Journal of Neurochemistry

Cover image for Vol. 140 Issue 3

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells

    Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki and Tetsuya Terasaki

    Accepted manuscript online: 23 JAN 2017 06:51AM EST | DOI: 10.1111/jnc.13960

  2. Psoriasin has divergent effects on the innate immune responses of murine glial cells

    Sandra Jansen, Eugenia Kress, Athanassios Fragoulis, Christoph J. Wruck, Ronald Wolf, Joachim Grötzinger, Matthias Michalek, Thomas Pufe, Simone C. Tauber and Lars-Ove Brandenburg

    Accepted manuscript online: 23 JAN 2017 06:51AM EST | DOI: 10.1111/jnc.13959

  3. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation

    Yue Zhang, Gina Hong, Kin Sing Stephen Lee, Bruce D. Hammock, Debebe Gebremedhin, David R. Harder, Raymond C. Koehler and Adam Sapirstein

    Version of Record online: 23 JAN 2017 | DOI: 10.1111/jnc.13933

    Thumbnail image of graphical abstract

    Inhibition of soluble epoxide hydrolase after oxygen-glucose deprivation in astrocytes stabilizes epoxyeicosatrienoic acids, which then augment the release of VEGF. Exposure of neurons to oxygen-glucose deprivation followed by the conditioned astrocyte medium increases neuronal phosphorylated Akt through VEGF receptor-2 signaling and leads to increased neuronal survival, thereby providing evidence of one way by which astrocytes can be leveraged for neuroprotection.

  4. Elevated intracellular Na+ concentrations in developing spinal neurons

    Casie Lindsly, Carlos Gonzalez-Islas and Peter Wenner

    Version of Record online: 23 JAN 2017 | DOI: 10.1111/jnc.13936

    Thumbnail image of graphical abstract

    Intracellular sodium and chloride levels are low in mature neurons. While chloride levels are believed to be much higher in developing neurons, it is assumed that sodium levels are low early in development. We find that sodium levels are relatively high in embryonic spinal neurons. Furthermore, we find that later in embryonic development sodium levels are reduced through the functional down-regulation of the NKCC1 transporter, and alteration of another unknown transporter (Na/K-ATPase and/or Transporter X). These results are important because the sodium gradient influences driving force for many ion transporters and will influence neuronal excitability.

  5. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation

    Benjamin D. Rowlands, Matthias Klugmann and Caroline D. Rae

    Version of Record online: 23 JAN 2017 | DOI: 10.1111/jnc.13916

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    Acetate is a poor substrate for energy generation and it also, at high concentrations (> 2 mmol/L), inhibits metabolism of glucose and of itself. Potassium depolarisation results in decreased use of acetate and decreased incorporation of acetate into glutamine showing that acetate metabolism does not necessarily reflect astrocytic activity. GABA is not only made via astrocytic glutamine, but acetate is converted as well directly to GABA in neurons. Acetate metabolism is likely regulated via acetylation of the metabolizing enzyme acetyl-CoA synthetase. Changes in acetate metabolism should be interpreted as modulation of metabolism through changes in cellular energetic status via altered enzyme acetylation levels rather than simply as a glial–neuronal adjustment of metabolic activity.