Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 12

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277

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  1. 1 - 12
  1. Original Articles

    1. Binge Alcohol Intake After Hypergravity Stress Sustainably Decreases AMPK and Transcription Factors Necessary for Hepatocyte Survival

      Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung and Sang Geon Kim

      Version of Record online: 30 NOV 2016 | DOI: 10.1111/acer.13265

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      Binge alcohol consumption elicits mitochondrial dysfunction and apoptosis in hepatocytes. This study showed that a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMPK, a key regulator of energy metabolism, and other molecules necessary for hepatocyte survival. Binge alcohol intake after hypergravity stress diminished the levels of AMPKα, FOXO1/3, STAT3, and other transcription factors in the liver of mice compared to individual treatment, and these changes were prevented by repetitive hypergravity loads.

    2. The Rate of Change in Alcohol Misuse Across Adolescence is Heritable

      Alexis C. Edwards, Jon Heron, Vladimir Vladimirov, Aaron R. Wolen, Daniel E. Adkins, Fazil Aliev, Matthew Hickman and Kenneth S. Kendler

      Version of Record online: 28 NOV 2016 | DOI: 10.1111/acer.13262

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      Growth in AUDIT scores from age 16 to 21 is modestly heritable (inline image = 0.26) and implicated genetic variants map to loci putatively active in brain tissue more frequently than expected by chance. These findings underscore the complex genomic nature of alcohol misuse across development and provide insight as to potential biological mechanisms impacting changes in use during this critical time frame.

  2. Letters to the Editor

    1. Response to Astley's Letter to the Editor

      Claire D. Coles, Amanda R. Gailey, Jennifer G. Mulle, Julie A. Kable, Mary Ellen Lynch and Kenneth Lyons Jones

      Version of Record online: 26 NOV 2016 | DOI: 10.1111/acer.13271

  3. Original Articles

    1. Alcohol Exposure Causes Overexpression of Heart Development-Related Genes by Affecting the Histone H3 Acetylation via BMP Signaling Pathway in Cardiomyoblast Cells

      Jin Shi, Weian Zhao, Bo Pan, Min Zheng, Lina Si, Jing Zhu, Lingjuan Liu and Jie Tian

      Version of Record online: 24 NOV 2016 | DOI: 10.1111/acer.13273

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      Following alcohol exposure, phosphorylation of SMAD1/5/8 and HATs activities was increased to a significant extent, while histone H3 acetylation and expression of heart development-related genes were increased accordingly. The said phenomenon was reverted upon dorsomorphin (a specific inhibitor of BMP signaling) treatment. This identified that BMP-mediated histone H3 acetylation might be one of the cellular mechanisms to control alcohol-induced overexpression of heart development-related genes. Dorsomorphin could be a potential way to block congenital heart disease through BMP targeting.

    2. The Use of Cardiac Orienting Responses as an Early and Scalable Biomarker of Alcohol-Related Neurodevelopmental Impairment

      Diego A. Mesa, Julie A. Kable, Claire D. Coles, Kenneth Lyons Jones, Lyubov Yevtushok, Yaroslav Kulikovsky, Wladimir Wertelecki, Todd P. Coleman, Christina D. Chambers and the CIFASD

      Version of Record online: 24 NOV 2016 | DOI: 10.1111/acer.13261

    3. Alcohol Misuse and Co-Occurring Mental Disorders Among New Soldiers in the U.S. Army

      Murray B. Stein, Laura Campbell-Sills, Joel Gelernter, Feng He, Steven G. Heeringa, Matthew K. Nock, Nancy A. Sampson, Xiaoying Sun, Sonia Jain, Ronald C. Kessler, Robert J. Ursano and On behalf of the Army STARRS Collaborators

      Version of Record online: 24 NOV 2016 | DOI: 10.1111/acer.13269

    4. The Effects of Ethanol Exposure During Distinct Periods of Brain Development on Oxidative Stress in the Adult Rat Brain

      Patricia S. Brocardo, Joana Gil-Mohapel, Ryan Wortman, Athena Noonan, Eric McGinnis, Anna R. Patten and Brian R. Christie

      Version of Record online: 11 NOV 2016 | DOI: 10.1111/acer.13266

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      This study shows that ethanol exposure during any of the three trimester equivalents significantly increased lipid peroxidation in the Cornus Ammonis (CA) and dentate gyrus (DG) hippocampal subregions, while also decreasing the levels of the endogenous antioxidant glutathione in the hippocampal CA and DG subregions as well as the prefrontal cortex of young adult animals. Therefore, we conclude that ethanol exposure during restricted periods of brain development can cause long-term effects in the adult brain by dysregulating its redox status.

  4. Letters to the Editor

  5. Original Articles

    1. The Influence of Mixers Containing Artificial Sweetener or Different Doses of Carbohydrate on Breath Alcohol Responses in Females

      Cassie Smith, Peter John Herzig, Andrew Davey, Ben Desbrow and Christopher Irwin

      Version of Record online: 7 NOV 2016 | DOI: 10.1111/acer.13264

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      The risk of alcohol-related harm increases as breath alcohol concentration (BrAC) rises. Consuming alcohol with mixers that contain sugar (carbohydrate, CHO) results in a lower peak BrAC and reduces total alcohol exposure in a dose–response manner, compared to drinks containing artificial sweetener or no sweetener (water). Consuming alcohol with mixers that contain sugar may translate to reduced risk of alcohol-related harms. These results require dissemination through educational messages so that alcohol consumers can make informed decisions about beverage selection.

  6. Commentary

  7. Erratum

    1. You have free access to this content
      Erratum

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011

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