Journal of Neurochemistry

Cover image for Vol. 132 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro

    Atsushi Yamasaki, Atsushi Kasai, Akihiro Toi, Maki Kurita, Saki Kimoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Akira Ito, Herbert Y. Meltzer, Yukio Ago, James A. Waschek, Yusuke Onaka, Toshio Matsuda, Akemichi Baba and Hitoshi Hashimoto

    Article first published online: 23 JAN 2015 | DOI: 10.1111/jnc.12999

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    Candidate-based screening for serotonergic induction using a rapid assay in mouse embryonic stem cells revealed that the bone morphogenetic protein (BMP) type I receptor kinase inhibitors selectively induce serotonergic differentiation, whereas the TGF-β receptor inhibitor SB-431542 inhibits the differentiation. These results suggest that inhibition of BMP type I receptors and concomitant activation of transforming growth factor-β (TGF-β) receptor signaling are involved in the early trajectory of serotonergic differentiation.

  2. Different effects of bisphenol-A on memory behavior and synaptic modification in intact and estrogen-deprived female mice

    Xiaohong Xu, Ting Gu and Qiaoqiao Shen

    Article first published online: 23 JAN 2015 | DOI: 10.1111/jnc.12998

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    We showed that bisphenol-A (BPA) improved ovariectomy (Ovx)-induced memory impairment but diminished the rescue effect of estradial on memory of Ovx mice. BPA increased the synaptic density of the Ovx hippocampus, but inhibited the enhancement of estradial on synaptogenesis of Ovx mice. Our findings provided evidence hat BPA interfered with hormonal regulation in synaptic plasticity and memory of female mice as a potent estrogen mimetic and as a disruptor of estrogen under various concentration of cycling estrogen.

  3. Elevated spinal monoamine neurotransmitters after antenatal hypoxia–ischemia in rabbit cerebral palsy model

    Alexander Drobyshevsky, Silvia Honda Takada, Kehuan Luo, Matthew Derrick, Lei Yu, Katharina A. Quinlan, Jeannette Vasquez-Vivar, Maria Inês Nogueira and Sidhartha Tan

    Article first published online: 23 JAN 2015 | DOI: 10.1111/jnc.12997

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    Following prenatal hypoxia–ischemia, newborn rabbits exhibit elevated levels of serotonin in the spinal cord that were linked to muscle hypertonia. Serotonergic terminal density was also increased in hypertonic newborns’ spinal cord. Intrathecal administration of the non-selective serotonin receptor inhibitor methysergide decreased muscle tone in hypertonic newborns only. Elevated spinal serotonin thus suggests a novel pathophysiological mechanism of hypertonia in cerebral palsy.

  4. S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo

    Huanying Shi, Xu Jing, Xinbing Wei, Ruth G. Perez, Manru Ren, Xiumei Zhang and Haiyan Lou

    Article first published online: 23 JAN 2015 | DOI: 10.1111/jnc.12986

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    The transcription factor Nrf2 is involved in cerebral ischemic disease and may be a promising target for the treatment of stroke. We provide novel evidence that SAC confers neuroprotection against ischemic stroke by activating the antioxidant Nrf2 signaling pathway. ARE, antioxidant response element; GCLC, glutathione cysteine ligase regulatory subunit; GCLM, glutathione cysteine ligase modulatory subunit; HO-1, heme oxygenase-1; JNK, c-Jun N-terminal kinase; Keap1, Kelch-like ECH-associated protein 1; Maf, musculoaponeurotic fibrosarcoma; Nrf2, nuclear factor erythroid-2-related factor 2; SAC, S-allyl cysteine; ROS, reactive oxygen species.

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