Sleep and Biological Rhythms

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Sleep substances, sleep architecture, and sleep sociology: Centennial anniversary of the first discovery of sleep substances by Kuniomi Ishimori
Yoshihiro URADE

A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia
Isa OKAJIMA, Yoko KOMADA , et al.

Humoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D₂ and related substances
Osamu HAYAISHI

Adenosine as a sleep factor
Tarja PORKKA-HEISKANEN and Anna V KALINCHUK

Narcolepsy, orexins and respiratory regulation
Fang HAN

The ATP–cytokine–adenosine hypothesis: How the brain translates past activity into sleep
Parijat SENGUPTA, Sandip ROY, et al.

Interaction between sleep mechanisms and orexin neurons
Junko HARA and Takeshi SAKURAI

Overview of sleep and sleep medicine in Asian countries
Yoan CHERASSE

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Sleep substances, sleep architecture, and sleep sociology - Centennial anniversary of the first discovery of sleep substances

At the beginning of the 20th century, Kuniomi Ishimori of Japan and Henri Piéron of France independently found that a dog will fall asleep after receiving an intracerebral injection of a brain extract or cerebrospinal fluid from another dog kept without sleep for a long time, and predicted the presence of “sleep substances” that accumulated in the brain while the animal was awake. On 24–27 October 2009, the Japanese Society of Sleep Research (JSSR) celebrated the centennial anniversary of Kuniomi Ishimori's landmark paper, “Sleep-inducing substance(s) demonstrated in the brain parenchyma of sleep-deprived animals – a true cause of sleep”, at a joint congress in the City of Osaka. Sleep professionals from around the world participated in the joint congress, and have kindly contributed their summaries of recent developments in sleep science to this special issue of Sleep and Biological Rhythms. Read more.