Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 3.842
ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- You have free access to this contentEating disorders: from bench to bedside and back
Silvana Gaetani, Adele Romano, Gustavo Provensi, Valdo Ricca, Thomas Lutz and Maria Beatrice Passani
Version of Record online: 21 OCT 2016 | DOI: 10.1111/jnc.13848
Our brain and gut are connected by an extensive network of neurons and a highway of chemicals and hormones that affect appetite and energy expenditure, emotions, memory, responses to stress and pain. Clinical and preclinical research is constantly adding new information to the field and orienting studies with the aim of providing a foundation for developing more specific and effective treatment approaches to pathological conditions.
- Widespread brain transcriptome alterations underlie the neuroprotective actions of dietary saffron
Nicholas V. Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas J. Burton, John Mitrofanis, Jonathan Stone and Daniel M. Johnstone
Version of Record online: 21 OCT 2016 | DOI: 10.1111/jnc.13857
We confirm previous reports that pre-conditioning by saffron consumption protects the brain of mice against parkinsonian MPTP insult. Intriguingly, 5 days of saffron pre-conditioning provided more robust neuroprotection than 10 days. Investigation of how saffron consumption influences the brain transcriptome revealed molecular changes consistent with neuroprotection as well as the up-regulation of some specific stress-inducible systems. These findings raise the possibility that saffron, like other phytochemicals, may act by inducing an adaptive stress response.
- Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor as a possible link between sympathoexcitation and inflammation
Olalekan M. Ogundele, Charles C. Lee and Joseph Francis
Version of Record online: 19 OCT 2016 | DOI: 10.1111/jnc.13842
We highlighted a possible mechanism through which an age-dependent change in IGF-1R/CamKIIα expression causes a simultaneous progression of inflammation and sympathoexcitation in the paraventricular nucleus of spontaneously hypertensive rats. Taken together, we found that the loss of IGF-1R/CamKIIα in the SHR, was associated with an increase in pro-inflammatory MAPK/ErK and HMGB1. Additionally, we recorded a decrease in GABA, and an elevated level of VGLUT 2/Tyrosine hydroxylase. Our results suggest a crucial role for IGF-1R/CamKIIα in the pathophysiology of PVN sympathoexcitation.
- Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats
Ying Xu, Ye Tian, Yue Tian, Xingyue Li and Ping Zhao
Version of Record online: 18 OCT 2016 | DOI: 10.1111/jnc.13851
Autophagy in cognitive and memory impairment induced by hypoxic-ischemic brain injury (HIBI) in neonates is not completely understood. We demonstrated that excessive autophagy flux aggravates brain injury and induces cognitive and memory impairment during adolescence. Autophagic inhibition reverses the results partly by attenuating the reduction of phosphorylated cAMP-response element-binding protein (p-CREB). The use of autophagy modulators in the immature brain would provide new protective strategy against HIBI.
- You have free access to this contentConverging evidence for regulation of dopamine neurotransmission by lithium : An Editorial Highlight for ‘Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens’
Version of Record online: 18 OCT 2016 | DOI: 10.1111/jnc.13846
Lithium is a cation that is the active component of several salts prescribed for bipolar disorder therapy since multiple decades. However, the biological mechanism of its effect lacks sufficient investigation. This Editorial highlights an article by Can and coworkers in which the authors uncovered an effect of chronic lithium treatment in limiting maladaptive dopamine release by ventral tegmental area dopamine neurons projecting to the nucleus accumbens. These new findings are presented in terms of their potential significance for the regulation of manic state and put in the context of existing evidence pointing toward a central role for lithium in the regulation of dopamine neurotransmission and dopamine receptor signaling.
Read the highlighted article ‘Chronic lithium treatment rectifies maladaptive dopamine release in the nucleus accumbens’ on doi/10.1111/jnc.13769.