Fundamental & Clinical Pharmacology

© Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd

Cover image for Vol. 27 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Pascal Bousquet and Atul Pathak

Impact Factor: 1.799

ISI Journal Citation Reports © Ranking: 2011: 155/261 (Pharmacology & Pharmacy)

Online ISSN: 1472-8206

  1. Original Articles

    1. Population pharmacokinetics of ertapenem in juvenile and old rats

      Audrey Boulamery, Amélie Marsot, Bernard Bruguerolle and Nicolas Simon

      Article first published online: 5 MAY 2013 | DOI: 10.1111/fcp.12017

    2. No differences between men and women in adverse drug reactions related to psychotropic drugs: a survey from France, Italy and Spain

      Paola D'Incau, Maryse Lapeyre-Mestre, Alfonso Carvajal, Monia Donati, Inés Salado, Lauriane Rodriguez, María Sáinz, Antonio Escudero and Anita Conforti

      Article first published online: 26 APR 2013 | DOI: 10.1111/fcp.12032

    3. Protective effects of ranolazine and propranolol, alone or combined, on the structural and functional alterations of cardiomyocyte mitochondria in a pig model of ischemia/reperfusion

      Leila Dehina, Jacques Descotes, Philippe Chevalier, Bernard Bui-Xuan, Caroline Romestaing, Nicole Dizerens, Zahida Mamou and Quadiri Timour

      Article first published online: 22 APR 2013 | DOI: 10.1111/fcp.12033

    4. Emulsified isoflurane protects rat heart in situ after regional ischemia and reperfusion

      Zhao-Yang Hu, Xia-Ying Peng, Fei Liu and Jin Liu

      Article first published online: 21 APR 2013 | DOI: 10.1111/fcp.12030

    5. Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats

      Manish Manohar Aglawe, Brijesh Gulabrao Taksande, Sharvari Shambabu Kuldhariya, Chandrabhan Tukaram Chopde, Milind Janrao Umekar and Nandkishor Ramdas Kotagale

      Article first published online: 18 APR 2013 | DOI: 10.1111/fcp.12034

    6. AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1

      Nicolas Vignier, Philippe Le Corvoisier, Charlotte Blard, Lucien Sambin, Feriel Azibani, Saskia Schlossarek, Claude Delcayre, Lucie Carrier, Luc Hittinger and Jin Bo Su

      Article first published online: 18 APR 2013 | DOI: 10.1111/fcp.12031

    7. Antisecretory effect of prescribed appetite stimulator drug cyproheptadine in rat intestine

      Bouchra Meddah, Nicolas Limas-Nzouzi, Godefroy Mamadou, Joe Miantezila, Imar Djibrine Soudy and Bruno Eto

      Article first published online: 9 APR 2013 | DOI: 10.1111/fcp.12029

    8. Interactions between angiotensin AT1 receptor antagonists and second-generation antiepileptic drugs in the test of maximal electroshock

      Krzysztof Łukawski, Agnieszka Janowska, Tomasz Jakubus and Stanisław J. Czuczwar

      Article first published online: 28 MAR 2013 | DOI: 10.1111/fcp.12023

    9. Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice

      Alper Kilicaslan, Muaz Belviranli, Nilsel Okudan and Esra Nurullahoglu Atalik

      Article first published online: 28 MAR 2013 | DOI: 10.1111/fcp.12027

    10. OPPIDUM surveillance program: 20 years of information on drug abuse in France

      Elisabeth Frauger, Christophe Moracchini, Reynald Le Boisselier, David Braunstein, Xavier Thirion and Joëlle Micallef, The French CEIP-A network

      Article first published online: 20 MAR 2013 | DOI: 10.1111/fcp.12024

    11. Effect of simvastatin on the antihypertensive activity of losartan in hypertensive hypercholesterolemic animals and patients: Role of nitric oxide, oxidative stress, and high-sensitivity C-reactive protein

      Ahmed O. Abdel-Zaher, Alaa Eldin A. Elkoussi, Lotfy H. Abudahab, Mohammed H. Elbakry and Elsayed Abu-Elwafa Elsayed

      Article first published online: 13 MAR 2013 | DOI: 10.1111/fcp.12020

    12. The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels

      Denise A.G. Tonelli, Marcela Pereira, Isadora P. Siba, Bruno J. Martynhak, Diego Correia, Plínio C. Casarotto, Caroline Biojone, Francisco S. Guimarães, Samia L.R. Joca and Roberto Andreatini

      Article first published online: 25 FEB 2013 | DOI: 10.1111/fcp.12022

  2. Review Articles

    1. Low-temperature plasmas at atmospheric pressure: toward new pharmaceutical treatments in medicine

      Mohammed Yousfi, Nofel Merbahi, Atul Pathak and Olivier Eichwald

      Article first published online: 25 FEB 2013 | DOI: 10.1111/fcp.12018

  3. Original Articles

    1. Investigation of drug–drug interactions between clopidogrel and fluoxetine

      Xavier Delavenne, Marion Magnin, Thierry Basset, Michele Piot, Nora Mallouk, Denis Ressnikoff, Arnauld Garcin, Silvy Laporte, Pierre Garnier and Patrick Mismetti

      Article first published online: 17 FEB 2013 | DOI: 10.1111/fcp.12021

    2. Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock

      Na Chen, Dianfeng Liu, Lanan Wassy Soromou, Jingjing Sun, Weiting Zhong, Weixiao Guo, Meixia Huo, Hongyu Li, Shuang Guan, Zhenwen Chen and Haihua Feng

      Article first published online: 17 FEB 2013 | DOI: 10.1111/fcp.12019

    3. Quantitative evaluation of the combination between cytotoxic drug and efflux transporter inhibitors based on a tumour growth inhibition model

      Alexandre Sostelly, Léa Payen, Jérôme Guitton, Attilio Di Pietro, Pierre Falson, Mylène Honorat, Ahcène Boumendjel, Annabelle Gèze, Gilles Freyer and Michel Tod

      Article first published online: 6 FEB 2013 | DOI: 10.1111/fcp.12005

    4. Exogenous NAD+ supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway

      Ling Liu, Ping Wang, Xinwei Liu, Dongwei He, Canxin Liang and Ying Yu

      Article first published online: 6 FEB 2013 | DOI: 10.1111/fcp.12016

    5. Rimantadine and 2-adamantanamine elicit local anesthesia to cutaneous nociceptive stimuli in a rat model

      Ching-Hsia Hung, Chin-Chen Chu, Yu-Chung Chen, Yu-Wen Chen and Jhi-Joung Wang

      Article first published online: 12 DEC 2012 | DOI: 10.1111/fcp.12012

    6. Pharmacological blockade of TRPV1 receptors modulates the effects of 6-OHDA on motor and cognitive functions in a rat model of Parkinson's disease

      Moazamehosadat Razavinasab, Ali Shamsizadeh, Mohammad Shabani, Masoud Nazeri, Mohammad Allahtavakoli, Majid Asadi-Shekaari, Saeed Esmaeli-Mahani and Vahid Sheibani

      Article first published online: 5 DEC 2012 | DOI: 10.1111/fcp.12015

    7. Drug interactions between antihypertensive drugs and non-steroidal anti-inflammatory agents: a descriptive study using the French Pharmacovigilance database

      Jean-Pascal Fournier, Agnès Sommet, Geneviève Durrieu, Jean-Christophe Poutrain, Maryse Lapeyre-Mestre and Jean-Louis Montastruc, the French Network of Regional Pharmacovigilance Centres

      Article first published online: 28 NOV 2012 | DOI: 10.1111/fcp.12014

    8. Retinoic acid improves recovery after nephrectomy and decreases renal TGF-β1 expression. Gender-related effects

      Dealmy Delgadillo, Olivier Barbier, Gerardo Sierra and Jose L. Reyes

      Article first published online: 28 NOV 2012 | DOI: 10.1111/fcp.12013

  4. Short Communications

    1. Effect of fluoxetine and pergolide on expression of nucleoside transporters and nucleic-related enzymes in mouse brain

      Katsuhito Nagai and Hiroki Konishi

      Article first published online: 7 NOV 2012 | DOI: 10.1111/fcp.12011

  5. Original Articles

    1. The effects of dexketoprofen on duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block with levobupivacaine

      Inci Kara, Seza Apiliogullari, Sengal Bagcı Taylan, Hulagu Bariskaner and Jale Bengi Celik

      Article first published online: 5 NOV 2012 | DOI: 10.1111/fcp.12010

    2. Therapeutic drug monitoring of imatinib in chronic myeloid leukemia: experience from 1216 patients at a centralized laboratory

      Stéphane Bouchet, Karine Titier, Nicholas Moore, Régis Lassalle, Basmah Ambrosino, Sylvie Poulette, Peter Schuld, Coralie Belanger, François-Xavier Mahon and Mathieu Molimard

      Article first published online: 31 OCT 2012 | DOI: 10.1111/fcp.12007

    3. Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery

      Ranjan Dohil, Betty L. Cabrera, Jon A. Gangoiti, Bruce A. Barshop and Patrice Rioux

      Article first published online: 31 OCT 2012 | DOI: 10.1111/fcp.12009

    4. Simvastatin induces osteogenic differentiation in human amniotic fluid mesenchymal stem cells (AFMSC)

      Felipe de Lara Janz, Giovani Marino Favero, Milton Sérgio Bohatch Jr, Adrianade Aguiar Debes and Sergio Paulo Bydlowski

      Article first published online: 24 OCT 2012 | DOI: 10.1111/fcp.12006

    5. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain

      Amit D. Kandhare, Pinaki Ghosh, Arvindkumar E. Ghule and Subhash L. Bodhankar

      Article first published online: 12 OCT 2012 | DOI: 10.1111/fcp.12003

    6. Oxidative capacities of cardiac and skeletal muscles of heart transplant recipients: mitochondrial effects of cyclosporin-A and its vehicle Cremophor-EL

      Benoit Banga N'Guessan, Hervé Sanchez, Joffrey Zoll, Florence Ribera, Stéphane Dufour, Eliane Lampert, Michel Kindo, Bernard Geny, Renée Ventura-Clapier and Bertrand Mettauer

      Article first published online: 9 OCT 2012 | DOI: 10.1111/fcp.12002

    7. Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation

      Giuseppe Derosa, Pietro Dario Ragonesi, Elena Fogari, Arrigo Francesco Giuseppe Cicero, Lucio Bianchi, Aldo Bonaventura, Davide Romano and Pamela Maffioli

      Article first published online: 8 OCT 2012 | DOI: 10.1111/fcp.12001

    8. The involvement of KATP channels in morphine-induced antinociception and hepatic oxidative stress in acute and inflammatory pain in rats

      Elham A. Afify, Mohamed M. Khedr, Amal G. Omar and Suzanne A. Nasser

      Article first published online: 3 OCT 2012 | DOI: 10.1111/fcp.12004

    9. Auto-amplification of cortisol actions in human carotid atheroma is linked to arterial remodeling and stroke

      Hanène Ayari, Liliana Legedz, Pierre Lantelme, Patrick Feugier, Jacques Randon, Catherine Cerutti, Olivier Lohez, Jean-Yves Scoazec, Jacques Yuan Li, Jouda Gharbi-Chihi and Giampiero Bricca

      Article first published online: 2 OCT 2012 | DOI: 10.1111/j.1472-8206.2012.01064.x

    10. Atorvastatin preconditioning improves the forward blood flow in the no-reflow rats

      Liang Shao, Yong Zhang, Aiqun Ma, Ping Zhang, Dayin Wu, Wenzhu Li, Jue Wang, Kun Liu and Zhaohui Wang

      Article first published online: 18 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01074.x

    11. Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels

      Sharlene Lopes Pereira, Arthur Eugen Kummerle, Carlos Alberto Manssour Fraga, Eliezer Jesus Barreiro, Roberto Takashi Sudo and Gisele Zapata-Sudo

      Article first published online: 7 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01076.x

    12. Pharmacokinetics and hematotoxicity of a novel copper-based anticancer agent: Casiopeina III-Ea, after a single intravenous dose in rats

      Guadalupe Vértiz, Luis Enrique García-Ortuño, Juan Pablo Bernal, María Elena Bravo-Gómez, Elena Lounejeva, Amada Huerta and Lena Ruiz-Azuara

      Article first published online: 7 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01075.x

    13. Holothuria grisea agglutinin (HGA): the first invertebrate lectin with anti-inflammatory effects

      Raniere da M. Moura, Karoline S. Aragão, Arthur A. de Melo, Rômulo F. Carneiro, César B. H. Osório, Patricia B. Luz, Alexandre F. S. de Queiroz, Elizeu A. dos Santos, Nylane M. N. de Alencar and Benildo S. Cavada

      Article first published online: 3 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01073.x

    14. Comparison of two doses of ketoprofen to treat pain: a double-blind, randomized, noninferiority trial

      Bruno Riou, Patrick Plaisance, François Lecomte, Louis Soulat, Philippe Orcel and Jean-Xavier Mazoit

      Article first published online: 3 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01072.x

    15. Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys

      Marjan Ajami, Sayed Hossein Davoodi, Rouhollah Habibey, Nasim Namazi, Mansoureh Soleimani and Hamidreza Pazoki-Toroudi

      Article first published online: 3 SEP 2012 | DOI: 10.1111/j.1472-8206.2012.01066.x

    16. Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice

      Rafael A. S. Rangel, Bruno G. Marinho, Patrícia D. Fernandes, Roberto S. de Moura and Marcos A. Lessa

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01068.x

    17. The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways

      Ali A. Alshatwi, E. Ramesh, V.S. Periasamy and P. Subash-Babu

      Article first published online: 23 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01061.x

    18. The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2

      Elodie Jouan, Marc Le Vee, Claire Denizot, Georges Da Violante and Olivier Fardel

      Article first published online: 23 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01071.x

    19. Involvement of monoaminergic system in the antidepressant-like effect of riparin I from Aniba riparia (Nees) Mez (Lauraceae) in mice

      Francisca Cléa Florenço de Sousa, Iris Cristina Maia Oliveira, Maria Izabel Gomes Silva, Carla Thiciane Vasconcelos de Melo, Vívian Romero Santiago, Raquell de Castro Chaves, Mariana Lima Fernandes, Stanley Juan Chaves Gutierrez, Silvânia Maria Mendes Vasconcelos, Danielle Silveira Macêdo and José Maria Barbosa Filho

      Article first published online: 23 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01069.x

    20. Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats

      Yuk-Man Leung, Chin-Chen Chu, Chang-Shin Kuo, Yu-Wen Chen, Ching-Hsia Hung and Jhi-Joung Wang

      Article first published online: 14 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01070.x

    21. Inhibition of G1 cell cycle arrest in human gingival fibroblasts exposed to phenytoin

      Reiri Takeuchi, Hiroko Matsumoto, Yoshiaki Akimoto and Akira Fujii

      Article first published online: 14 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01065.x

    22. A template model for studying anticancer drug efflux transporter inhibitors in vitro

      Alexandre Sostelly, Léa Payen, Jérôme Guitton, Attilio Di Pietro, Pierre Falson, Mylène Honorat, Glaucio Valdameri, Annabelle Geze, Ahcène Boumendjel, Gilles Freyer and Michel Tod

      Article first published online: 8 AUG 2012 | DOI: 10.1111/j.1472-8206.2012.01054.x

    23. Clinical pharmacology of single- and multiple-ascending doses of ACT-178882, a new direct renin inhibitor, and its pharmacokinetic interaction with food and midazolam

      Jasper Dingemanse, Laurent Nicolas and Christoph Binkert

      Article first published online: 31 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01060.x

    24. Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study

      Danijela Gnjidic, David G. Le Couteur, Sarah N. Hilmer, Robert G. Cumming, Fiona M. Blyth, Vasi Naganathan, Louise Waite, David J. Handelsman and Bell J.S.

      Article first published online: 31 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01063.x

  6. Case Reports

    1. VFEND® (voriconazole)-associated hypoglycaemia without identified drug interaction

      Marion Lyoen, Florian Rostain, Aurélie Grimault, Anne Minello and Catherine Sgro

      Article first published online: 27 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01062.x

  7. Original Articles

    1. Antidepressant-like effect of bis-eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system

      Jeferson Falcão do Amaral, Maria Izabel Gomes Silva, Manuel Rufino de Aquino Neto, Brinell Arcanjo Moura, Alyne Mara Rodrigues de Carvalho, Patrícia Freire Vasconcelos, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Silvânia Maria Mendes Vasconcelos, Danielle Silveira Macêdo and Francisca Cléa Florenço de Sousa

      Article first published online: 25 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01058.x

    2. Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study

      Nelly Agrinier, Nathalie Thilly, Jean-Marc Boivin, Brigitte Dousset, François Alla and Faiez Zannad

      Article first published online: 13 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01053.x

    3. Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo

      Samir Attoub, Olivier Sperandio, Haider Raza, Kholoud Arafat, Suhail Al-Salam, Mahmood Ahmed Al Sultan, Maha Al Safi, Takashi Takahashi and Abdu Adem

      Article first published online: 13 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01056.x

  8. Short Communications

    1. Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47phox subunit in monocytes from type 2 diabetes patients

      Guillaume Vaquer, Richard Magous, Gérard Cros, Anne Wojtusciszyn, Eric Renard, Hughes Chevassus, Pierre Petit, Anne-Dominique Lajoix and Catherine Oiry

      Article first published online: 10 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01057.x

  9. Original Articles

    1. Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-α) pathways

      Wladmir Dal Bó, Ana Paula Luiz, Daniel F. Martins, Leidiane Mazzardo-Martins and Adair R.S. Santos

      Article first published online: 8 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01052.x

    2. Modulation of bone turnover in orchidectomized rats treated with raloxifene and risedronate

      Naglaa F. Khedr, Nahla E. El-Ashmawy, Hoda A. El-Bahrawy, Ali A. Haggag and Eman E. El-Abd

      Article first published online: 4 JUL 2012 | DOI: 10.1111/j.1472-8206.2012.01047.x

    3. N-methyl-D-aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE)

      Christopher Bolton, Elizabeth G. Wood and Samir S. Ayoub

      Article first published online: 29 JUN 2012 | DOI: 10.1111/j.1472-8206.2012.01050.x

    4. Daphnetin prevents chronic unpredictable stress-induced cognitive deficits

      Min-Jing Liao, Lian-Feng Lin, Xing Zhou, Xiao-Wen Zhou, Xiao Xu, Xin Cheng, Qin Gao and Huan-Min Luo

      Article first published online: 21 JUN 2012 | DOI: 10.1111/j.1472-8206.2012.01049.x

    5. Comparative study between atorvastatin and losartan on high fat diet-induced type 2 diabetes mellitus in rats

      Ahmed A. Mourad, Gehan H. Heeba, Ashraf Taye and Mohamed A. El-Moselhy

      Article first published online: 19 JUN 2012 | DOI: 10.1111/j.1472-8206.2012.01048.x

    6. Involvement of α2-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice

      Shaifali Bhalla, Shridhar V. Andurkar and Anil Gulati

      Article first published online: 11 JUN 2012 | DOI: 10.1111/j.1472-8206.2012.01046.x

    7. Wnt-4 potently inhibits capillary outgrowth from rat aorta in 3D culture

      Bernard Jover, Daphné Girardot, Françoise de Courtois Roy de Vacquières, Daniel Casellas and Jean-Pierre Molès

      Article first published online: 21 MAY 2012 | DOI: 10.1111/j.1472-8206.2012.01044.x

    8. Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice

      Mao Horio, Yuko Fujita and Kenji Hashimoto

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1472-8206.2012.01045.x

    9. Dimethylsulfoxide potentiates the nerve conduction–blocking effect of lidocaine without augmentation of the intracellular lidocaine concentration in the giant axon of crayfish in vitro

      Takeshi Yano, Shoichiro Ibusuki, Mayumi Takasaki and Isao Tsuneyoshi

      Article first published online: 12 APR 2012 | DOI: 10.1111/j.1472-8206.2012.01043.x

    10. Inhibitory effects of sigma-1 ligands on handling-induced tachycardia in conscious tethered rats

      Annie Delaunois, Pierrette De Ron, Eric Detrait and Michel Guyaux

      Article first published online: 5 APR 2012 | DOI: 10.1111/j.1472-8206.2012.01042.x

    11. Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters

      Geisson Marcos Nardi, Angela Cristina Bet, Regina Sordi, Daniel Fernandes and Jamil Assreuy

      Article first published online: 5 APR 2012 | DOI: 10.1111/j.1472-8206.2012.01041.x

    12. Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress

      Ritu Chhillar and Dinesh Dhingra

      Article first published online: 28 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01040.x

    13. Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation

      Céline Chu, Marie-Sophie Noël-Hudson, Valérie Boige, Diane Goéré, Sylvie Marion, Mélanie Polrot, Ludovic Bigot, Patrick Gonin, Robert Farinotti and Laurence Bonhomme-Faivre

      Article first published online: 28 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01035.x

    14. Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes

      Hari Babu Lingaiah, Nandakumar Natarajan, Rengarajan Thamaraiselvan, Perumal Srinivasan and Balasubramanian Maruthaiveeran Periyasamy

      Article first published online: 21 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01039.x

    15. Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice

      Marianne Haddad, Virginie Beray-Berthat, Bérard Coqueran, Michel Plotkine, Catherine Marchand-Leroux and Isabelle Margaill

      Article first published online: 21 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01036.x

    16. The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats

      Fei Xu, Bingxi Zhang and Tianzuo Li

      Article first published online: 21 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01034.x

    17. Anticonvulsive effect of atorvastatin on pentylenetetrazole-induced seizures in mice: the role of nitric oxide pathway

      Kasra Moazzami, Sahra Emamzadeh-Fard and Mohammad Shabani

      Article first published online: 19 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01038.x

    18. Remodeling of ventricular repolarization in a chronic doxorubicin cardiotoxicity rat model

      Sergey Kharin, Valeria Krandycheva, Alena Tsvetkova, Marina Strelkova and Dmitry Shmakov

      Article first published online: 19 MAR 2012 | DOI: 10.1111/j.1472-8206.2012.01037.x

    19. Mitochondrial basis of the anti-arrhythmic action of lidocaine and modulation by the n-6 to n-3 PUFA ratio of cardiac phospholipids

      Luc Demaison, Daniel Moreau, Fabienne Clauw, Catherine Vergely and Luc Rochette

      Article first published online: 24 FEB 2012 | DOI: 10.1111/j.1472-8206.2012.01031.x

    20. Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice

      Walter Mendes de Oliveira Júnior, Rubens Batista Benedito, Wendel Batista Pereira, Paula de Arruda Torres, Carlos Alberto Fernandes Ramos, Jéssica Pereira Costa, Adriana da Rocha Tomé, Damião Pergentino de Sousa, Rivelilson Mendes de Freitas, Margareth de Fatima Formiga Melo Diniz and Reinaldo Nóbrega de Almeida

      Article first published online: 20 FEB 2012 | DOI: 10.1111/j.1472-8206.2012.01030.x

    21. Beneficial effects of beta-blockers on left ventricular function and cellular energy reserve in patients with heart failure

      Roberto Spoladore, Gabriele Fragasso, Gianluca Perseghin, Francesco De Cobelli, Antonio Esposito, Francesco Maranta, Giliola Calori, Massimo Locatelli, Guido Lattuada, Paola Scifo, Alessandro Del Maschio and Alberto Margonato

      Article first published online: 9 FEB 2012 | DOI: 10.1111/j.1472-8206.2012.01029.x

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