Alcoholism: Clinical and Experimental Research

Cover image for Vol. 40 Issue 8

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 2.829

ISI Journal Citation Reports © Ranking: 2015: 5/18 (Substance Abuse)

Online ISSN: 1530-0277


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  1. Original Articles

    1. Combining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism

      Janice C. Froehlich, Stephen M. Fischer, Julian E. Dilley, Emily R. Nicholson, Teal N. Smith, Nick J. Filosa and Logan C. Rademacher

      Version of Record online: 29 JUL 2016 | DOI: 10.1111/acer.13157

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      This study compared the efficacy of varenicline (VAR) and naltrexone (NTX) alone, and in combination (VAR + NTX), on alcohol intake in rats selectively bred for high alcohol drinking (alcohol-preferring or P rats). Low, ineffective doses of VAR and NTX became effective when given together. Using low doses of VAR and NTX in a combination that maintains efficacy, while reducing side effects, may improve compliance and clinical outcomes for alcoholics and heavy drinkers who want to reduce their alcohol intake.

    2. Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers

      Tam T. Nguyen-Louie, Ashley Tracas, Lindsay M. Squeglia, Georg E. Matt, Sonja Eberson-Shumate and Susan F. Tapert

      Version of Record online: 27 JUL 2016 | DOI: 10.1111/acer.13160

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      Locally weighted scatter plot smoothing (LOWESS) regressions depict the relationships between alcohol use and verbal learning and memory (VLM) standard scores controlling for predrinking VLM, attention problems, and reading achievement. Higher recent peak estimated blood alcohol concentration linearly predicted poorer performances on VLM in adolescent drinkers; there was also a significant quadratic relationship between recognition total hits and blood alcohol level (ps < 0.05). The effect of alcohol quantity on VLM followed a linear dose-dependent relationship, highlighting the importance of potential variations in alcohol's effects on cognition between and within drinking groups.

    3. Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue

      Kristen T. Crowell, Jennifer L. Steiner, Catherine S. Coleman and Charles H. Lang

      Version of Record online: 27 JUL 2016 | DOI: 10.1111/acer.13159

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      These data identify a novel S6K1-dependent signaling pathway in white adipose tissue (WAT) that is increased by alcohol, in response to both chronic consumption and acute administration. They also show that alcohol induces a seemingly paradoxical concurrent increase in protein synthesis with a loss of adipose tissue mass. The alcohol-induced increase in global protein synthesis in this tissue differs from the decrease observed in many other tissues under comparable situations. It appears that an increase in autophagy, but not pyroptosis, may contribute to the decrease in WAT mass produced by chronic alcohol intake and may at least partially explain the changes in body composition produced by excessive alcohol consumption.

    4. Corticostriatal and Dopaminergic Response to Beer Flavor with Both fMRI and [11C]raclopride Positron Emission Tomography

      Brandon G. Oberlin, Mario Dzemidzic, Jaroslaw Harezlak, Maria A. Kudela, Stella M. Tran, Christina M. Soeurt, Karmen K. Yoder and David A. Kareken

      Version of Record online: 26 JUL 2016 | DOI: 10.1111/acer.13158

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      Using positron emission tomography (PET), we previously showed that beer flavor, absent intoxication, elicited human right ventral striatal (VST) dopamine release. Here, we examined a subset of these beer drinkers with a matched fMRI flavor paradigm. Both fMRI and dopaminergic PET showed rightward-biased VST flavor activation. In fMRI, beer flavor activated orbitofrontal cortex, with medial orbital activation correlating with beer “wanting.” Both study modalities converge in suggesting right-lateralized VST activation to alcohol cues, with medial orbital cortex reflecting beer wanting.

  2. Retraction

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  3. Commentary

  4. Original Articles

    1. You have full text access to this OnlineOpen article
      Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis

      Viranuj Sueblinvong, Stephen T. Mills, David C. Neujahr, Young-Mi Go, Dean P. Jones and David M. Guidot

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13148

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      We determined that chronic alcohol ingestion primes the lung for disrepair following an acute injury, and that this is mediated in part through TGFβ1-mediated suppression of Nrf2-ARE activity. In this study, we report that alcohol suppresses the expression of thioredoxin-1 (Trx1), a redox regulator required for optimal Nrf2-ARE signaling, in both the cytosol and the nucleus of lung fibroblasts. Importantly, nuclear overexpression of Trx-1 inhibits alcohol-induced TGFβ1 expression, restores Nrf2-ARE activity, and attenuates alcohol-mediated fibroproliferative disrepair following experimental bleomycin-induced lung injury.

    2. Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence

      Anke Post, Trevor S. Smart, Kimberley Jackson, Joanne Mann, Richard Mohs, Linda Rorick-Kehn, Michael Statnick, Raymond Anton, Stephanie S. O'Malley and Conrad J. Wong

      Version of Record online: 20 JUL 2016 | DOI: 10.1111/acer.13147

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      This was a proof-of-concept study to evaluate the efficacy of LY2940094, a nociceptin/orphanin FQ peptide receptor antagonist, in reducing alcohol consumption in actively alcohol-drinking patients with alcohol dependence. Although not reducing the number of drinks per day, LY2940094, compared to placebo, did reduce heavy drinking days and increased abstinence days in patients with alcohol dependence.

    3. Neurobehavioral Deficits Consistent Across Age and Sex in Youth with Prenatal Alcohol Exposure

      Amy L. Panczakiewicz, Leila Glass, Claire D. Coles, Julie A. Kable, Elizabeth R. Sowell, Jeffrey R. Wozniak, Kenneth Lyons Jones, Edward P. Riley, Sarah N. Mattson and the CIFASD

      Version of Record online: 19 JUL 2016 | DOI: 10.1111/acer.13153

    4. Mandating Treatment Based on Interlock Performance: Evidence for Effectiveness

      Robert B. Voas, A. Scott Tippetts, Gwen Bergen, Milton Grosz and Paul Marques

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13149

    5. Dissociating Affective and Cognitive Theory of Mind in Recently Detoxified Alcohol-Dependent Individuals

      Pierre Maurage, Fabien D'Hondt, Philippe de Timary, Charlotte Mary, Nicolas Franck and Elodie Peyroux

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/acer.13155

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      Performance (percentage of correct answers) in alcohol-dependent and healthy control individuals for global score and affective–cognitive subscales of the Movie for Assessment of Social Cognition (MASC), an experimental task exploring Theory of Mind (ToM) abilities (ns, nonsignificant; *p < 0.001). This figure illustrates that alcohol dependence is not related to a generalized ToM deficit, but to a dissociation between preserved cognitive ToM and impaired affective one. Such ecological evaluation of social cognition shows that emotional-affective deficits play a crucial role in alcohol dependence.

    6. Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance

      Jeff Boissoneault, Ian Frazier, Ben Lewis and Sara Jo Nixon

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13154

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      Acute moderate alcohol administration differentially affected posterior alpha power (PAP) during working memory maintenance in older and younger social drinkers (p < 0.001). The 0.04 g/dl dose level was associated with greater PAP than placebo or the 0.065 g/dl dose level in younger adults, but the opposite pattern was seen in older adults. Results bolster the growing body of evidence that older adults are differentially sensitivity to the neurobehavioral effects of acute moderate alcohol intake.

    7. Desire to Drink Alcohol is Enhanced with High Caffeine Energy Drink Mixers

      Cecile A. Marczinski, Mark T. Fillmore, Amy L. Stamates and Sarah F. Maloney

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13152

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      The purpose of this laboratory-based study was to investigate whether energy drink mixers increase the desire to drink alcohol. Social drinkers attended six sessions that involved consumption of alcohol and energy drinks, alone and in combination, and completed ratings on the Desire-for-Drug questionnaire. The results indicated that energy drink mixers increased desire for more alcohol ratings beyond that observed with alcohol alone. Thus, energy drink mixers may increase the reinforcing properties of alcohol and contribute to binge drinking.

    8. Effect of Acute Ethanol Administration on the Hippocampal Region Neural Activity Using a Microelectrode Array

      Yameng Zhang, Hejuan Yu, Weitao Li, Yamin Yang, Xiao Wang and Zhiyu Qian

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13144

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      We divided ICR mice into 3 groups (ethanol group (1.5 g/kg), saline group (1.5 g/kg), and control group), inserted microelectrodes in the hippocampus region of mice, recorded spikes and local field potentials, and analyzed firing characteristics, wavelet entropy, relative energy. We found that acute ethanol administration could inhibit excitatory neurons firing by modulating low-frequency oscillation. The finding provided insights into the relationship between local neuronal populations and corresponding brain activity.

    9. Implicit Alcohol Approach and Avoidance Tendencies Predict Future Drinking in Problem Drinkers

      Laura Martin Braunstein, Alexis Kuerbis, Kevin Ochsner and Jon Morgenstern

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/acer.13151

  5. Erratum

    1. You have free access to this content

      Version of Record online: 18 JUN 2016 | DOI: 10.1111/acer.13145

      This article corrects:

      A New Genomewide Association Meta-Analysis of Alcohol Dependence

      Vol. 39, Issue 8, 1388–1395, Version of Record online: 14 JUL 2015

    2. You have free access to this content

      Version of Record online: 13 JUN 2016 | DOI: 10.1111/acer.13143

      This article corrects:
    3. You have free access to this content

      Version of Record online: 14 FEB 2012 | DOI: 10.1111/j.1530-0277.2012.01778.x

      This article corrects:

      fMRI Differences Between Subjects with Low and High Responses to Alcohol During a Stop Signal Task

      Vol. 36, Issue 1, 130–140, Version of Record online: 17 OCT 2011


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