Cover image for Vol. 58 Issue 2

Edited By: Astrid Nehlig, PhD, Michael Sperling, MD. and Gary W. Mathern, MD.

Impact Factor: 4.706

ISI Journal Citation Reports © Ranking: 2015: 25/193 (Clinical Neurology)

Online ISSN: 1528-1167

Virtual Issues

Clinical Trials Virtual Issue

Epilepsia is happy to introduce a series of “Virtual Issues” to our readers.  These Virtual Issues consist of papers that have appeared in the Journal over the past few years on a particular topic or theme. 

The present Virtual Issue, on “Clinical Trials,” offers a look at important discussions, insight from experts, and research accomplishments in this area of epilepsy research. This collection is intended to help epilepsy researchers put their own studies in perspective and provide a data base upon which new investigations can build.

The editors of Epilepsia hope that this consolidated and convenient format will be of value to you. We value your comments on this new initiative and look forward to your suggestions about topics for future Virtual Issues.

If you are looking to publish clinical trial results, please take advantage of our fast-track review process and send your papers to: http://mc.manuscriptcentral.com/epilepsia.

The articles in this virtual issue are sourced solely from the most trusted, well-respected epilepsy journal, Epilepsia. Find articles of interest to you using our quick reference menu below:


Efficacy, tolerability, and safety of rapid initiation of topiramate versus phenytoin in patients with new-onset epilepsy: A randomized double-blind clinical trial

A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures
Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo-controlled trial
Rufinamide: Clinical pharmacokinetics and concentration-response relationships in patients with epilepsy

The adverse event profile of pregabalin: A systematic review and meta-analysis of randomized controlled trials
Long-term add-on pregabalin treatment in patients with partial-onset epilepsy: Pooled analysis of open-label clinical trials
Pregabalin add-on therapy using a flexible, optimized dose schedule in refractory partial epilepsies: A double-blind, randomized, placebo-controlled, multicenter trial

Short-course of prednisolone in solitary cysticercus granuloma: A randomized, double-blind, placebo-controlled trial

Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: A double-blind, randomized, pacebo-controlled trial
A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy
Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures
Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: A randomized, double-blind, placebo-controlled, noninferiority trial

Effects of lamotrigine compared with levetiracetam on anger, hostility, and total mood in patients with partial epilepsy

Lacosamide as adjunctive therapy for partial-onset seizures: A randomized controlled trial
Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results for a randomized controlled trial

Intranasal versus intravenous lorazepam for control of acute seizures in children: A randomized open-label study

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy
A blinded, crossover study of the efficacy of the ketogenic diet

Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta-analysis
An exploratory randomized controlled trial of immediate versus delayed withdrawal of antiepileptic drugs in patients with psychogenic nonepileptic attacks (PNEAs)
Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy
Historical control monotherapy design in the treatment of epilepsy
When clinical trials make history: Demonstrating efficacy of new antiepileptic drugs as monotherapy
Epilepsy surgery, antiepileptic drug trials, and the role of evidence
Using the internet to recruit patients for epilepsy trials: Results of a New Zealand pilot study

Genetics and the SCN1A gene Virtual Issue

Epilepsia is happy to introduce a new "Virtual Issue" to our readers.

The articles in this virtual issue are sourced solely from the #1 epilepsy journal, Epilepsia and include relevant papers from experienced authors around the world. The editors of Epilepsia hope that this consolidated and convenient format will be of value to you. We value your comments on this new initiative and look forward to your suggestions about topics for future Virtual Issues.

Find articles of interest to you using our quick reference menu below

General & EducationTrauma

General Genetics Studies and Commentary

Genetic testing in the epilepsies: Report of the ILAE Genetics Commission
Ottman R, Hirose S, Jain S, Lerche H, Lopes-Cendes I, Noebels JL, Serratosa J, Zara F, Scheffer I (2010)

The Epilepsy Genetic Association Database (epiGAD): Analysis of 165 genetic association studies, 1998-2008
Tan NCK & Berkovic SF (2010)

High-density SNP screen of sodium channel genes by haplotype tagging and DNA pooling for association with idiopathic generalized epilepsy
Makoff M, Lai T, Barratt C, Valentin A, Moran N, Asherson P, Nashef L (2010)

Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies
Greenberg DA, Subaran R (2011)

SCN1A Studies

Clinical spectrum of SCN1A mutations
Gambardella A, Marini C (2009)

Sodium channel SCN1A and epilepsy: Mutations and mechanisms
Escayg A, Goldin AL (2010)

Variable epilepsy phenotypes associated with a familial intragenic deletion of the SCN1A gene
Guerrini R, Cellini E, Mei D, Metitieri T, Petrelli C, Pucatti D, Marini C, Zamponi N (2010)

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs
Thompson CH, Kahlig KM, George AL Jr (2011)

SCN1A duplications and deletions detected in Dravet syndrome: Implications for molecular diagnosis
Marini C, Scheffer IE, Nabbout R, Mei D, Cox K, Dibbens LM, McMahon JM, Iona X, Carpintero RS, Elia M, Cilio MR, Specchio N, Giordano L, Striano P, Gennaro E, Cross JH, Kivity S, Neufeld MY, Afawi Z, Andermann E, Keene D, Dulac O, Zara F, Berkovic SF, Guerrini R, Mulley JC (2009)

The genetics of Dravet syndrome
Marini C, Scheffer IE, Nabbout R, Suls A, De Jonghe P, Zara F, Guerrini R (2011)

Adults with a history of possible Dravet syndrome: An illustration of the importance of analysis of the SCN1A gene
Verbeek NE, van Kempen M, Gunning WB, Renier WO, Westland B, Lindhout D, Brilstra EH (2011)

Insights into pathophysiology and therapy from a mouse model of Dravet syndrome
Oakley JC, Kalume F, Catterall WA (2011)

Balanced translocation in a patient with severe myoclonic epilepsy of infancy disrupts the sodium channel gene SCN1A
Møller RS, Schneider LM, Hansen CP, Bugge M, Ullmann R, Tommerup N, Tümer Z (2008)

Seven novel SCN1A mutations in Chinese patients with severe myoclonic epilepsy of infancy
Sun H, Zhang Y, Liang J, Liu X, Ma X, Qin J, Qi Y, Wu X (2008)

Microchromosomal deletions involving SCN1A and adjacent genes in severe myoclonic epilepsy in infancy
Wang JW, Kurahashi H, Ishii A, Kojima T, Ohfu M, Inoue T, Ogawa A, Yasumoto S, Oguni H, Kure S, Fujii T, Ito M, Okuno T, Shirasaka Y, Natsume J, Hasegawa A, Konagaya A, Kaneko S, Hirose S (2008)

Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation
Hindocha N, Nashef L, Elmslie F, Birch R, Zuberi S, Al-Chalabi A, Crotti L, Schwartz PJ, Makoff A (2008)

Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+?
Sijben AEJ, Sithinamsuwan P, Radhakrishnan A, Badawy RAB, Dibbens L, Mazarib A, Lev D, Lerman-Sagie T, Straussberg R, Berkovic SF, Scheffer IE (2009)

Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy
Zhang C, Wong V, Ng PW, Lui CHT, Sin NC, Wong KS, Baum L, Kwan P (2010)