Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Analysis of the amyloid precursor protein role in neuritogenesis reveals a biphasic SH-SY5Y neuronal cell differentiation model

    Joana Fernandes da Rocha, Odete A. B. da Cruz e Silva and Sandra Isabel Vieira

    Article first published online: 21 MAY 2015 | DOI: 10.1111/jnc.13133

    Thumbnail image of graphical abstract

    We show that SH-SY5Y cells differentiation (‘Diff.’) induced by 10 µM retinoic acid (RA) is biphasic, and describe the behaviour of the Alzheimer's amyloid precursor protein APP and its secreted sAPP fragment in this model. This includes a unique sAPP/APP peak in the first phase, and a plateau for holoAPP in the second phase, both related to APP neuritogenic functions.

  2. Akt1 phosphorylates Nicastrin to regulate its protein stability and activity

    Eun-Hye Jo, Ji-Seon Ahn, Jung-Soon Mo, Ji-Hye Yoon, Eun-Jung Ann, Hyeong-Jin Baek, Hye-Jin Lee, Seol-Hee Kim, Mi-Yeon Kim and Hee-Sae Park

    Accepted manuscript online: 21 MAY 2015 08:21AM EST | DOI: 10.1111/jnc.13173

  3. Sulforaphane enhances temozolomide-induced apoptosis due to downregulation of miR-21 via Wnt/β-catenin signaling in glioblastoma

    FengMing Lan, Qiang Pan, Huiming Yu and Xiao Yue

    Accepted manuscript online: 20 MAY 2015 01:58AM EST | DOI: 10.1111/jnc.13174

  4. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells

    Ya Feng, Te Liu, Su-Yan Dong, Yan-Jie Guo, Joseph Jankovic, Huaxi Xu and Yun-Cheng Wu

    Accepted manuscript online: 20 MAY 2015 01:27AM EST | DOI: 10.1111/jnc.13172

  5. NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits

    Ciaran Lane, Jiansong Qi and James P. Fawcett

    Article first published online: 19 MAY 2015 | DOI: 10.1111/jnc.13137

    Thumbnail image of graphical abstract

    Reduction in NCK proteins in the developing CNS leads to a reduction in TAG1+ve commissural tract thickness, a reduction in growth cone complexity of DCC+ve spinal interneurons, and a reduction in DCC mRNA. These are consistent with an in vivo role for NCK in the development of critical DCC spinal circuits, and may be important for the normal development of spinal circuits critical for walking.

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