Journal of Neurochemistry

Cover image for Vol. 132 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.244

ISI Journal Citation Reports © Ranking: 2013: 63/252 (Neurosciences); 74/291 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects

    Zhi Ruan, Hong Min Wang, Xiao Tian Huang, Yan Fu, Jian Wu, Chun Yan Ye, Jin Long Li, Lei Wu, Qi Gong, Wei Min Zhao and Hai Yan Zhang

    Article first published online: 27 FEB 2015 | DOI: 10.1111/jnc.13046

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    We documented for the first time that 28-O-caffeoyl betulin (B-CA), a novel synthetic caffeoyl triterpene inspired from active natural principles of Celastrus orbiculatus Thunb, possessed robust neuroprotection with a wide and clinically useful therapeutic time window against ischemic stroke, correlating with the anti-inflammatory and hypothermic effects. Thus, this novel caffeoyl triterpene derivative may lead toward the development of effective therapeutic strategies for the treatment of ischemic stroke.

  2. Increased expression of receptor for activated C kinase 1 in temporal lobe epilepsy

    Xin Xu, Xiaoyan Yang, Yan Xiong, Juan Gu, Changlong He, Yida Hu, Fei Xiao, Guojun Chen and Xuefeng Wang

    Article first published online: 26 FEB 2015 | DOI: 10.1111/jnc.13052

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    Mesial temporal lobe epilepsy is associated with increased neurogenesis and neuronal plasticity. We demonstrate expression of receptor for activated C kinase 1 (RACK1) and other markers associated with neuronal migration, synaptic plasticity and neurogenesis in the epileptic human and animal brains. The expression of tubulin, beta 2B class IIb (TUBB2B), associated with neuronal migration was decreased. Our findings raise the possibility that RACK1 is functionally relevant in epilepsy pathophysiology.

  3. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

    Hanaa S. Sallam, Batbayar Tumurbaatar, Wen-Ru Zhang, Demidmaa Tuvdendorj, Manisha Chandalia, Filippo Tempia, Fernanda Laezza, Giulio Taglialatela and Nicola Abate

    Article first published online: 26 FEB 2015 | DOI: 10.1111/jnc.13043

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    We observed evidence of biochemical and functional changes in hippocampal synapses in mice in response to high-fat diet. Such effects were more pronounced in a transgenic animal model of adipocyte insulin resistance (AtENPP1-Tg) compared to their wild-type littermates. Animals exhibited alterations in synaptic lipid composition, decreased basal synaptic transmission at the Schaffer collaterals to CA1 synapses, decreased GluN1 receptor phosphorylation, decreased insulin receptor expression, and increased FFA1 receptor expression. We believe that our results provide a novel mechanistic link between obesity, adipose tissue dysfunction, and increased risk for cognitive impairment. CA, cornu ammonis; CA1, hippocampal cornu ammonis 1; DAG, diacylglycerol; FFA, free fatty acids; FFA1, free fatty acid receptor 1; GluN1, NMDA receptor 1 subunit; HFD, high-fat diet.

  4. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

    Antonella Tramutola, Judy C. Triplett, Fabio Di Domenico, Dana M. Niedowicz, Michael P. Murphy, Raffaella Coccia, Marzia Perluigi and D. Allan Butterfield

    Article first published online: 26 FEB 2015 | DOI: 10.1111/jnc.13037

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    The figure represents the three different stages of Alzheimer Disease: Preclinical Alzheimer Disease (PCAD), Mild cognitive impairment (MCI) and late stage of Alzheimer Disease. The progression of the disease is associated with a reduction in autophagy (Beclin-1 and LC-3) observed in Inferior parietal lobe of PCAD, MCI, and AD subjects (light red). Related to the autophagy impairment, the graph shows the impairment of PI3K/Akt/mTOR in MCI and AD subjects (dark red).

  5. Molecular determinants of transport stimulation of EAAT2 are located at interface between the trimerization and substrate transport domains

    Ole V. Mortensen, José L. Liberato, Joaquim Coutinho-Netto, Wagner F. dos Santos and Andréia C. K. Fontana

    Article first published online: 26 FEB 2015 | DOI: 10.1111/jnc.13047

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    We identified a domain (purple star) in the glutamate transporter EAAT2 that is important for transport stimulation through a spider venom, and suggest a mechanism for enhanced transporter function through facilitated substrate translocation (arrow). Because the dysfunction of glutamate transporters is implicated in the pathogenesis of neurological disorders, understanding the mechanisms of enhanced transport could have therapeutic implications.