Journal of Neurochemistry

Cover image for Vol. 130 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity

    Kirstie H. Stansfield, Terry Jo Bichell, Aaron B. Bowman and Tomás R. Guilarte

    Article first published online: 2 SEP 2014 | DOI: 10.1111/jnc.12926

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    In this study, we provide evidence that brain-derived neurotrophic factor (BDNF) concentrations are decreased in the striatum of manganese-exposed mice and non-human primates with implications to medium spiny neuron (MSN) pathology. Manganese (Mn) effects on huntingtin protein levels and phosphorylation at serine 421 may be associated with impaired cortical–striatal BDNF transport and reduced BDNF concentrations in the striatum. These findings suggest a mechanism by which exposure to excess manganese alters MSN morphology and influences basal ganglia function. Htt = Huntingtin protein.

  2. Continuous Infusion of Substance P into Rat Striatum Alleviates Nociceptive Behavior via Phosphorylation of Extracellular-Signal Regulated Kinase ½

    Yoki Nakamura, Hiroki Izumi, Ryo Fukushige, Takumi Shimizu, Kyohei Watanabe, Norimitsu Morioka, Aldric Hama, Hiroyuki Takamatsu and Yoshihiro Nakata

    Accepted manuscript online: 30 AUG 2014 03:33AM EST | DOI: 10.1111/jnc.12938

  3. Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stress-triggered changes in several brain regions

    Lidia I. Serova, Marcela Laukova, Lishay G. Alaluf and Esther L. Sabban

    Article first published online: 30 AUG 2014 | DOI: 10.1111/jnc.12847

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    Blockade of brain melanocortine receptor 4 (MC4R) with intranasal infusion of the MC4R antagonist HS014 to rats prior to single prolonged stress (SPS) leads to faster termination of stress responses (30 min later) and prevents or attenuates SPS-triggered abnormal gene expression related to post-traumatic stress disorder (7 days later). Targeting of brain MC4R is a promising strategy to protect HPA axis, LC-NE (locus coeruleus-norepinephrine) systems and hippocampus from overstimulation.

  4. Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex

    Christof Hiebel, Tanja Kromm, Marcel Stark and Christian Behl

    Article first published online: 26 AUG 2014 | DOI: 10.1111/jnc.12839

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    Regulation of the autophagic flux in certain physiological situations such as an imbalance of nutrient supply as well as in pathological stages is of major importance for neuronal and non-neuronal cells. CB1 (Cannabinoid receptor 1) affects the metabolism of cells directly. In this study, we provide evidence that CB1 signaling has a direct influence on autophagy which might help the cell to find the right adjustment to different metabolic states and CB1 activity exerts its modulatory action independent of the canonical mTOR- and BECLIN1-complexes regulating autophagy.

  5. Addition of docosahexaenoic acid, but not arachidonic acid, activates glutathione and thioredoxin antioxidant systems in murine hippocampal HT22 cells: potential implications in neuroprotection

    Verónica Casañas-Sánchez, José A. Pérez, Noemí Fabelo, Antonio V. Herrera-Herrera, Cecilia Fernández, Raquel Marín, María C. González-Montelongo and Mario Díaz

    Article first published online: 26 AUG 2014 | DOI: 10.1111/jnc.12833

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    DHA improves the antioxidant capacity of cultured hippocampal HT22 cells. We propose that DHA supplementation induces the remodelling of membrane phospholipids, and also triggers a transcriptional program to increase the expression of members of the glutathione and thioredoxin systems. We postulate that this transcriptional effect is mediated by a signal arising from non-enzymatic oxidation of DHA.