Journal of Neurochemistry

Cover image for Vol. 134 Issue 5

Edited By: Jörg Schulz

Impact Factor: 4.281

ISI Journal Citation Reports © Ranking: 2014: 55/252 (Neurosciences); 72/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

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Recently Published Articles

  1. Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats

    Lili Fang, Xue Li, Yinbo Zhong, Jing Yu, Lina Yu, Haibin Dai and Min Yan

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13277

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    Cerebral microvascular endothelial cells (ECs) are crucial for brain vascular repair and maintenance, but their physiological function is impaired during ischemic stroke and diabetes. In this study, we found methylglyoxal (MGO) decreased human brain microvascular endothelial cells (HBMEC) cell viability in a concentration and time dependent manner, which was accompanied by the responsive autophagy activation. Autophagy inhibitors exacerbated (MGO)-induced HBMEC injury. FAK phosphorylation inhibitor PF573228 inhibited MGO-triggered autophagy and enhanced LDH release. Meanwhile, the similar autophagy activation in brain vascular ECs was observed during permanent middle cerebral artery occlusion (pMCAO)-induced cerebral ischemia in diabetic rats, and chloroquine -induced autophagy inhibition enhanced BBB permeability. This study indicates that autophagy triggered by MGO defends HBMEC against injuries.

  2. Inhibiting amyloid β-protein assembly: Size–activity relationships among grape seed-derived polyphenols

    Eric Y. Hayden, Ghiam Yamin, Shiela Beroukhim, Benson Chen, Mikhail Kibalchenko, Lin Jiang, Lap Ho, Jun Wang, Giulio M. Pasinetti and David B. Teplow

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13270

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    Grape seed polyphenolic extracts have been shown to inhibit the aggregation of Aβ in vitro and to ameliorate neuropathology and behavioral deficits in a mouse model of AD. The active agent in the extracts is a mixed population of polyphenolic compounds, including monomers, dimers, and oligomers. We found that monomers were the most potent inhibitors, when the number concentration of phenolic groups was considered. We developed a model of polyphenol:Aβ complexation that offers an explanation for the effects of functional group polyvalency on inhibitor activity. Our data emphasize the importance of an in-depth understanding of the mechanism(s) underlying ‘concentration dependence’ in inhibitor systems involving polyfunctional agents.

  3. Laminin promotes metalloproteinase-mediated dystroglycan processing to regulate oligodendrocyte progenitor cell proliferation

    Cindy V. Leiton, Azeez Aranmolate, Christopher Eyermann, Michael J. Menezes, Luisa F. Escobar-Hoyos, Solomon Husain, Steve J. Winder and Holly Colognato

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13241

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    A subset of dystroglycan expressed in oligodendrocyte progenitors is cleaved by (1) a metalloproteinase, and, predicted, (2) by a γ-secretase to generate an intracellular β−dystroglycan fragment. Cleavage occurs preferentially following attachment to the dystroglycan extracellular ligand, laminin-211. The intracellular portion of cleaved dystroglycan then promotes oligodendrocyte progenitor proliferation, providing a novel reciprocal mechanism by which laminin–dystroglycan interactions influence oligodendroglial development. MMP, matrix metalloproteinase.

  4. Resveratrol prevents cadmium activation of Erk1/2 and JNK pathways from neuronal cell death via protein phosphatases 2A and 5

    Chunxiao Liu, Ruijie Zhang, Chenxia Sun, Hai Zhang, Chong Xu, Wen Liu, Wei Gao, Shile Huang and Long Chen

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13233

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    Resveratrol, a natural polyphenol compound, has been found to exert neuroprotective effects. This study uncovers that resveratrol prevents cadmium (Cd)-induced activation of Erk1/2 and JNK pathways and neuronal cell death via activating PP2A and PP5. The findings propose that resveratrol may serve as a potential therapeutic agent in the prevention of Cd-induced neurodegenerative diseases.

  5. Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats

    Hui Shu, Guo-qing Zheng, Xiaona Wang, Yanyun Sun, Yushan Liu, John Michael Weaver, Xianzhi Shen, Wenlan Liu and Xinchun Jin

    Article first published online: 2 SEP 2015 | DOI: 10.1111/jnc.13283

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    Our study showed the brain region and mechanism underlying nicotine-induced spatial working memory improvement. In response to nicotine treatment, VTA-hippocampus circuit is activated and MMP-9 activation in dorsal hippocampus mediates the memory improvement. Our data suggest nicotine increases spatial working memory by activating MMP-9 in dorsal hippocampus. Nicotine improves spatial working memory by enhancing an ability to use Win-shift strategy and increasing correct choice. This effect is mediated by the VTA-hippocampus circuit and MMP-9 in dHPC is activated with intra-VTA nicotine infusion in rats.