Journal of Neurochemistry

Cover image for Vol. 132 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Glycine bidirectionally regulates ischemic tolerance via different mechanisms including NR2A-dependent CREB phosphorylation

    Zheng Chen, Bin Hu, Fuzhou Wang, Linlin Du, Baosheng Huang, Lixin Li, Jia Qi and Xiang Wang

    Article first published online: 28 JAN 2015 | DOI: 10.1111/jnc.12994

    Thumbnail image of graphical abstract

    A model of glycine induced dose-dependent bidirectional regulations in ischemic tolerance. (a) Under low dose of Gly pre-treatment, glycine induces NMDAR potentiation and CREB-dependent neuroprotection through the NMDAR co-agonist binding site. (b) Under high dose of Gly pre-treatment, the excessive glycine in synaptic cleft can activate neighboring extrasynaptic sites and combine to the GlyRs. Then, the deteriorative effects would be triggered after NMDAR endocytosis and synaptic depression. AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CREB, cAMP response element-binding protein; Gly, glycine; GlyR, glycine receptor; GlyT1, gycine transportor 1; NMDAR, N-methyl-d-aspartate receptor.

  2. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects

    Zhi Ruan, Hong Min Wang, Xiao Tian Huang, Yan Fu, Jian Wu, Chun Yan Ye, Jin Long Li, Lei Wu, Qi Gong, Wei Min Zhao and Hai Yan Zhang

    Accepted manuscript online: 27 JAN 2015 09:39AM EST | DOI: 10.1111/jnc.13046

  3. Molecular determinants of transport stimulation of EAAT2 are located at interface between the trimerization and substrate transport domains

    Ole V. Mortensen, José L. Liberato, Joaquim Coutinho-Netto, Wagner F. dos Santos and Andréia C. K. Fontana

    Accepted manuscript online: 27 JAN 2015 09:38AM EST | DOI: 10.1111/jnc.13047

  4. Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 (CB1) receptors located on glutamatergic neurons and on astrocytes

    Ilaria Belluomo, Isabelle Matias, Camille Pernègre, Giovanni Marsicano and Francis Chaouloff

    Accepted manuscript online: 27 JAN 2015 09:38AM EST | DOI: 10.1111/jnc.13044