Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277


  1. 1 - 40
  1. Original articles

    1. Elevated Glutamate Levels in the Left Dorsolateral Prefrontal Cortex Are Associated with Higher Cravings for Alcohol

      Mark A. Frye, David J. Hinton, Victor M. Karpyak, Joanna M. Biernacka, Lee J. Gunderson, Jennifer Geske, Scott E. Feeder, Doo-Sup Choi and John D. Port

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13131

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      Quantifying craving longitudinally during the course of withdrawal, early abstinence, and relapse is essential for optimal management of alcohol use disorder (AUD). To identify biological correlates of craving, we used magnetic resonance spectroscopy (1H-MRS) to investigate the correlation between craving and glutamate levels in the left dorsolateral prefrontal cortex (LDLPFC) of patients with AUD. Our data indicate that glutamate levels in LDLPFC are positively associated with alcohol craving intensity in patients with AUD

  2. Original Articles

    1. You have full text access to this OnlineOpen article
      Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis

      Viranuj Sueblinvong, Stephen T. Mills, David C. Neujahr, Young-Mi Go, Dean P. Jones and David M. Guidot

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13148

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      We determined that chronic alcohol ingestion primes the lung for disrepair following an acute injury, and that this is mediated in part through TGFβ1-mediated suppression of Nrf2-ARE activity. In this study, we report that alcohol suppresses the expression of thioredoxin-1 (Trx1), a redox regulator required for optimal Nrf2-ARE signaling, in both the cytosol and the nucleus of lung fibroblasts. Importantly, nuclear overexpression of Trx-1 inhibits alcohol-induced TGFβ1 expression, restores Nrf2-ARE activity, and attenuates alcohol-mediated fibroproliferative disrepair following experimental bleomycin-induced lung injury.

    2. Medial Prefrontal Cortical Dopamine Responses During Operant Self-Administration of Sweetened Ethanol

      James M. Doherty, Christina J. Schier, Ashley A. Vena, Geoffrey A. Dilly and Rueben A. Gonzales

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13141

    3. Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence

      Anke Post, Trevor S. Smart, Kimberley Jackson, Joanne Mann, Richard Mohs, Linda Rorick-Kehn, Michael Statnick, Raymond Anton, Stephanie S. O'Malley and Conrad J. Wong

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13147

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      This was a proof-of-concept study to evaluate the efficacy of LY2940094, a nociceptin/orphanin FQ peptide receptor antagonist, in reducing alcohol consumption in actively alcohol-drinking patients with alcohol dependence. Although not reducing the number of drinks per day, LY2940094, compared to placebo, did reduce heavy drinking days and increased abstinence days in patients with alcohol dependence.

    4. Neurobehavioral Deficits Consistent Across Age and Sex in Youth with Prenatal Alcohol Exposure

      Amy L. Panczakiewicz, Leila Glass, Claire D. Coles, Julie A. Kable, Elizabeth R. Sowell, Jeffrey R. Wozniak, Kenneth Lyons Jones, Edward P. Riley, Sarah N. Mattson and the CIFASD

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/acer.13153

    5. A Cross-National Examination of Differences in Classification of Lifetime Alcohol Use Disorder Between DSM-IV and DSM-5: Findings from the World Mental Health Survey

      Tim Slade, Wai-Tat Chiu, Meyer Glantz, Ronald C. Kessler, Luise Lago, Nancy Sampson, Ali Al-Hamzawi, Silvia Florescu, Jacek Moskalewicz, Sam Murphy, Fernando Navarro-Mateu, Yolanda Torres de Galvis, Maria Carmen Viana, Miguel Xavier and Louisa Degenhardt

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13134

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      • Compared with DSM-IV AUD (12.3%, SE = 0.3%), the DSM-5 definition yielded slightly lower prevalence estimates (10.8%, SE = 0.2%).
      • Diagnostic switching was common with almost one-third of all DSM-IV abuse cases switching to subthreshold in DSM-5 and one-quarter of all DSM-IV diagnostic orphans switching to mild DSM-5 AUD.
      • Despite this, new cases of DSM-5 AUD were largely similar to those who maintained their AUD across both classifications. Similarly, new DSM-5 non-cases were similar to those who were subthreshold across both classifications.
  3. Original articles

    1. Associations Between the Phosphatidylethanol Alcohol Biomarker and Self-Reported Alcohol Use in a Sample of HIV-Infected Outpatient Drinkers in Western Kenya

      Rebecca K. Papas, Benson N. Gakinya, Michael M. Mwaniki, Alfred K. Keter, Hana Lee, Michelle P. Loxley, Debra A. Klein, John E. Sidle, Steve Martino, Joyce B. Baliddawa, Kathryn L. Schlaudt and Stephen A. Maisto

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13132

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      A direct alcohol biomarker called phosphatidylethanol (PEth) has been shown to validate heavy, daily drinking, but indicates mixed results for moderate and nondaily drinkers. We compared PEth results to self-report among 127 HIV-infected drinkers in western Kenya indicating moderate–heavy nondaily alcohol use using the Timeline Followback. Agreement between self-report and PEth levels was better among men than women and at second of 2 study time points. Thirteen interviews among study completers with negative PEth baseline results showed consistency with self-report.

  4. Original Articles

    1. Alcohol Suppresses Tonic GABAA Receptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High-Alcohol-Consuming Genotypes

      Joshua S. Kaplan, Claudia Mohr, Caroline M. Hostetler, Andrey E. Ryabinin, Deborah A. Finn and David J. Rossi

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13136

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      Insensitivity to EtOH-induced disruption of cerebellar processing is a risk factor for excessive alcohol consumption in rodents and humans. We report that GABAergic inhibition of cerebellar granule cells shows opposite responses to EtOH (suppression versus enhancement) in high and low EtOH consuming rodent genotypes (prairie voles/C57BL/6J mice versus Sprague-Dawley rats/DBA/2J mice) respectively. The opposite response to EtOH is due to differential expression of nNOS, the inhibition of which underlies EtOH enhancement of GABAergic transmission in low EtOH consuming genotypes.

    2. Mandating Treatment Based on Interlock Performance: Evidence for Effectiveness

      Robert B. Voas, A. Scott Tippetts, Gwen Bergen, Milton Grosz and Paul Marques

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13149

    3. Dissociating Affective and Cognitive Theory of Mind in Recently Detoxified Alcohol-Dependent Individuals

      Pierre Maurage, Fabien D'Hondt, Philippe de Timary, Charlotte Mary, Nicolas Franck and Elodie Peyroux

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13155

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      Performance (percentage of correct answers) in alcohol-dependent and healthy control individuals for global score and affective–cognitive subscales of the Movie for Assessment of Social Cognition (MASC), an experimental task exploring Theory of Mind (ToM) abilities (ns, nonsignificant; *p < 0.001). This figure illustrates that alcohol dependence is not related to a generalized ToM deficit, but to a dissociation between preserved cognitive ToM and impaired affective one. Such ecological evaluation of social cognition shows that emotional-affective deficits play a crucial role in alcohol dependence.

    4. Treatment Utilization Among Adolescent Substance Users: Findings from the 2002 to 2013 National Survey on Drug Use and Health

      Sarah P. Haughwout, Thomas C. Harford, I-Jen P. Castle and Bridget F. Grant

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13137

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      Adolescent substance users face serious consequences and benefit from early diagnosis and treatment. From 2002 to 2013, treatment utilization was low among past-year substance users with and without SUD (11.4% and 1.4%); most adolescents received treatment for polysubstance use, and in a self-help group. Criminal justice involvement and perceiving a need for treatment increased treatment utilization among all adolescents, while differences in correlates were found among SUD groups and gender. Treatment gaps persisted among minorities and insurance coverages, and must be addressed.

    5. Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance

      Jeff Boissoneault, Ian Frazier, Ben Lewis and Sara Jo Nixon

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13154

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      Acute moderate alcohol administration differentially affected posterior alpha power (PAP) during working memory maintenance in older and younger social drinkers (p < 0.001). The 0.04 g/dl dose level was associated with greater PAP than placebo or the 0.065 g/dl dose level in younger adults, but the opposite pattern was seen in older adults. Results bolster the growing body of evidence that older adults are differentially sensitivity to the neurobehavioral effects of acute moderate alcohol intake.

    6. Desire to Drink Alcohol is Enhanced with High Caffeine Energy Drink Mixers

      Cecile A. Marczinski, Mark T. Fillmore, Amy L. Stamates and Sarah F. Maloney

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13152

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      The purpose of this laboratory-based study was to investigate whether energy drink mixers increase the desire to drink alcohol. Social drinkers attended six sessions that involved consumption of alcohol and energy drinks, alone and in combination, and completed ratings on the Desire-for-Drug questionnaire. The results indicated that energy drink mixers increased desire for more alcohol ratings beyond that observed with alcohol alone. Thus, energy drink mixers may increase the reinforcing properties of alcohol and contribute to binge drinking.

    7. Effect of Acute Ethanol Administration on the Hippocampal Region Neural Activity Using a Microelectrode Array

      Yameng Zhang, Hejuan Yu, Weitao Li, Yamin Yang, Xiao Wang and Zhiyu Qian

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13144

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      We divided ICR mice into 3 groups (ethanol group (1.5 g/kg), saline group (1.5 g/kg), and control group), inserted microelectrodes in the hippocampus region of mice, recorded spikes and local field potentials, and analyzed firing characteristics, wavelet entropy, relative energy. We found that acute ethanol administration could inhibit excitatory neurons firing by modulating low-frequency oscillation. The finding provided insights into the relationship between local neuronal populations and corresponding brain activity.

    8. Implicit Alcohol Approach and Avoidance Tendencies Predict Future Drinking in Problem Drinkers

      Laura Martin Braunstein, Alexis Kuerbis, Kevin Ochsner and Jon Morgenstern

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13151

    9. An Exploratory Association Study of Alcohol Use Disorder and DNA Methylation

      Sarah L. Hagerty, L. Cinnamon Bidwell, Nicole Harlaar and Kent E. Hutchison

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/acer.13138

    10. Effects of Heavy Drinking on T-Cell Phenotypes Consistent with Immunosenescence in Untreated HIV Infection

      Kaku A. So-Armah, E. Jennifer Edelman, Debbie M. Cheng, Margaret F. Doyle, Gregory J. Patts, Natalia Gnatienko, Evgeny M. Krupitsky, Jeffrey H. Samet and Matthew S. Freiberg

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/acer.13142

    11. Role for the Rostromedial Tegmental Nucleus in Signaling the Aversive Properties of Alcohol

      Elizabeth J. Glover, Molly J. McDougle, Griffin S. Siegel, Thomas C. Jhou and L. Judson Chandler

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/acer.13140

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      The neurobiological mechanism for alcohol's aversive properties is not well understood. To explore a role for the RMTg, conditioned taste aversion (CTA) was produced in rats in the paired condition in response to saccharin and i.p. drug pairings. In the unpaired condition, drug exposure and saccharin exposure were unpaired. CTA enhanced cFos expression in the RMTg and lateral habenula (LHb) but not the hippocampus. cFos correlated positively with CTA magnitude. These data suggest that the RMTg and LHb are involved in ethanol-induced CTA.

    12. Factors Explaining Variation in Alcohol Use Disorder Prevalence Across Border and Nonborder Communities in Texas

      Sarah E. Zemore, Cheryl J. Cherpitel, Yu Ye, Guilherme Borges, Libo Li and Lynn S. Wallisch

      Version of Record online: 6 JUL 2016 | DOI: 10.1111/acer.13124

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      U.S. border populations are, overall, at heightened risk for AUD's, but risk can vary substantially among border cities. We sought to describe and explain variation in AUD across 3 Texas (2 border and one off-;border) communities: Laredo, McAllen/Brownsville, and San Antonio (N = 2336). Analyses suggested large site differences in AUD among men; further, differences were explained via environmental factors, stressors, drinking motives, and heavy drinking. Findings support our conceptual model as an initial framework for understanding heterogeneity within the border region.

    13. Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero

      Catina Crismale-Gann, Hillary Stires, Tiffany A. Katz and Wendie S. Cohick

      Version of Record online: 4 JUL 2016 | DOI: 10.1111/acer.13139

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      Alcohol exposure in utero increases mammary tumor susceptibility in adult rat offspring 23 weeks after carcinogen administration. The present work shows that at an earlier time point, tumors from alcohol-exposed offspring exhibit markers indicative of more aggressive luminal tumors relative to controls. IGF-II mRNA is increased in these tumors as well as in normal contralateral mammary glands. We conclude that fetal alcohol exposure promotes a more aggressive tumor phenotype and that alterations in IGF-II expression may contribute to these changes.

    14. You have full text access to this OnlineOpen article
      Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4

      Franziska Degenhardt, Laurenz Krämer, Josef Frank, Jens Treutlein, Stefanie Heilmann-Heimbach, Julian Hecker, Heide Löhlein Fier, Maren Lang, Stephanie H. Witt, Anna C. Koller, Karl Mann, Sabine Hoffmann, Falk Kiefer, Rainer Spanagel, Marcella Rietschel and Markus M. Nöthen

      Version of Record online: 4 JUL 2016 | DOI: 10.1111/acer.13125

    15. Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice

      Kyle D. Ketchesin, Gwen S. Stinnett and Audrey F. Seasholtz

      Version of Record online: 4 JUL 2016 | DOI: 10.1111/acer.13119

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      Dysregulation of the corticotropin releasing factor (CRF) system has been observed in rodent models of binge drinking. We examined the role and regulation of CRF-binding protein (CRFBP), a key regulator of CRF activity, in mice exposed to the drinking in the dark (DID) paradigm. CRF-BP mRNA expression was significantly decreased in the medial prefrontal cortex after 3 and 6 cycles of DID, which may allow for increased CRF signaling at CRF receptor 1 and contribute to excessive binge-like ethanol consumption.

  5. Commentary

  6. Original Articles

    1. Alcohol Vapor Inhalation as a Model of Alcohol-Induced Organ Disease

      Alan J. Mouton, John K. Maxi, Flavia Souza-Smith, Gregory J. Bagby, Nicholas W. Gilpin, Patricia E. Molina and Jason D. Gardner

      Version of Record online: 4 JUL 2016 | DOI: 10.1111/acer.13133

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      Sprague–Dawley rats were exposed to chronic intermittent ethanol vapor (CIEV) inhalation, which has previously been used exclusively for neurobehavioral and addiction studies. CIEV led to pathological changes commonly observed in alcohol-induced liver injury, including increased plasma ALT (A) and triglycerides (C). CIEV also altered hepatic alcohol-metabolizing enzymes, including increased Cyp2e1 (D) and decreased ADH (E). These data suggest that CIEV is a potential preclinical alternative to standard ingestion models for studying the biomedical consequences of chronic alcohol abuse.

  7. Critical Reviews

    1. An Update on Fetal Alcohol Syndrome—Pathogenesis, Risks, and Treatment

      Keshav K. Gupta, Vinay K. Gupta and Tomohiro Shirasaka

      Version of Record online: 4 JUL 2016 | DOI: 10.1111/acer.13135

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      This article is an update on fetal alcohol syndrome (FAS), its pathogenesis, potential treatments, and preventative measures. Risk factors for the development of FAS and alcohol's mechanisms as a teratogen are also discussed. With FAS being the most extreme type of fetal alcohol spectrum disorder, knowledge of this condition can help to tackle alcohol consumption during pregnancy. We invite the readership to gain a detailed yet simple understanding of this broad and complex topic.

  8. Original Articles

    1. Trauma- and Stress-Induced Response in Veterans with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder

      Elizabeth Ralevski, Steven Southwick, Eric Jackson, Jane Serrita Jane, Melanie Russo and Ismene Petrakis

      Version of Record online: 1 JUL 2016 | DOI: 10.1111/acer.13120

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      This is the first study to explore the effects of trauma-induced and stress-induced cues on alcohol craving, and its relationship to drinking in individuals with PTSD and comorbid AUD. Trauma cues produced strongest craving for alcohol and were positively correlated with baseline levels of drinking. The results highlight that trauma cues are more salient in inducing craving than stress cues and underscore the importance of adequate treatment of PTSD as trauma reminders may be an important factor in craving and relapse.

  9. Letters to the Editor

    1. Microbiota and Alcoholic Liver Disease

      Peng Chen, Yukiko Miyamoto, Magdalena Mazagova, Kuei-Chuan Lee, Lars Eckmann and Bernd Schnabl

      Version of Record online: 1 JUL 2016 | DOI: 10.1111/acer.13129

  10. Commentary

    1. Comment on Niemelä and Colleagues (2016)

      Anne Gifford and Cynthia Bearer

      Version of Record online: 1 JUL 2016 | DOI: 10.1111/acer.13128

  11. Original Articles

    1. Adolescent Women Induce Lower Blood Alcohol Levels Than Men in a Laboratory Alcohol Self-Administration Experiment

      Elisabeth Jünger, Gabriela Gan, Inge Mick, Christian Seipt, Alexandra Markovic, Christian Sommer, Martin H. Plawecki, Sean O'Connor, Michael N. Smolka and Ulrich S. Zimmermann

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/acer.13122

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      In a sample of 82 adolescents (18 to 19 years), we tested the effects of Family History of alcoholism (negative = FHN vs. positive = FHP) and sex (men vs. women) on free-access intravenous alcohol self-administration measured by the mean arterial Blood Alcohol Concentration (aBAC). Our findings suggest no role for FH as a risk factor for alcohol consumption in that age group, but imply that young women preferentially self-infuse alcohol to lower aBACs than men when asked to produce pleasant alcohol effects, F(1, 78) = 10.0, < 0.01.

    2. The Impact of the Minimum Legal Drinking Age on Alcohol-Related Chronic Disease Mortality

      Andrew D. Plunk, Melissa J. Krauss, Husham Syed-Mohammed, Michael Hur, Patricia A. Cavzos-Rehg, Laura J. Bierut and Richard A. Grucza

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/acer.13123

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      The 21 drinking exhibits appear to have numerous public health benefits, but no studies to date have examined whether it is associated with lower risk for alcohol-related chronic disease later in life. Using United States national vital statistics data linked with historical state MLDA policy data, we found that the 21 MLDA is associated with lower risk from alcohol-related chronic disease across the lifespan, at least for those who did not attend college.

  12. Letters to the Editor

  13. Original Articles

    1. Assessment of Withdrawal and Hangover is Confounded in the Alcohol Use Disorder and Associated Disabilities Interview Schedule: Withdrawal Prevalence is Likely Inflated

      Cassandra L. Boness, Sean P. Lane and Kenneth J. Sher

      Version of Record online: 24 JUN 2016 | DOI: 10.1111/acer.13121

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      Studies using the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) are consistently observed to have higher endorsement rates of alcohol withdrawal when compared to studies using other diagnostic instruments. This inflation appears to relate to the instrument's confounding of effects from the morning after drinking (hangover) with those from the days following (withdrawal). Results indicated that endorsement of AUDADIS withdrawal symptoms is more likely driven by hangover experiences than withdrawal in the days following quitting or cutting down.

  14. Erratum

    1. You have free access to this content

      Version of Record online: 18 JUN 2016 | DOI: 10.1111/acer.13145

      This article corrects:

      A New Genomewide Association Meta-Analysis of Alcohol Dependence

      Vol. 39, Issue 8, 1388–1395, Version of Record online: 14 JUL 2015

    2. You have free access to this content

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/acer.13143

      This article corrects:
  15. Original Articles

  16. Erratum

    1. You have free access to this content

      Version of Record online: 12 MAY 2016 | DOI: 10.1111/acer.13117

      This article corrects:

      A Comparison Among 5 Methods for the Clinical Diagnosis of Fetal Alcohol Spectrum Disorders

      Vol. 40, Issue 5, 1000–1009, Version of Record online: 29 MAR 2016

    2. You have free access to this content
    3. You have free access to this content
    4. You have free access to this content

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011


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