Journal of Neurochemistry

Cover image for Vol. 138 Issue 5

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. C-terminal of human histamine H1 receptors regulates their agonist-induced clathrin-mediated internalization and G-protein signaling

    Shigeru Hishinuma, Hiroki Nozawa, Chizuru Akatsu and Masaru Shoji

    Accepted manuscript online: 27 AUG 2016 01:10AM EST | DOI: 10.1111/jnc.13834

  2. β-Caryophyllene Protects In Vitro Neurovascular Unit against Oxygen-Glucose Deprivation and Re-oxygenation-Induced Injury

    Xiaocui Tian, Jianhua Peng, Jianjun Zhong, Mei Yang, Jinwei Pang, Jie n, Minghang Li, Ruidi An, Qian Zhang, Lu Xu and Zhi Dong

    Accepted manuscript online: 27 AUG 2016 01:10AM EST | DOI: 10.1111/jnc.13833

  3. The oligodendrocyte-specific antibody ‘CC1’ binds Quaking 7

    Jenea M. Bin, Stephanie N. Harris and Timothy E. Kennedy

    Version of Record online: 24 AUG 2016 | DOI: 10.1111/jnc.13745

    Thumbnail image of graphical abstract

    The monoclonal antibody anti-adenomatous polyposis coli (APC) clone CC1, is the antibody most commonly used to specifically label the cell bodies of mature oligodendrocytes. Despite being raised against APC, previous studies showed this antibody binds another unknown antigen. We show that the CC1 antibody binds Quaking (QKI) 7, an RNA-binding protein which is highly up-regulated in myelinating oligodendrocytes.

  4. Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells

    Jaishree Jalewa, Mohit Kumar Sharma and Christian Hölscher

    Version of Record online: 24 AUG 2016 | DOI: 10.1111/jnc.13736

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    GLP-1, GIP and dual incretin receptor agonists showed protective effects in SH-SY5Y cells treated with the stressor Rotenone. The novel GLP-1/GIP dual receptor agonist was superior and effective at a tenfold lower concentration compared to the other analogues. The drugs protected the cells from rotenone-induced impairment in cell growth and Akt activation, mitochondrial damage, impairments of autophagy and apoptotic cell signalling. See paper for details.

  5. You have free access to this content
    Targeting innate immunity for neurodegenerative disorders of the central nervous system (pages 653–693)

    Katrin I. Andreasson, Adam D. Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C. Lee, Donovan Low, Marina A. Lynch, Alon Monsonego, M. Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A. Sandusky, Maj-Linda B. Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town and Linda J. Van Eldik

    Version of Record online: 24 AUG 2016 | DOI: 10.1111/jnc.13667

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    Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7–9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.

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