Journal of Neurochemistry

Cover image for Vol. 139 Issue 5

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. An Isogenic Blood-Brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes and Neurons Derived from Human Induced Pluripotent Stem Cells

    Scott G. Canfield, Matthew J. Stebbins, Bethsymarie Soto Morales, Shusaku W. Asai, Gad D. Vatine, Clive N. Svendsen, Sean P. Palecek and Eric V. Shusta

    Accepted manuscript online: 9 DEC 2016 07:01AM EST | DOI: 10.1111/jnc.13923

  2. Network-based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation

    Patrick Kia Ming Lee, Wilson Wen Bin Goh and Judy Chia Ghee Sng

    Accepted manuscript online: 9 DEC 2016 06:56AM EST | DOI: 10.1111/jnc.13921

  3. Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells

    Arik J. Hone, J. Michael McIntosh, Lola Rueda-Ruzafa, Juan Passas, Cristina de Castro-Guerín, Jesús Blázquez, Carmen González-Enguita and Almudena Albillos

    Version of Record online: 9 DEC 2016 | DOI: 10.1111/jnc.13883

    Thumbnail image of graphical abstract

    Varenicline is a nicotinic receptor agonist used to treat nicotine addiction. We assessed nicotine and varenicline's effects on cell excitability via endogenously expressed α3β4 nicotinic receptors in human adrenal chromaffin cells. Therapeutic concentrations of nicotine or varenicline failed to evoke action potentials. However, simultaneous exposure to nicotine in the presence of varenicline evoked robust action potential firing. We propose that the use of varenicline and nicotine concomitantly may contribute to some of the side effects associated with varenicline therapy.

  4. Involvement of chemokine CXCL11 in the development of morphine tolerance in rats with cancer-induced bone pain

    Genhua Guo, Yawen Peng, Bingrui Xiong, Daiqiang Liu, Huilian Bu, Xuebi Tian, Hui Yang, Zhen Wu, Fei Cao and Feng Gao

    Accepted manuscript online: 7 DEC 2016 05:10PM EST | DOI: 10.1111/jnc.13919

  5. Role and regulation of p27 in neuronal apoptosis

    Surbhi Jaiswal and Pushkar Sharma

    Accepted manuscript online: 7 DEC 2016 05:10PM EST | DOI: 10.1111/jnc.13918