Alcoholism: Clinical and Experimental Research

Cover image for Vol. 41 Issue 1

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277


  1. 1 - 22
  1. Original Articles

    1. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice

      Scott A. Wegner, Katherine A. Pollard, Viktor Kharazia, David Darevsky, Luz Perez, Sanjoy Roychowdhury, Allison Xu, Dorit Ron, Laura E. Nagy and Frederic Woodward Hopf

      Version of Record online: 19 JAN 2017 | DOI: 10.1111/acer.13303

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      The present study discovered that even limited voluntary binge-like intake can damage the liver. Using different drinking models we were able to directly compare the effects of excessive versus more moderate levels of alcohol consumption. Excessive alcohol consumption produced multiple signs of liver dysfunction, including increased liver triglycerides, lipogenesis, and alcohol clearance, which were not present after moderate alcohol consumption. Importantly, our study demonstrates that even a short history of excessive drinking can result in multiple symptoms of early stage liver pathology.

  2. Commentary

  3. Critical Reviews

    1. Posttraumatic Stress Disorder and Alcohol Use Disorder: A Critical Review of Pharmacologic Treatments

      Ismene L. Petrakis and Tracy L. Simpson

      Version of Record online: 19 JAN 2017 | DOI: 10.1111/acer.13297

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      This is a critical review of the literature to date on pharmacotherapy treatments of alcohol use disorders (AUD) and posttraumatic stress disorder (PTSD). Relevant studies included those evaluating (i) treatments for PTSD, (ii) medications for AUD and (iii) medications targeting both. Most studies found that PTSD symptoms and drinking outcomes improved significantly over time. While there are some contradictory results, individuals with AUD and comorbid PTSD can safely be prescribed medications used in non-comorbid populations and patients improve with treatment.

  4. Commentary

  5. Original Articles

    1. Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats

      Ulrich Frischknecht, Derik Hermann, Nuran Tunc-Skarka, Guo-Ying Wang, Markus Sack, Julia van Eijk, Traute Demirakca, Claudia Falfan-Melgoza, Bertram Krumm, Sandra Dieter, Rainer Spanagel, Falk Kiefer, Karl F. Mann, Wolfgang H. Sommer, Gabriele Ende and Wolfgang Weber-Fahr

      Version of Record online: 18 JAN 2017 | DOI: 10.1111/acer.13308

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      Associations of higher markers of glutamatergic metabolism with lower hippocampal volumes after alcohol withdrawal were revealed by MR spectroscopy and MR imaging in alcohol dependent patients and in an animal model that was designed to parallel the patient situation. In both species, reductions in N-acetylaspartate – a marker of neuronal integrity – recovered quickly after alcohol withdrawal unless a severe withdrawal syndrome occurred. Results are discussed in light of the glutamate hypothesis of alcoholism and possible alternatives.

    2. The Effect of Reference Group Classification and Change in Alcohol Consumption on the Association Between Alcohol Consumption and Cardiovascular Disease

      Ji-Eun Park, Yeonhee Ryu and Sung-Il Cho

      Version of Record online: 18 JAN 2017 | DOI: 10.1111/acer.13299

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      The alcohol-related risk of CVD did not change substantially when lifetime abstainers or non-drinkers were used as the reference group. Although the risk associated with alcohol consumption less than 15 g/d was significantly lower than that associated with non-drinking, it was not significant when occasional drinking was included in the reference group. The alcohol-related risk of CVD was different when simple or time-dependent analysis was used. The effect of alcohol consumption may differ according to reference group and type of analysis.

  6. Critical Reviews

    1. Biomarkers for the Detection of Prenatal Alcohol Exposure: A Review

      Heidi Bager, Lars Porskjær Christensen, Steffen Husby and Lene Bjerregaard

      Version of Record online: 18 JAN 2017 | DOI: 10.1111/acer.13309

  7. Original Articles

    1. Ethanol Induces Platelet Apoptosis

      Lei Liu, Mengxing Chen, Lili Zhao, Qing Zhao, Renping Hu, Jie Zhu, Rong Yan and Kesheng Dai

      Version of Record online: 12 JAN 2017 | DOI: 10.1111/acer.13295

    2. Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol

      Vikas N. Kodali, Joseph L. Jacobson, Nadine M. Lindinger, Neil C. Dodge, Christopher D. Molteno, Ernesta M. Meintjes and Sandra W. Jacobson

      Version of Record online: 11 JAN 2017 | DOI: 10.1111/acer.13307

    3. Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study

      Kathleen K. Bucholz, Vivia V. McCutcheon, Arpana Agrawal, Danielle M. Dick, Victor M. Hesselbrock, John R. Kramer, Samuel Kuperman, John I. Nurnberger Jr, Jessica E. Salvatore, Marc A. Schuckit, Laura J. Bierut, Tatiana M. Foroud, Grace Chan, Michie Hesselbrock, Jacquelyn L. Meyers, Howard J. Edenberg and Bernice Porjesz

      Version of Record online: 10 JAN 2017 | DOI: 10.1111/acer.13293

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      Development of alcohol use disorder was decomposed into 4 stages: time to first drink, from first drink to first problem and from first drink to first AUD diagnosis, and from first problem to first diagnosis, in high-risk youth. Significant influences were consistent, with cannabis ever-use and externalizing disorders elevating the likelihood of each stage, and peer and parental AUD linked to 3 of 4 stages. The marked elevations of all AUD stages for cannabis use underscore the importance of studying this relationship.

    4. Cellular GABAergic Neuroactive Steroid (3α,5α)-3-Hydroxy-Pregnan-20-One (3α,5α-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study

      Ahmet Sait Hasirci, Antoniette M. Maldonado-Devincci, Matthew C. Beattie, Todd K. O'Buckley and A. Leslie Morrow

      Version of Record online: 9 JAN 2017 | DOI: 10.1111/acer.13300

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      The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) enhances GABAergic activity and contributes to ethanol actions. 3α,5α-THP immunohistochemistry was studied in postmortem brain of individuals diagnosed with alcohol use disorder (AUD). 3α,5α-THP immunoreactivity was increased by 23.2 ± 9% in the ventral tegmental area of AUD patients compared to age-matched controls, an effect that is likely independent of sex and liver disease. 3α,5α-THP may be dysregulated in AUD patients.

    5. The Measurement of Adolescent Alcohol Problems via Item Response Theory and Their 15-Year Prospective Associations with Alcohol and Other Psychiatric Disorders

      Michael Windle and Rebecca C. Windle

      Version of Record online: 9 JAN 2017 | DOI: 10.1111/acer.13301

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      Item-response theory modeling was used to scale a unidimensional measure of adolescent alcohol problems, including drinking and driving, and then related to alcohol and other psychiatric disorders that occurred over a 15-year period. Receiver Operating Curve analysis indicated that the diagnostic accuracy (or area under the curve) of the adolescent alcohol problems scores for an alcohol diagnosis by age 33 was 0.70.

    6. Health Risk Factors Associated with Lifetime Abstinence from Alcohol in the 1979 National Longitudinal Survey of Youth Cohort

      William C. Kerr, Camillia K. Lui, Edwina Williams, Yu Ye, Thomas K. Greenfield and E. Anne Lown

      Version of Record online: 7 JAN 2017 | DOI: 10.1111/acer.13302

    7. Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification

      Géraldine Petit, Olivier Luminet, Mariana Cordovil de Sousa Uva, Pauline Monhonval, Sophie Leclercq, Quentin Spilliaert, François Zammit, Pierre Maurage and Philippe de Timary

      Version of Record online: 6 JAN 2017 | DOI: 10.1111/acer.13292

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      Alcohol detoxification is associated with improvements of depression symptoms and craving. Clear links exist between depression and craving intensity, but are gender dependent. For men, depression is essentially present at the beginning of detoxification (BOD), where it is related to craving. For women, severe depression symptoms are present in 60% at the BOD and persist at the end of detoxification (EOD) in 23%. At the EOD, craving is related to depression symptoms in women only.

    8. Alcohol-Impaired Driving and Perceived Risks of Legal Consequences

      Frank A. Sloan, Sabrina A. McCutchan and Lindsey M. Eldred

      Version of Record online: 5 JAN 2017 | DOI: 10.1111/acer.13298

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      Legal sanctions are a common strategy to reduce DWI. However, it is unclear that sanctioning affects individual risk perceptions so as to deter alcohol-impaired driving. We found that higher probabilities as estimated by individuals of being pulled over when driving while alcohol-impaired corresponded to less alcohol-impaired driving. There was generally no statistical relationship between perceptions of criminal sanctions for DWI and alcohol-impaired driving. Subjective beliefs about penalties for alcohol-impaired driving corresponded to beliefs of law enforcement and criminal defense attorneys.

  8. Critical Reviews

    1. Inhalation of Alcohol Vapor: Measurement and Implications

      Robert Ross MacLean, Gerald W. Valentine, Peter I. Jatlow and Mehmet Sofuoglu

      Version of Record online: 5 JAN 2017 | DOI: 10.1111/acer.13291

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      Despite isolated public health concern, exposure to alcohol vapor has not been comprehensively studied. Inhaled alcohol initially bypasses first-pass metabolism and rapidly reaches the brain, potentially increasing the risk of addiction. A review of the existing literature indicates that inhalation of alcohol vapor corresponds to measurable biomarkers of acute alcohol exposure, specifically ethyl glucuronide, but not other established biomarkers of oral consumption. Notably, no studies have focused on vulnerable populations such as adolescents or individuals with alcohol use disorder.

  9. Original Articles

    1. The Age-Varying Association of Student Status with Excessive Alcohol Use: Ages 18 to 30 Years

      Rebecca J. Evans-Polce, Jennifer L. Maggs, Jeremy Staff and Stephanie T. Lanza

      Version of Record online: 30 DEC 2016 | DOI: 10.1111/acer.13294

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      This study examined, in a national sample of US adults, how the association between student status and excessive alcohol use changes from late adolescence through young adulthood and whether the association of student status with excessive alcohol use is different for students residing with versus away from parents during the school year. We found that student status does not universally confer similar risk for excessive alcohol use across the ages of 18–years or across living situations.

    2. Estrogen Receptors α and β Play Major Roles in Ethanol-Evoked Myocardial Oxidative Stress and Dysfunction in Conscious Ovariectomized Rats

      Fanrong Yao and Abdel A. Abdel-Rahman

      Version of Record online: 29 DEC 2016 | DOI: 10.1111/acer.13290

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      Estrogen-dependent myocardial dysfunction caused by ethanol has been documented in our previous studies, but the implicated estrogen receptor (ER) subtypes remain elusive. Here, we employed gain-of-function approach using selective ER agonists. The findings support major roles for ERα (PPT)-mediated increase in catalase and ERβ (DPN)-mediated reduction in ALDH2 activities in restoring ethanol-evoked myocardial oxidative stress/dysfunction in ovariectomized rats. These biochemical effects lead to enhanced myocardial ERK1/2 and eNOS phosphorylation, elevated ROS and MDA production, which ultimately lead to myocardial dysfunction

  10. Commentary

    1. Alcohol Relapse and Change Needs a Broader View than Counting Drinks

      Carlo C. DiClemente and Michele A. Crisafulli

      Version of Record online: 28 DEC 2016 | DOI: 10.1111/acer.13288

  11. Erratum

    1. You have free access to this content

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011


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