Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 8

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277

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  1. 1 - 33
  1. Original Articles

    1. Neighborhood-Level Drinking Norms and Alcohol Intervention Outcomes in HIV Patients Who Are Heavy Drinkers

      Jennifer C. Elliott, Erin Delker, Melanie M. Wall, Tianshu Feng, Efrat Aharonovich, Melissa Tracy, Sandro Galea, Jennifer Ahern, Aaron L. Sarvet and Deborah S. Hasin

      Version of Record online: 20 AUG 2016 | DOI: 10.1111/acer.13198

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      Using a sample of HIV-infected heavy drinkers, this study evaluated whether effects of two alcohol interventions (Motivational Interviewing [MI] alone or supplemented with an interactive technological enhancement called Healthcall) varied according to acceptability of drinking in participants’ neighborhoods. Results suggested that the efficacy of MI alone differed according to neighborhood norms, with MI alone only demonstrating effects in more permissive neighborhoods. The efficacy of MI + HealthCall did not vary by neighborhood, suggesting more robust effects of this intervention on drinking reduction.

      Intervention effects at selected levels of neighborhood unacceptability of drinking: Illustration of significant interaction between neighborhood drinking norm and intervention condition on drinks per drinking day.

    2. Hospital Admissions Before an Alcohol-Related Death Among Middle-Aged Employed Men and Women: A Cohort Study Using Routine Data

      Tapio Paljärvi, Pekka Martikainen, Jussi Vahtera, Taina Leinonen and Pia Mäkelä

      Version of Record online: 18 AUG 2016 | DOI: 10.1111/acer.13183

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      We found that the majority of the middle-aged persons who were in employment at the age of 35 and who ultimately died due to alcohol-related causes at ages 45–54 interacted with hospitals frequently and already several years before death. However, because only a relative small proportion of these persons received an alcohol-related diagnosis before death, it should be established whether procedures enhancing the recording of alcohol-related diagnoses could facilitate timely management of problem drinking at hospitals.

  2. Commentary

  3. Original Articles

    1. Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis

      Jeffrey D. Wardell, Vijay A. Ramchandani and Christian S. Hendershot

      Version of Record online: 16 AUG 2016 | DOI: 10.1111/acer.13174

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      This study examined the associations between drinking motives and subjective responses to alcohol during an intravenous alcohol session (target BAC = 80 mg%). Enhancement motives predicted greater stimulation and less sedation, whereas coping motives predicted greater sedation. Stimulation mediated the associations of enhancement motives with alcohol wanting and liking, whereas coping motives were directly associated with wanting and liking. Results suggest that drinking motives are linked with sensitivity to alcohol's subjective effects, which may underlie state motivation to consume alcohol at the event level.

    2. Cognitive Biases for Social Alcohol-Related Pictures and Alcohol Use in Specific Social Settings: An Event-Level Study

      Martine Groefsema, Rutger Engels, Emmanuel Kuntsche, Koen Smit and Maartje Luijten

      Version of Record online: 11 AUG 2016 | DOI: 10.1111/acer.13165

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      This study revealed approach biases in non-dependent drinkers, to both non-social and social alcohol-related pictures. These biases were not directly related to drinking in real-life settings, however cognitive biases moderated the association between the number of friends present and alcohol use. These results suggest that implicit biases exist in non-dependent drinkers, and that cognitive biases can have subtle effects on drinking in a social setting. As most observed effects were gender-situation specific, replication of these effects is warranted.

    3. Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats

      Johanna Uhari-Väänänen, Atso Raasmaja, Pia Bäckström, Ville Oinio, Mikko Airavaara, Petteri Piepponen and Kalervo Kiianmaa

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/acer.13176

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      The opioidergic system has been implicated in the control of ethanol (EtOH) intake and reward. However, the exact mechanisms of opioidergic involvement remain to be elucidated. In this study, alcohol-preferring AA rats received intra-accumbal microinfusions of drugs acting on μ- and κ-opioid receptors and their effects on acute EtOH intake were monitored. The μ-opioid receptor antagonist CTOP increased and agonist DAMGO tended to decrease EtOH intake. The results suggest that accumbal μ- but not κ-opioid receptors participate in controlling EtOH intake.

    4. Neural Correlates and Connectivity Underlying Stress-Related Impulse Control Difficulties in Alcoholism

      Dongju Seo, Cheryl M. Lacadie and Rajita Sinha

      Version of Record online: 8 AUG 2016 | DOI: 10.1111/acer.13166

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      Brain Stress Response and Impulse Control Problems in Alcohol-Dependent Patients. The current study shows that hypoactive function and disrupted network connectivity in regions involving the ventromedial prefrontal cortex, caudate, and left lateral/dorsolateral prefrontal cortex underlie stress-related impulse control difficulties in alcohol-dependent patients. Additionally, they are characterized by altered connectivity with other brain areas, marked by decreased connectivity with prefrontal regulatory regions, but increased connectivity with sensory and motor regions.

    5. Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS

      Claire Heit, Peter Eriksson, David C. Thompson, Georgia Charkoftaki, Kristofer S. Fritz and Vasilis Vasiliou

      Version of Record online: 8 AUG 2016 | DOI: 10.1111/acer.13156

    6. Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand-Alone and Treatment Add-On Compared with Standard Outpatient Treatment

      Brian D. Kiluk, Kathleen A. Devore, Matthew B. Buck, Charla Nich, Tami L. Frankforter, Donna M. LaPaglia, Brian T. Yates, Melissa A. Gordon and Kathleen M. Carroll

      Version of Record online: 4 AUG 2016 | DOI: 10.1111/acer.13162

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      In a randomized trial with 68 individuals, results indicated a computer-based CBT program (CBT4CBT) delivered as an add-on to standard treatment was superior to standard treatment at increasing alcohol abstinence, and not significantly different from standard treatment when delivered as a virtual stand-alone. CBT4CBT demonstrated potential as a virtual stand-alone treatment in conjunction with minimal clinical monitoring, particularly with respect to treatment retention, satisfaction, and cost savings.

    7. Emergency Department Visits for Adverse Drug Reactions Involving Alcohol: United States, 2005 to 2011

      I-Jen P. Castle, Chuanhui Dong, Sarah P. Haughwout and Aaron M. White

      Version of Record online: 4 AUG 2016 | DOI: 10.1111/acer.13167

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      Alcohol may interact with medications and cause adverse drug reactions (ADR). In 2005 to 2011, incidence of ED visits for ADR involving alcohol (ADR-A) increased for people ages 21 to 34 and females ages 55+. ADR-A visits more likely involved males, patients ages 21 to 54, and 2+ implicated drugs, and they had more serious outcomes. The most common medications involved in ADR-A visits were CNS agents, followed by psychotherapeutic agents. Involvement of certain medications in ADR-A visits varied by sex and age.

    8. High-Intensity Drinking Among Young Adults in the United States: Prevalence, Frequency, and Developmental Change

      Megan E. Patrick, Yvonne M. Terry-McElrath, Deborah D. Kloska and John E. Schulenberg

      Version of Record online: 4 AUG 2016 | DOI: 10.1111/acer.13164

    9. Cognitive Bias Modification Training During Inpatient Alcohol Detoxification Reduces Early Relapse: A Randomized Controlled Trial

      Victoria Manning, Petra K. Staiger, Kate Hall, Joshua B.B. Garfield, Gabriella Flaks, Daniel Leung, Laura K. Hughes, Jarrad A. G. Lum, Dan I. Lubman and Antonio Verdejo-Garcia

      Version of Record online: 4 AUG 2016 | DOI: 10.1111/acer.13163

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      In a RCT, 83 alcohol-dependent patients received either cognitive bias modification (CBM) or sham training (controls), during inpatient withdrawal. Among the 86% followed up 2 weeks postdischarge, significantly higher rates of abstinence were reported among the CBM group relative to controls if they completed the intended protocol of four training sessions (p = 0.02). The findings demonstrate the feasibility of CBM delivered during alcohol detoxification and support earlier research suggesting it may be a useful, low-cost adjunctive treatment to improve treatment outcomes.

  4. Critical Reviews

    1. Disentangling the Role of Astrocytes in Alcohol Use Disorder

      Louise Adermark and M. Scott Bowers

      Version of Record online: 1 AUG 2016 | DOI: 10.1111/acer.13168

  5. Acknowledgment

    1. Acknowledgment

      Version of Record online: 1 AUG 2016 | DOI: 10.1111/acer.13170

  6. Original Articles

    1. Combining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism

      Janice C. Froehlich, Stephen M. Fischer, Julian E. Dilley, Emily R. Nicholson, Teal N. Smith, Nick J. Filosa and Logan C. Rademacher

      Version of Record online: 29 JUL 2016 | DOI: 10.1111/acer.13157

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      This study compared the efficacy of varenicline (VAR) and naltrexone (NTX) alone, and in combination (VAR + NTX), on alcohol intake in rats selectively bred for high alcohol drinking (alcohol-preferring or P rats). Low, ineffective doses of VAR and NTX became effective when given together. Using low doses of VAR and NTX in a combination that maintains efficacy, while reducing side effects, may improve compliance and clinical outcomes for alcoholics and heavy drinkers who want to reduce their alcohol intake.

    2. Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers

      Tam T. Nguyen-Louie, Ashley Tracas, Lindsay M. Squeglia, Georg E. Matt, Sonja Eberson-Shumate and Susan F. Tapert

      Version of Record online: 27 JUL 2016 | DOI: 10.1111/acer.13160

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      Locally weighted scatter plot smoothing (LOWESS) regressions depict the relationships between alcohol use and verbal learning and memory (VLM) standard scores controlling for predrinking VLM, attention problems, and reading achievement. Higher recent peak estimated blood alcohol concentration linearly predicted poorer performances on VLM in adolescent drinkers; there was also a significant quadratic relationship between recognition total hits and blood alcohol level (ps < 0.05). The effect of alcohol quantity on VLM followed a linear dose-dependent relationship, highlighting the importance of potential variations in alcohol's effects on cognition between and within drinking groups.

    3. Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue

      Kristen T. Crowell, Jennifer L. Steiner, Catherine S. Coleman and Charles H. Lang

      Version of Record online: 27 JUL 2016 | DOI: 10.1111/acer.13159

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      These data identify a novel S6K1-dependent signaling pathway in white adipose tissue (WAT) that is increased by alcohol, in response to both chronic consumption and acute administration. They also show that alcohol induces a seemingly paradoxical concurrent increase in protein synthesis with a loss of adipose tissue mass. The alcohol-induced increase in global protein synthesis in this tissue differs from the decrease observed in many other tissues under comparable situations. It appears that an increase in autophagy, but not pyroptosis, may contribute to the decrease in WAT mass produced by chronic alcohol intake and may at least partially explain the changes in body composition produced by excessive alcohol consumption.

    4. Corticostriatal and Dopaminergic Response to Beer Flavor with Both fMRI and [11C]raclopride Positron Emission Tomography

      Brandon G. Oberlin, Mario Dzemidzic, Jaroslaw Harezlak, Maria A. Kudela, Stella M. Tran, Christina M. Soeurt, Karmen K. Yoder and David A. Kareken

      Version of Record online: 26 JUL 2016 | DOI: 10.1111/acer.13158

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      Using positron emission tomography (PET), we previously showed that beer flavor, absent intoxication, elicited human right ventral striatal (VST) dopamine release. Here, we examined a subset of these beer drinkers with a matched fMRI flavor paradigm. Both fMRI and dopaminergic PET showed rightward-biased VST flavor activation. In fMRI, beer flavor activated orbitofrontal cortex, with medial orbital activation correlating with beer “wanting.” Both study modalities converge in suggesting right-lateralized VST activation to alcohol cues, with medial orbital cortex reflecting beer wanting.

  7. Retraction

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  8. Commentary

  9. Original Articles

    1. You have full text access to this OnlineOpen article
      Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis

      Viranuj Sueblinvong, Stephen T. Mills, David C. Neujahr, Young-Mi Go, Dean P. Jones and David M. Guidot

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13148

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      We determined that chronic alcohol ingestion primes the lung for disrepair following an acute injury, and that this is mediated in part through TGFβ1-mediated suppression of Nrf2-ARE activity. In this study, we report that alcohol suppresses the expression of thioredoxin-1 (Trx1), a redox regulator required for optimal Nrf2-ARE signaling, in both the cytosol and the nucleus of lung fibroblasts. Importantly, nuclear overexpression of Trx-1 inhibits alcohol-induced TGFβ1 expression, restores Nrf2-ARE activity, and attenuates alcohol-mediated fibroproliferative disrepair following experimental bleomycin-induced lung injury.

    2. Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence

      Anke Post, Trevor S. Smart, Kimberley Jackson, Joanne Mann, Richard Mohs, Linda Rorick-Kehn, Michael Statnick, Raymond Anton, Stephanie S. O'Malley and Conrad J. Wong

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13147

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      This was a proof-of-concept study to evaluate the efficacy of LY2940094, a nociceptin/orphanin FQ peptide receptor antagonist, in reducing alcohol consumption in actively alcohol-drinking patients with alcohol dependence. Although not reducing the number of drinks per day, LY2940094, compared to placebo, did reduce heavy drinking days and increased abstinence days in patients with alcohol dependence.

    3. Neurobehavioral Deficits Consistent Across Age and Sex in Youth with Prenatal Alcohol Exposure

      Amy L. Panczakiewicz, Leila Glass, Claire D. Coles, Julie A. Kable, Elizabeth R. Sowell, Jeffrey R. Wozniak, Kenneth Lyons Jones, Edward P. Riley, Sarah N. Mattson and the CIFASD

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/acer.13153

    4. Mandating Treatment Based on Interlock Performance: Evidence for Effectiveness

      Robert B. Voas, A. Scott Tippetts, Gwen Bergen, Milton Grosz and Paul Marques

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13149

    5. Dissociating Affective and Cognitive Theory of Mind in Recently Detoxified Alcohol-Dependent Individuals

      Pierre Maurage, Fabien D'Hondt, Philippe de Timary, Charlotte Mary, Nicolas Franck and Elodie Peyroux

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13155

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      Performance (percentage of correct answers) in alcohol-dependent and healthy control individuals for global score and affective–cognitive subscales of the Movie for Assessment of Social Cognition (MASC), an experimental task exploring Theory of Mind (ToM) abilities (ns, nonsignificant; *p < 0.001). This figure illustrates that alcohol dependence is not related to a generalized ToM deficit, but to a dissociation between preserved cognitive ToM and impaired affective one. Such ecological evaluation of social cognition shows that emotional-affective deficits play a crucial role in alcohol dependence.

    6. Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance

      Jeff Boissoneault, Ian Frazier, Ben Lewis and Sara Jo Nixon

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13154

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      Acute moderate alcohol administration differentially affected posterior alpha power (PAP) during working memory maintenance in older and younger social drinkers (p < 0.001). The 0.04 g/dl dose level was associated with greater PAP than placebo or the 0.065 g/dl dose level in younger adults, but the opposite pattern was seen in older adults. Results bolster the growing body of evidence that older adults are differentially sensitivity to the neurobehavioral effects of acute moderate alcohol intake.

    7. Desire to Drink Alcohol is Enhanced with High Caffeine Energy Drink Mixers

      Cecile A. Marczinski, Mark T. Fillmore, Amy L. Stamates and Sarah F. Maloney

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13152

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      The purpose of this laboratory-based study was to investigate whether energy drink mixers increase the desire to drink alcohol. Social drinkers attended six sessions that involved consumption of alcohol and energy drinks, alone and in combination, and completed ratings on the Desire-for-Drug questionnaire. The results indicated that energy drink mixers increased desire for more alcohol ratings beyond that observed with alcohol alone. Thus, energy drink mixers may increase the reinforcing properties of alcohol and contribute to binge drinking.

    8. Effect of Acute Ethanol Administration on the Hippocampal Region Neural Activity Using a Microelectrode Array

      Yameng Zhang, Hejuan Yu, Weitao Li, Yamin Yang, Xiao Wang and Zhiyu Qian

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13144

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      We divided ICR mice into 3 groups (ethanol group (1.5 g/kg), saline group (1.5 g/kg), and control group), inserted microelectrodes in the hippocampus region of mice, recorded spikes and local field potentials, and analyzed firing characteristics, wavelet entropy, relative energy. We found that acute ethanol administration could inhibit excitatory neurons firing by modulating low-frequency oscillation. The finding provided insights into the relationship between local neuronal populations and corresponding brain activity.

    9. Implicit Alcohol Approach and Avoidance Tendencies Predict Future Drinking in Problem Drinkers

      Laura Martin Braunstein, Alexis Kuerbis, Kevin Ochsner and Jon Morgenstern

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13151

  10. Erratum

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      Erratum

      Version of Record online: 18 JUN 2016 | DOI: 10.1111/acer.13145

      This article corrects:

      A New Genomewide Association Meta-Analysis of Alcohol Dependence

      Vol. 39, Issue 8, 1388–1395, Version of Record online: 14 JUL 2015

    2. You have free access to this content
      Erratum

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/acer.13143

      This article corrects:
    3. You have free access to this content
      Erratum

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011

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