Journal of Neurochemistry

Cover image for Vol. 132 Issue 3

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone

    Sylwia Kedracka-Krok, Bianka Swiderska, Urszula Jankowska, Bozena Skupien-Rabian, Joanna Solich, Katarzyna Buczak and Marta Dziedzicka-Wasylewska

    Article first published online: 30 JAN 2015 | DOI: 10.1111/jnc.13007

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    Using two-dimensional differential electrophoresis, we demonstrate that chronic treatment the healthy rats with anti-psychotics, clozapine and risperidone, induce changes in expression of cytoskeletal, synaptic, and regulatory proteins in the cerebral cortex. While risperidone increases the level of proteins regulating cell proliferation, namely, fatty acid-binding protein-7 and translin-associated factor X, the clozapine significantly up-regulates calcium sensors, i.e., visinin-like protein 1 and neurocalcin δ. 2D DIGE, Differential in Gel Electrophoresis; Cy2, Cy3, and Cy5 are cyanine dyes.

  2. COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model

    Dominique Garin, Angélique Virgone-Carlotta, Bülent Gözel, Fatima Oukhatar, Pascale Perret, Danièle Marti-Battle, Monique Touret, Philippe Millet, Michel Dubois-Dauphin, David Meyronet, Nathalie Streichenberger, Frank M. Laferla, Martine Demeunynck, Sabine Chierici, Marcelle Moulin Sallanon and Catherine Ghezzi

    Article first published online: 30 JAN 2015 | DOI: 10.1111/jnc.12951

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    Previous work has shown that naturally fluorescent proflavine derivatives label Abeta plaques. Our aim was to further characterize the properties of one of them: 3-acetylamino-6-[3-(propargylamino) propanoyl]aminoacridine (COB231). We demonstrated the Abeta deposit binding properties of COB231 in vitro on Alzheimer (AD) patient brain slices (see image showing COB231 labelling of Abeta deposits), and in vivo in an AD mice model. These results are particularly attractive with regard to the flexible chemistry of COB231 that allows further radiolabelling for in vivo imaging or combination with a therapeutic agent targeting Abeta aggregates.

  3. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb

    Tyler S. Crum, Amanda M. Gleixner, Jessica M. Posimo, Daniel M. Mason, Matthew T. Broeren, Scott D. Heinemann, Peter Wipf, Jeffrey L. Brodsky and Rehana K. Leak

    Accepted manuscript online: 29 JAN 2015 09:17AM EST | DOI: 10.1111/jnc.13041

  4. Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms

    Limin Wu, Yang Du, Josephine Lok, Eng H. Lo and Changhong Xing

    Article first published online: 29 JAN 2015 | DOI: 10.1111/jnc.13023

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    Angiogenesis is an important part of stroke recovery. In the present study, we examined the hypothesis that lipocalin-2 (LCN2) may enhance angiogenesis in brain endothelial cells. LCN2 promoted tube formation and migration via iron and ROS-related pathways in rat brain endothelial cells. ROS scavengers, Nox inhibitors and iron chelators all dampened the ability of LCN2 to enhance in vitro angiogenesis. These findings support the idea that LCN2 that is released by damaged neurons may act as a ‘help me’ signal that promotes neurovascular recovery after stroke and brain injury.

  5. The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice

    Kenta Murata, Yuta Yoshino, Kazuhiro Tsuruma, Shigeki Moriguchi, Atsushi Oyagi, Hirotaka Tanaka, Mitsue Ishisaka, Masamitsu Shimazawa, Kohji Fukunaga and Hideaki Hara

    Article first published online: 29 JAN 2015 | DOI: 10.1111/jnc.13010

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    Glycoprotein nonmelanoma protein B (GPNMB) is widely expressed in neurons. We investigated the role of GPNMB on memory by using transgenic mice over-expressing GPNMB (Tg) and GPNMB extracellular fragment (ECF)-treated mice. Both mice exhibited memory improvement. In Tg mice, protein levels of phosphorylated α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluA1, CaMK2 (Ca2+/calmodulin-dependent protein kinase 2), and GSK3β (glycogen synthase kinase 3β) were increased. Tg mice and ECF-treated hippocampus promoted LTP. These findings suggest that GPNMB might become a novel target for research on higher order brain functions.