Cover image for Vol. 17 Issue 12

Edited By: Professor O. James Garden

Impact Factor: 2.675

ISI Journal Citation Reports © Ranking: 2014: 36/76 (Gastroenterology & Hepatology); 46/198 (Surgery)

Online ISSN: 1477-2574

Virtual Journal Club

HPB Virtual Journal Club

The Editors of HPB are pleased to offer an exciting new educational module to our website: HPB Virtual Journal Club. Our goal is to provide you with an easy and enjoyable method for learning about a key HPB topic. We select the key recent articles and media for you, and provide Learning Objectives around which to build your discussion. We encourage you to gather your colleagues and learn together through HPB Virtual Journal Club. Enjoy!

O. James Garden
Mark P. Callery
Saxon Connor
Stephen J Wigmore
Ewen Harrison
Rebecca Minter

List of issues

Issue 10, September 2015: “Pancreatic Anastomoses”
read online

Issue 9, May 2015: “Management Options for Benign Liver Lesions”
read online

Issue 8, February 2015: “Gallbladder Cancer"
read online

Issue 7, April 2014: “Management of Gallstones"
read online

Issue 6, October 2013: “Making Progress Against Pancreatic Cancer"
read online

Issue 5, August 2013: “Improving long term outcomes in HCC"
read online

Issue 4, June 2013: “Mucinous cystic (MCN) or intraductal papillary mucinous (IPMN) neoplasms of the pancreas and bile duct"
read online

Issue 3, May 2012: “Advances in Contemporary Liver Resection Surgery”
read online

Issue 2, August 2011, updated July 2013: “Biliary Injury: Avoidance, Diagnosis & Management”
read online

Issue 1, March 2011: “Update on Acute Pancreatitis”
read online

HPB Virtual Journal Club Number 10, September 2015

“Pancreatic Anastomoses”

Welcome to the latest VJC focusing on the technical aspects associated with the pancreatic anastomosis following pancreaticoduodenectomy.

The learning objectives are as follows:

  • To understand the morbidity associated with post-operative pancreatic fistula (POPF) and why it is important to minimise the risk of POPF.
  • To understand the type of possible pancreatic reconstructions and the outcomes associated with each.
  • To be able to interpret the literature describing various techniques by understanding the risk factors for pancreatic anastomotic failure that may alter reported outcomes.
  • To understand that Somatostatin analogues would appear to have a harmful effect.
  • To understand that the risk of POPF can be predicted early by the use of serum amylase.
  • To understand options for the pancreatic remnant when faced with reoperation.
  • To understand the key technical components of performing a Blumgart pancreaticojejunsotomy.
  1. Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the French Surgical Association
    Addeo P, Delpero JR, Paye F, Oussoultzoglou E, Fuchshuber PR, Sauvanet A, Sa Cunha A, Le Treut YP, Adham M, Mabrut JY, Chiche L, Bachellier P; French Surgical Association (AFC). HPB 2014;16(1):46-55.
  2. Isolated Roux loop pancreaticojejunostomy versus pancreaticogastrostomy after pancreaticoduodenectomy: a prospective randomized study.
    El Nakeeb A, Hamdy E, Sultan AM, Salah T, Askr W, Ezzat H, Said M, Zeied MA, Abdallah T. HPB. 2014;16(8):713-22.
  3. Pancreaticogastrostomy is associated with significantly less pancreatic fistula than pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: a meta-analysis of seven randomized controlled trials.
    Liu FB, Chen JM, Geng W, Xie SX, Zhao YJ, Yu LQ, Geng XP.HPB. 2015;17(2):123-30.
  4. Comparison of Modified Blumgart pancreaticojejunostomy and Pancreaticogastrostomy after Pancreaticoduodenectomy.
    Shyr, Y, Wang S, Chen S; Shyr B. HPB 2015 in press
  5. Prophylactic octreotide for pancreatoduodenectomy: more harm than good?
    McMillan MT, Christein JD, Callery MP, Behrman SW, Drebin JA, Kent TS, Miller BC, Lewis RS Jr, Vollmer CM Jr. HPB. 2014;16(10):954-62.
  6. Relaparotomy for a pancreatic fistula after a pancreaticoduodenectomy: a comparison of different surgical strategies.
    Balzano G1, Pecorelli N, Piemonti L, Ariotti R, Carvello M, Nano R, Braga M, Staudacher C. HPB 2014;16(1):40-5.
  7. Serum amylase on the night of surgery predicts clinically significant pancreatic fistula after pancreaticoduodenectomy..
    Lavanniya K. Palani Velu, Vishnu V. Chandrabalan, Salman Jabbar, Donald C. McMillan, Colin J. McKay, C. Ross Carter, Nigel B. Jamieson and Euan J. Dickson. HPB 2014;16(7): 610–619.
  8. Jayaraman S. How to perform a Blumgart laparoscopic pancreaticojejunostomy (Video).http://pie.med.utoronto.ca/TVASurg/TVASurg_content/surg/TP_pjBlumgart.html

HPB Virtual Journal Club Number 9, May 2015

“Management Options for Benign Liver Lesions”

General surgeons and certainly HPB specialists worldwide will frequently encounter asymptomatic and symptomatic benign liver lesions. While most can be observed with surveillance imaging and clinical exam updates, some pose a threat of progression to complications and even malignancy. We feel this topic is ripe for an update to our HPB community, especially since these lesions are more and more often managed through today’s advancing minimally-invasive surgical techniques. These recently published HPB articles provide your Journal Club the content to meet our Learning Objectives:

  • Understand the prevalence, investigation and management options for liver lesions discovered incidentally upon imaging.
  • Assess the changing management strategies available for benign liver tumors based on a large single institution experience.
  • Understand when and whether surgical resection is indicated for focal nodular hyperplasia (FNH) of the liver.
  • Understand the safe principles for observation and the roles of resection and interventional embolization in the management of liver adenoma.
  • Understand the true incidence, associated risk factors and etiology of malignant progression of hepatocellular adenomas as detailed through a systematic review of over 1600 cases.
  • Evaluate outcomes of hepatectomy when indicated for benign liver lesions.
  • Understand why minimally-invasive hepatectomy is safe and applicable in experienced hands for benign liver lesions based on Level I data.

1. Hepatic incidentaloma: the rule of tens
Jonathan B. Koea
HPB Volume 15, Issue 5, May 2013, Pages: 379 – 383.

2. Changes in the management of benign liver tumours: an analysis of 285 patients
James J. Mezhir, Lindsay T. Fourman, Richard K. Do, Brian Denton, Peter J. Allen, Michael I. D’Angelica, Ronald P. DeMatteo, Yuman Fong and William R. Jarnagin
HPB Volume 15, Issue 2, February 2013, Pages: 156 – 163.

3. Focal nodular hyperplasia: a review of current indications for and outcomes of hepatic resection
Alex P. Navarro, Dhanwant Gomez, Christopher M. Lamb, Adam Brooks and Lain C. Cameron
HPB Volume 16, Issue 6, June 2014, Pages: 503 – 511.

4. Management of hepatocellular adenoma: comparison of resection, embolization and observation
Ami M. Karkar, Laura H. Tang, Nilesh D. Kashikar, Mithat Gonen, Stephen B. Solomon, Ronald P. DeMatteo, Michael I. D’Angelica , Camilo Correa-Gallego, William R. Jarnagin, Yuman Fong, George I. Getrajdman, Peter Allen and T. Peter Kingham
HPB Volume 15, Issue 3, March 2013, Pages: 235 – 243.

5. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases
Jan H. M. B. Stoot, Robert J. S. Coelen, Mechteld C. de Jong and Cornelis H. C. Dejong
HPB Volume 12, Issue 8, October 2010, Pages: 509 – 522.

6. Outcomes of liver resection in hepatocellular adenoma and focal nodular hyperplasia
Matthanja Bieze, Olivier R. C. Busch, Pieter J. Tanis, Joanne Verheij, Saffire S. K. S. Phoa, Dirk J. Gouma and Thomas M. van Gulik
HPB Volume 16, Issue 2, February 2014, Pages: 140 – 149.

7. Short- and long-term outcomes after laparoscopic and open hepatic resection: systematic review and meta-analysis
Reza Mirnezami, Alexander H. Mirnezami, Kandiah Chandrakumaran, Mohammad Abu Hilal, Neil W. Pearce, John N. Primrose and Robert P. Sutcliffe
HPB Volume 13, Issue 5, March 2011, Pages: 295 – 308.

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HPB Virtual Journal Club Number 8, February 2015

“Gallbladder Cancer”

Welcome to HPB virtual journal club highlighting gallbladder (GB) cancer.
The learning objectives are as follows:

  • Understand risk factors for developing and GB cancer
  • Understand role of molecular markers in predicting prognosis for GB cancer
  • Understand the role of PET and a period of observation in the staging of GB cancer
  • Understand the importance of assessing the duodenum when staging GB ca
  • Understand the technical factors of GB Ca surgery including nodal dissection, whether to take the extrahepatic dile duct and how to perform an extended cholecystectomy

1. Modern perspectives on factors predisposing to the development of gallbladder cancer
Charles H. C. Pilgrim, Ryan T. Groeschl, Kathleen K. Christians and T. Clark Gamblin
HPB Volume 15, Issue 11, November 2013, Pages: 839 – 844.

2. Molecular prognostic markers in gallbladder carcinoma.
Jagannath P., Callery M.
HPB Volume 14, Issue 9, September 2012, Pages: 571 – 572.

3. Impact of pre-operative positron emission tomography in gallbladder cancer
Universe Leung, Neeta Pandit-Taskar, Carlos U. Corvera, Michael I. D'Angelica, Peter J. Allen, T Peter Kingham, Ronald P. DeMatteo, William R. Jarnagin and Yuman Fong
HPB Volume 16, Issue 11, November 2014, Pages: 1023 – 1030. Early view.

4. Incidental pT2-T3 gallbladder cancer after a cholecystectomy: outcome of staging at 3 months prior to a radical resection
Fabio Ausania, Theodoris Tsirlis, Steven A. White, Jeremy J. French, Bryon C. Jaques, Richard M. Charnley and Derek M. Manas
HPB Volume 15, Issue 8, August 2013, Pages: 633 – 637.

5. A prospective analysis of the preoperative assessment of duodenal involvement in gallbladder cancer
Raja Kalayarasan, Amit Javed, Amarender S. Puri, Sunil K. Puri, Puja Sakhuja and Anil K. Agarwal
HPB Volume 15, Issue 3, March 2013, Pages: 203 – 209.

6. Patterns of recurrence after resection of gallbladder cancer without routine extrahepatic bile duct resection
Jimme K. Wiggers, Bas Groot Koerkamp, Zachri Ovadia, Olivier R. C. Busch, Dirk J. Gouma and Thomas M. van Gulik
HPB Volume 16, Issue 7, July 2014, Pages: 635 – 640.

7. Role of routine 16b1 lymph node biopsy in the management of gallbladder cancer: an analysis
Anil K. Agarwal, Raja Kalayarasan, Amit Javed and Puja Sakhuja
HPB Volume 16, Issue 3, March 2014, Pages: 229 – 234.

8. Technical description of a regional lymphadenectomy in radical surgery for gallbladder cancer
Durgatosh Pandey
HPB Volume 14, Issue 3, March 2012, Pages: 216 – 219.

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HPB Virtual Journal Club Number 7, April 2014

“Management of Gallstones”

Welcome to another virtual journal club from HPB.
This quarter we wish to highlight recent publications in HPB addressing the management of gallstones. The learning objectives are as follows:

  • Understand risk factors such that may signal a difficult cholecystectomy may lie ahead.
  • Understand the management options and likely outcomes associated with management synchronous of Choledocholithiasis and acute cholecystectomy
  • Consider how best to approach patient with cirrhosis and symptomatic gallstones
  • Consider how the critical view should be safely established and whether the use of a checklist or photo documentation may improve successful achievement of the critical view.
  • Consider the indications and likely outcomes when using percutaneous cholecystostomy.
  • To understand decision making associated with management of Mirizzi’s syndrome.

1.Laparoscopic cholecystectomy is more difficult after a previous endoscopic retrograde cholangiography
Jan Siert Kayitsinga Reinders, Dirk Joan Gouma, Joos Heisterkamp, Ellen Tromp, Bert van Ramshorst and Djamila Boerma
HPB Volume 15, Issue 3, March 2013, Pages: 230 – 234

2. Laparoscopic or open cholecystectomy in cirrhosis: a systematic review of outcomes and meta-analysis of randomized trials
Jerome M. Laurence, Peter D. Tran, Arthur J. Richardson, Henry C. C. Pleass, and Vincent W. T. Lam
HPB Volume 14, Issue 3, March 2012, Pages: 153 – 161

3.Are we getting the critical view? A prospective study of photographic documentation during laparoscopic cholecystectomy
Tracey Lam, Val Usatoff and Steven T. F. Chan
HPB Volume 16, Issue 9, September 2014, Pages: 859 – 863

4. Predicting gangrenous cholecystitis.
Bin Wu, Thomas J. Buddensick, Hamid Ferdosi, Dusty Marie Narducci, Amanda Sautter, Lisa Setiawan, Haroon Shaukat, Mustafa Siddique, Gisela N. Sulkowski, Farin Kamangar, Gopal C. Kowdley and Steven C. Cunningham
HPB Volume 16, Issue 9, September 2014, Pages: 801 – 806

5.Clinical outcomes of a percutaneous cholecystostomy for acute cholecystitis: a multicentre analysis .
Pandanaboyana Sanjay, Devender Mittapalli, Aseel Marioud, Richard D White, Rishi Ram and Afshin Alijani
HPB Volume 15, Issue 7, July 2013, Pages: 511 – 516

6. Using a standardized method for laparoscopic cholecystectomy to create a concept operation-specific checklist.
Saxon J. Connor, William Perry, Leslie Nathanson, Thomas B. Hugh and Thomas J. Hugh
HPB Volume 16, Issue 5, May 2014, Pages: 422 – 429

7. VIDEO: Management of complicated biliary disease
S. Connor

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HPB Virtual Journal Club Number 6, October 2013

“Making Progress Against Pancreatic Cancer”

Though slow, progress is being made worldwide against pancreatic cancer. Advances in imaging, staging, resection, and palliation are being realized and are helping more and more patients. New outcome metrics are being refined to reflect and drive overall quality of care. This occurs in parallel to technical advances for pancreatectomy. While a breakthrough systemic therapy is still awaited, new and aggressive chemotherapy, radiation therapy and soon biotherapy regimens are being advanced. These recently published HPB articles together with an expert procedure video provide your Journal Club the content to meet these Learning Objectives:

  • Using a review of 66 literature articles, understand the roles of contemporary imaging modalities in the diagnosis and determination of resectability of pancreatic cancer.
  • Understand the purpose and value of pancreatic cancer clinical care guidelines, and how non-compliance and variations in care can undermine quality and patients outcomes.
  • Understand whether contemporary imaging and staging modalities of pancreatic head cancers can accurately predict the need and extent of vascular resection during open pancreaticoduodenectomy.
  • Understand the challenges and technical feasibility of major venous resection during total laparoscopic pancreaticoduodenectomy.
  • Understand the utility, options and outcomes for various operative and non-operative palliation measures for unresectable pancreatic cancer.
  • Review an expert opinion of why deliberate multimodal therapy of cancer cachexia will be essential in our next era of pancreatic cancer care.

1. Multimodality imaging of pancreatic ductal adenocarcinoma: a review of the literature
Shailesh V. Shrikhande, Savio George Barreto, Mahesh Goel, Supreeta Arya
HPB Volume 14, Issue 10, October 2012, Pages: 658 – 668

2.Failure to comply with NCCN guidelines for the management of pancreatic cancer compromises outcomes
Brendan C. Visser, Yifei Ma, Yulia Zak, George A. Poultsides, Jeffrey A. Norton, Kim F. Rhoads
HPB Volume 14, Issue 8, August 2012, Pages: 539 – 547

3.Highlights in this issue (August 2013)
Saxon Connor, Stephen Wigmore and Mark Callery
HPB Volume 15, Issue 8, August 2013

4.Radiologic and intraoperative detection of need for mesenteric vein resection in patients with adenocarcinoma of the head of the pancreas
Matthew R. Porembka, William G. Hawkins, David C. Linehan, Feng Gao, Changqing Ma, Elizabeth M. Brunt, Steven M. Strasberg
HPB Volume 13, Issue 9, September 2011, Pages: 633 – 642

5. Major venous resection during total laparoscopic pancreaticoduodenectomy
Michael L. Kendrick, Guido M. Sclabas
HPB Volume 13, Issue 7, July 2011, Pages: 454 – 458

6.Operative procedures for unresectable pancreatic cancer: does operative bypass decrease requirements for postoperative procedures and in-hospital days?
John M Lyons, Ami Karkar, Camilo C. Correa-Gallego, Michael I. D'Angelica, Ronald P. DeMatteo, Yuman Fong, T. Peter Kingham, William R. Jarnagin, Murray F. Brennan, Peter J. Allen
HPB Volume 14, Issue 7, July 2012, Pages: 469 – 475

7.Cachexia in pancreatic cancer: new treatment options and measures of success
Kenneth C. H. Fearon and Vickie E. Baracos
HPB Volume 12, Issue 5, June 2010, Pages: 323 – 324

8. VIDEO: Pancreatic Cancer
Michael Kendrick

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HPB Virtual Journal Club Number 5, August 2013

"Improving long term outcomes in hepatocellular carcinoma (HCC)"

Hepatocellular carcinoma is a global health problem which occurs in patients from countries with high incidence of viral hepatitis but also in patients with other kinds of liver disease.

There are many available treatment options for patients with HCC but choosing the one likely to give the best outcome and in the context of sometimes limited resource can be difficult. These recently published HPB articles provide your Journal Club the content to meet these Learning Objectives:

At the conclusion of this journal club, participants will be able to:

1. Delineate the role and success of prospective screening for patients at high risk for the development of HCC, and outline the impact of screening with respect to identification of patients with potentially curable disease.

2. Define the appropriate management strategy for patients with multiple tumors, including consideration of tumors exhibiting different behaviors.

3. Delineate how viral status impacts outcome following liver transplantation for HCC.

4. Define how treatment of underlying viral disease is advantageous if treatment can be tolerated in terms of long-term survival and likelihood of recurrence.

5. Describe the potential impact that obesity may pose for recurrence of HCC in patients undergoing liver transplant.

1Prospective screening increases the detection of potentially curable hepatocellular carcinoma: results in 8900 high-risk patients Francesco Izzo, Mauro Piccirillo, Vittorio Albino, Raffaele Palaia, Andrea Belli, Vincenza Granata, Sergio Setola, Roberta Fusco, Antonella Petrillo, Raffaele Orlando, Grazia Tosone, Fabrizio Scordino and Steven A. Curley  
2Pre-liver transplant biopsy in hepatocellular carcinoma: a potential criterion for exclusion from transplantation?
Richard S. Young, Mohammed Aldiwani, Abdul R. Hakeem, Amit Nair, Ashley Guthrie, Judy Wyatt, Darren Treanor, Gareth Morris-Stiff, Rebecca L. Jones and K. Rajendra Prasad
3Viral status at the time of liver transplantation for hepatocellular carcinoma: a modern predictor of longterm survival
Ryan T. Groeschl, Johnny C. Hong, Kathleen K. Christians, Kiran K. Turaga, Susan Tsai, Charles H. C. Pilgrim and T. Clark Gamblin
Obesity portends increased morbidity and earlier recurrence following liver transplantation for hepatocellular carcinoma
Abhishek Mathur, Edson S. Franco, John P. Leone, Hussein Osman-Mohamed, Haydy Rojas, Nyingi Kemmer, Guy W. Neff, Alexander S. Rosemurgy and Angel E. Alsina
5 Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma
Junichi Shindoh, Kiyoshi Hasegawa, Yosuke Inoue, Takeaki Ishizawa, Rihito Nagata, Taku Aoki, Yoshihiro Sakamoto, Yasuhiko Sugawara, Masatoshi Makuuchi and Norihiro Kokudo

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HPB Virtual Journal Club Number 4, June 2013

“Mucinous cystic (MCN) or intraductal papillary mucinous (IPMN) neoplasms of the pancreas and bile duct”

Patients presenting with either MCN or IPMN of the pancreas have become a common scenario for most HPB surgeons. The investigation, diagnosis and management remain topical issues in this ever changing field. More recently a similar entity within the bile duct has been recognized. A selection of the best articles published in HPB on these topics over the last year are included for your review.

The learning objectives are as follows:

1. Understand enucleation is a viable alternative to standard resection for side branch IPMN of the pancreas

2. Understand the risk of future disease in the pancreatic remnant in those patients who have undergone segmental resection for IPMN of the pancreas.

3. Understand that a selective approach to resection of asymptomatic cystic lesions of the pancreas can be safely adopted

4. Understand the differences in molecular profiling and pathological features between IPMN of the bile duct as compared to the pancreas

5. Update your knowledge with regard to clinical presentation and radiological findings and management of biliary mucinous cystic neoplasms and understand how they differ from biliary and pancreatic IPMN

1 Side-branch intraductal papillary mucinous neoplasms of the pancreatic head/uncinate: resection or enucleation?
Turrini O, Schmidt CM, Pitt HA, Guiramand J, Aguilar-Saavedra JR, Aboudi S, Lillemoe KD, Delpero JR.
HPB 2011; 13:126-31
2 Outcome of the pancreatic remnant following segmental pancreatectomy for non-invasive intraductal papillary mucinous neoplasm.
Miller JR, Meyer JE, Waters JA, Al-Haddad M, Dewitt J, Sherman S, Lillemoe KD, Schmidt CM.
HPB 2011; 13: 759-66
3 Natural history of asymptomatic pancreatic cystic neoplasms
Gareth Morris-Stiff, Gavin A. Falk, Sricharan Chalikonda, R. Matthew Walsh
HPB 2012;
GNAS codon 201 mutations are uncommon in intraductal papillary neoplasms of the bile duct.
Matthaei H, Wu J, Dal Molin M, Debeljak M, Lingohr P, Katabi N, Klimstra DS, Adsay NV, Eshleman JR, Schulick RD, Kinzler KW, Vogelstein B, Hruban RH, Maitra A.
HPB 2012; 14: 677-83
5A  Invasive biliary mucinous cystic neoplasm: a review.
Simo KA, Mckillop IH, Ahrens WA, Martinie JB, Iannitti DA, Sindram D.
HPB 2012; 14: 725-40

The management of hepatobiliary cystadenomas: lessons learned.
Martel, G., Alsharif, J., Aubin, J.-M., Marginean, C., Mimeault, R., Fairfull-Smith, R. J., Mohammad, W. M. and Balaa, F. K

HPB 2012

6VIDEO: Laparoscopic pancreatoduodenectomy for large-sized IPMN
Hiroki Sunagawa

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HPB Virtual Journal Club Number 3, May 2012

“Advances in Contemporary Liver Resection Surgery”

As morbidity and mortality rates continue to fall worldwide for liver resection surgery, new outcome metrics are being refined to reflect overall quality better. This occurs in parallel to technical advances for hepatectomy. As a result, the indications for liver resection broaden, and this is especially true for the management of colorectal cancer liver metastases. These recently published HPB articles together with expert procedure videos provide your Journal Club the content to meet these Learning Objectives:

  • Understand why mortality data following liver resection is most meaningful and accurate using 90-day mortality rates.
  • Understand how a pre-operative validated nomogram can predict the risk of peri-operative mortality after liver resection for cancer.
  • Understand today’s newest definition for post-hepatectomy hemorrhage as standardized by a collaborative international study group.
  • Understand how new technology can enable surgeons to limit intra-operative blood loss and improve outcomes for hepatectomy.
  • Review short- and long-term outcomes achieved by experts utilizing extended left hepatectomy for colorectal cancer liver metastases.
  • Review outcomes achieved by experts utilizing repeat hepatectomy for recurrent colorectal cancer liver metastases.
  • Understand how FDG-PET/CT can optimize pre-operative staging and guide management decisions for patients with colorectal cancer liver metastases.

1 Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterion
Skye C. Mayo, Andrew D. Shore, Hari Nathan, Barish H. Edil, Kenzo Hirose, Robert A. Anders, Christopher L. Wolfgang, Richard D. Schulick, Michael A. Choti and Timothy M. Pawlik
HPB 2011; 13: 473-482.
2 External validation of a pre-operative nomogram predicting peri-operative mortality risk after liver resections for malignancy
Mashaal Dhir, Srinevas K. Reddy, Lynette M. Smith, Fred Ullrich, James Wallis Marsh, Allan Tsung, David A. Geller and Chandrakanth Are
HPB 2011; 13: 817-822.
3 Post-hepatectomy haemorrhage: a definition and grading by the International Study Group of Liver Surgery (ISGLS)
Nuh N. Rahbari, O. James Garden, Robert Padbury, Guy Maddern, Moritz Koch, Thomas J. Hugh, Sheung Tat Fan, Yuji Nimura, Joan Figueras, Jean-Nicolas Vauthey, Myrddin Rees, Rene Adam, Ronald P. DeMatteo, Paul Greig, Val Usatoff, Simon Banting, Masato Nagino, Lorenzo Capussotti, Yukihiro Yokoyama, Mark Brooke-Smith, Michael Crawford, Christopher Christophi, Masatoshi Makuuchi, Markus W. Büchler and Jürgen Weitz
HPB 2011; 13: 528-535.
Modification of right hepatectomy results in improvement outcome: a retrospective comparative study
Jeff Siu-Wang Wong, Kit-Fai Lee, Yue-Sun Cheung, Ching-Ning Chong, John Wong and Paul Bo-San Lai
HPB 2011; 13: 431-437.
Short- and long-term results of extended left hepatectomy for colorectal metastases
Dennis A. Wicherts, Robbert J. de Haas, Paola Andreani, Arie Ariche, Chady Salloum, Gérard Pascal, Denis Castaing, René Adam and Daniel Azoulay
HPB 2011; 13: 536-543.
6 Repeat hepatectomy for recurrent colorectal liver metastases is associated with a high survival rate
Andreas Andreou, Antoine Brouquet, Eddie K. Abdalla, Thomas A. Aloia, Steven A. Curley and Jean-Nicolas Vauthey
HPB 2011; 13: 774-782.
7 The role of 18FDG PET/CT in the management of colorectal liver metastases
Alec H. Engledow, James R.A. Skipworth, Farrokh Pakzad, Charles Imber, Peter J. Ell and Ashley M. Groves
HPB 2012; 14: 20-25.
8VIDEO: IVC Techniques in Liver Resection
Peter Lodge, Rajendra Prasad and Giles Toogood
9VIDEO: The Extraglissonian Approach
Professor Joan Figueras Felip

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HPB Virtual Journal Club Number 2. Updated July 2013

“Biliary Injury: Avoidance, Diagnosis & Management”

Biliary Injury is the most severe complication of laparoscopic cholecystectomy. It causes lasting morbidity, can be fatal, increases health care costs, and often results in litigation. These recently published HPB articles together with an expert video provide your Journal Club the content to meet these Learning Objectives:

  • Understand the significance of biliary injury on patients long term quality of life
  • Understand that fundus first cholecystectomy should be avoided when faced with a hostile gallbladder.
  • Compare two papers that reach different conclusions regarding the timing of repair of biliary injury.
  • Review an expert video to learn four technical maneuvers that can help you avoid biliary injury during Cholecystectomy.
  • Understand the role and outcomes of hepatectomy or liver transplant following biliary injury.

1 The long-term effect of bile duct injuries on health-related quality of life: a meta-analysis.
Landman MP, Feurer ID, Moore DE, Zaydfudim V, Pinson CW.
HPB (2013); 15(4):252-9
2 Primary versus delayed repair for bile duct injuries sustained during cholecystectomy: results of a survey of the Association Francaise de Chirurgie.
Iannelli A, Paineau J, Hamy A, Schneck AS, Schaaf C, Gugenheim J.
HPB (2012);
3 Laparoscopic bile duct injuries: timing of surgical repair does not influence success rate. A multivariate analysis of factors influencing surgical outcomes
Lygia Stewart, Lawrence W. Way
HPB 2009; 11: 516-522.
VIDEO: Prevention of Bile Duct Injuries
Saxon Connor
''Extreme' vasculobiliary injuries: association with fundus-down cholecystectomy in severely inflamed gallbladders.
Strasberg SM, Gouma DJ.
HPB 2012; 14(1):1-8
6 Hepatic resection for post-cholecystectomy bile duct injuries: a literature review
Stéphanie Truant, Emmanuel Boleslawski, Gilles Lebuffe, Géraldine Sergent, François-René Pruvot
HPB 2010; 12: 334-341.
7 Experience using liver transplantation for the treatment of severe bile duct injuries over 20 years in Argentina: results from a National Survey. Ardiles V, McCormack L, Quiñonez E, Goldaracena N, Mattera J, Pekolj J, Ciardullo M, de Santibañes E.
HPB (2011); 13(8):544-50

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HPB Virtual Journal Club Number 1, March 2011

“Update on Acute Pancreatitis”

Acute pancreatitis is a common disease worldwide which causes significant morbidity and mortality and strains the resources of all healthcare systems. We have both evidence-based treatment guidelines and new minimally-invasive treatment approaches to consider. These recently published HPB articles together with an expert procedure video provide your Journal Club the content to meet these Learning Objectives:

  • Understand the recent incidence of acute pancreatitis and what might contribute to the best treatment outcomes.
  • Understand the patterns of individual and cumulative organ dysfunction in fatal pancreatitis.
  • Understand how well evidence-based treatment guidelines for pancreatitis are actually being followed.
  • Understand the incidence of and risk factors for post-ERCP pancreatitis.
  • Review today’s techniques and outcomes for minimally invasive pancreatic necrosectomy. A comprehensive literature review and expert educational video are provided.
  • Understand how minimally invasive pancreatic necrosectomy compares economically to the conventional open approach.

1 National hospital volume in acute pancreatitis: analysis of the Nationwide Inpatient Sample 1998–2006
Anand Singla, Nicholas G. Csikesz, Jessica P. Simons, You Fu Li, Sing Chau Ng, Jennifer F. Tseng and Shimul A. Shah
HPB 2009; 11: 391-397.
2 Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records
Damian J. Mole, Bayanne Olabi, Victoria Robinson, O. James Garden and Rowan W. Parks
HPB 2009; 11: 166-170.
3 Surgical management of acute pancreatitis in Italy: lessons from a prospective multicentre study
Paolo De Rai, Alessandro Zerbi, Laura Castoldi, Claudio Bassi, Luca Frulloni, Generoso Uomo, Armando Gabbrielli, Raffaele Pezzilli, Giorgio Cavallini and Valerio Di Carlo, the ProInf-AISP (Progetto Informatizzato Pancreatite Acuta, Associazione Italiana per lo Studio del Pancreas [Computerized Project on Acute Pancreatitis, Italian Association for the Study of the Pancreas]) Study Group
HPB 2010; 12: 597-604.
Risk of pancreatitis after endoscopic retrograde cholangiopancreatography and endoscopic biliary drainage
Hiroyuki Matsubayashi, Akira Fukutomi, Hideyuki Kanemoto, Atsuyuki Maeda, Kazuya Matsunaga, Katsuhiko Uesaka, Yosuke Otake, Noriaki Hasuike, Yuichiro Yamaguchi, Hisatomo Ikehara, Kohei Takizawa, Kentaroh Yamazaki and Hiroyuki Ono
HPB 2009; 11: 222-228.
Current status of minimally invasive necrosectomy for post-inflammatory pancreatic necrosis
Benoy Idicula Babu and Ajith Kumar Siriwardena
HPB 2009; 11: 222-228.
6VIDEO: Performing pancreatic necrosectomy via a minimally invasive approach
Saxon Connor
7 A comparison of the hospital costs of open vs. minimally invasive surgical management of necrotizing pancreatitis
Edwin Beenen, Lisa Brown and Saxon Connor
 HPB 2011; 13: 178-184.

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