Journal of Neurochemistry

Cover image for Vol. 130 Issue 3

Edited By: Jörg Schulz

Impact Factor: 3.973

ISI Journal Citation Reports © Ranking: 2012: 71/252 (Neurosciences); 83/290 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex

    Christof Hiebel, Tanja Kromm, Marcel Stark and Christian Behl

    Accepted manuscript online: 28 JUL 2014 04:20AM EST | DOI: 10.1111/jnc.12839

  2. A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain

    Sergey V. Matveev, Hans Peter Spielmann, Brittney M. Metts, Jing Chen, Fredrick Onono, Haining Zhu, Stephen W. Scheff, Lary C. Walker and Harry LeVine III

    Article first published online: 27 JUL 2014 | DOI: 10.1111/jnc.12815

    Thumbnail image of graphical abstract

    A lipid-associated subpopulation of Aβ accounts for the high-affinity binding of Pittsburgh compound B (PIB) in Alzheimer's disease brain. Mass spectrometry of the isolated PIB-binding site from frontal cortex identified Aβ peptides and a set of plaque-associated proteins in AD but not age-matched normal brain. The PIB-binding site may represent a particularly pathogenic entity and/or report local pathologic conditions.

  3. Hypoxia-inducible factor-1α mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells

    Hecheng Wang, Miao Sun, Huan Yang, Xiaosheng Tian, Yawei Tong, Ting Zhou, Tao Zhang, Yaoyun Fu, Xiangyang Guo, Dongsheng Fan, Albert Yu, Ming Fan, Xuefei Wu, Weizhong Xiao and Dehua Chui

    Article first published online: 27 JUL 2014 | DOI: 10.1111/jnc.12795

    Thumbnail image of graphical abstract

    HIF-1 binded to and disassociated HDAC-1 from NEP promoter, activating NEP gene expression at early stage of hypoxia. HDAC-1 protein level was elevated at late stage of hypoxia that exceeded the binding capacity of HIF-1 to prevent association of HDAC-1 from NEP promoter, leading to suppression of NEP.

  4. Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy

    Paitoon Srimontri, Shogo Endo, Toshiro Sakamoto, Yoshiaki Nakayama, Akira Kurosaka, Shigeyoshi Itohara, Yoshio Hirabayashi and Keiko Kato

    Accepted manuscript online: 26 JUL 2014 02:26AM EST | DOI: 10.1111/jnc.12838