Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

    Zhuang Wu, Linlang Li, Long-Tai Zheng, Zhihong Xu, Lin Guo and Xuechu Zhen

    Accepted manuscript online: 29 MAY 2015 01:32PM EST | DOI: 10.1111/jnc.13182

  2. Neurometabolic coupling between neural activity, glucose, and lactate in activated visual cortex

    Baowang Li and Ralph D. Freeman

    Article first published online: 29 MAY 2015 | DOI: 10.1111/jnc.13143

    Thumbnail image of graphical abstract

    Dynamic changes in energy metabolites can be measured directly with high spatial and temporal resolution by use of enzyme-based microelectrodes. Here, to examine neuro-metabolic coupling during brain activation, we use combined microelectrodes to simultaneously measure extracellular glucose, lactate, and neural responses in the primary visual cortex to visual stimulation. We demonstrate rapid decreases in glucose and increases in lactate during neural activation. Changes in glucose and lactate signals are transient and closely coupled with neuronal firing.

  3. Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB

    Emin D. Ozkan, Massimiliano Aceti, Thomas K. Creson, Camilo S. Rojas, Christopher R. Hubbs, Megan N. McGuire, Priyanka P. Kakad, Courtney A. Miller and Gavin Rumbaugh

    Article first published online: 29 MAY 2015 | DOI: 10.1111/jnc.13146

    Thumbnail image of graphical abstract

    Non-muscle myosin II is an actin binding protein with three isoforms in the brain (IIA, IIB and IIC) encoded by the myh9, myh10, and myh14 genes in mice, respectively. We have studied the structure and the function of hippocampal CA1 neurons missing NMIIB and/or NMIIA proteins at different times during development. We have discovered that NMIIB is the major isoform regulating Schaffer collateral inputs, and that this regulation is restricted to early postnatal development.

  4. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

    Ryoichi Takahashi, Kenjiro Ono, Yusaku Takamura, Mineyuki Mizuguchi, Tokuhei Ikeda, Hisao Nishijo and Masahito Yamada

    Accepted manuscript online: 27 MAY 2015 07:14AM EST | DOI: 10.1111/jnc.13180

  5. The mechanistic target of rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons

    Somhrita Dutta, Ibolya Rutkai, Prasad V. G. Katakam and David W. Busija

    Accepted manuscript online: 27 MAY 2015 07:07AM EST | DOI: 10.1111/jnc.13181

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