Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation
Therese Fagerqvist, Veronica Lindström, Eva Nordström, Anna Lord, Stina M. E. Tucker, Xingjian Su, Charlotte Sahlin, Alex Kasrayan, Jessica Andersson, Hedvig Welander, Thomas Näsström, Mats Holmquist, Heinrich Schell, Philipp J. Kahle, Hannu Kalimo, Christer Möller, Pär Gellerfors, Lars Lannfelt, Joakim Bergström and Martin Ingelsson
Article first published online: 27 FEB 2013 | DOI: 10.1111/jnc.12175
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and transgenic mice expressing the disease-causing A30P mutation.
Aggregation of α-synuclein with formation of toxic oligomers/protofibrils is a central feature in the brain of Parkinson's disease and dementia with Lewy bodies. We developed monoclonal antibodies with high affinity and strong selectivity against such α-synuclein species. The novel antibodies recognize relevant α-synuclein pathology in both transgenic mice (A) and human brain. Apart from advancing our understanding of the disease processes, these antibodies may be valuable both for immunotherapy and as reagents in biomarker assays.