The Rate of Change in Alcohol Misuse Across Adolescence is Heritable
Alexis C. Edwards, Jon Heron, Vladimir Vladimirov, Aaron R. Wolen, Daniel E. Adkins, Fazil Aliev, Matthew Hickman and Kenneth S. Kendler
Version of Record online: 28 NOV 2016 | DOI: 10.1111/acer.13262
Growth in AUDIT scores from age 16 to 21 is modestly heritable ( = 0.26) and implicated genetic variants map to loci putatively active in brain tissue more frequently than expected by chance. These findings underscore the complex genomic nature of alcohol misuse across development and provide insight as to potential biological mechanisms impacting changes in use during this critical time frame.