Max Kreifeldt, Chelsea Cates-Gatto, Amanda J. Roberts and Candice Contet
Figure 4. Ethanol-induced hypothermia and chronic tolerance in BK β1- and β4-deficient mice. The hypothermic effect of ethanol (4 g/kg, i.p.) was measured in BK β1 ((A) WT, n = 7; Het, n = 8; KO, n = 5) and BK β4 ((B) WT, n = 9; Het, n = 8; KO, n = 8) mice. CIE exposure produced tolerance to hypothermia in both strains, as reflected by a smaller drop in body temperature post-CIE (black stars: two, p < 0.01; three stars, p < 0.001). There was a significant effect of genotype in BK β1 mice post-CIE 60 and 120 min postinjection, as well as in BK β4 mice prior to the injection (white stars, p < 0.05).