Journal of Neurochemistry

Cover image for Journal of Neurochemistry

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Locus coeruleus response to single-prolonged stress and early intervention with intranasal neuropeptide Y

    Esther L. Sabban, Marcela Laukova, Lishay G. Alaluf, Emelie Olsson and Lidia I. Serova

    Article first published online: 30 SEP 2015 | DOI: 10.1111/jnc.13347

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    Single-prolonged stress (SPS)-triggered long-term changes in the locus coeruleus/norepinephrine (LC/NE) system with increased tyrosine hydroxylase (TH) protein and CRH receptor 1(CRHR1) mRNA and lower neuropeptide Y receptor 2 (Y2R) mRNA levels as well as elevated corticotropin-releasing hormone (CRH) in the central nucleus of amygdala (CeA) that were prevented by early intervention with intranasal neuropeptide Y (NPY). SPS treatment led to increased sensitivity of LC to mild stress of elevated plus maze (EPM), with elevated mRNA for NE biosynthetic enzymes in subset of animals.

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    Endogenous recovery after brain damage: molecular mechanisms that balance neuronal life/death fate

    Luis B. Tovar-y-Romo, Andrés Penagos-Puig and Josué O. Ramírez-Jarquín

    Article first published online: 29 SEP 2015 | DOI: 10.1111/jnc.13362

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    Under neurodegenerative conditions, endogenously activated mechanisms balance out molecular cues that determine whether neurons contend toxicity or die. Many processes involved in endogenous repair may as well lead to tissue damage depending on the strength of stimuli. Signaling mediated by trophic factors and neuroinflammation are examples of these processes as they regulate different mechanisms that mediate neuronal demise including necrosis, apoptosis, necroptosis, pyroptosis and autophagy. In this review, we discuss recent findings on balanced regulation and their involvement in neuronal death.

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    Main path and byways: non-vesicular glutamate release by system xc as an important modifier of glutamatergic neurotransmission

    Ann Massie, Séverine Boillée, Sandra Hewett, Lori Knackstedt and Jan Lewerenz

    Article first published online: 29 SEP 2015 | DOI: 10.1111/jnc.13348

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    System xc constitutes an important source of extrasynaptic glutamate in the brain. By modulating the tone of extrasynaptic metabotropic or ionotropic glutamate receptors, it affects excitatory neurotransmission, the threshold for overexcitation and excitotoxicity and, as a consequence, behavior. This review describes the current knowledge of how system xc is regulated and involved in physiological as well as pathophysiological brain functioning.

  4. Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

    Liangliang Zhao, Majda Hadziahmetovic, Chenguang Wang, Xueying Xu, Ying Song, H.A. Jinnah, Jolanta Wodzinska, Jared Iacovelli, Natalie Wolkow, Predrag Krajacic, Alyssa Cwanger Weissberger, John Connelly, Michael Spino, Michael K. Lee, James Connor, Benoit Giasson, Z. Leah Harris and Joshua L. Dunaief

    Article first published online: 29 SEP 2015 | DOI: 10.1111/jnc.13292

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    Above: Iron (Fe) normally moves from capillaries to glia to neurons. It is exported from the glia by ferroportin (Fpn) with ferroxidases ceruloplasmin (Cp) and/or Hephaestin (Heph). Below: In mice with mutation of Cp and Heph, iron accumulates in glia, while neurons have low iron levels. Both neurons and glia degenerate and mice become ataxic unless given an iron chelator.

  5. Regulation of the orexigenic neuropeptide, enkephalin, by PPARδ and fatty acids in neurons of the hypothalamus and forebrain

    Kinning Poon, Mohammad Alam, Olga Karatayev, Jessica R. Barson and Sarah F. Leibowitz

    Article first published online: 29 SEP 2015 | DOI: 10.1111/jnc.13298

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    Our findings show that PPARδ in forebrain and hypothalamic neurons negatively regulates enkephalin (ENK), a peptide known to promote ingestive behavior. This inverse relationship is consistent with our additional findings, that a saturated (palmitic; PA) compared to a monounsaturated fatty acid (oleic; OA) has a strong stimulatory effect on ENK and weak effect on PPARδ. These results suggest that PPARδ protects against the neuronal effects of fatty acids, which differentially affect neurochemical systems involved in ingestive behavior.