Journal of Neurochemistry

Cover image for Vol. 130 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

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  2. Characterization of [3H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand

    Claudia Rangel-Barajas, Maninder Malik, Michelle Taylor, Kim A. Neve, Robert H. Mach and Robert R. Luedtke

    Article first published online: 19 AUG 2014 | DOI: 10.1111/jnc.12825

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    Based upon the results from direct and competitive radioligand binding studies using stably transfected HEK293 cells and rat brain (caudate and nucleus accumbens) tissue, the novel tritium-labeled arylamide phenylpiperazine [3H]LS-3-134 appears to be a high affinity (human Kd = 0.06 ± 0.01 nM and rat Kd = 0.2 ± 0.02 nM) D3 versus D2 dopamine receptor selective (> 100-fold) radioligand that can be used to quantitate the expression and regulation of the D3 dopamine receptor subtype.

  3. Stimulatory role of the chemokine CCL2 in the migration and peptide expression of embryonic hypothalamic neurons

    Kinning Poon, Hui T. Ho, Jessica R. Barson and Sarah F. Leibowitz

    Article first published online: 16 AUG 2014 | DOI: 10.1111/jnc.12827

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    Our results demonstrate that the chemokine, CCL2, functions through its receptor, CCR2, to stimulate the migration and expression of the orexigenic peptides, enkephalin (ENK) and galanin (GAL), in developing embryonic hypothalamic neurons that are important for controlling ingestive behavior. This evidence reveals broad effects of CCL2 in the developing hypothalamus, showing this chemokine system to be tightly linked to the hypothalamic peptide neurons.

  4. Hydrogen Sulfide is Essential for Schwann Cell Responses to Peripheral Nerve Injury

    Byung Sun Park, Hyun-Wook Kim, Im Joo Rhyu, Chan Park, Seung Geun Yeo, Youngbuhm Huh, Na Young Jeong and Junyang Jung

    Accepted manuscript online: 14 AUG 2014 06:20AM EST | DOI: 10.1111/jnc.12932

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    The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function

    Philip W. Beesley, Rodrigo Herrera-Molina, Karl-Heinz Smalla and Constanze Seidenbecher

    Article first published online: 14 AUG 2014 | DOI: 10.1111/jnc.12816

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    Neuroplastins are neuronal cell adhesion molecules, which induce neurite outgrowth and play important roles in synaptic maturation and plasticity. This review summarizes the functional implications of Neuroplastins for correct synaptic membrane protein localization, neuronal energy supply, expression of LTP and LTD, animal and human behaviour, and pathophysiology and disease. It focuses particularly on Neuroplastin binding partners and signalling mechanisms, and proposes perspectives for future research on these important immunoglobulin superfamily members.