Journal of Neurochemistry

Cover image for Vol. 139 Issue 1

Edited By: Jörg Schulz

Impact Factor: 3.842

ISI Journal Citation Reports © Ranking: 2015: 71/256 (Neurosciences); 83/289 (Biochemistry & Molecular Biology)

Online ISSN: 1471-4159

Special Issues

More Special Issues coming soon!


Journal of Neurochemistry celebrates its 60th Anniversary

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Parkinson's Disease

Journal of Neurochemistry special issue on Parkinson's Disease

Synucleinopathies are characterized by abnormal accumulation of alpha-synuclein (aSyn) that spreads in the brain along characteristic pathways (Brundin 2016) and causes neurodegeneration. Parkinson's disease (PD) with distinct neuroanatomical characteristics (Wurst et al. 2016), dementia with Lewy bodies and multiple system atrophy are the most common examples. Not least due to its broad prevalence and devastating course, Parkinson's disease has particular societal relevance. The Journal of Neurochemistry therefore dedicates this special issue to the neuroanatomy and pathology of this neurodegenerative disease, extending to the available models and clinical approaches that may help us cure Parkinson’s.


Frontotemporal Dementia

Special Issue on Frontotemporal Dementia

Neurodegenerative disorders are a major social and economical challenge in our ageing society. While research on Alzheimer's disease, and specifically its molecular mechanisms, genetics and even therapeutic attempts made rather dramatic progress during the last 2.5 decades research on frontotemporal dementias (FTD) lacked a bit behind. The extremely exciting and rapid progress in all aspects of FTD research, be it diagnosis and biomarker research, mechanisms, genetics and even therapeutic attempts, is critically summarized by leading specialist in the field in this Special Issue of the Journal of Neurochemistry, edited by Christian Haass and Manuela Neumann.

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Journal of Neurochemistry special issue on Neuroinflammation: A Two Way Street Directing CNS Injury and Repair

Neuroinflammation accompanies a wide range of central nervous system diseases, including infection, trauma, and neurodegeneration. Microglia play an essential role, yet it remains to be determined what signals are critical for dictating whether microglia assume a protective versus destructive state. In this special issue, a broad range of articles cover aspects from microglial morphology to their role in neuroprotection, the inflammasome in various neurodegenerative diseases, and the clinical approaches to target immune dysfunction.

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150 Years of Friedreich Ataxia Research

Journal of Neurochemistry special issue on 150 Years of Friedreich Ataxia Research

In 1863, Nikolaus Friedreich (1825-1882) identified a new spinal disease, Friedreich Ataxia (FRDA). It took another 120 years to determine the genetic defect underlying the disease. The identification of mutations in the gene encoding frataxin (FXN) initiated the rapid growth of a scientific field in which FRDA became a model disorder. Frataxin has been found to locate to mitochondria, control mitochondrial iron homoeostasis and, if deficient, lead to oxidative stress. Genetically, it is a recessively inherited disorder caused by an expansion mutation of GAA repeats in the first intron within the FXN gene, leading to a largely reduced expression of the frataxin protein. The discovery that frataxin expression can be modulated by epigenetic mechanisms has opened new research avenues and treatment strategies. This special issue is aimed at providing a comprehensive overview of the underlying molecular and cellular mechanisms, pathology, clinical picture and assessment scales as well as potential therapeutic approaches in FRDA.

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Novel Therapeutic Strategies and Targets for the Treatment of Stroke Special Issue 123: s2

Journal of Neurochemistry special issue on Novel Therapeutic Strategies and Targets for the Treatment of Stroke

This Special Issue is a collection of original articles and reviews reflecting the interests of those stroke clinicians and scientists who contributed to the First Turkish International Stroke Meeting ‘Novel Therapeutic Strategies and Targets for the Treatment of Stroke’, which was held in October, 2011, in Antalya. In that meeting, and with the assistance of a small conference grant from the ISN, we discussed findings upon which to build potential future therapeutic approaches. The goal was to increase understanding of the manner in which multiple injury mechanisms converge and interact, leading to the pathology observed during and after stroke.

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Alzheimers Special issue 120:s1

Journal of Neurochemistry special issue on Alzheimer’s disease: ‘amyloid cascade hypothesis – 20 years on’

This special issue of Journal of Neurochemistry is devoted to the explosion of knowledge that has occurred in our understanding of the molecular and cellular basis underlying Alzheimer’s disease (AD), particularly in the twenty years that have now passed since the description of the first mutation in the amyloid precursor protein (APP) gene (Goate et al. (1991) Nature 349, 704–706). As a consequence of that discovery, the amyloid cascade hypothesis of disease progression has been at the centre of gravity of much AD research and development. Has it stood the test of time?

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 Special Issue: 23rd Biennial Meeting of ISN/ESN, Athens, Greece, 28 August - 1 September 2011

Proceedings from the 23rd Biennial Meeting of ISN/ESN, Athens, Greece, 28 August - 1 September 2011

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