Journal of Neurochemistry

Cover image for Vol. 141 Issue 1

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of Ih currents

    Weipang Chang, Hirosato Kanda, Ryo Ikeda, Jennifer Ling and Jianguo G. Gu

    Version of Record online: 27 MAR 2017 | DOI: 10.1111/jnc.14009

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    This study shows (i) tactile sensitivity of Merkel discs can be modulated by exogenously applied serotonin, and (ii) the modulation may be partially because of 5-HT2 receptor-mediated potentiation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity at the Aβ-afferent endings of whisker afferent fibers. These findings support the excitatory role of metabotropic 5-HT receptors in modulating the tactile sensitivity of Merkel discs.

  2. You have free access to this content
    Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex

    Makoto Tsuda, Kohei Koga, Tao Chen and Min Zhuo

    Version of Record online: 27 MAR 2017 | DOI: 10.1111/jnc.14001

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    Neuropathic pain is a debilitating chronic pain condition occurring after nerve damage. Nerve injury-induced neuronal hyperexcitability in the spinal dorsal horn (SDH) involves signals from microglia. In the anterior cingulate cortex (ACC), nerve injury produces pre- and postsynaptic long-term plasticity, which contributes to negative emotions and anxiety. As there are direct and indirect connections between these two regions, we think that understanding the link between the SDH and ACC may provide us with insights into the mechanisms for amplifying pain signals under chronic pain conditions.

  3. Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility

    Holly C. Hunsberger, Gregory W. Konat and Miranda N. Reed

    Version of Record online: 27 MAR 2017 | DOI: 10.1111/jnc.13999

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    Intraperitoneal injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC), results in a robust elevation of extracellular (tonic) glutamate in the hippocampus. Here, we showed that tonic glutamate levels positively correlate with the susceptibility to kainic acid (KA)-induced seizures. The elevation of tonic glutamate by PIC challenge likely results from the hyperexcitability of hippocampal neurons. In addition, tonic glutamate level might be increased directly by inflammatory milieu in the hippocampal parenchyma. Tonic glutamate enhances and/or sustains neuronal excitability likely through extrasynaptic receptors. We posit that both, neuronal hyperexcitability and elevated tonic glutamate contribute to the exacerbation of seizure susceptibility.

  4. A decrease in eukaryotic elongation factor 2 phosphorylation is required for local translation of sensorin and long-term facilitation in Aplysia

    Patrick K. McCamphill, Larissa Ferguson and Wayne S. Sossin

    Accepted manuscript online: 27 MAR 2017 02:56AM EST | DOI: 10.1111/jnc.14030

  5. RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Müller glia cells

    Yuki Inoue, Masamitsu Shimazawa, Yasuhiro Noda, Ryota Nagano, Tomohiro Otsuka, Yoshiki Kuse, Yukimichi Nakano, Kazuhiro Tsuruma, Yasuhiro Nakagami and Hideaki Hara

    Accepted manuscript online: 27 MAR 2017 02:56AM EST | DOI: 10.1111/jnc.14029