Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 4.244
ISI Journal Citation Reports © Ranking: 2013: 63/251 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- Continuous Infusion of Substance P into Rat Striatum Alleviates Nociceptive Behavior via Phosphorylation of Extracellular-Signal Regulated Kinase ½
Yoki Nakamura, Hiroki Izumi, Ryo Fukushige, Takumi Shimizu, Kyohei Watanabe, Norimitsu Morioka, Aldric Hama, Hiroyuki Takamatsu and Yoshihiro Nakata
Accepted manuscript online: 30 AUG 2014 03:33AM EST | DOI: 10.1111/jnc.12938
- Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stress-triggered changes in several brain regions
Lidia I. Serova, Marcela Laukova, Lishay G. Alaluf and Esther L. Sabban
Article first published online: 30 AUG 2014 | DOI: 10.1111/jnc.12847
Blockade of brain melanocortine receptor 4 (MC4R) with intranasal infusion of the MC4R antagonist HS014 to rats prior to single prolonged stress (SPS) leads to faster termination of stress responses (30 min later) and prevents or attenuates SPS-triggered abnormal gene expression related to post-traumatic stress disorder (7 days later). Targeting of brain MC4R is a promising strategy to protect HPA axis, LC-NE (locus coeruleus-norepinephrine) systems and hippocampus from overstimulation.
- Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex
Christof Hiebel, Tanja Kromm, Marcel Stark and Christian Behl
Article first published online: 26 AUG 2014 | DOI: 10.1111/jnc.12839
Regulation of the autophagic flux in certain physiological situations such as an imbalance of nutrient supply as well as in pathological stages is of major importance for neuronal and non-neuronal cells. CB1 (Cannabinoid receptor 1) affects the metabolism of cells directly. In this study, we provide evidence that CB1 signaling has a direct influence on autophagy which might help the cell to find the right adjustment to different metabolic states and CB1 activity exerts its modulatory action independent of the canonical mTOR- and BECLIN1-complexes regulating autophagy.
- Addition of docosahexaenoic acid, but not arachidonic acid, activates glutathione and thioredoxin antioxidant systems in murine hippocampal HT22 cells: potential implications in neuroprotection
Verónica Casañas-Sánchez, José A. Pérez, Noemí Fabelo, Antonio V. Herrera-Herrera, Cecilia Fernández, Raquel Marín, María C. González-Montelongo and Mario Díaz
Article first published online: 26 AUG 2014 | DOI: 10.1111/jnc.12833
DHA improves the antioxidant capacity of cultured hippocampal HT22 cells. We propose that DHA supplementation induces the remodelling of membrane phospholipids, and also triggers a transcriptional program to increase the expression of members of the glutathione and thioredoxin systems. We postulate that this transcriptional effect is mediated by a signal arising from non-enzymatic oxidation of DHA.
- Morphine and cocaine increase serum- and glucocorticoid-inducible kinase 1 activity in the ventral tegmental area
Elizabeth A. Heller, Sophia Kaska, Barbara Fallon, Deveroux Ferguson, Pamela J. Kennedy, Rachael L. Neve, Eric J. Nestler and Michelle S. Mazei-Robison
Article first published online: 26 AUG 2014 | DOI: 10.1111/jnc.12925
We find that repeated, but not acute, morphine or cocaine administration induces an increase in serum- and glucocorticoid-inducible kinase (SGK1) gene expression and activity in the ventral tegmental area (VTA). This increase in SGK1 activity may play a role in drug-dependent behaviors and suggests a novel signaling cascade for potential intervention in drug dependence and addiction.