Journal of Neurochemistry

Cover image for Vol. 132 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb

    Tyler S. Crum, Amanda M. Gleixner, Jessica M. Posimo, Daniel M. Mason, Matthew T. Broeren, Scott D. Heinemann, Peter Wipf, Jeffrey L. Brodsky and Rehana K. Leak

    Article first published online: 5 MAR 2015 | DOI: 10.1111/jnc.13041

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    The olfactory bulb is affected in the early phases of many age-related neurodegenerative disorders. Here, we described the impact of aging on multiple heat shock proteins (Hsps), such as Hsp70, in the female rat olfactory bulb in vivo. Using multiple proteasome and Hsp70 inhibitors (see schematic), we found that proteotoxicity elicited a compensatory increase in Hsp70 in primary olfactory bulb cells in vitro. Hsp70 then reduced the proteotoxic buildup of ubiquitinated proteins and robustly protected against cell death according to three independent viability assays. Thus, olfactory bulb neurons can mount impressive natural adaptations to proteotoxic injury, perhaps explaining why neurodegenerative disorders are so delayed in onset and so slow to progress.

  2. Corticosterone Primes the Neuroinflammatory Response to DFP in Mice:Potential Animal Model of Gulf War Illness

    James P. O'Callaghan, Kimberly A. Kelly, Alicia R. Locker, Diane B. Miller and Steve M. Lasley

    Accepted manuscript online: 5 MAR 2015 08:17AM EST | DOI: 10.1111/jnc.13088

  3. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion

    Zhenhua Xu, Hongkwan Cho, Matthew J. Hartsock, Katherine L. Mitchell, Junsong Gong, Lijuan Wu, Yanhong Wei, Shuang Wang, Rajesh K. Thimmulappa, Michael B. Sporn, Shyam Biswal, Derek S. Welsbie and Elia J. Duh

    Article first published online: 4 MAR 2015 | DOI: 10.1111/jnc.13064

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    Oxidative stress is thought to be an important mediator of retinal ganglion cell death in ischemia-reperfusion injury. We found that the transcription factor NF-E2-related factor 2 (Nrf2), a major regulator of oxidative stress, is an important endogenous neuroprotective molecule in retinal ganglion cells in ischemia-reperfusion, exerting a cell-autonomous protective effect.  The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) reduces neurodegeneration following ischemia-reperfusion in an Nrf2-dependent fashion. This suggests that Nrf2-activating drugs including triterpenoids could be a therapeutic strategy for retinal neuroprotection.

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    Effect of α-synuclein on membrane permeability and synaptic transmission: a clue to neurodegeneration?

    Alexei Surguchev and Andrei Surguchov

    Article first published online: 4 MAR 2015 | DOI: 10.1111/jnc.13045

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    This is an Editorial highlighting the article “Extracellular α-synuclein alters synaptic transmission in rain neurons by perforating the neuronal plasma membrane” by Pacheco and coauthors, in this issue of Journal of Neurochemistry. The authors demonstrate, using a variety of techniques, that alpha-synuclein possesses neurotoxicity toward brain neuronal plasma membranes exposed directly to extracellular alpha-synuclein oligomers. Extracellular oligomeric α-synuclein rapidly associates to hippocampal membranes and induces pore formation in the hippocampal cells. This increases membrane conductance and calcium influx. Oligomeric α-synuclein also induces changes in synaptic current activity in hippocampal neurons. The authors’ findings support the pathogenic role of extracellular alpha-synuclein in the brain, and should provide a new strategy for the treatment of Parkinson's disease and other synucleinopathies, neurodegenerative diseases with aberrant accumulation of aggregated alpha-synuclein in neurons, nerve fibers or glial cells.

    Read the full article‘Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma’ on membrane doi: 10.1111/jnc.13060