Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 4.061
ISI Journal Citation Reports © Ranking: 2011: 59/244 (Neurosciences); 77/290 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
Recently Published Articles
- The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain
Daigo Homma, Setsuko Katoh, Hirofumi Tokuoka and Hiroshi Ichinose
Article first published online: 22 MAY 2013 | DOI: 10.1111/jnc.12287
Tetrahydrobiopterin (BH4) is an essential cofactor of tyrosine hydroxylase (TH). We found that BH4 and dopa administration in infancy restored the loss of TH protein caused by BH4 deficiency and that the effects of these treatments are attenuated in young adulthood. These findings indicate that the post-natal augmentation of TH protein requires catecholamines and suggest that there is a critical period for the dopaminergic development.
- You have free access to this contentDevelopmental vulnerability of synapses and circuits associated with neuropsychiatric disorders
Peter Penzes, Andres Buonanno, Maria Passafaro, Carlo Sala and Robert A. Sweet
Article first published online: 22 MAY 2013 | DOI: 10.1111/jnc.12261
- Involvement of α2-antiplasmin in dendritic growth of hippocampal neurons
Eri Kawashita, Yosuke Kanno, Haruka Asayama, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo and Hiroyuki Matsuno
Article first published online: 22 MAY 2013 | DOI: 10.1111/jnc.12281
The α2-Antiplasmin (α2AP) protein regulates cellular functions independently or dependently of plasmin, and is highly expressed in the hippocampus. However, the role of α2AP was unclear. Here, we first report that α2AP induces dendritic growth in hippocampal neurons through p38 MAPK activation, independent of plasmin, providing new insights into the role of α2AP in the CNS.
- Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β
Urte Neniskyte and Guy C. Brown
Article first published online: 22 MAY 2013 | DOI: 10.1111/jnc.12288
We report here that nanomolar Aβ can induce neuronal loss in culture by activating microglia to release MFG-E8 (Milk-fat globule-EGF factor 8 protein), which binds and opsonizes neurons for phagocytosis by microglia, thereby killing the neurons by phagoptosis. The essential role of MFG-E8 in Aβ-induced phagoptosis, suggests this bridging protein as a potential therapeutic target for Alzheimer's and other neurological diseases involving inflammatory neuronal loss.
- The mood stabilizer valproate activates human FGF1 gene promoter through inhibiting HDAC and GSK-3 activities
Chien-Yu Kao, Yi-Chao Hsu, Jen-Wei Liu, Don-Ching Lee, Yu-Fen Chung and Ing-Ming Chiu
Article first published online: 21 MAY 2013 | DOI: 10.1111/jnc.12292
We show that the mood-stabilizing drugs, valproic acid (VPA) and Li+, could up-regulate FGF-1B promoter through inhibition of HDACs and GSK-3. We further demonstrate that treatment of VPA increases histone acetylation around the regulatory region (18-bp cis-element) of FGF-1B promoter. Importantly, VPA could induce more neuronal differentiation in FGF-1B positive neural stem/progenitor cells than FGF-1B negative cells.