Alcoholism: Clinical and Experimental Research

Cover image for Vol. 39 Issue 11

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 3.205

ISI Journal Citation Reports © Ranking: 2014: 5/18 (Substance Abuse)

Online ISSN: 1530-0277


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  1. Original Articles

    1. Investigating the Joint Development of Approach Bias and Adolescent Alcohol Use

      Tim Janssen, Mark D. Wood, Helle Larsen, Margot Peeters, Wilma A. M. Vollebergh and Reinout W. Wiers

      Article first published online: 23 NOV 2015 | DOI: 10.1111/acer.12899

    2. The Effect and Underlying Mechanism of Ethanol on Intracellular H+-Equivalent Membrane Transporters in Human Aorta Smooth Muscle Cells

      Shih-Hurng Loh, Chung-Yi Lee, Gunng-Shinng Chen, Ching-Hsia Wu, Chan-Jun Tsao, Shou-Jou Shih, Chou Chi-Chung, Chien-Sung Tsai and Yi-Ting Tsai

      Article first published online: 18 NOV 2015 | DOI: 10.1111/acer.12892

  2. Critical Reviews

    1. Systematic Review of Fetal Alcohol Spectrum Disorder Interventions Across the Life Span

      Natasha Reid, Sharon Dawe, Douglas Shelton, Paul Harnett, Judith Warner, Eleanor Armstrong, Kim LeGros and Frances O'Callaghan

      Article first published online: 18 NOV 2015 | DOI: 10.1111/acer.12903

  3. Original Articles

    1. Exposure to Chronic Mild Stress Differentially Alters Corticotropin-Releasing Hormone and Arginine Vasopressin mRNA Expression in the Stress-Responsive Neurocircuitry of Male and Female Rats Prenatally Exposed to Alcohol

      Ni Lan, Kim G. C. Hellemans, Linda Ellis and Joanne Weinberg

      Article first published online: 18 NOV 2015 | DOI: 10.1111/acer.12916

      Thumbnail image of graphical abstract

      Prenatal alcohol exposure (PAE) results in HPA dysregulation. We investigated underlying mechanisms in adult PAE and control animals following chronic mild stress (CMS). CMS differentially altered the balance between CRH and AVP in PAE and PF males, but not in females, compared to their control counterparts, with a possible shift toward greater CRH mediation in PAE, and AVP mediation in PF. Thus, HPA dysregulation appears to occur through different mechanisms, and in a stress- and sex-dependent manner, in PAE and PF animals.

  4. Commentary

    1. Feeding Two Birds with One Scone: The Case of Varenicline

      Henri-Jean Aubin and Amandine Luquiens

      Article first published online: 18 NOV 2015 | DOI: 10.1111/acer.12907

  5. Original Articles

    1. BK Channel β1 Subunit Contributes to Behavioral Adaptations Elicited by Chronic Intermittent Ethanol Exposure

      Max Kreifeldt, Chelsea Cates-Gatto, Amanda J. Roberts and Candice Contet

      Article first published online: 18 NOV 2015 | DOI: 10.1111/acer.12911

      Thumbnail image of graphical abstract

      Figure 4. Ethanol-induced hypothermia and chronic tolerance in BK β1- and β4-deficient mice. The hypothermic effect of ethanol (4 g/kg, i.p.) was measured in BK β1 ((A) WT, n = 7; Het, n = 8; KO, n = 5) and BK β4 ((B) WT, n = 9; Het, n = 8; KO, n = 8) mice. CIE exposure produced tolerance to hypothermia in both strains, as reflected by a smaller drop in body temperature post-CIE (black stars: two, < 0.01; three stars, < 0.001). There was a significant effect of genotype in BK β1 mice post-CIE 60 and 120 min postinjection, as well as in BK β4 mice prior to the injection (white stars, < 0.05).

    2. Withdrawal from Chronic Alcohol Induces a Unique CCL2 mRNA Increase in Adolescent But Not Adult Brain—Relationship to Blood Alcohol Levels and Seizures

      Kathryn M. Harper, Darin J. Knapp and George R. Breese

      Article first published online: 11 NOV 2015 | DOI: 10.1111/acer.12898

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      Some adolescent rats show an exaggerated CCL2 mRNA response to withdrawal from 7% continuous (CAD) and cycled alcohol (CyAD) at 24 hours into withdrawal. During withdrawal from continuous CAD or CyAD, Wistar adolescents show elevated IL-1β (A; ANOVA F(2, 20) = 6.7, p < 0.01), TNFα (B; Kruskal–Wallis H = 12.2, 2 df, p < 0.01) and CCL2 (C; Kruskal–Wallis H = 16.0, 2 df, p < 0.01). Note different y-axis scales used on A, B, and C. N = 7 to 8 per group. Data presented as mean ± SEM. Post hoc CAD or CyAD versus control *p < 0.05, **p < 0.01. T-test CAD versus control ^p < 0.05.

    3. Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury

      Peng Chen, Yukiko Miyamoto, Magdalena Mazagova, Kuei-Chuan Lee, Lars Eckmann and Bernd Schnabl

      Article first published online: 11 NOV 2015 | DOI: 10.1111/acer.12900

      Thumbnail image of graphical abstract

      This study demonstrates that germ-free mice are more susceptible to acute alcohol-induced liver injury. The commensal microbiota is important for promoting normal liver function in the face of acute injury. The observed phenotype in germ-free mice is likely caused by a combination of three factors, involving increases in the production of alcohol-derived toxic metabolites, steatosis, and inflammation.

    4. Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

      Paul G. Thomes, Casey S. Trambly, Howard S. Fox, Dean J. Tuma and Terrence M. Donohue Jr.

      Article first published online: 11 NOV 2015 | DOI: 10.1111/acer.12904

      Thumbnail image of graphical abstract

      Confocal micrograph of mouse hepatocytes from pair-fed (control) and ethanol-fed GFP-LC3 transgenic mice. Autophagosomes (AVs): green puncta. Lysosomes: red puncta. AV-lysosome fusion events: yellow or orange puncta. Larger green structures are nuclei. Hepatocytes from the ethanol-fed mouse exhibit larger and more numerous AVs, lower lysosome numbers, and lower AV-lysosome fusion events than cells from the control mouse. Results indicate that chronic ethanol feeding causes AV accumulation, by reducing AV-lysosome fusion, thus slowing autophagy.

    5. Social Goals and Grade as Moderators of Social Normative Influences on Adolescent Alcohol Use

      Samuel N. Meisel and Craig R. Colder

      Article first published online: 11 NOV 2015 | DOI: 10.1111/acer.12906

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      The current study examined whether agentic and communal social goals and grade moderated the relationship between descriptive and injunctive social norms and alcohol use. Results suggested different moderational effects of each social goal and across grade. This study highlights that whether adolescents conform to social norms depends on their social goals. Findings have potential implications for whom and when normative feedback interventions might be most effective during this developmental period.

    6. Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus

      Mary-Louise Risher, Hannah G. Sexton, W. Christopher Risher, Wilkie A. Wilson, Rebekah L. Fleming, Roger D. Madison, Scott D. Moore, Cagla Eroglu and H. Scott Swartzwelder

      Article first published online: 5 NOV 2015 | DOI: 10.1111/acer.12913

  6. Critical Reviews

    1. How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal

      Ansel T. Hillmer, Graeme F. Mason, Lisa M. Fucito, Stephanie S. O'Malley and Kelly P. Cosgrove

      Article first published online: 28 OCT 2015 | DOI: 10.1111/acer.12893

  7. Commentary

  8. Original Articles

    1. Unhealthy Alcohol Use is Associated with Monocyte Activation Prior to Starting Antiretroviral Therapy

      Adam W. Carrico, Peter W. Hunt, Nneka I. Emenyonu, Winnie Muyindike, Christine Ngabirano, Debbie M. Cheng, Michael R. Winter, Jeffrey H. Samet and Judith A. Hahn

      Article first published online: 28 OCT 2015 | DOI: 10.1111/acer.12908

  9. Erratum

    1. You have free access to this content

      Article first published online: 17 JUN 2015 | DOI: 10.1111/acer.12793

      This article corrects:

      Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers

      Vol. 37, Issue Supplement s1, E161–E171, Article first published online: 18 OCT 2012

    2. You have free access to this content

      Article first published online: 13 MAY 2015 | DOI: 10.1111/acer.12768

      This article corrects:

      Commentary: Doxasozin for Alcoholism

      Vol. 37, Issue 2, 191–193, Article first published online: 27 DEC 2012

    3. You have free access to this content

      Article first published online: 17 MAR 2015 | DOI: 10.1111/acer.12723

      This article corrects:

      How Is the Liver Primed or Sensitized for Alcoholic Liver Disease?

      Vol. 25, Issue Supplement s1, 171S–181S, Article first published online: 11 APR 2006

    4. You have free access to this content

      Article first published online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Article first published online: 17 OCT 2011


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