Journal of Neurochemistry

Cover image for Vol. 133 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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    Thumbnail image of graphical abstract

    By monitoring endocytosis with whole-cell membrane capacitance measurement, this study demonstrated that acute disruption of cholesterol with cholesterol oxidase or methyl-β-cyclodextrin impaired slow clathrin-mediated endocytosis, rapid endocytosis, and endocytosis of pre-existing retrievable membrane at a large mammalian nerve terminal, the calyx of Held. This data suggest a universal cholesterol requirement in distinct pathways of synaptic vesicle endocytosis.

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    Accepted manuscript online: 5 MAY 2015 01:50AM EST | DOI: 10.1111/jnc.13154

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