Use of paracetamol during pregnancy and child neurological development
Laurence de Fays, Karen Van Malderen, Karen De Smet, Javier Sawchik, Veerle Verlinden, Jamila Hamdani, Jean-Michel Dogné and Bernard Dan
Article first published online: 7 APR 2015 | DOI: 10.1111/dmcn.12745
What this paper adds
- Animal data suggest that therapeutic doses of paracetamol may alter cognition and behaviour.
- Epidemiological studies suggest a weak to moderate association between antenatal exposure to paracetamol and neurodevelopment or attention-deficit–hyperactivity disorder, but limitations in the studies' design and weakness of the observed associations prevent causal inference.
- Given the current knowledge, paracetamol is still to be considered safe in pregnancy and should remain the first line for the treatment of pain and fever.