Wound Repair and Regeneration

Cover image for Vol. 24 Issue 6

Edited By: Jeffrey M. Davidson, Ph.D.

Impact Factor: 2.628

ISI Journal Citation Reports © Ranking: 2015: 12/61 (Dermatology); 50/200 (Surgery); 56/124 (Medicine Research & Experimental); 110/187 (Cell Biology)

Online ISSN: 1524-475X

Author Guidelines

Wound Repair and Regeneration: The International Journal of Tissue Repair and Regeneration is the official publication of the Wound Healing Society, the European Tissue Repair Society, the Japanese Society for Wound Healing, and the Australian Wound Management Association. This Journal publishes original scientific and/or clinical papers on the broadly defined topics of wound healing and tissue regeneration. Articles that significantly advance the knowledge of processes involved with wound healing and regeneration in all tissues and organisms, or that provide new insights into clinical therapies will be given highest priority. Manuscripts that describe product evaluations will be considered but will receive lower priority. The Journal also welcomes articles that provide the reader with a thorough understanding of a specific methodology or technique pertinent to wound healing and regeneration studies. These articles will be subjected to the same peer review as regular research articles.

Questions about submissions can be directed to: wrr_edoffice@wiley.com

Authors for whom English is a second language should have their manuscripts professionally edited by a native English speaker before submission. Wiley Editing Services is one resource for English-language editing. More information can be found at:http://wileyeditingservices.com/en/. All services are paid for and arranged by the author, and use of this service does not guarantee acceptance or preference for publication.


Short Submissions

Biomedical Hypothesis should present an untested original hypothesis backed up solely by a survey of previously published results rather than any new evidence. Hypotheses should not be reviews and should not contain new data. They should be short articles (abstract of 150 words, body of the paper should be 500-1500 words, 2 figures or tables, 10-15 references) outlining significant progress in thinking that would also be testable, though not so easily testable that readers will wonder why the testing has not already been done.

Brief Communication may report original data or discuss published articles (abstract of 150 words or less, body of the paper should not exceed 1,500 words, 2 figures or tables, and 15 references). Brief Communications that contain original data will be fully peer-reviewed. In published form they should not to exceed 3 printed journal pages.

Letter to the Editor is usually written in response to a recent published article in the journal (Letters should not have an abstract; body of the letter should not exceed 1,000 words, 2 figures or tables, and 10 references). The Editor will normally solicit a response from the authors of the cited article. All Letters to the Editor are subject to editing and possible abridgment.

Case Report and Case Series. This journal does not review or publish this type of submission. Case studies should be submitted to a wound care journal.

Commentary. This type of submission is by invitation only.

Editorial. This type of submission is by invitation only.

Supplement. This type of submission is by invitation only.

Full Papers:

Original Research Article can be in 1 of 4 subcategories: Clinical Science, Basic Science, Regeneration Science or Young Investigator Award, that focuses on original, unpublished data generated by the submitting authors that is relevant to wound healing, tissue repair and regeneration, with the exceptions of hard tissues such as bone and cartilage, highly specialized tissues such as nerve, or other topics that are deemed by the editors to be outside the scope of interest of a general wound healing readership (abstract should not exceed 300 words, the body of the text should not exceed 21 manuscript pages, tables and figures should be limited to those needed to provide the most concise display of experimental design, compiled results and conceptual interpretations; in total not to exceed 8, and references should not exceed 40).

Clinical Science Articles cover human clinical trials, meta-analyses and other work relevant to investigation of evidence-based, advanced wound treatment and care. Clinical trials should be registered in clinicaltrials.gov or comparable public database, and the appropriate citation included in the article.

Basic Science Articles focus on new paradigms for advancing the basic understanding of wounds and healing, development of novel interventions and analyses, and other research involving in vitro, in vivo or in silico (mathematical) models. Analytical studies of human material beyond the realm of clinical care may also be considered as Basic rather than Clinical Research.

Regeneration Science deals with the unique restoration of tissues and organs beyond the normal capabilities of post-natal healing. It involves the regrowth of lost or destroyed organ components to their original pre-wounded structure and function.

Young Investigator Award Article. If the lead author has been recognized as a Young Investigator finalist at the annual meeting of the European Tissue Repair Society or the Wound Healing Society, and this paper is a report based on your presentation at the meeting, this option should be used. The cover letter must include documentation of this award.

Perspective Article [Invited Submissions Only]is a concise, contemporary review of a timely and relevant topic in the field of wound healing, tissue repair or regeneration, focusing on citations within the past 5 to 8 years (the body should not exceed 30 manuscript pages, should have not more than 6 total figures and tables, and should have a sufficient, but not excessive number of references ideally not to exceed 150). At least one of the article figures should provide a lucid, graphic depiction of critical concepts contained within the article, potentially suitable as cover art. Color charges will be waived for this illustration. Note: authors should submit an initial proposal and article outline via email to the editorial office prior to submission. Unsolicited Perspective articles will be returned.

Technical Article describes a novel or re-worked methodology relevant to the study of wounds and wound healing. It is shorter than an original research paper (the body should not exceed 12 manuscript pages, figures and tables should be limited to those that are essential, but should not exceed 6 in total and should not exceed 30 references).

Submission of Manuscript

The Journal requires submission of manuscripts using our online manuscript processing system WRR-Manuscript Central ™. This system may be accessed at http://mc.manuscriptcentral.com/wrr. Authors MUST suggest the names of three reviewers for the manuscript, ONE OF WHICH MUST BE AN EDITORIAL BOARD MEMBER. However, selection of the referees will be determined by the Editor. Authors are also encouraged to indicate individuals they feel should NOT be considered as reviewers.

The Journal requires that for each submission, the submitting author provides written assurance that the paper has not been previously published and that no other submission or publication will be made. Abstracts of oral or poster presentations are not considered to constitute prior publication. Copyright to all papers is vested in the Wound Healing Society.  Manuscripts purporting to contain original material will be considered for publication with the understanding that neither the article nor any of its essentials, including tables and figures, has been or will be published or submitted for publication elsewhere before appearing in this Journal. When submitting a paper, the submitting author should always make a full statement to the editor-in-chief about all submissions and previous reports that might be regarded as redundant, duplicate or overlapping significantly with the presently submitted paper to WRR. The submitting author should also alert the Editor-in-Chief if the research in the current submission to WRR includes subjects about which a previous report has been published. Any such research should be referred to and referenced in the WRR paper. The Editor-in-chief will assess the information provided by the submitting author and subsequently may request copies of such previously published, in-press, or submitted (to another journal) papers before further review is permitted. It is the responsibility of the submitting author to disclose to the Editor any significant financial interests they may have in products mentioned in their manuscript. This information will be deemed confidential and will only be disclosed to manuscript reviewers if, in the opinion of the Editor, the information is directly pertinent for an informed review.

General Instructions
Manuscripts must be submitted for review through the WRR website at http://mc.manuscriptcentral.com/wrr. Step-by-step instructions for formatting and uploading manuscripts are available on the opening screen of the site. Save your text and tables as Word or RTF (rich text format) files. Figures should be submitted in TIFF (min 300dpi resolution), EPS (vector graphics), PDF (with fonts embedded), PPT/PPTX, DOC/DOCX, or AI format. Type the manuscript using a 12-point font size, set text margins at 1inch from edge, number your manuscript pages beginning with the title page, and double-space all elements of the paper, organized in the following order:
1. Cover Letter with Assurances
2. Title Page
3. Abstract
4. Introduction
5. Materials and Methods
6. Results
7. Discussion
8. Acknowledgments
9. Footnotes
10. References
11. Tables
12. Figure Captions

*Upload Figures and any supplementary files separately

Cover letter with Assurances
This letter from the submitting author must provide written assurance that the paper has not been previously published and that no other submission or publication of the original work has been or will be made. Abstracts or oral or poster presentation are not considered to constitute prior publication. The submitting author must further assure that every author listed meets the qualifications for authorship (see below) and has had the opportunity to read and comment upon the submitted manuscript.  

Title page
The title page should include (a) the title of the article, which should be concise but informative; (b) first name, middle initial, and last name of each author, with highest academic degree(s) and institutional affiliation; (c) name of department(s) and institution(s) to which the work should be attributed; (d) name, address, telephone number, fax number, and email address of corresponding author; (e) name and address and email address of the author to whom requests for reprints should be addressed, (f) short running title, and (g) key words.

All persons designated as authors must qualify for authorship according to guidelines established by the International Committee of Medical Journal Editors (http://www.icmje.org/). Each author should have participated sufficiently in the work to take public responsibility for the content. Participation solely in the acquisition of funding or the collection of data does not justify authorship.  General supervision of the research group is also not sufficient for authorship.

The second page should contain an abstract of not more than 300 words. The abstract should state the purpose of the investigation, basic procedures, main findings (BE SPECIFIC), and the principal conclusion. Emphasize new or unique aspects of the investigation.  Abbreviations should not be used in the abstract. Generally, the abstract should be a single paragraph and should NOT be structured into separate sections with headings.

The text of the manuscript should be divided into the following sections with headings: Introduction, Methods, Results, Discussion, Acknowledgments;Longer articles may be further divided with appropriate subheadings. For original research papers, the body of the text including title page should not exceed 21 pages, and the number of references should be limited to 40 or fewer.  Tables and figures should be used to support all reported results, but should not be redundant and should be limited to those necessary for data presentation and interpretation.  For perspective articles, the manuscript length and number of references may be greater, and will be determined by the Editor.

State the purpose of the article; for original research, the statement of a hypothesis to be tested is appropriate. Summarize the rationale for the study, giving only pertinent references, and do not review the subject extensively.  Do not include data or conclusions in this section from the work to be reported.

Materials and Methods
Identify the methods, apparatus (include manufacturer's name, city and state or country in parentheses), and procedures in sufficient detail to allow other workers to reproduce the results. Give references for established methods; provide references and brief descriptions for methods that have been published but are not well known; and describe in greater detail new or substantially modified methods (if deemed necessary, a diagram or flow chart may be used for complex procedures). Identify precisely all drugs and chemicals used, including generic name(s), dose(s), and route(s) of administration.

Ethical Considerations
Human Investigations: Manuscripts reporting data obtained from research conducted in human subjects must comply with the ethical rules for human experimentation that are stated in the 1975 Declaration of Helsinki, including approval by the institutional review board - or human experimentation committee. Authors must disclose this compliance within the Materials and Methods section.

Animal Investigations
Study protocols must be in compliance with the institution's guidelines or the National Research Council's criteria for humane care as outlined in the 'Guide for the Care and Use of Laboratory Animals' prepared by the Institute of Laboratory Animal Resources and published by the National Institutes of Health (NIH Publication No. 86-23, Revised 1985, http://books.nap.edu/catalog/5140.html). Researchers from countries other than the US are encouraged to consider guidelines of the Association for Assessment and Accreditation of Laboratory Animal Care, international (http://www.aaalac.org/index.cfm) and to recommend membership in this organization to their institutions. A statement of assurance of the humane treatment of research animals must be provided within the Materials and Methods section.

Statistical methods must be described in sufficient detail to enable a knowledgeable reader with access to the original data to verify the reported results. Whenever possible, quantify findings and present them with appropriate indicators of measurement error or uncertainty. Statistical probability (p) should be reported in tables, figures, and figure legends at only one of the following levels: p

The narrative of the text should take the reader through a logical progression of data consideration and interpretation. Present results in a logical sequence in the text, tables, and illustrations.  DO NOT repeat in the text all the data in the tables or illustrations; emphasize or summarize only important observations. 

Significant Figures: Quantitative data should be expressed in accordance with the precision of the measurement technique reflected by the use of an appropriate number of significant figures, which is dependent on the standard deviation. In general, the standard deviation is expressed with 1 or 2 significant figures and the associated value should agree in place with the expressed standard deviation. For example, 10.3798 ± 0.2573 should be expressed as 10.4 ± 0.3 or 10.4 (0.3) and 357.521 ± 15.36 should be expressed as 358 ± 15 or 358 (15), where the second value is the standard deviation.

Emphasize the new and important aspects of the study and the conclusions that follow from them. DO NOT repeat in detail data or other material given in the Introduction or Results sections. Include in the Discussion section the implications of the findings and their limitations, including implications for future research. It is appropriate to briefly discuss how the results fit into (or deviate from) the larger body of published work on the topic. Link the conclusions with the goals of the study, and avoid unqualified statements and conclusions not supported by the data. State the hypotheses when warranted but clearly label them as such.

This section should contain one or more statements that specify (a) contributions that need acknowledgment but do not justify authorship; (b) acknowledgment of technical help; (c) acknowledgments of financial material support (specify the nature of the support); (d) financial relationships that may pose a conflict of interest.

Source of funding: Identify all internal and external sources of financial support for the work.

Pursuant to US National Institutes of Health (NIH) mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see www.wiley.com/go/nihmandate.

For other funding agencies with similar open-access requirements, indicate the source of funding and notify the editorial office of this requirement in a statement on the Title page of the submitted manuscript.

Conflict of Interest disclosure statement: Include a statement disclosing any potential financial conflicts of interest (or none) for all of the authors.

List of Abbreviations and Other Footnotes
All nonstandard abbreviations should be grouped in alphabetical order into one footnote, with all footnotes placed on a separate page of the manuscript following the acknowledgments. Footnotes in the text should be denoted with a superscript Arabic numeral.

Number references consecutively in the order in which they are mentioned in the text. Identify references in text, tables, and figure legends by superscript numerals. References cited only in tables or figure legends should be numbered last. Use the style of the following examples, which are based with slight modification on the formats set forth in 'Uniform Requirements for Manuscripts Submitted to Biomedical Journals,' (http://www.nlm.nih.gov/bsd/uniform_requirements.html). The titles of journals should be abbreviated according to the style used in the list of Journals Indexed for MEDLINE, as found in PubMed, posted by the US National Library of Medicine.

List all authors and/or editors up to 7; if more than 7, list the first 6 followed by “et al.” Include the first and last page of each reference.
'Unpublished observations' and 'personal communications' may not be used as references but should be inserted in parentheses in the text.
Include among the references papers accepted but not yet published; designate the journal and add 'In press.' Examples of correct reference styles are given below:

Articles in Journals

Standard Journal Article - List all authors:
Whitby DJ, Ferguson MW. Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991;147:207-15.

Organization as Author:
The Royal Marsden Hospital Bone-Marrow Transplantation Team. Failure of syngeneic bone-marrow graft without preconditioning in post-hepatitis marrow aplasia. Lancet 1977;2:742-4.

No Author Given:
Coffee drinking and cancer of the pancreas [editorial]. BMJ 1981;283:628.

Volume with Supplement:
Magni F, Rossoni G, Berti F. BN-52021 protects guinea pig from heart anaphylaxis. Pharmacol Res Commun 1988;20 (5 Suppl):75-8.

Issue with Supplement:
Gardos G, Cole JO, Haskell D, Marby D, Paine SS, Moore P.  The natural history of tardive dyskinesia. J Clin Psychopharamacol 1988;8(4 Suppl):31S-37S.

Issue with Part:
Reif S, Terranova VP, EL-Bendary M, Lebenthal E, Petell JK. Modulation of extracellular matrix proteins in rat liver during development. Hepatology 1990;12(3 pt 1):519-25.

Article Containing Comment:
Piccoli A, Bossatti A. Early steroid therapy in IgA neuropathy: still an open question [comment]. Nephron 1989;51:289-91. Comment on Nephron 1989;48:12-7.

Article Comment On:
Kobayashi Y, Fuji K, Hiki Y, Tateno S, Kurokawa A, Kamiyama M. Steroid therapy in IgA nephropathy: a retrospective study in heavy proteinuric cases [see comments]. Nephron 1989;51:289-91.

Books and Other Monographs

Personal Author(s):
Majno GA. The heading hand: man and wound in the ancient world. Cambridge: Harvard Univ Press, 1975.

Chapters in a Book:
Philips C, Wenstrup RJ. Biosynthetic and genetic disorders of collagen. In: Cohen IK, Diegelmann RF, Lindblad WJ, editors. Wound healing: biochemical and clinical aspects. Philadelphia: Saunders, 1992:152-77.

Conference Proceedings:
Harely NH. Comparing radon daughter dosimetric and risk models. In: Gammage RB, Kaye SV, editors. Indoor air and human health. Proceedings of the Seventh Life Sciences Symposium; 1984 Oct 19-31; Knoxville (TN) Chelsea (MI): Lewis 1985;6-78.

Unpublished Material:
In press (use only if accepted in book or journal format)
McMahon SB, Monroe JG.  Role of primary response genes in generating cellular responses to growth factors. FASEB J. In press.

Type each table double-spaced on a separate page. DO NOT submit tables as photographs or digital images (pdf files). Number tables consecutively using Arabic numerals in the order of their first citation in the text and supply a brief title for each.  Place explanatory matter in footnotes, not in the heading. Explain in footnotes all nonstandard abbreviations that are used in each table. DO NOT use internal horizontal and vertical rules. The use of too many tables in relation to the length of the text can produce difficulties in the page layout. The Editor may recommend removal or modification of tables if the page layout is untenable. If the table has been published previously, written permission must be obtained and appropriate acknowledgment must be made. Large data tables may be included as supporting information and referenced in the text as being available online (the author(s) should coordinate this with the managing editor).

Figure Legends
Type figures captions double-spaced starting on a separate page following the tables, with Arabic numerals corresponding to the illustrations. Explain each symbol used in the illustration, such as arrows, and other visual aids. Scale bars should be labeled within the image, but original magnification may also be stated in the legend.

Units of Measurement
Measurements of length, height, weight, and volume must be reported in metric units or their decimal multipliers. Temperatures should be given in degrees Celsius and blood pressures in millimeters of mercury. All hematologic and clinical chemistry measurements should be reported in the metric system in terms of the International System of Units (SI).

All figures must be either professionally drawn and photographed or produced with appropriate computer graphics. All figures must be submitted electronically according to the specifications outlined below. Failure to submit images according to these specifications will result in reproductions that are small and illegible or in images that are declined. Figures should be submitted in TIFF (min 300dpi resolution), EPS (vector graphics), PDF (with fonts embedded), PPT/PPTX, DOC/DOCX, or AI format

Color photographs should be saved in CMYK at 600 dpi at 5 inches in width. Black and white photographs should be saved in greyscale at 600 dpi at 5 inches in width. New line drawings should be prepared in Microsoft Word, PowerPoint, or Illustrator without embedded images from other sources. Existing line drawings should be scanned at 1200 dpi at a minimum of 5 in in width and saved as EPS files (flow charts must not exceed 7 inches in width). All lettering should be done professionally and be of adequate size to retain clarity after reduction (final letter size in print is 1.5mm high or larger). It is understood that figures will be reproduced at a width of one column (approx. 5 inches), two columns (approx. 10 inches). All figures must be referred to specifically in the text, and numbered in order of appearance in the text. Graphs should be labeled with font size that will be legible in published format; groups or categories should be indicated within the graph whenever possible and error bars and statistical differences included where appropriate. More detailed information on the submission of electronic artwork can be found at http://authorservices.wiley.com/prep_illust.asp.

Photomicrographs should include a scale bar embedded in the image.  For multiple panels of the same magnification in one figure, only the first panel needs to have a scale bar.

If photographs of persons are used, either the subjects must not be identifiable or their pictures must be accompanied by written permission to use the photograph.

The manipulation of photographs by computer or other means may include a vast array of changes. These include addition of text or graphics, change of color, brightness, or contrast: enlargement; or other changes to image quality. Processes that destroy photographs in order to deceive an audience represent unethical manipulation. Distortion of photographs may be achieved by over or under exposure of the file at the time of photography or through computer manipulation. The WHS considers the manipulation of photographs used in presentation to patients, the media, in journals, or at scientific meetings for the purpose of deceiving the audience to be against the ethical standards of the Society.

Figures should be numbered using Arabic numerals consecutively according to the order in which they are cited in the text. If a figure has been published previously, acknowledge the original source and submit written permission from the copyright holder to reproduce the material.

Wound Repair and Regeneration will publish illustrations in color.  However, the authors are responsible for all publication costs associated with color reproduction. Color charges are $800.00 per page; there is a discounted rate of $600.00 per page for WHS, ETRS and JSWH members (to receive discount, corresponding author must be an active member of the Wound Healing Society, excluding students and trainees). Figures should not be submitted in color if authors do not wish to pay for the color cost. NOTE: If color is "informative" and information conveyed through the use of color will not translate into gray scale, the figure will require color publication in print with associated color page charges. Color figures intended for gray scale print publication should not have color descriptors in the figure legends.

Copyright Release Form
After the paper is accepted, the Corresponding Author will receive an email prompting him or her to log in to Author Services, where via the Wiley Author Licensing Service (WALS) he or she will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions: http://authorservices.wiley.com/bauthor/faqs_copyright.asp

For authors choosing OnlineOpen

Creative Commons Attribution License OAA
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit: http://www.wiley.com/go/funderstatement

Single reprints should be obtained directly from the author. A reprint order form will be sent to authors at the time of page proofs.

NIH Mandate
Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see www.wiley.com/go/nihmandate.

Author Services
Online production tracking is available for your article through Wiley-Blackwell's Author Services. Author Services enables authors to track their article -once it has been accepted- through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production so they don't need to contact the production editor to check on progress. Visit http://authorservices.wiley.com/bauthor for more details about online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

NEW: OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see:

Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website here:

Prior to acceptance there is no requirement to inform the Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.