Journal of Neurochemistry
© International Society for Neurochemistry

Edited By: Jörg Schulz
Impact Factor: 4.061
ISI Journal Citation Reports © Ranking: 2011: 59/244 (Neurosciences); 77/290 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Chronic methamphetamine results in glutamate release and synaptic plasticity, likely involving AMPA receptors. Metabotropic glutamate receptor group 1 subtype 5 (mGlu5) activates striatal-enriched tyrosine phosphatase isoform 61 (STEP61) to internalize AMPARs. We reveal that repeated methamphetamine increased cell surface AMPAR subunits and decreased STEP61 levels in rat cortex; this change was not seen after mGlu5 antagonist treatment.
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