Journal of Neurochemistry

Cover image for Vol. 141 Issue 1

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

Mark A Smith Prize


The Mark A. Smith Prize
The Editors' Award will now be known as the Mark A. Smith prize to pay tribute to Mark's long service to the Journal as a Handling Editor and recently Deputy Chief Editor, Reviews. Tragically, Mark was killed in a vehicle accident on December 19, 2010.

This annual award, instigated in 2009, is in recognition of the contribution of an outstanding young scientist to an exceptional research paper published in the Journal of Neurochemistry.

To be eligible, first or last authors must be 35 years or younger on the date of submission of the article and no more than 8 years beyond PhD. The Chief and Deputy Chief Editors select the winning paper from all the qualifying articles that appear 'early view' in the award year.

The 2015 Mark A. Smith Prize Winner

2014 Mark A. Smith Prize WinnerCongratulations to Yuda Huo, for The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking
Journal of Neurochemistry (2015) J Neurochem 134(6), 1067–1080.
Yuda Huo, Natasha Khatri, Qingming Hou, James Gilbert, Guan Wang and Heng-Ye Man. DOI: 10.1111/jnc.13194
The article has broad relevance in the field of protein ubiquitination, a highly dynamic and reversible process, achieved via the balance between ubiquitination and deubiquitination. The glutamatergic AMPARs, which mediate most of the excitatory synaptic transmission in the brain, are known to be subjected to Nedd4-mediated ubiquitination; however, the deubiquitination process and the responsible deubiquitinating enzymes (DUBs) for mammalian AMPARs remain elusive. We find that AMPARs are subject to K63-type ubiquitination, and identify USP46 as the DUB for AMPARs. USP46 deubiquitinates AMPARs in vitro and in vivo. Up- or down-regulation of USP46 leads to changes in AMPAR ubiquitination, surface expression, and trafficking, as well as the strength of synaptic transmission. USP46-mediated regulation of AMPAR ubiquitination and turnover may play an important role in synaptic plasticity and brain function.

Yuda Huo has co-authored a number of relevant articles in the field in the past, using a variety of biochemical, molecular and cell biological as well as imaging methods. He is currently working at Boston University, USA under the guidance of Dr. Heng-ye Man to pursue his PhD degree in Neuroscience.


The 2014 Mark A. Smith Prize Winner

2014 Mark A. Smith Prize Winner Congratulations to Stefania Averaimo PhD, for CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells (2014) J Neurochem 131(4), 444-456.
Stefania Averaimo, Marta Gritti, Erica Barini, Laura Gasparini and Michele Mazzanti. DOI: 10.1111/jnc.12832

Dr. Averaimo received her doctorate degree in 2012 at the University of Milan, Italy, in the laboratory of Prof. Mazzanti. She published her work in a number of papers and scientific meetings. She is currently a postdoctoral fellow in Dr Prof. Xavier Nicol’s lab at the Institut de la Vision in Paris, France, working on retinal axon guidance and regeneration.


The 2013 Mark A. Smith Prize Winner

2013 Mark A. Smith Prize WinnerCongratulations to Dr. Hikita, PhD, for Rac1-mediated indentation of resting neurons promotes the chain migration of new neurons in the rostral migratory stream of post-natal mouse brain J Neurochem 128(6), 790-797. Takao Hikita, Akihisa Ohno, Masato Sawada, Haruko Ota and Kazunobu Sawamoto. DOI: 10.1111/jnc.12518
Dr. Hikita earned his PhD in the Department of Cell Pharmacology at the Nagoya University Graduate School of Medicine in Japan. He currently holds a PostDoc position at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany. The winning paper sheds light on cell migration mechanisms using cutting edge techniques such as live cell imaging, and thus has broad appeal and impact in the neurochemistry and neuroscience fields.
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The 2012 Mark A. Smith Prize Winner

2012 Mark A. Smith Prize Winner

Congratulations to Sonya B. Dumanis, PhD, for APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals J Neurochem 124(1), 4-14. Sonya B. Dumanis, Amanda M. DiBattista, Matthew Miessau, Charbel E. H. Moussa and G. William Rebeck. DOI: 10.1111/j.1471-4159.2012.07908.x
The article was highlighted in “Apolipoprotein E Acts at Presynaptic Sites… Among Others” in the same issue.
Dr. Dumanis earned her B.A. with major Neuroscience & Behavior at Columbia University, New York City. She continued her studies at Georgetown University, Washington D.C. where she completed her PhD in William Rebeck’s lab in 2013. She has authored and co-authored a number of research papers, presented her work at international meetings and was awarded several prizes such as a National Science Foundation Graduate Research Fellowship and Predoctoral National Research Service Award (NRSA).


The 2011 Mark A. Smith Prize Winner

2011 Mark A. Smith Prize Winner

Congratulations to Joanne L. Bailey, PhD, for In vitro CNS tissue analogues formed by self-organization of reaggregated post-natal brain tissue, J. Neurochem. 117, 1020-1032. Joanne L. Bailey, Vincent O’Connor,Matthew Hannah, Lindsay Hewlett, Thelma E. Biggs, Lars E. Sundstrom, Matt W. Findlay, and John E. Chad (2011).

 Dr. Bailey earned a first-class honours degree from the University of Southampton in 2006 and completed her PhD in 2010. Currently, Joanne is a research fellow in Dr. Tracey Newman’s laboratory in the Faculty of Medicine at the University of Southampton


The 2010 Mark A. Smith Prize Winner

Mark A Smith Prize winner 2010

Congratulations to Jennie Cederholm for Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor, J. Neurochem. 115, 1245-1255. Jennie M. E. Cederholm, Nathan L. Absalom, Silas Sugiharto, Renate Griffith, Peter R. Schofield and Trevor M. Lewis (2010).


The 2009 Editors' Award winner
Congratulations to Gautam K. Gandhi MD, PhD forAstrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons J. Neurochem.111, 522-536. Gautam K. Gandhi, Nancy F. Cruz, Kelly K. Ball, Gerald A. Dienel (2009).

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