Journal of Neurochemistry
© International Society for Neurochemistry
Edited By: Jörg Schulz
Impact Factor: 4.281
ISI Journal Citation Reports © Ranking: 2014: 56/252 (Neurosciences); 72/290 (Biochemistry & Molecular Biology)
Online ISSN: 1471-4159
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Recently Published Articles
- You have full text access to this OnlineOpen articleComplex regulation of the regulator of synaptic plasticity histone deacetylase 2 in the rodent dorsal horn after peripheral injury
Maria Maiarù, Oakley B. Morgan, Keri K. Tochiki, Eleanor J. Hobbiger, Kaveeta Rajani, Dorothy W. U. Overington and Sandrine M. Géranton
Version of Record online: 27 MAY 2016 | DOI: 10.1111/jnc.13621
Our manuscript describes for the first time the regulation of the memory regulator histone deacetylase 2 (HDAC2) in the superficial dorsal horn of adult rats following peripheral injury. Our cell-specific approach has revealed a complex pattern of expression of spinal HDAC2 that depends on the injury and the cell type, suggesting a sophisticated regulation of gene expression by HDAC2.
- You have full text access to this OnlineOpen articleProteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain
Thilo Kähne, Sandra Richter, Angela Kolodziej, Karl-Heinz Smalla, Rainer Pielot, Alexander Engler, Frank W. Ohl, Daniela C. Dieterich, Constanze Seidenbecher, Wolfgang Tischmeyer, Michael Naumann and Eckart D. Gundelfinger
Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13636
How does the protein composition of synapses change in different brain areas upon auditory learning? We unravel discrete proteome changes in mouse auditory cortex, frontal cortex, hippocampus, and striatum functionally implicated in the learning process. We identify not only common but also area-specific biological pathways and cellular processes modulated 24 h after training, indicating individual contributions of the regions to memory processing.
- Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry
Louise Carlred, Wojciech Michno, Ibrahim Kaya, Peter Sjövall, Stina Syvänen and Jörg Hanrieder
Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13645
Hanrieder et al. described an imaging mass spectrometry based study on comprehensive spatial profiling of C-terminally truncated Aβ species within individual plaques in tgArcSwe mice. Here, brain region-dependent differences in Aβ truncation and other plaque-associated proteins, such as macrophage migration inhibitory factor, were observed. The data shed further light on plaque-associated molecular mechanisms implicated in Alzheimer's pathogenesis.
- The astrocytic response to the dopaminergic denervation of the striatum
Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate and Manuel Rodriguez
Accepted manuscript online: 26 MAY 2016 11:05PM EST | DOI: 10.1111/jnc.13684
- l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro
Aditi Banerjee, Swagata Ghatak and Sujit Kumar Sikdar
Version of Record online: 26 MAY 2016 | DOI: 10.1111/jnc.13638
Insufficient blood supply to the brain leads to cerebral ischaemia and increase in extracellular lactate concentrations. We incubated hippocampal astrocytes in lactate and observed increase in TREK1 channel expression via protein kinase A (PKA). Inhibition of TREK1, PKA and metabolic impairment of astrocytes prevented lactate from reducing cell death in ischaemic hippocampus. This pathway serves as an alternate mechanism of neuroprotection.