Journal of Neurochemistry

Cover image for Vol. 134 Issue 4

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses

    Roberta De Simone, Maria Antonietta Ajmone-Cat, Manuela Pandolfi, Antonietta Bernardo, Chiara De Nuccio, Luisa Minghetti and Sergio Visentin

    Article first published online: 3 AUG 2015 | DOI: 10.1111/jnc.13244

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    We show that the mitochondrial uncoupling protein-2 (UCP2) is central to the process of microglial activation, with opposite regulation of M1 and M2 responses. In UCP2-silenced microglia, lipopolysaccharide (LPS) triggers an enhanced inflammatory response characterized by a greater expression of M1 genes, whereas interleukin-4 (IL-4) fails in inducing M2 genes and reducing M1 genes. We propose UCP2 manipulation as a potential strategy for redirecting microglial response towards protective phenotypes.

  2. Pinnatoxins E, F and G target multiple nicotinic receptor subtypes

    Shane D. Hellyer, Dinesh Indurthi, Thomas Balle, Vanda Runder-Varga, Andrew I. Selwood, Joel D.A. Tyndall, Mary Chebib, Lesley Rhodes and D. Steven Kerr

    Article first published online: 3 AUG 2015 | DOI: 10.1111/jnc.13245

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    We used a three-pronged approach of radioligand binding, electrophysiological recording and molecular modelling to determine the nicotinic antagonist properties of the marine algal pinnatoxins E, F and G. These high-affinity toxins bind to and antagonize muscle nicotinic receptors, as well as homomeric and heteromeric neuronal nicotinic receptors, and show a preference for homomeric neuronal and muscle-type receptors over heteromeric neuronal receptors. Modelling of pinnatoxin/receptor interactions revealed potential determinants for binding to each of the receptor subtypes. This high-affinity nicotinic binding presumably underlies the neuromuscular and CNS symptoms associated with pinnatoxin intoxication.

  3. Headless Myo10 is a regulator of microtubule stability during neuronal development

    Huali Yu, Dong Sun, Nannan Wang, Min Wang, Yongsheng Lan, Wenqiang Fan, Yang Zhao, Weixiang Guo and Xiaojuan Zhu

    Article first published online: 3 AUG 2015 | DOI: 10.1111/jnc.13238

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    In this study, we demonstrate that headless myosin X (hMyo10) is involved in microtubule stability regulation, which is important for neuronal morphogenesis and migration. In vitro studies reveal that hMyo10 regulates Tau-1 positive axon formation through stabilizing microtubules. Furthermore, in vivo studies reveal that hMyo10-mediated microtubule stability has a profound effect on radial cortical neuronal migration and apical dendritic arborization.

  4. Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study

    Carlo Cervellati, Alessandro Trentini, Arianna Romani, Tiziana Bellini, Cristina Bosi, Beatrice Ortolani, Amedeo Zurlo, Angelina Passaro, Davide Seripa and Giovanni Zuliani

    Article first published online: 3 AUG 2015 | DOI: 10.1111/jnc.13240

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    Our study showed that in patients with mild cognitive impairment (MCI) low serum levels of paraoxonase-1 (PON-1) activity is associated with a higher likelihood of developing Vascular Dementia, but not Alzheimer's Disease. The observed connection might be explained by the ability of PON-1 to retard low-density lipoprotein (LDL) oxidation, decrease oxidative stress, attenuate inflammation, and increase cholesterol efflux.

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    The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease

    Yan Xu, Yulin Deng and Hong Qing

    Article first published online: 3 AUG 2015 | DOI: 10.1111/jnc.13234

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    The milestone study on the phosphorylation of α-synuclein mainly at Ser129, Ser87, and Tyr125 relating to PD in recent years as well as some clinical application exploration are overviewed. The potential pathways of the phosphorylated α-synuclein related to PD are also summarized. The review may supply more ideas and thinking on this issue for the scientists in related research field.