Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 9

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277

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  1. 1 - 44
  1. Original Articles

    1. Exploration of Core Symptoms for the Diagnosis of Alcohol Dependence in the ICD-10

      Atsushi Yoshimura, Yasunobu Komoto and Susumu Higuchi

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13225

    2. Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice

      Emily L. Newman, Georgia Gunner, Polly Huynh, Darrel Gachette, Stephen J. Moss, Trevor G. Smart, Uwe Rudolph, Joseph F. DeBold and Klaus A. Miczek

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13215

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      Alcohol dependence is associated with single-nucleotide polymorphisms in GABRA2, the gene encoding the GABAA receptor α2-subunit. Gabra2 point-mutated mice consumed alcohol in drinking-in-the-dark, continuous, or intermittent access to alcohol protocols. Compared to wild-types, α2(H101R) mice with benzodiazepine-insensitive α2-containing receptors (HR) escalated their binge-like intake and α2(Q241M) mutants with allopregnanolone- and THDOC-insensitive α2-containing receptors reduced their chronic drinking (QM). These findings suggest distinctive roles for select amino acids in the Gabra2 mouse gene in binge-like and chronic alcohol intake.

    3. Effects of Ethanol on Cellular Composition and Network Excitability of Human Pluripotent Stem Cell-Derived Neurons

      Zoe H. Larsen, Praveen Chander, Jason A. Joyner, Crina M. Floruta, Tess L. Demeter and Jason P. Weick

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13218

  2. Commentary

  3. Original Articles

    1. FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence

      Primavera A. Spagnolo, Vijay A. Ramchandani, Melanie L. Schwandt, Laura E. Kwako, David T. George, Leah M. Mayo, Cecilia J. Hillard and Markus Heilig

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13210

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      In patients with PTSD and comorbid alcohol dependence, a common single nucleotide polymorphism (C385A) in the fatty acid amide hydrolase (FAAH) gene is associated with a marked increase in serum anandamide levels and with faster decline of the anxiety responses to a stressor. These findings indicate that FAAH 385A variation facilitates habituation to and extinction of chronic stress response, without influencing response to acute stress. This points to the endocannabinoid pathway as a promising target for future antistress therapeutics.

    2. Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus

      Luli R. Akinfiresoye, Clive Miranda, David M. Lovinger and Prosper N'Gouemo

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13223

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      The role of cAMP-dependent protein kinase A (PKA) signaling in the mechanisms that underlie neuronal hyperexcitability that drives alcohol withdrawal-induced seizures (AWSs) initiated in the inferior colliculus (IC) is poorly understood. We found that PKA activity and PKACα protein expression were increased in the IC and preceded the occurrence of AWSs, and inhibiting PKA activity within the IC suppressed AWSs. We conclude that altered PK activity in the IC plays a key role in the pathogenesis of AWSs.

    3. Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18

      Murali Ganesan, Larisa Y. Poluektova, Dean J. Tuma, Kusum K. Kharbanda and Natalia A. Osna

      Version of Record online: 26 SEP 2016 | DOI: 10.1111/acer.13226

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      IFNα is an important innate immunity factor, which controls HCV replication and spread via the JAK-STAT1 pathway activation. Here, we investigated the mechanisms which major ethanol metabolite, acetaldehyde, uses to enhance HCV RNA by decreasing IFNα-induced STAT1 phosphorylation in liver cells. Acetaldehyde inhibits STAT1 phosphorylation by increasing USP18 expression. This dysregulates IFNαR2-JAK1 cross-talk and destabilizes STAT1 by de-ISGylation followed by proteasome degradation of K48-polyubiquitinated STAT1. Finally, acetaldehyde weakens antiviral IFNα signaling in infected hepatocytes thereby upregulating HCV RNA levels.

  4. Commentary

  5. Original Articles

    1. Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults

      Adam J. Woods, Eric C. Porges, Vaughn E. Bryant, Talia Seider, Assawin Gongvatana, Christopher W. Kahler, Suzanne de la Monte, Peter M. Monti and Ronald A. Cohen

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13211

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      As we age, our susceptibility to negative consequences of heavy alcohol consumption for thinking, memory, and motor skills appears to increase. While there were no significant cognitive differences evident in younger adults that did and did not drink heavily, current heavy alcohol consumption in older adults was associated with significantly poorer cognitive function in learning, memory, and speeded motor function, as well as a global marker of cognition.

    2. Association of Specific Traumatic Experiences With Alcohol Initiation and Transitions to Problem Use in European American and African American Women

      Kimberly B. Werner, Carolyn E. Sartor, Vivia V. McCutcheon, Julia D. Grant, Elliot C. Nelson, Andrew C. Heath and Kathleen K. Bucholz

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13220

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      We examined the risk conferred by specific trauma exposures and PTSD for stages of alcohol involvement in European American (EA) and African American women (n = 3,787; mean age 24.5 years; 85.4% were EA). Results show that interpersonal trauma experiences are important contributors to all stages of alcohol involvement in EA women only. Findings highlight the role of trauma experiences in alcohol-related pathology and the importance of considering race when considering the link between traumatic experiences and alcohol involvement.

  6. Critical Reviews

    1. Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

      Emily C. Williams, Judith A. Hahn, Richard Saitz, Kendall Bryant, Marlene C. Lira and Jeffrey H. Samet

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13204

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      This narrative review finds that alcohol use is associated with HIV acquisition and transmission, lack of viral suppression, common comorbid conditions (e.g., hepatitis C, tuberculosis, cardiovascular disease, frailty/falls, depression, trauma, and other substance use disorders), and ultimately mortality among people living with HIV (PLWH). Associations between alcohol use and HIV-related care and outcomes may disproportionately affect vulnerable subgroups of PLWH. Interventions to address drinking and subsequently improve HIV-related risks and outcomes have been tested with limited success to date.

  7. Original Articles

    1. Immediate Neural Plasticity Involving Reaction Time in a Saccadic Eye Movement Task is Intact in Children With Fetal Alcohol Spectrum Disorder

      Angelina Paolozza, Douglas P. Munoz, Donald Brien and James N. Reynolds

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13224

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      In individuals performing eye movement tasks, the location of a previous visual target can influence performance on the next trial, representing a form of immediate neural plasticity. In this study, the previous trial effect on reaction time was not different in children with FASD, suggesting that immediate neural plasticity in response to sensory information remains intact. In contrast, the previous trial effect on amplitude suggests that the motor component of eye movements may be differentially vulnerable to prenatal alcohol exposure.

    2. Parameters of Context-Induced Ethanol (EtOH)-Seeking in Alcohol-Preferring (P) Rats: Temporal Analysis, Effects of Repeated Deprivation, and EtOH Priming Injections

      Sheketha R. Hauser, Gerald A. Deehan Jr, Christopher P. Knight, Jamie E. Toalston, William J. McBride and Zachary A. Rodd

      Version of Record online: 22 SEP 2016 | DOI: 10.1111/acer.13205

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      Alcohol craving in humans can lead to alcohol relapse. Factors influencing alcohol craving include time from last drink, the number of cycles of alcohol abuse and abstinence, and unintentional exposure to alcohol. This research examined human factors in a rodent model of alcohol craving. The data indicated that alcohol craving in rats is greatest during the 6th week of abstinence, is enhanced in rats given multiple cycles of alcohol abuse and abstinence, and that priming with alcohol increases alcohol craving. Depicts the expression of alcohol craving during 1-, 2-, 4-, 6- or 8-weeks of abstinence. Alcohol craving in rats was enhanced during 2-, 4-, 6- and 8-weeks of abstinence and the expression of alcohol craving was the greatest during the 6th week of abstinence. In addition, the expression of alcohol craving remains elevated on the 2nd test day during 4- and 6-weeks of abstinence.

    3. Interactive Effects of Ethanol and HIV-1 Proteins on Novelty-Seeking Behaviors and Addiction-Related Gene Expression

      Taylor Wingo, Tanseli Nesil, Sulie L. Chang and Ming D. Li

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13206

    4. Assays of Gamma-Glutamyl Transferase and Carbohydrate-Deficient Transferrin Combination from Maternal Serum Improve the Detection of Prenatal Alcohol Exposure

      Onni Niemelä, Solja Niemelä, Annukka Ritvanen, Mika Gissler, Aini Bloigu, Marja Vääräsmäki, Eero Kajantie, Martha M. Werler and Heljä-Marja Surcel

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13207

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      Alcohol use during pregnancy leads to detrimental fetotoxic effects. We evaluated possible biomarkers for neonatal alcohol exposure by measuring serum GGT, CDT, GGT-CDT combination, and EtG from 1936 mothers classified as follows: (i) Alcohol-abusing mothers with FAS children, (ii) Alcohol-consuming mothers with non-FAS children, (iii) Mothers with no current alcohol consumption during pregnancy and non-FAS children, and (iv) Lifelong abstainers with non-FAS children. The data suggest that GGT-CDT improves the detection of prenatal alcohol exposure and associated high-risk pregnancies.

    5. Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers

      Julie A. Kable, Claire D. Coles, Kenneth L. Jones, Lyubov Yevtushok, Yaroslav Kulikovsky, Wladimir Wertelecki, Christina D. Chambers and the CIFASD

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13221

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      Prenatal alcohol exposure (PAE) has been found to impact neurophysiological encoding of environmental events in the first year of life but has not been evaluated beyond the first year of life. Toddler's cardiac orienting responses (OR) collected during a habituation/dishabituation learning paradigm were sensitive to the effects of PAE. The magnitude of the OR was more sensitive to the impact of PAE than in previous research with younger infants, and this may be a function of brain maturation.

  8. Critical Reviews

    1. Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

      Jorge Montesinos, Silvia Alfonso-Loeches and Consuelo Guerri

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13208

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      Diagram of TLR4 and NLRP3 inflammasome receptors activation and alcohol-induced neuroinflammation. Activation of TLR4 by LPS or ethanol or HMGB1 is initiated by TLR4 recruitment into lipid rafts, stimulating several kinases pathways and downstream transcription factors which trigger cytokine/chemokine generation. TLR4-activation also promotes pro-IL1β production which, along with the presence of other stimuli (i.e., mitochondrial ROS generation), triggers NLRP3 inflammasome complex recruitment, activating caspase-1, which cleaves pro-IL1β into active IL-1β, as well as other cytokines (IL-18 and alarmins).

  9. Erratum

    1. You have free access to this content
      Erratum

      Version of Record online: 21 SEP 2016 | DOI: 10.1111/acer.13237

      This article corrects:

      Interactive and Indirect Effects of Anxiety and Negative Urgency on Alcohol-Related Problems

      Vol. 39, Issue 7, 1267–1274, Version of Record online: 29 MAY 2015

    2. You have free access to this content
      Erratum

      Version of Record online: 20 SEP 2016 | DOI: 10.1111/acer.13236

      This article corrects:
  10. Original Articles

    1. Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship

      Jeremy W. Duncan, Shakevia Johnson, Xiao Zhang, Baoying Zheng, Jia Luo, Xiao-Ming Ou, Craig A. Stockmeier and Jun Ming Wang

      Version of Record online: 20 SEP 2016 | DOI: 10.1111/acer.13209

    2. Hazardous Alcohol Use Associated with Increased Sexual Risk Behaviors Among People Who Inject Drugs

      Nadia Fairbairn, Kanna Hayashi, M-J Milloy, Seonaid Nolan, Paul Nguyen, Evan Wood and Thomas Kerr

      Version of Record online: 17 SEP 2016 | DOI: 10.1111/acer.13216

    3. The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking

      Ellen L. Burnham, Alicia McNally, Jeanette Gaydos and Lou Ann S. Brown

      Version of Record online: 14 SEP 2016 | DOI: 10.1111/acer.13201

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      Bronchoscopy with bronchoalveolar lavage (BAL) was performed in otherwise healthy, smoking-matched subjects with alcohol use disorders and controls. Thiol quantities (including glutathione and cysteine species) in the initial 50-ml aliquot of BAL were determined to parallel quantities in subsequently collected BAL aliquots (Figure), suggesting that a small volume BAL procedure may be suitable to assess pulmonary oxidative stress within the alveoli. Alcohol use disorders and cigarette smoking modestly increased upper airways oxidative stress relative to lower.

  11. Critical Reviews

    1. Alcohol Policies and Suicide: A Review of the Literature

      Ziming Xuan, Timothy S. Naimi, Mark S. Kaplan, Courtney L. Bagge, Lauren R. Few, Stephen Maisto, Richard Saitz and Robert Freeman

      Version of Record online: 12 SEP 2016 | DOI: 10.1111/acer.13203

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      The figure shows a shift of the distribution of population suicide risk to a favorable (lower) direction through better implementation of effective alcohol policies. By making alcohol less available at the population level, it is possible to reduce the average risk of suicide especially those where alcohol is involved. Consistent with the prevention paradox, this population-based approach is likely to maximize public health benefit and have a long-lasting influence on reducing suicide and related social burden.

  12. Original Articles

    1. Addressing Inconsistencies in the Social Norms Drinking Literature: Development of the Injunctive Norms Drinking and Abstaining Behaviors Questionnaire

      Samuel N. Meisel, Craig R. Colder and Jennifer P. Read

      Version of Record online: 12 SEP 2016 | DOI: 10.1111/acer.13202

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      Motivated by inconsistent associations between injunctive norms (INs) and drinking outcomes, this study developed a new measure of INs (the IN Drinking and Abstaining Behaviors Questionnaire) that addressed psychometric weaknesses of prior measures. Analysis supported a three-factor solution and the IN Drinking Behaviors factor consistently predicted drinking outcomes across three referents. Findings suggest that prior inconsistencies in the relationship between INs and drinking are attributable to poor measurement of INs and that INs are a robust correlate of drinking.

    2. Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse

      Stephen A. Maisto, Corey R. Roos, Kevin A. Hallgren, Dezarie Moskal, Adam D. Wilson and Katie Witkiewitz

      Version of Record online: 3 SEP 2016 | DOI: 10.1111/acer.13173

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      This study tested the power of seven definitions of during-treatment “relapse” based on drinking quantity within a single drinking episode to predict alcohol use and psychosocial end of treatment and 12-month post-treatment outcomes. Secondary analyses of data from Projects MATCH and COMBINE were conducted. No definition of relapse stood out as the best predictor. Advances in AUD research may require reconceptualization of relapse as a multifaceted dynamic process when examining AUD clinical course.

    3. Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients

      Vatsalya Vatsalya, Ming Song, Melanie L. Schwandt, Matthew C. Cave, Shirish S. Barve, David T. George, Vijay A. Ramchandani and Craig J. McClain

      Version of Record online: 2 SEP 2016 | DOI: 10.1111/acer.13197

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      EPA levels were significantly increased in male alcohol-dependent patients who exhibited mild liver injury; however, there was no response change in females. On the other hand, DHA levels were reduced in females who exhibited mild liver injury, while in males with mild liver injury, there was an increase in DHA levels supporting protective or anti-inflammatory response.

    4. Possible Mechanisms of Ethanol-Mediated Colorectal Carcinogenesis: The Role of Cytochrome P4502E1, Etheno-DNA Adducts, and the Anti-Apoptotic Protein Mcl-1

      Bruno Christian Koehler, Tatjana Arslic-Schmitt, Theresa Peccerella, Anna-Lena Scherr, Henning Schulze-Bergkamen, Thomas Bruckner, Georg Gdynia, Dirk Jäger, Sebastian Mueller, Helmut Bartsch and Helmut K. Seitz

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/acer.13180

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      Chronic alcohol consumption is a risk factor for colorectal cancer. In 32 colorectal biopsies from alcoholics and 12 from control patients, no significant difference between CYP2E1 levels as well as mutagenic etheno-DNA adducts was observed. Both CYP2E1 and etheno-DNA adducts correlate significantly with each other (p < 0.0001). Although apoptosis was not affected, the anti-apoptotic protein Mcl-1 was significantly increased in the alcoholic, which gives injured cells a survival benefit and may be one mechanism in alcohol-mediated colorectal carcinogenesis.

    5. Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

      Murali Ganesan, Dan Feng, Ryan W. Barton, Paul G. Thomes, Benita L. McVicker, Dean J. Tuma, Natalia A. Osna and Kusum K. Kharbanda

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/acer.13214

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      Dietary creatine supplementation did not prevent alcoholic steatosis despite its known efficacy in preventing high-fat diet-induced fat accumulation in the liver. The lower hepatocellular SAM: SAH ratio seen in the ethanol-fed rats was also not normalized or SAM levels spared when these rats were fed the creatine-supplemented ethanol diet. Betaine, a pro-methylating agent that maintains the hepatocellular SAM: SAH ratio still remains our best option for treating alcoholic steatosis.

  13. Critical Reviews

    1. Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder

      Amy W. Lasek

      Version of Record online: 1 SEP 2016 | DOI: 10.1111/acer.13200

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      Extracellular matrix (ECM) compartments in the brain. Ethanol alters the function of all three compartments. (A). Basement membrane located on the basolateral side of endothelial cells of blood vessels is part of the blood–brain barrier (B). Interstitial matrix is found between neuronal and glial cells of the brain parenchyma. Regulation of ECM is controlled by proteases such as the matrix metalloproteinases (MMPs) and affects synaptic plasticity. (C). Perineuronal nets form lattice-like structures around neurons and also regulate neuronal activity.

  14. Original Articles

    1. Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake

      Camilla Karlsson, Abdul Maruf Asif Aziz, Faazal Rehman, Caleb Pitcairn, Riccardo Barchiesi, Estelle Barbier, Mikaela Wendel Hansen, Don Gehlert, Pia Steensland, Markus Heilig and Annika Thorsell

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/acer.13181

    2. Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice

      Gunnar Sørensen, S. Barak Caine and Morgane Thomsen

      Version of Record online: 31 AUG 2016 | DOI: 10.1111/acer.13199

    3. Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice

      Qian Sun, Wenliang Zhang, Wei Zhong, Xinguo Sun and Zhanxiang Zhou

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/acer.13172

    4. Moderate Prenatal Alcohol Exposure Alters Functional Connectivity in the Adult Rat Brain

      Carlos I. Rodriguez, Suzy Davies, Vince Calhoun, Daniel D. Savage and Derek A. Hamilton

      Version of Record online: 29 AUG 2016 | DOI: 10.1111/acer.13175

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      The effects of moderate prenatal alcohol exposure (PAE) on specific brain regions, neurotransmitters, and behaviors have received considerable attention. In contrast, the effects of moderate PAE on whole-brain functional network connectivity (FNC) remain under-represented in the animal literature. Here, we report that moderate PAE contributes to persistent brain region- and sex-dependent changes in FNC in anesthetized rats. Understanding FNC changes may contribute to the development of novel approaches for understanding fetal alcohol spectrum disorders and evaluating potential treatment strategies.

    5. Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol Intake

      Sandra Sanchez-Roige, David N. Stephens and Theodora Duka

      Version of Record online: 26 AUG 2016 | DOI: 10.1111/acer.13184

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      Young adults (18–33 years old) with a family history of alcoholism exhibited a different pattern of impulsive behaviour from family history negative individuals, showing greater waiting impulsivity, but less impulsivity during decision making. Under alcohol (0.8 g/kg), they were also less able to stop an already-initiated response. Importantly, individual alcohol drinking history did not contribute to this effect. Increased waiting impulsivity may be useful in assessing premorbid risk for heavy drinking and one that may be modified by acute alcohol intake.

    6. Trends and Correlates of Disparities in Alcohol-Related Mortality Between Hispanics and Non-Hispanic Whites in the United States, 1999 to 2014

      Maria C. Mejia de Grubb, Jason L. Salemi, Sandra J. Gonzalez, Roger J. Zoorob and Robert S. Levine

      Version of Record online: 25 AUG 2016 | DOI: 10.1111/acer.13182

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      Population-based multiple cause of death data were used to describe temporal trends of alcohol-related mortality between Hispanics and NH whites in the United States. This figure, particularly the boxed inset, shows that although the gap in alcohol-related mortality between NH white and Hispanic women increased from 1999 to 2014, the same disparity among men, which was pronounced in earlier years, was eliminated by 2012. The understanding of factors associated with changing disparities may assist in tailoring prevention efforts that meet the needs of minority populations.

    7. Neighborhood-Level Drinking Norms and Alcohol Intervention Outcomes in HIV Patients Who Are Heavy Drinkers

      Jennifer C. Elliott, Erin Delker, Melanie M. Wall, Tianshu Feng, Efrat Aharonovich, Melissa Tracy, Sandro Galea, Jennifer Ahern, Aaron L. Sarvet and Deborah S. Hasin

      Version of Record online: 20 AUG 2016 | DOI: 10.1111/acer.13198

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      Using a sample of HIV-infected heavy drinkers, this study evaluated whether effects of two alcohol interventions (Motivational Interviewing [MI] alone or supplemented with an interactive technological enhancement called Healthcall) varied according to acceptability of drinking in participants’ neighborhoods. Results suggested that the efficacy of MI alone differed according to neighborhood norms, with MI alone only demonstrating effects in more permissive neighborhoods. The efficacy of MI + HealthCall did not vary by neighborhood, suggesting more robust effects of this intervention on drinking reduction.

      Intervention effects at selected levels of neighborhood unacceptability of drinking: Illustration of significant interaction between neighborhood drinking norm and intervention condition on drinks per drinking day.

    8. Hospital Admissions Before an Alcohol-Related Death Among Middle-Aged Employed Men and Women: A Cohort Study Using Routine Data

      Tapio Paljärvi, Pekka Martikainen, Jussi Vahtera, Taina Leinonen and Pia Mäkelä

      Version of Record online: 18 AUG 2016 | DOI: 10.1111/acer.13183

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      We found that the majority of the middle-aged persons who were in employment at the age of 35 and who ultimately died due to alcohol-related causes at ages 45–54 interacted with hospitals frequently and already several years before death. However, because only a relative small proportion of these persons received an alcohol-related diagnosis before death, it should be established whether procedures enhancing the recording of alcohol-related diagnoses could facilitate timely management of problem drinking at hospitals.

  15. Commentary

  16. Original Articles

    1. Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis

      Jeffrey D. Wardell, Vijay A. Ramchandani and Christian S. Hendershot

      Version of Record online: 16 AUG 2016 | DOI: 10.1111/acer.13174

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      This study examined the associations between drinking motives and subjective responses to alcohol during an intravenous alcohol session (target BAC = 80 mg%). Enhancement motives predicted greater stimulation and less sedation, whereas coping motives predicted greater sedation. Stimulation mediated the associations of enhancement motives with alcohol wanting and liking, whereas coping motives were directly associated with wanting and liking. Results suggest that drinking motives are linked with sensitivity to alcohol's subjective effects, which may underlie state motivation to consume alcohol at the event level.

    2. Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats

      Johanna Uhari-Väänänen, Atso Raasmaja, Pia Bäckström, Ville Oinio, Mikko Airavaara, Petteri Piepponen and Kalervo Kiianmaa

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/acer.13176

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      The opioidergic system has been implicated in the control of ethanol (EtOH) intake and reward. However, the exact mechanisms of opioidergic involvement remain to be elucidated. In this study, alcohol-preferring AA rats received intra-accumbal microinfusions of drugs acting on μ- and κ-opioid receptors and their effects on acute EtOH intake were monitored. The μ-opioid receptor antagonist CTOP increased and agonist DAMGO tended to decrease EtOH intake. The results suggest that accumbal μ- but not κ-opioid receptors participate in controlling EtOH intake.

  17. Erratum

    1. You have free access to this content
      Erratum

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011

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