Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 5

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 3.205

ISI Journal Citation Reports © Ranking: 2014: 5/18 (Substance Abuse)

Online ISSN: 1530-0277


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  1. Original Articles

    1. Characterization of the Pharmacokinetics of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 in Human Whole Blood After Alcohol Consumption in a Clinical Laboratory Study

      Martin A. Javors, Nathalie Hill-Kapturczak, John D. Roache, Tara E. Karns-Wright and Donald M. Dougherty

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13062

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      The purpose of this study was to characterize the pharmacokinetics of PEth 16:0/18:1 and 16:0/18:2 in blood of 27 participants in a human laboratory study. Blood samples were collected immediately after consumption of low (0.25 and 0.50 g/kg) doses of ethanol and then every 3 days for 2 weeks during abstinence. Our results indicate that ethanol produced increased PEth levels in all participants and PEth levels correlated with absorption of ethanol. Also, the measurement of these 2 PEth homologues may provide additional information to estimate the time from last, previous drinking.

  2. Critical Reviews

    1. Alcohol Use and Breast Cancer: A Critical Review

      Kevin D. Shield, Isabelle Soerjomataram and Jürgen Rehm

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13071

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      The global burden of breast cancer is large and growing, and, accordingly, there is a need for increased attention to breast cancer prevention. This review found that the biological pathways for alcohol-associated breast carcinogenesis are multifold and that even light alcohol consumption is causally related to breast cancer. Furthermore, this review estimated that alcohol caused 144,000 breast cancer cases and 38,000 breast cancer deaths globally in 2012, with 18.8% of these cases and 17.5% of these deaths affecting light drinkers.

  3. Original Articles

    1. Associations Between Cerebellar Subregional Morphometry and Alcoholism History in Men and Women

      Kayle S. Sawyer, Marlene Oscar-Berman, Susan Mosher Ruiz, Daniel A. Gálvez, Nikos Makris, Gordon J. Harris and Eve M. Valera

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13074

    2. Alcohol Increases Delay and Probability Discounting of Condom-Protected Sex: A Novel Vector for Alcohol-Related HIV Transmission

      Patrick S. Johnson, Mary M. Sweeney, Evan S. Herrmann and Matthew W. Johnson

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13079

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      Alcohol intoxication may cause sexual HIV risk behavior (unprotected sex) via delay and/or probability discounting. This study examined effects of acute alcohol administration on 23 recreational drinkers' discounting of hypothetical delayed or probabilistic sexual or monetary outcomes. Alcohol decreased likelihood of waiting to use a condom (Sexual Delay Discounting Task), decreased likelihood of condom use when STI risk was uncertain (Sexual Probability Discounting Task), but had virtually no effect on monetary discounting, suggesting alcohol has domain-specific effects on decision-making.

  4. Critical Reviews

    1. A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury

      Shaogui Wang, Pal Pacher, Robert C. De Lisle, Heqing Huang and Wen-Xing Ding

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13078

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      1. Cell death and cell survival are closely associated with alcoholic liver disease.
      2. Ethanol metabolism leads to increased oxidative stress resulting in mitochondrial damage and apoptosis in hepatocytes.
      3. Chronic alcohol consumption increases gut permeability and elevated systemic levels of gut-derived endotoxins resulting in increased production of TNF-α from activated Kupffer cells.
      4. Depending on the cIAP levels and caspase-8 activation in hepatocytes, TNF-α either induces apoptosis or necroptosis by activating Bid-mediated mitochondrial apoptotic pathway or ripoptosome or necrosome.
  5. Original Articles

    1. Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes

      Gretchen Bandoli, Claire D. Coles, Julie A. Kable, Wladimir Wertelecki, Irina V. Granovska, Alla O. Pashtepa, Christina D. Chambers and the CIFASD

      Article first published online: 30 APR 2016 | DOI: 10.1111/acer.13081

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      From a sample of pregnant women in Ukraine recruited based upon periconceptional alcohol use, we found prenatal alcohol exposure (PAE) was independently associated with deficits in neurodevelopmental outcomes at 6 and 12 months; however, level of prenatal depressive symptoms was not. We found marginal evidence of synergism of PAE and depressive symptoms in neurodevelopmental assessments. Healthcare providers should be aware of this possible synergism in their efforts to mitigate the neurodevelopmental effects of these co-occurring exposures.

  6. Critical Reviews

  7. Commentary

  8. Original Articles

    1. Alcohol Intake and Reduced Mortality in Patients with Traumatic Brain Injury

      Jin Seong Cho, Sang Do Shin, Eui Jun Lee, Kyoung Jun Song, Hyun Noh, Yu Jin Kim, Seung Chul Lee, Ju Ok Park, Seong Chun Kim and Seung-sik Hwang

      Article first published online: 21 APR 2016 | DOI: 10.1111/acer.13065

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      Mortality rate due to traumatic brain injury in the alcohol-intake group appears to be lower compared to that in the no-alcohol-intake group after adjusting for main confounding variables.

    2. A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder

      Daniel J. O. Roche, Megan M. Yardley, Katy F. Lunny, Stan G. Louie, Daryl L. Davies, Karen Miotto and Lara A. Ray

      Article first published online: 18 APR 2016 | DOI: 10.1111/acer.13064

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      Ivermectin (30 mg) did not increase the number or severity of adverse effects during alcohol administration. However, ivermectin also did not affect cue-induced craving and subjective response to alcohol. These pilot results suggest that ivermectin is safe in combination with an intoxicating dose of alcohol, but do not indicate that this dose of ivermectin produces anti-alcohol effects in humans. Additional studies testing larger samples and alternate dosing regimens are needed to test the potential efficacy of ivermectin as an alcoholism treatment.

    3. Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men

      Akira Yokoyama, Yoko Kamada, Hiromi Imazeki, Emiko Hayashi, Shigenori Murata, Kenji Kinoshita, Tetsuji Yokoyama and Yoshinori Kitagawa

      Article first published online: 18 APR 2016 | DOI: 10.1111/acer.13073

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      To study the effects of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genotypes on the alcohol elimination rate (AER) and salivary acetaldehyde levels, we measured the salivary ethanol and acetaldehyde levels twice at a one-hour interval in 99 intoxicated Japanese alcoholic men. The enhanced AER in ADH1B*2 carriers and the increased salivary acetaldehyde levels in ALDH2*1/*2 carriers among intoxicated alcoholics provide possible mechanisms explaining how each genetic polymorphism affects the risk of alcoholism and upper aerodigestive tract cancer.

    4. Destination Memory in Korsakoff's Syndrome

      Mohamad El Haj, Roy P. C. Kessels, Christian Matton, Jean-Eudes Bacquet, Laurent Urso, Gaëlle Cool, Florence Guidez, Stéphanie Potier, Jean-Louis Nandrino and Pascal Antoine

      Article first published online: 18 APR 2016 | DOI: 10.1111/acer.13070

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      Destination memory refers to the ability to remember to whom information was previously transmitted. Our study tested destination memory in Korsakoff's syndrome. Participants with Korsakoff's syndrome were instructed to tell proverbs to pictures of celebrities. In a subsequent recognition test, they had to indicate whether they had previously told that proverb to that celebrity or not. Results showed compromise of destination memory in Korsakoff's syndrome. Note. Elvis Presley's image is covered by creative commons copyright.

  9. Commentary

    1. Of Alcohol and Liver Transplant, Here and There

      Marco A. Olivera-Martinez

      Article first published online: 15 APR 2016 | DOI: 10.1111/acer.13061

  10. Original Articles

    1. Estimation of Unrecorded Alcohol Consumption in Low-, Middle-, and High-Income Economies for 2010

      Jürgen Rehm, Elisabeth Larsen, Candace Lewis-Laietmark, Paul Gheorghe, Vladimir Poznyak, Dag Rekve and Alexandra Fleischmann

      Article first published online: 15 APR 2016 | DOI: 10.1111/acer.13067

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      Consumption of unrecorded alcohol is common, but there has been relatively little systematic monitoring. As a newly established part of the WHO global monitoring, a Delphi expert was conducted to assess level and characteristics of unrecorded consumption in 46 member states. One hundred experts responded. Main results included a systematic gradient of the proportion of unrecorded alcohol of total consumption by wealth of a country, with unrecorded alcohol being relatively most important in low-income countries (see Figure).

    2. Osteoprotegerin Levels Decrease in Abstinent Alcohol-Dependent Patients

      Peter Malik, Gabriele von Gleissenthall, Rudolf W. Gasser, Roy Moncayo, Johannes M. Giesinger and Sergei Mechtcheriakov

      Article first published online: 8 APR 2016 | DOI: 10.1111/acer.13063

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      Our main finding is that OPG levels decreased significantly during 8 weeks of abstinence. RANKL levels were normal at baseline and did also not change during the 8-week observation period. RANKL/OPG ratio, being low overall, did decrease slightly, but not significantly, pointing to an excess of bone formation. OC levels increased over 8 weeks. Our results indicate an increase of bone formation during abstinence and could point to the risk for reduced BMD being reversible with abstinence.

  11. Erratum

    1. You have free access to this content

      Article first published online: 14 MAR 2016 | DOI: 10.1111/acer.13058

      This article corrects:
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      Article first published online: 4 FEB 2016 | DOI: 10.1111/acer.13016

      This article corrects:
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      Article first published online: 30 JAN 2016 | DOI: 10.1111/acer.13017

      This article corrects:
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      Article first published online: 17 JUN 2015 | DOI: 10.1111/acer.12793

      This article corrects:

      Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers

      Vol. 37, Issue Supplement s1, E161–E171, Article first published online: 18 OCT 2012

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      Article first published online: 13 MAY 2015 | DOI: 10.1111/acer.12768

      This article corrects:

      Commentary: Doxasozin for Alcoholism

      Vol. 37, Issue 2, 191–193, Article first published online: 27 DEC 2012

    7. You have free access to this content

      Article first published online: 17 MAR 2015 | DOI: 10.1111/acer.12723

      This article corrects:

      How Is the Liver Primed or Sensitized for Alcoholic Liver Disease?

      Vol. 25, Issue Supplement s1, 171S–181S, Article first published online: 11 APR 2006

    8. You have free access to this content

      Article first published online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Article first published online: 17 OCT 2011


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