Journal of Neurochemistry

Cover image for Vol. 137 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 56/252 (Neurosciences); 72/290 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. You have full text access to this OnlineOpen article
    Complex regulation of the regulator of synaptic plasticity histone deacetylase 2 in the rodent dorsal horn after peripheral injury

    Maria Maiarù, Oakley B. Morgan, Keri K. Tochiki, Eleanor J. Hobbiger, Kaveeta Rajani, Dorothy W. U. Overington and Sandrine M. Géranton

    Version of Record online: 27 MAY 2016 | DOI: 10.1111/jnc.13621

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    Our manuscript describes for the first time the regulation of the memory regulator histone deacetylase 2 (HDAC2) in the superficial dorsal horn of adult rats following peripheral injury. Our cell-specific approach has revealed a complex pattern of expression of spinal HDAC2 that depends on the injury and the cell type, suggesting a sophisticated regulation of gene expression by HDAC2.

  2. You have full text access to this OnlineOpen article
    Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain

    Thilo Kähne, Sandra Richter, Angela Kolodziej, Karl-Heinz Smalla, Rainer Pielot, Alexander Engler, Frank W. Ohl, Daniela C. Dieterich, Constanze Seidenbecher, Wolfgang Tischmeyer, Michael Naumann and Eckart D. Gundelfinger

    Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13636

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    How does the protein composition of synapses change in different brain areas upon auditory learning? We unravel discrete proteome changes in mouse auditory cortex, frontal cortex, hippocampus, and striatum functionally implicated in the learning process. We identify not only common but also area-specific biological pathways and cellular processes modulated 24 h after training, indicating individual contributions of the regions to memory processing.

  3. Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

    Louise Carlred, Wojciech Michno, Ibrahim Kaya, Peter Sjövall, Stina Syvänen and Jörg Hanrieder

    Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13645

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    Hanrieder et al. described an imaging mass spectrometry based study on comprehensive spatial profiling of C-terminally truncated Aβ species within individual plaques in tgArcSwe mice. Here, brain region-dependent differences in Aβ truncation and other plaque-associated proteins, such as macrophage migration inhibitory factor, were observed. The data shed further light on plaque-associated molecular mechanisms implicated in Alzheimer's pathogenesis.

  4. The astrocytic response to the dopaminergic denervation of the striatum

    Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate and Manuel Rodriguez

    Accepted manuscript online: 26 MAY 2016 11:05PM EST | DOI: 10.1111/jnc.13684

  5. l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro

    Aditi Banerjee, Swagata Ghatak and Sujit Kumar Sikdar

    Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13638

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    Insufficient blood supply to the brain leads to cerebral ischaemia and increase in extracellular lactate concentrations. We incubated hippocampal astrocytes in lactate and observed increase in TREK1 channel expression via protein kinase A (PKA). Inhibition of TREK1, PKA and metabolic impairment of astrocytes prevented lactate from reducing cell death in ischaemic hippocampus. This pathway serves as an alternate mechanism of neuroprotection.