Journal of Neurochemistry

Cover image for Vol. 134 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5

    Chunxiao Liu, Ruijie Zhang, Chenxia Sun, Hai Zhang, Chong Xu, Wen Liu, Wei Gao, Shile Huang and Long Chen

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13233

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    Resveratrol, a natural polyphenol compound, has been found to exert neuroprotective effects. This study uncovers that resveratrol prevents cadmium (Cd)-induced activation of Erk1/2 and JNK pathways and neuronal cell death via activating PP2A and PP5. The findings propose that resveratrol may serve as a potential therapeutic agent in the prevention of Cd-induced neurodegenerative diseases.

  2. Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats

    Hui Shu, Guo-qing Zheng, Xiaona Wang, Yanyun Sun, Yushan Liu, John Michael Weaver, Xianzhi Shen, Wenlan Liu and Xinchun Jin

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13283

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    Our study showed the brain region and mechanism underlying nicotine-induced spatial working memory improvement. In response to nicotine treatment, VTA-hippocampus circuit is activated and MMP-9 activation in dorsal hippocampus mediates the memory improvement. Our data suggest nicotine increases spatial working memory by activating MMP-9 in dorsal hippocampus. Nicotine improves spatial working memory by enhancing an ability to use Win-shift strategy and increasing correct choice. This effect is mediated by the VTA-hippocampus circuit and MMP-9 in dHPC is activated with intra-VTA nicotine infusion in rats.

  3. Locus Coeruleus Response to Single Prolonged Stress and Early Intervention with Intranasal Neuropeptide Y

    Esther L. Sabban, Marcela Laukova, Lishay G. Alaluf, Emelie Olsson and Lidia I. Serova

    Accepted manuscript online: 2 SEP 2015 04:16AM EST | DOI: 10.1111/jnc.13347

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    The pathogenic role of the inflammasome in neurodegenerative diseases

    Leslie C. Freeman and Jenny P.-Y. Ting

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13217

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    We here review the role of the inflammasome in the pathogenesis of traumatic brain injury (TBI). TBI is initiated by physical force exerted to head, resulting in neuronal injury and death. Primary insult is followed by a secondary cascade of events following neuroinflammation such as mitochondrial dysfunction, production of reactive oxygen species, potassium effluxes, and release of circulating DNA. These events can potentially trigger the activation of NLRP3, NLRP1, and AIM2 during TBI but have yet to be confirmed (dashed lines). NLRP3, NLRP1, and AIM2 associate with the adaptor protein ASC, which initiates the cleavage of pro-caspase-1 to the mature form of caspase-1 which cleaves pro-IL-1β and pro-IL-18 into their mature forms of IL-1β and IL-18.

  5. Impact of cerebrospinal fluid matrix on the detection of Alzheimer's disease with Aβ42 and influence of disease on the total-Aβ42/Aβ40 ratio

    J. Randall Slemmon, Alice Shapiro, Marc Mercken, Johannes Streffer, Gary Romano, Niels Andreasen, Henrik Zetterberg and Kaj Blennow

    Accepted manuscript online: 1 SEP 2015 01:48PM EST | DOI: 10.1111/jnc.13297