Journal of Neurochemistry

Cover image for Vol. 144 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.083

ISI Journal Citation Reports © Ranking: 2016: 66/259 (Neurosciences); 78/290 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Corticotropin-releasing hormone-binding protein is upregulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons

    Naoki Adachi, Shingo Suzuki, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-ichi Ohta, Yohei Hirai, Takanori Miki and Hisatsugu Koshimizu

    Accepted manuscript online: 22 JAN 2018 03:03AM EST | DOI: 10.1111/jnc.14310

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    Complex neuroprotective and neurotoxic effects of histone deacetylases

    Elizabeth A. Thomas and Santosh R. D'Mello

    Accepted manuscript online: 22 JAN 2018 02:41AM EST | DOI: 10.1111/jnc.14309

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    An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia

    Brittani R. Price, Christopher M. Norris, Pradoldej Sompol and Donna M. Wilcock

    Version of Record online: 22 JAN 2018 | DOI: 10.1111/jnc.14273

    Thumbnail image of graphical abstract

    We propose that hyperhomocysteinemia (HHcy) results in a pro-inflammatory response at the vasculature, which activates the matrix metalloproteinase MMP9. MMP9 subsequently cleaves the a-b dystroglycan complex, leading to disruption of the astrocytic connection with the vasculature. MMP9 also degrades the dystrophin Dp71 anchoring complex, resulting in the down-regulation of astrocytic end-foot channels. The end result of the end-foot disruption is impaired potassium homeostasis in the brain and impaired neurovascular coupling.

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    Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

    Jianhua Zhang, M Lillian Culp, Jason G Craver and Victor Darley-Usmar

    Accepted manuscript online: 17 JAN 2018 07:35AM EST | DOI: 10.1111/jnc.14308

  5. Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase (FGAMS) in neurons

    Colleen A. Mangold, Pamela J. Yao, Mei Du, Willard M. Freeman, Stephen J. Benkovic and Moriah L. Szpara

    Accepted manuscript online: 16 JAN 2018 09:36AM EST | DOI: 10.1111/jnc.14304