Journal of Neurochemistry

Cover image for Vol. 138 Issue 3

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Increased Ubqln2 Expression Causes Neuron Death in Transgenic Rats

    Bo Huang, Qinxue Wu, Hongxia Zhou, Cao Huang and Xu-Gang Xia

    Accepted manuscript online: 26 JUL 2016 06:50AM EST | DOI: 10.1111/jnc.13748

  2. Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier

    Maj Schneider Thomsen, Svend Birkelund, Annette Burkhart, Allan Stensballe and Torben Moos

    Accepted manuscript online: 26 JUL 2016 06:50AM EST | DOI: 10.1111/jnc.13747

  3. Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig

    Stephanie M. Miller, Susan M. Sullivan, Zoe Ireland, Kirat K. Chand, Paul B. Colditz and S. Tracey Bjorkman

    Accepted manuscript online: 26 JUL 2016 06:50AM EST | DOI: 10.1111/jnc.13746

  4. A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity (pages 479–494)

    Jack T. Rogers, Vivek Venkataramani, Cecilia Washburn, Yanyan Liu, Vinusha Tummala, Hong Jiang, Ann Smith and Catherine M. Cahill

    Version of Record online: 26 JUL 2016 | DOI: 10.1111/jnc.13671

    Thumbnail image of graphical abstract

    We propose the following cascade for Lead (Pb) toxicity to neurons; by targeting the interaction between Iron regulatory protein-1 and Iron-responsive elements, Pb caused translational repression of proteins that control intracellular iron homeostasis, including the Alzheimer's amyloid precursor protein (APP) that stabilizes the iron exporter ferroportin, and the ferroxidase heavy subunit of the iron-storage protein, ferritin. When unregulated, IRE-independent over-expression of APP695 protected SH-SY5Y neurons from Pb toxicity. There is a novel and key role for APP in maintaining safe levels of intracellular iron pertinent to lead toxicity.

  5. The Oligodendrocyte-Specific Antibody “CC1” Binds Quaking 7

    Jenea M Bin, Stephanie N Harris and Timothy E Kennedy

    Accepted manuscript online: 25 JUL 2016 03:05PM EST | DOI: 10.1111/jnc.13745