Journal of Neurochemistry

Cover image for Vol. 139 Issue 1

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury

    Louis J. Sparvero, Andrew A. Amoscato, Arthur B. Fink, Tamil Anthonymuthu, Lee Ann New, Patrick M. Kochanek, Simon Watkins, Valerian E. Kagan and Hulya Bayır

    Version of Record online: 26 SEP 2016 | DOI: 10.1111/jnc.13840

    Thumbnail image of graphical abstract

    Traumatic brain injury (TBI) leads to changes in ion fluxes and alterations in mitochondrial function. Mitochondrial signaling strongly depends on cardiolipin (CL), which is selectively oxidized and presents itself as a target for redox therapy following TBI. We describe a mass spectrometric lipid imaging study that reports regio-specific changes in rat brain CL in a controlled cortical impact (CCI) model of traumatic brain injury (TBI). While MALDI-MS imaging revealed that TBI caused decreases in CL in the contusional area 3 h after injury, it also revealed decreases extending well beyond the area of impact into histologically normal tissue in the hippocampus and thalamic regions. The more unsaturated CL species were most susceptible to loss.

  2. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner

    Lawrence C. Blume, Sandra Leone-Kabler, Deborah J. Luessen, Glen S. Marrs, Erica Lyons, Caroline E. Bass, Rong Chen, Dana E. Selley and Allyn C. Howlett

    Version of Record online: 26 SEP 2016 | DOI: 10.1111/jnc.13767

    Thumbnail image of graphical abstract

    The CB1R-interacting protein CRIP1a functions to differentially modulate agonist-promoted versus non-agonist-mediated CB1R internalization and cell surface equilibrium. Association of CRIP1a with the CB1R precludes agonist-driven internalization via a mechanism involving β-arrestin, clathrin and dynamin. CRIP1a also functions to fine-tune CB1R cell surface levels through delivery of newly synthesized CB1R receptors to the plasma membrane.

  3. Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis

    Osamu Imamura, Masaaki Arai, Minori Dateki and Kunio Takishima

    Accepted manuscript online: 24 SEP 2016 11:30AM EST | DOI: 10.1111/jnc.13856

  4. [18F]JNJ42259152 binding to phosphodiesterase PDE10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP

    Maarten Ooms, Bala Attili, Sofie Celen, Michel Koole, Alfons Verbruggen, Koen Van Laere and Guy Bormans

    Accepted manuscript online: 24 SEP 2016 11:25AM EST | DOI: 10.1111/jnc.13855

  5. Metabolic profile of injured human spinal cord determined using surface microdialysis

    Suliang Chen, Isaac Phang, Argyro Zoumprouli, Marios C. Papadopoulos and Samira Saadoun

    Accepted manuscript online: 24 SEP 2016 11:20AM EST | DOI: 10.1111/jnc.13854