Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

    Ryoichi Takahashi, Kenjiro Ono, Yusaku Takamura, Mineyuki Mizuguchi, Tokuhei Ikeda, Hisao Nishijo and Masahito Yamada

    Accepted manuscript online: 27 MAY 2015 07:14AM EST | DOI: 10.1111/jnc.13180

  2. The mechanistic target of rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons

    Somhrita Dutta, Ibolya Rutkai, Prasad V. G. Katakam and David W. Busija

    Accepted manuscript online: 27 MAY 2015 07:07AM EST | DOI: 10.1111/jnc.13181

  3. Inhibition of microglial activation contributes to propofol-induced protection against post-cardiac arrest brain injury in rats

    Wei Wang, Rui Lu, Da-yun Feng, Li-rong Liang, Bing Liu and Hui Zhang

    Accepted manuscript online: 27 MAY 2015 07:04AM EST | DOI: 10.1111/jnc.13179

  4. Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner

    Lik-Wei Wong, Han-Shen Tae and Brett A. Cromer

    Accepted manuscript online: 27 MAY 2015 06:53AM EST | DOI: 10.1111/jnc.13175

  5. Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway

    Jian Xu, Pradeep Kurup, Ethan Foscue and Paul J. Lombroso

    Article first published online: 25 MAY 2015 | DOI: 10.1111/jnc.13160

    Thumbnail image of graphical abstract

    STEP61, PTPα, Fyn, and NMDA receptor (NMDAR) have been implicated in ethanol intake behaviors in the dorsomedial striatum (DMS) in rodents. Here, we report that PTPα is a novel substrate for STEP61. Upon ethanol exposure, STEP61 is phosphorylated and inactivated by protein kinase A (PKA) signaling in the DMS. As a result of STEP61 inhibition, there is an increase in the phosphorylation of PTPα, which translocates to lipid rafts and activates Fyn and subsequent NMDAR signaling. The results demonstrate a synergistic regulation of Fyn-NMDAR signaling by STEP61 and PTPα, which may contribute to the regulation of ethanol-related behaviors. NMDA, N-methyl-d-aspartate; PTPα, receptor-type protein tyrosine phosphatase alpha; STEP, STriatal-Enriched protein tyrosine Phosphatase.

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