Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 4.244
ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- You have full text access to this OnlineOpen articleEpidermal fatty acid-binding protein protects nerve growth factor-differentiated PC12 cells from lipotoxic injury
Jo-Wen Liu, Manuel Montero, Liming Bu and Marino De Leon
Article first published online: 19 SEP 2014 | DOI: 10.1111/jnc.12934
Epidermal fatty acid-binding protein (E-FABP) may protect nerve cells from the damaging exposure to high levels of free fatty acids (FA). We show that E-FABP can neutralize the effects of reactive oxygen species (ROS) generated by the high levels of FA in the cell and protect PC12 cells from lipotoxic injuries common in Type 2 diabetes neuropathy. Potentially, E-FABP gene up-regulation may be mediated through the NFkB pathway and future studies are needed to further evaluate this proposition.
- Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS
Biljana Georgievska, Susanne Gustavsson, Johan Lundkvist, Jan Neelissen, Susanna Eketjäll, Veronica Ramberg, Tjerk Bueters, Karin Agerman, Anders Juréus, Samuel Svensson, Stefan Berg, Johanna Fälting and Urban Lendahl
Article first published online: 18 SEP 2014 | DOI: 10.1111/jnc.12937
Aggregation of amyloid beta (Aβ) peptides in the brain is a central aspect of Alzheimer's disease. In this study, we demonstrate that inhibition of Aβ formation by BACE1 inhibitors needs to be carried out in the brain and that reduction of Aβ in the periphery is not sufficient to reduce brain Aβ levels. This information is useful for developing future Aβ-targeting therapies for Alzheimer's disease.
- HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism
Kelly A. Krogh, Elizabeth Lyddon and Stanley A. Thayer
Article first published online: 18 SEP 2014 | DOI: 10.1111/jnc.12936
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV-infected patients. HIV-infected cells within the CNS release neurotoxic viral proteins such as the transactivator of transcription (Tat). (a) Stylized traces (red lines) depict time-dependent, biphasic changes in NMDA-evoked increases in [Ca2+]i following exposure to HIV-1 Tat for the time indicated above the trace. Initially, Tat potentiates NMDA-evoked responses. Subsequently, NMDARs adapt following activation of a previously reported signaling pathway (Krogh et al. 2014). (b) Tat interacts with LRP leading to Src-dependent potentiation of the NMDAR and activation of the NOS/sGC/PKG signaling pathway. PKG activates a RhoA/ROCK signaling pathway leading to remodeling of the actin cytoskeleton and subsequent reduction of NMDAR function.
- HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line
Vaishnavi Sunil Jadhav, Karl-Heinz Krause and Sunit K. Singh
Article first published online: 18 SEP 2014 | DOI: 10.1111/jnc.12933
Activated microglial cells mediated neuroinflammatory events are observed in HIV-associated neurological disorders. The reduction in miR-17 levels was observed in microglial cells exposed to HIV-1 Tat C protein. miR-17 regulated the expression of NOX2 and NOX4, which in turn regulated the reactive oxygen species (ROS) production in microglial cells. Increased ROS production led to the activation of microglial cells and increased cytokine production. This study thus demonstrated a novel miR-17-mediated regulatory pathway of ROS production in microglial cells. HMC3 = human microglia clone 3 cell lines.
- The Ratio of Acetate-to-Glucose Oxidation in Astrocytes from a Single 13C NMR Spectrum of Cerebral Cortex
Isaac Marin-Valencia, Ali M Hooshyar, Kumar Pichumani, Dean A Sherry and Craig R. Malloy
Accepted manuscript online: 17 SEP 2014 08:55AM EST | DOI: 10.1111/jnc.12948