Letters in Applied Microbiology

Cover image for Vol. 66 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: J.-Y. Maillard

Impact Factor: 1.575

ISI Journal Citation Reports © Ranking: 2016: 96/125 (Microbiology); 109/160 (Biotechnology & Applied Microbiology)

Online ISSN: 1472-765X

Associated Title(s): Journal of Applied Microbiology


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  1. Original Articles

    1. Identification and characterization of a new three-component nicotinic acid hydroxylase NahAB1B2 from Pusillimonas sp. strain T2

      M. Yuan, Y. Zhang, L. Zhao, Y. Ma, Q. He, J. He and J. Qiu

      Version of Record online: 8 FEB 2018 | DOI: 10.1111/lam.12850

      Thumbnail image of graphical abstract

      Significance and Impact of the Study: Nicotinic acid (NA) serves as a model system for the degradation of N-heterocyclic aromatic compounds and the microbial degradation mechanisms are diverse. This is the first time that a three-component hydroxylase has been identified. This study provides a novel insight into the NA degradation by bacteria.

    2. Acetoacetate and ethyl acetoacetate as novel inhibitors of bacterial biofilm

      S.M. Horne, M. Schroeder, J. Murphy and B.M. Prüβ

      Version of Record online: 8 FEB 2018 | DOI: 10.1111/lam.12852

      Thumbnail image of graphical abstract

      Significance and Impact of the Study: Bacterial biofilms are communities of bacteria that form on surfaces and are extremely difficult to remove by conventional physical or chemical techniques, antibiotics or the human immune system. Despite advanced technologies, biofilm still contributes to 60 to 80% of human bacterial infections (NIH and CDC) and cause problems in many natural, environmental, bioindustrial or food processing settings. The discovery of novel substances that inhibit biofilm without increasing the virulence of the bacteria opens doors for countless applications where a reduction of biofilm is desired.

    3. Development of a semi-continuous two-stage simultaneous saccharification and fermentation process for enhanced 2,3-butanediol production by Klebsiella oxytoca

      S.-K. Moon, D.-K. Kim, J.M. Park, J. Min and H. Song

      Version of Record online: 2 FEB 2018 | DOI: 10.1111/lam.12845

      Thumbnail image of graphical abstract

      Significance and Impact of the Study: There is growing interest in the production of 2,3-butanediol (2,3-BD) from renewable resources by microbial fermentation because of its wide applications to specialty and commodity chemical industries. Klebsiella oxytoca usually produces 2,3-BD as a major end product during the fermentation of carbohydrates. This is the first study to provide a high-efficiency simultaneous saccharification and 2,3-BD fermentation process. Also, this study proves the stability of a metabolically engineered 2,3-BD overproducing K. oxytoca strain for industrial application.


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