Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?
Dieter Lemke, Markus Weiler, Jonas Blaes, Benedikt Wiestler, Leonie Jestaedt, Ann-Catherine Klein, Sarah Löw, Günter Eisele, Bernhard Radlwimmer, David Capper, Kirsten Schmieder, Michel Mittelbronn, Stephanie E. Combs, Martin Bendszus, Michael Weller, Michael Platten and Wolfgang Wick
Article first published online: 18 JUL 2014 | DOI: 10.1111/jnc.12802
Markers used to define glioma-initiating cells (GIC) are generally not defining a more resistant, but rather a more sensitive group of glioma cells. An exemption is CD44 expression. Also proliferation of the GIC culture itself was not systematically associated with radiosensitivity or – resistance, but a SOX-2 positive, proliferative subgroup within a GIC culture is showing the highest radiosensitivity.