Loeffen, Bart P C van de Warrenburg, Michèl A A P Willemsen and The A-T Study Group

      Version of Record online: 20 MAR 2017 | DOI: 10.1111/dmcn.13424

      What this paper adds

      • Recommendations for the clinical management of patients with ataxia-telangiectasia.
      • Many health issues must be taken into account.
  22. Original Articles

    1. You have free access to this content
      Course of employment in adults with cerebral palsy over a 14-year period

      Joyce L Benner, Sander R Hilberink, Thessa Veenis, Wilma M A van der Slot and Marij E Roebroeck

      Version of Record online: 17 MAR 2017 | DOI: 10.1111/dmcn.13423

      What this paper adds

      • Employment in adults with cerebral palsy is consistently lower compared with the general population.
      • Up to age 45, employment remains stable over time.
      • Weekly work hours decline over time, specifically in females.
  23. Systematic Reviews

    1. Selective voluntary motor control measures of the lower extremity in children with upper motor neuron lesions: a systematic review

      Julia Balzer, Marietta L van der Linden, Thomas H Mercer and Hubertus J A van Hedel

      Version of Record online: 8 MAR 2017 | DOI: 10.1111/dmcn.13417

      What this paper adds

      • Very few studies evaluate validity and reliability of selective voluntary motor control measures.
      • Responsiveness studies of selective voluntary motor control measures are lacking.
      • We can currently recommend the Selective Control Assessment of the Lower Extremity measure/tool.
      • The evidence level of objective interval-scaled selective voluntary motor control measures is limited.
    2. Outcomes after scoliosis surgery for children with cerebral palsy: a systematic review

      Rachel Toovey, Adrienne Harvey, Michael Johnson, Louise Baker and Katrina Williams

      Version of Record online: 6 MAR 2017 | DOI: 10.1111/dmcn.13412

      What this paper adds

      • Scoliosis surgery in children with cerebral palsy has a moderately high complication rate (38%).
      • Surgery is indicated for deformity correction but evidence is lacking for improved functional outcomes, caregiver outcomes, and quality of life.
  24. Original Articles

    1. The cost-effectiveness of a web-based multimodal therapy for unilateral cerebral palsy: the Mitii randomized controlled trial

      Tracy Comans, Gabor Mihala, Leanne Sakzewski, Roslyn N Boyd and Paul Scuffham

      Version of Record online: 1 MAR 2017 | DOI: 10.1111/dmcn.13414

      What this paper adds

      • A multimodal web-based programme delivered at home confers better effectiveness than usual care rehabilitation in children with unilateral cerebral palsy.
      • Additional costs per motor and process skills (Assessment of Motor and Process Skills) or occupational performance (Canadian Occupational Performance Measure) responder were relatively small.
      • For the limited costs and greater gains in health outcomes, the Mitii web-based programme offers a cost-effective adjunct to direct rehabilitation.
    2. Inter- and intrarater clinician agreement on joint motion patterns during gait in children with cerebral palsy

      Angela Nieuwenhuys, Eirini Papageorgiou, Guy Molenaers, Davide Monari, Tinne de Laet and Kaat Desloovere

      Version of Record online: 22 FEB 2017 | DOI: 10.1111/dmcn.13404

      What this paper adds

      • Intra- and interrater agreement was found on joint motion patterns in cerebral palsy.
      • Intrarater agreement is rater-specific and not generalizable to all clinicians.
      • Experienced raters better identified knee patterns in stance and ankle patterns in swing.
  25. Commentary

    1. Clinical trials in childhood stroke: from consensus to reality

      Mitchell S V Elkind

      Version of Record online: 22 FEB 2017 | DOI: 10.1111/dmcn.13408

      This commentary is on the original article by Steinlin et al.

  26. Original Articles

    1. Planning interventional trials in childhood arterial ischaemic stroke using a Delphi consensus process

      Maja Steinlin, Finbar O'callaghan and Mark T Mackay

      Version of Record online: 25 JAN 2017 | DOI: 10.1111/dmcn.13393

      What this paper adds

      • Example of a Delphi consensus process to evaluate research questions and design for a research protocol.
      • Most important and feasible study evaluated: steroid aspirin versus aspirin alone in focal arteriopathies in childhood stroke.
      • Suggests a randomized clinical trial with high dose steroids/aspirin versus aspirin alone in the acute phase with blinded outcome: time to recovery.
      • Current treatment decisions in Europe, Australia, and New Zealand show steroids to be used in focal arteriopathy in the majority of centers.
    2. Psychosocial function in the first year after childhood stroke

      Mardee Greenham, Vicki Anderson, Stephen Hearps, Michael Ditchfield, Lee Coleman, Mark T Mackay, Paul Monagle and Anne L Gordon

      Version of Record online: 25 JAN 2017 | DOI: 10.1111/dmcn.13387

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