Journal of Neurochemistry

Cover image for Vol. 143 Issue 2

Edited By: Jörg Schulz

Impact Factor: 4.083

ISI Journal Citation Reports © Ranking: 2016: 65/258 (Neurosciences); 77/286 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells

    Nobutaka Takahashi, Anton N. Shuvaev, Ayumu Konno, Yasunori Matsuzaki, Masashi Watanave and Hirokazu Hirai

    Accepted manuscript online: 19 OCT 2017 11:26AM EST | DOI: 10.1111/jnc.14239

  2. Intra-arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model

    Vibhuti, Rehan Khan, Alpana Sharma, Suman Jain, Sujata Mohanty and Kameshwar Prasad

    Accepted manuscript online: 19 OCT 2017 11:25AM EST | DOI: 10.1111/jnc.14241

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    Nutrient-driven O-GlcNAc in proteostasis and neurodegeneration

    Ilhan Akan, Stephanie Olivier-Van Stichelen, Michelle R. Bond and John A. Hanover

    Accepted manuscript online: 19 OCT 2017 11:25AM EST | DOI: 10.1111/jnc.14242

  4. “Epigenetic control of early neurodegenerative events in Diabetic Retinopathy by the histone deacetylase SIRT6”

    María A. Zorrilla-Zubilete, Ada Yeste, Francisco J. Quintana, Debra Toiber, Raul Mostoslavsky and Dafne M. Silberman

    Accepted manuscript online: 19 OCT 2017 11:25AM EST | DOI: 10.1111/jnc.14243

  5. Ethanol stimulates the in vivo axonal movement of neuropeptide dense-core vesicles in Drosophila motor neurons

    Gary J. Iacobucci and Shermali Gunawardena

    Version of Record online: 18 OCT 2017 | DOI: 10.1111/jnc.14230

    Thumbnail image of graphical abstract

    Ethanol is a widely abused drug, but detailed physiological and molecular effects of ethanol consumption are only recently being understood. For Drosophila, ethanol is a naturally occurring environmental chemical that elicits behavioral changes making them an ideal model system for studying the effects of ethanol. This study found that, in Drosophila, low doses of ethanol results in the stimulation of neuropeptide vesicle transport with a bias toward the anterograde direction. We propose that this effect is mediated via GSK-3β-mediated modulation of kinesin-1 motor proteins. Thus, modulation of peptideric neurons may underlie the toxic and behavioral effects of ethanol and provide a novel target for therapeutics.