In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis
N. Guo, J. Wu, J. Fan, P. Yuan, Q. Shi, K. Jin, W. Cheng, X. Zhao, Y. Zhang, W. Li, X. Tang and L. Yu
Article first published online: 12 DEC 2013 | DOI: 10.1111/lam.12195
Significance and Impact of the Study: This is the first report on the in vitro synergistic antimycobacterial effects of isoimperatorin (IO) in combination with three first-line drugs: rifampin (RMP), isoniazid (INH) and ethambutol (EMB). The results indicated that the antimycobacterial activity of IO was modest; however, IO was a useful and effective agent against Myco. tuberculosis when it was combined with first-line antimycobacterial drugs and is worthy of further development as a lead compound for the development of novel antimycobacterial therapeutic agents.