British Journal of Pharmacology

Cover image for Vol. 173 Issue 16

Editor-in-Chief: Professor A. Ahluwalia

Impact Factor: 5.259

ISI Journal Citation Reports © Ranking: 2015: 17/253 (Pharmacology & Pharmacy)

Online ISSN: 1476-5381

Associated Title(s): British Journal of Clinical Pharmacology, Pharmacology Research & Perspectives


Editor's Choice


Editor's Choice articles are picked out as being of particular interest to British Journal of Pharmacology readers. All articles below are free to access for a period of six months after their publication on this page.

2016

July 2016 - Issue 15

Effects of target binding kinetics on in vivo drug efficacy: koff, kon and rebinding
Full Text: HTML PDF (2198k)

July 2016 - Issue 14

Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity
Full Text: HTML PDF (1950k)

July 2016 - Issue 13

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice
Full Text: HTML PDF (1461k)

June 2016 - Issue 12

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm
Full Text: HTML PDF (953k)

Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease
Full Text: HTML PDF (2847k)

June 2016 - Issue 11

New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis
Full Text: HTML PDF(1576k)

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation
Full Text: HTML PDF(516k)

May 2016 - Issue 10

Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain
Full Text: HTML PDF(672k)

Antinociceptive effects of sinomenine in a rat model of postoperative pain
Full Text: HTML PDF(463k)

May 2016 - Issue 9

Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18
Abstract | Full Text: HTML PDF (1248k)

Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo
Abstract | Full Text: HTML PDF (473k)

April 2016 - Issue 8

Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon
Abstract | Full Text: HTML PDF (395k)

Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task
Abstract | Full Text: HTML PDF (1060k)

The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release
Abstract | Full Text: HTML PDF (752k)

On the different experimental manifestations of two-state ‘induced-fit’ binding of drugs to their cellular targets
Abstract | Full Text: HTML PDF (2879k)

March 2016 - Issue 7

The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma
Abstract | Full Text: HTML PDF (623k)

March 2016 - Issue 6

Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway
Abstract | Full Text: HTML PDF (3821k)

March 2016 - Issue 5

N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor
Abstract | Full Text: HTML PDF (2098k)

February 2016 - Issue 3

Natural and synthetic flavonoid modulation of TRPC5 channels
Abstract | Full Text: HTML PDF (2120k)

Meningeal blood flow is controlled by H2S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway
Abstract | Full Text: HTML PDF (1787k)

January 2016 - Issue 1

Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity
Abstract | Full Text: HTML PDF (1606k)

2015

November 2015 - Issue 22

Hydrogen peroxide activates store-operated Ca2+ entry in coronary arteries
Abstract | Full Text: HTML PDF (1722k)

November 2015 - Issue 21

Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins
Abstract | Full Text: HTML PDF (1249k)

Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia
Abstract | Full Text: HTML PDF (2836k)

October 2015 - Issue 20

Combining citrulline with atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity.
Abstract | Full Text: HTML PDF (1475k)

α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation.
Abstract | Full Text: HTML PDF (1475k)

September 2015 - Issue 18

Activation of EP(4) receptors prevents endotoxin-induced neutrophil infiltration into the airways and enhances microvascular barrier function
Abstract | Full Text: HTML PDF (1558k)

Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB- and MAPK-ERK1/2-mediated COX-2 expression
Abstract | Full Text: HTML PDF (1010k)

September 2015 - Issue 17

Gaddum Memorial Lecture 2014: receptors as an evolving concept: from switches to biased microprocessors
Abstract | Full Text: HTML PDF (1107k)

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis
Abstract | Full Text: HTML PDF (2183k)

August 2015 - Issue 15

Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced obesity is partly mediated by an angiotensin
Abstract | Full Text: HTML PDF (1112k)

July 2015 - Issue 14

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
Abstract | Full Text: HTML PDF (2228k)

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels
Abstract | Full Text: HTML PDF (831k)

July 2015 - Issue 13

α-Galactosylceramide suppresses murine eosinophil production through interferon-γ-dependent induction of NO synthase and CD95
Abstract | Full Text: HTML PDF (1107k)

April 2015 - Issue 7

Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice
Abstract | Full Text: HTML PDF (818k)

S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms
Abstract | Full Text: HTML PDF (1972k)

March 2015 - Issue 6

Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II-induced hypertensive heart disease in rats
Abstract | Full Text: HTML PDF (1075k)

March 2015 - Issue 5

The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system
Abstract | Full Text: HTML PDF (1345k)

February 2015 - Issue 4

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
Abstract | Full Text: HTML PDF (902k)

Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study
Abstract | Full Text: HTML PDF (2680k)

February 2015 - Issue 3

Inhibition of monoacylglycerol lipase reduces nicotine withdrawal
Abstract | Full Text: HTML PDF (824k)

January 2015 - Issue 1

Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells
Abstract | Full Text: HTML PDF (2324k)


2014

December 2014 - Issue 23

Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
Abstract | Full Text: HTML PDF (1130k)

Analgesic tolerance to morphine is regulated by PPARγ
Abstract | Full Text: HTML PDF (701k)

November 2014 - Issue 22

Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice
Abstract | Full Text: HTML PDF (1103k)

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription
Abstract | Full Text: HTML PDF (2228k)

November 2014 - Issue 21

Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs
Abstract | Full Text: HTML PDF (1249k)

October 2014 - Issue 20

The behavioural response of mice lacking NK1 receptors to guanfacine resembles its clinical profile in treatment of ADHD
Abstract | Full Text: HTML PDF (798k)

October 2014 - Issue 19

Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure–activity relationship studies
Abstract | Full Text: HTML PDF (2238k)

September 2014 - Issue 18

Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10
Wakako Fujita, Ivone Gomes and Lakshmi A Devi
Abstract | Full Text: HTML PDF (970k)

Therapeutic use of botulinum toxin in migraine: mechanisms of action
Roshni Ramachand Ran and Tony L Yaksh
Abstract | Full Text: HTML PDF (923k)

Late, never or non-existent: the inaccessibility of preclinical evidence for new drugs
C A Federico, B Carlisle, J Kimmelman and D A Fergusson
Abstract | Full Text: HTML PDF (764k) | Supporting Information

September 2014 - Issue 17

Coating doxorubicin-loaded nanocapsules with alginate enhances therapeutic efficacy against Leishmania in hamsters by inducing Th1-type immune responses
S Kansal, R Tand On, A Verma, P Misra, A K Choudhary, R Verma, P R P Verma, A Dube And P R Mishra
Abstract | Full Text: HTML PDF (1343k)

August 2014 - Issue 16

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism
Linda Console-Bram, Eugen Brailoiu, Gabriela Cristina Brailoiu, Haleli Sharir And Mary E Abood
Abstract | Full Text: HTML PDF (1114k)

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants
F Cattaruzza, S Amadesi, J F Carlsson, J E Murphy, V Lyo, K Kirkwood, G S Cottrell, M Bogyo, W Knecht and N W Bunnett
Abstract | Full Text: HTML PDF (1076k)

August 2014 - Issue 15

Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion
Jie Qu, Qiong Zhou, Ying Du, Wei Zhang, Miao Bai, Zhuo Zhang, Ye Xi, Zhuyi Li and Jianting Miao
Abstract | Full Text: HTML PDF (1625k)

Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration
Hiroki Kaneko, Fuxiang Ye, Ryo Ijima, Shu Kachi, Seiichi Kato, Masatoshi Nagaya, Akiko Higuchi and Hiroko Terasaki
Abstract | Full Text: HTML PDF (1092k)

July 2014 - Issue 14

Regulation of ACh release from guinea pig bladder urothelial cells: potential role in bladder filling sensations
L M McLatchie, J S Young and C H Fry
Abstract | Full Text: HTML PDF (986k) | Supporting Information

Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium
Inês Carneiro, M Alexandrina Timóteo, Isabel Silva, Cátia Vieira, Catarina Baldaia, Fátima Ferreirinha, Miguel Silva-Ramos, and Paulo Correia-de-Sá
Abstract | Full Text: HTML PDF (3039k)

June 2014 - Issue 12

Effects of a new advanced glycation inhibitor, LR-90, on mitigating arterial stiffening and improving arterial elasticity and compliance in a diabetic rat model: aortic impedance analysis
S Satheesan, J L Figarola, T Dabbs, S Rahbar and R Ermel
Abstract | Full Text: HTML PDF (3039k)

June 2014 - Issue 11

Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway
Jung Ok Ban, Dae Hwan Kim, Hee Pom Lee, Chul Ju Hwang, Jung-Hyun Shim, Dae Joong Kim, Tae Myoung Kim, Heon-Sang Jeong, Seong Su Nah, Hanyong Chen, Zigang Dong, Young Wan Ham, Youngsoo Kim, Sang-Bae Han and Jin Tae Hong
Abstract | Full Text: HTML PDF (1912k)

May 2014 - Issue 10

Pharmacological profiling of the TRPV3 channel in recombinant and native assays
Olivera Grubisha, Adrian J Mogg, Jessica L Sorge, Laura-Jayne Ball, Helen Sanger, Cara L A Ruble, Elizabeth A Folly, Daniel Ursu and Lisa M Broad
Abstract | Full Text: HTML PDF (2881k) | Supporting Information

TThe TRPA1 channel in migraine mechanism and treatment
S Benemei, C Fusi, Gabriela Trevisan and Pierangelo Geppetti
Abstract | Full Text: HTML PDF (847k)

May 2014 - Issue 9

The contribution of VEGF signalling to fostamatinib-induced blood pressure elevation
M Skinner, K Philp, D Lengel, L Coverley, E Lamm Bergström, P Glaves, H Musgrove, H Prior, M Braddock, R Huby, J O Curwen, P Duffy and A R Harmer
Abstract | Full Text: HTML PDF (1275k) | Supporting Information

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