Journal of Neurochemistry

Cover image for Vol. 139 Issue 5

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Docosahexaenoic acid up-regulates both PI3K/AKT-dependent FABP7–PPARγ interaction and MKP3 that enhance GFAP in developing rat brain astrocytes

    Sachin Tripathi, Rajesh Kushwaha, Juhi Mishra, Manoj Kumar Gupta, Harish Kumar, Somali Sanyal, Dhirendra Singh, Sabyasachi Sanyal, Amogh Anant Sahasrabuddhe, Mohan Kamthan, Mohana Krishna Reddy Mudiam and Sanghamitra Bandyopadhyay

    Version of Record online: 7 DEC 2016 | DOI: 10.1111/jnc.13879

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    Docosahexaenoic acid (DHA), though known to promote neurodevelopment, has been less studied for its effect on astrocyte marker, glial fibrillary acidic protein (GFAP). Here we proved that DHA causes GFAP induction in developing rat brain. The steps include, DHA promotes PI3K/AKT signalling (1) that activates PPARγ (2) and induces FABP7 via ER6 and DR6-PPREs on FABP7 gene (3). FABP7 undergoes physical interaction with PPARγ (4) to induce FABP7-PPARγ protein/protein complex that suppresses CDK5-PPARγ (5) and thereby p-PPARγ. PI3K/AKT pathway also stimulates MKP3 expression (6) that inactivates (7) and thereby suppresses activation of ERK[RIGHTWARDS ARROW]CDK5 and the generation of CDK5-PPARγ and p-PPARγ(Ser112). MKP3 also partially up-regulates FABP7-PPARγ levels in lieu of CDK5-PPARγ (8). Attenuation of CDK5-PPARγ and p-PPARγ ultimately culminates in enhanced GFAP expression and astroglial activation (9).

  2. Role of Wnt/β-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity: a possible novel target for addiction treatment

    Santiago Cuesta, Jorgelina Batuecas, Maria J. Severin, Alejandrina Funes, Silvana B. Rosso and Alejandra M. Pacchioni

    Version of Record online: 7 DEC 2016 | DOI: 10.1111/jnc.13863

    Thumbnail image of graphical abstract

    Cocaine addiction is a chronic relapsing disorder. Persistent vulnerability to relapse arises from a number of long-lasting adaptations in the reward circuitry that mediate the enduring response to the drug. Activity of the canonical or Wnt/β-catenin pathway in the prefrontal cortex (PFC) is very important in the early stages of cocaine-induced neuroadaptations. Here, we evaluated the role Wnt/β-catenin pathway in cocaine-induced long-term neuroadaptations. We found that a cocaine challenge, after withdrawal, increased nucleus accumbens (NAcc)'s β-catenin levels only in animals that expressed behavioral sensitization. Moreover, we found that the pharmacological activation of the pathway has long-term effect on the cocaine-induced neuroplasticity at behavioral and molecular levels.

  3. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation

    Benjamin D Rowlands, Matthias Klugmann and Caroline D Rae

    Accepted manuscript online: 7 DEC 2016 07:41AM EST | DOI: 10.1111/jnc.13916

  4. Dopamine dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons

    Yan Li, Xin Chen, Rhonda Dzakpasu and Katherine Conant

    Accepted manuscript online: 7 DEC 2016 07:38AM EST | DOI: 10.1111/jnc.13915

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    Vascular inter-regulation of inflammation: molecular and cellular targets for CNS therapy

    Marta Machado-Pereira, Tiago Santos, Liliana Bernardino and Raquel Ferreira

    Accepted manuscript online: 7 DEC 2016 07:38AM EST | DOI: 10.1111/jnc.13914