British Journal of Pharmacology

Cover image for Vol. 172 Issue 10

Editor-in-Chief: Professor J.C. (Ian) McGrath

Impact Factor: 4.99

ISI Journal Citation Reports © Ranking: 2013: 21/256 (Pharmacology & Pharmacy)

Online ISSN: 1476-5381

Associated Title(s): British Journal of Clinical Pharmacology, Pharmacology Research & Perspectives

Themed Issues: Call for Papers


Call for papers

Click here for Author Guidelines.

Click here to submit your paper today for one of the following Themed Issues.



Themed Issues in Progress

Inflammation: Maladies, Models, Mechanisms & Molecules
We are proud to announce a themed issue of the BJP on Inflammation: Maladies, Models, Mechanisms & Molecules.

The Editors are happy to receive and to consider for publication three types of articles:

  1. Articles containing only new and original findings.
  2. Reviews addressing key relevant areas.
  3. Articles which are a mix of original findings (presented in sufficient detail with clear methods) and review.

The Editors are seeking manuscripts that contain original data directly pertinent to the themes outlined below. A limited number of papers containing both original data and review material will be considered for inclusion. Review papers are being directly commissioned, but further proposals will be considered. Prospective authors are encouraged to contact the Editors to discuss their potential contribution.

Themed issues are an important part of the journal and their creation is multi-step process that involves hard work and commitment from many people. The following are guidelines to ensure that the process of runs smoothly and in a timely fashion. Please read this document carefully.

Aims and Scope of the Themed issue
Such a diverse topic so where to begin? Inflammation is from the Latin inflammo meaning “I ignite, set alight”. The Concise English Dictionary yields Inflammation; state of being in flame; morbid heat of a part of the body with pain, redness, and swelling; kindling of the passions. Indeed workers in this field, be their organ of focus the brain, airways or heart, or the pathological consequences of inflammatory disorders, are passionate about this topic. The signposts of inflammation were described by Celsus as pain, heat, redness, swelling to which was later added, loss of function. The Scottish surgeon, John Hunter, recognised these in his treatise on gunshot wounds in 1794, which also emphasised fever. In identifying tumours as wounds that do not heal, Dvorak established the broader reach of inflammatory processes, to the current day when these processes are seen as integral to the pathophysiology of most chronic diseases.

Inflammation from a pharmacological perspective obviously concentrates more on underlying molecular mechanisms, innovative therapeutic targets, anti-inflammatory drugs (new or “pipeline”) and their application to disease management. However, they are so many exciting challenges here for pharmacologists. One only has to think about plasma- and cell-derived mediators and their likely targets. Then, from a different perspective there are pro-inflammatory molecules from microbial pathogens or injured host cells, the PAMPS and DAMPs, respectively. Receptors – well here aficiandos can talk about the latest stunning advances in cytokine, lysophospholipid and pattern recognition receptors relevant to inflammation. The active nature of Inflammation-resolution provides yet further therapeutic opportunities.

This Themed Issue will bring together contributions from established and emerging workers in the field to provide an up to date account of how and why inflammation is such an attractive area for drug targets. The Themed Issue will provide a timely overview of this critical field and map key future directions for research relevant to pharmacology of inflammation and its relevance to tissue damage and pathophysiology.

Topics will include areas such as:

  1. Therapies already in clinical use (e.g. fingolimod, therapeutic monoclonal antibodies, novel immune-neutralisation technologies).
  2. Molecules in advanced stages of development e.g. STAT3 pathway inhibitors.
  3. Potential therapeutic approaches for treatment/prevention of inflammatory disorders.
  4. New identified targets for inflammation and its signalling pathways.
  5. Advances in pertinent receptor pharmacology (e.g. lysophospholipid and pattern recognition receptors).
  6. Target validation.
  7. New insights into polymorphisms, epigenetics, somatic mutations and inflammation.
  8. Systems biology, genomics and proteomics relevant to inflammation as a networked process.
  9. Models of inflammatory disease.

Guest Editors: Professor Alastair Stwart, Michael Spedding and Philip Beart
Submission Deadline: 15th March 2015


Updating Neuropathology and Neuropharmacology of Monoaminergic systems
Monoaminergic neurotransmitters such as dopamine, serotonin, noradrenaline or histamine play a central role in the pathophysiology of major neuropsychiatric illnesses, including anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementias. Numerous medicines targeting monoaminergic systems have been used successfully in the treatment of these brain disorders. Although most of the current monoaminergic-based medicines require adjustments due to the emergence of side effects, the efficacy of these medicines stress the strategy to act on monoaminergic systems to correct abnormal signaling of monoaminergic neurotransmitters. Neurotransmitter-binding proteins such as receptors, transporters and common metabolic enzymes are the starting points for development of new tools to diagnose and drugs to treat specific clusters of symptoms. Structure-based drug design, synthetic chemistry and pharmacological characterization will inform the choice of lead compounds to treat select subsets of brain malfunction. The new strategies of treatment would permit to correct the side-effects of some existing medicine such as L-DOPA, antipsychotic drugs, anxiolytics and antidepressant drugs. Brand new strategies of treatments or new models aimed at studying brain disorders afferent to neuropathology of monoaminergic systems needs a deep pharmacological evaluation. The purpose of this special issue is to collect relevant research and review papers covering the wide spectrum of both neuropathology and neuropharmacology of monoaminergic system.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editors: Giuseppe Di Giovanni, Rona Ramsay and Philippe De Deurwaerdère
Submission Deadline: 31st October 2015


Redox biology and oxidative stress in health and disease

Themed issue by COST Action BM1203 (EU-ROS)

Many diseases and drug-induced complications are associated with – or even caused by – an imbalance between the formation of reactive oxygen and nitrogen species (RONS) and antioxidant enzymes catalyzing the breakdown of these harmful oxidants leading to a deviation from the steady state. More recent evidence suggests that the nature and subcellular localization of these reactive species largely determines the pathogenesis of the above mentioned processes. During the last two decades, our understanding of redox biology and oxidative stress in health and disease was considerably extended. The dogma that RONS only play a detrimental role was replaced by new concepts of redox biology, based on important physiological functions of RONS in immune response and fundamental cellular processes (e.g. differentiation, proliferation, migration and apoptosis) as well as activation of endogenous protective pathways such as ischemic preconditioning. Physiological requirement for redox biological processes may be one of the reasons for the rather disappointing outcome of antioxidant therapies so far. The present themed issue is a forum for opinions of interdisciplinary experts in the field of redox biology and oxidative stress research. The contributions cover sources, pathways and targets of RONS in physiology and disease as well as the most recent developments in the development of tools for redox biology and oxidative stress research (e.g. RONS imaging, biomarker and drug development).

Andreas Daiber, Chair of the COST Action BM1203 (EU-ROS)

Fabio Di Lisa, Vice Chair of the COST Action BM1203 (EU-ROS)

Peter Ferdinandy, MC member of the COST Action BM1203 (EU-ROS)

Yves Frapart, MC member of the COST Action BM1203 (EU-ROS)

Submission deadline: This Themed Issue is now CLOSED for Submissions


Annexins VII
We invite submission of original research articles for our planned themed issue. The themed issue will include review articles (already invited) from a selection of worldwide experts.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editor: Prof. Rod Flower
Submission deadline: This Themed Issue is now CLOSED for Submissions


Epigenetics and Therapy
We invite submission of original research articles for our planned themed issue on pharmacological aspects of epigenetics. Aberrations in the epigenome have been shown to play a role in numerous disorders. As epigenetic modifications including DNA methylation, histone covalent modifications and non-coding RNA mechanisms are dynamic and reversible, they become a tool for synthetic and natural molecules to exert specific effects. Although susceptible to changes, epigenetic marks are heritable and can be transferred to next generations which adds additional layers of complexity and increases the significance of drugs modifying the epigenome. We are particularly interested in articles elaborating on epigenetic mechanisms of known and new compounds and their role in modulating the disease state.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editors: Dr Barbara Stefanska and Prof. David MacEwan
Submission deadline: This Themed Issue is now CLOSED for Submissions


5th BPS Focused Meeting on Cell Signalling
In Association with the Biochemical Society, the fifth of the BPS's popular cell signalling focused meetings will be held at the University of Leicester in 2014. This two-day conference brings together an exciting list of international speakers, talks chosen from the submitted abstracts and a dynamic poster session. This themed issue will include review articles (already invited) from a selection of worldwide experts.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editors: Dr Gary Willars
Submission deadline: This Themed Issue is now CLOSED for Submissions


Endocannabinoids: Synthesis and Function
The BPS is supporting a symposium on "Endocannabinoids: Synthesis and Function" the International Conference on the Bioscience of Lipids in Aberdeen in June 2014 - to see more details of the programme for the meeting please visit the conference website: http://www.abdn.ac.uk/events/icbl-2014/ Details of the programme can be found at  http://www.abdn.ac.uk/events/icbl-2014/documents/ICBL_Programme_V8.pdf.  The speakers will be preparing reviews and original articles for a themed issue of the BJP on the subject of endocannabinoids and the journal is therefore inviting authors to submit their original articles on research in this area

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editor: Professor Cherry Wainwright
Submission deadline: This Themed Issue is now CLOSED for Submissions


Chinese Innovation in Cardiovascular Drug Discovery
The British Journal of Pharmacology is pleased to invite submission of original research articles and review articles for a planned themed issue on Chinese innovation in cardiovascular drug discovery. Lifestyles in China have drastically changed in parallel with China’s economic boom. This has led to a greater prevalence of obesity, diabetes and hypertension, and an epidemic of cardiovascular disease (CVD). Recent epidemiological data show that one in five Chinese adults is suffering from CVD and this number is expected to double in the coming decade; approximately 3.5 million Chinese adults die of CVD annually, which accounts for 41% of total deaths, placing CVD as the leading cause of death in China. Facing this increasingly serious medical concern and economic burden, the Chinese government, academics and pharmaceutical industries are targeting funding and expertise and promoting both basic and translational research to identify and verify new drug targets, and pursue subsequent drug development. The goal of this themed issue is to highlight current progress in the identification of potential drug targets and new treatment routes in the CVD field, and provide overviews of the status of drug development in clinical trials. We cordially welcome submission of articles elaborating on cardiovascular drug discovery based in China.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editor: Dr Xin Wang, Professor Baofeng Yang and Professor Yong Ji
This themed issue is now closed for submissions.


Conditioning the heart: pathways to translation – scope for drug discovery
BJP is pleased to announce a themed issue devoted to the translational opportunities offered by heart conditioning. To paraphrase a well-known investigator in the field, writing about preconditioning some years ago, “if we could bottle it, we’d make a fortune”. However, despite several decades of research on preconditioning, postconditioning and pharmacological conditioning, we have yet to see therapeutic realization of the potential powerful effects of conditioning on infarction, mechanical dysfunction and arrhythmias associated with acute myocardial ischaemia and reperfusion. The main goal of this themed issue is not only to summarize the current state of the art but to provide a critical overview of the opportunities for this strong endogenous mechanism to get a broader translatability in the clinic. BJP invites submission of articles relevant to this topic for inclusion in the themed issue: “Conditioning the heart: pathways to translation – scope for drug discovery”.

Topics included in this issue are: Preconditioning and postconditioning signaling in the heart, Remote conditioning of the heart, anaesthetics as cardioprotectants, Protein kinase G, Adenosine receptors, p38 MAPK, Protein kinase C, mPTP and Mitochondria, hexokinase, caveolins and NO dependent pathways in cardioprotection, conditioning in diseased models and many more.

Please go here to submit your article and ensure that you mention clearly that you wish it to be considered for this themed issue.

Guest Editor: Dr Nina Hauck-Weber
Submission deadline: This Themed Issue is now CLOSED for Submissions

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