Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 4.244
ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- Regulation of RAGE splicing by hnRNP A1 and Tra2β-1 and its potential role in AD pathogenesis
Xiao-Yan Liu, Hong-Lei Li, Jia-Bin Su, Fei-Hong Ding, Jing-Jing Zhao, Fang Chai, Yuan-Xin Li, Shi-Cao Cui, Feng-Yan Sun, Zhi-Ying Wu, Ping Xu and Xian-Hua Chen
Article first published online: 2 MAR 2015 | DOI: 10.1111/jnc.13069
The receptor for advanced glycation end products (RAGE) gene expresses two major alternative splicing isoforms, membrane-bound RAGE (mRAGE) and secretory RAGE (esRAGE). Both isoforms play important roles in Alzheimer's disease (AD) pathogenesis. Mechanism for imbalanced expression of these two isoforms in AD brain remains elusive. We proposed here a hypothetic model to illustrate that impaired glucose metabolism in AD brain may increase the expression of splicing protein hnRNP A1 and reduce Tra2β-1, which cause the imbalanced expression of mRAGE and esRAGE.
- Schwann cells contribute to neurodegeneration in transthyretin amyloidosis
Tatsufumi Murakami, Kazunori Sango, Kazuhiko Watabe, Naoko Niimi, Shizuka Takaku, Zhenghua Li, Ken-ichi Yamamura and Yoshihide Sunada
Article first published online: 2 MAR 2015 | DOI: 10.1111/jnc.13068
We established a spontaneously immortalized Schwann cell line derived from familial amyloidotic polyneuropathy transgenic mice. Conditioned medium from the cells contained variant transthyretin (TTR), and inhibited neurite outgrowth of neurons. TTR aggregates were observed in the Schwann cells and satellite cells of aged mice. Proteasome inhibition induced TTR aggregates as aggresomes in the cultured cells. These results support the hypothesis that Schwann cells contribute to neurodegeneration in familial amyloidotic polyneuropathy (FAP).
- Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine
Li-Min Mao, Bing Xue, Dao-Zhong Jin and John Q. Wang
Article first published online: 2 MAR 2015 | DOI: 10.1111/jnc.13067
Acute injection of amphetamine increased phosphorylation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunits at a protein kinase A (PKA)-sensitive site (S845) in the rat hippocampus. This increase was dose- and time-dependent and correlated with an increase in surface GluA1 expression. Thus, amphetamine can upregulate GluA1 phosphorylation and surface trafficking of GluA1 in hippocampal neurons in vivo.
- G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells
Joseph B. Altmann, Guang Yan, Jeffrey F. Meeks, Mary E. Abood, Eugen Brailoiu and G. Cristina Brailoiu
Article first published online: 2 MAR 2015 | DOI: 10.1111/jnc.13066
Activation of the G protein-coupled estrogen receptor (GPER) in rat brain microvascular endothelial cells (RBMVEC) increases [Ca2+]i by promoting Ca2+ influx. The increase in [Ca2+]i leads to membrane hyperpolarization, nitric oxide (NO) production, and to cytoskeletal changes and increased cell stiffness. Our results unravel the mechanisms underlying GPER-mediated effects in RBMVEC with implications for the effect of estrogen on cerebral microvasculature.
- Estrogen receptor-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells
Juhee Lim, Hueng-Sik Choi and Hyun Jin Choi
Accepted manuscript online: 2 MAR 2015 02:57AM EST | DOI: 10.1111/jnc.13085