Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 3.842
ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- You have full text access to this OnlineOpen articleThe therapeutic potential of targeting chemokine signalling in the treatment of chronic pain
Karli Montague and Marzia Malcangio
Version of Record online: 24 FEB 2017 | DOI: 10.1111/jnc.13927
Chronic pain is poorly treated at present thus alternative therapies are essential. The critical role of chemokine-mediated communication between non-neuronal cells and neurons in the CNS and PNS in chronic pain has recently been appreciated. Here we discuss the therapeutic potential of targeting this chemokine-mediated communication, which is currently emerging as a promising strategy to treat chronic pain in patients.
- Involvement of chemokine CXCL11 in the development of morphine tolerance in rats with cancer-induced bone pain
Genhua Guo, Yawen Peng, Bingrui Xiong, Daiqiang Liu, Huilian Bu, Xuebi Tian, Hui Yang, Zhen Wu, Fei Cao and Feng Gao
Version of Record online: 24 FEB 2017 | DOI: 10.1111/jnc.13919
Chronic treatment with morphine induces the development of morphine antinociceptive tolerance. In this study, we provide novel evidence that spinal CXCL11, which could be released by both astrocytes and neurons, contributes to the development of morphine tolerance. This finding has significant therapeutic implications in prophylactically inhibiting morphine tolerance.
- You have free access to this contentNociception modulation by supraspinal group III metabotropic glutamate receptors
Enza Palazzo, Ida Marabese, Livio Luongo, Francesca Guida, Vito de Novellis and Sabatino Maione
Version of Record online: 22 FEB 2017 | DOI: 10.1111/jnc.13725
The modulatory actions of glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), are exerted through the activation of metabotropic glutamate receptors (mGluRs). Novel ligands that are selective for group III mGluR subtypes have recently been developed. These compounds, which mainly target allosteric sites and act as positive or negative allosteric modulators (PAMs or NAMs) of glutamate transmission, contribute to the understanding of the functional roles of group III mGluRs in a number of pathological conditions, such as epilepsy, anxiety, neurodegenerative diseases, and chronic pain. This review summarizes recent studies on group III mGluRs in animal models of chronic pain which evidenced an opposite modulation of mGluR7 and mGluR8 on pain responses and their capability to affect pain responses only in pathological states.
- Effects of cold temperatures on the excitability of rat trigeminal ganglion neurons that are not for cold sensing
Hirosato Kanda and Jianguo G. Gu
Version of Record online: 22 FEB 2017 | DOI: 10.1111/jnc.13511
It is generally thought that cold temperatures suppress the excitability of primary afferent neurons that are not for the perception of cold. Here, we show that cooling temperatures increase excitability of many nociceptive-like trigeminal ganglion neurons that are not for the perception of cold. We demonstrate that inhibition of M-currents and increase in membrane input resistance by cooling temperatures are two mechanisms by which cooling temperatures enhance the excitability of these sensory neurons.