Alcoholism: Clinical and Experimental Research

Cover image for Vol. 39 Issue 11

Edited By: Henry R. Kranzler, M.D.

Impact Factor: 3.205

ISI Journal Citation Reports © Ranking: 2014: 5/18 (Substance Abuse)

Online ISSN: 1530-0277

Author Guidelines

NIH Public Access Mandate
For those interested in the Wiley-Blackwell policy on the NIH Public Access Mandate, please visit our policy statement. Frequently asked questions are answered here.

Author Guidelines

Alcoholism: Clinical and Experimental Research is the official publication of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism. It is a peer-reviewed, multidisciplinary journal that publishes papers based on original research that make substantial contributions to the understanding of the etiology, treatment, and prevention of alcohol-related disorders. Two kinds of papers may be submitted, full-length papers and critical reviews. Papers that the editors consider to have cross-disciplinary interest and significance may be highlighted as Feature Articles. The journal will also publish invited reviews and editorial commentaries.

Ethical/Legal Considerations

Conflict of Interest: This publication requires that all authors disclose any potential sources of conflict of interest. Any interest or relationship, financial or otherwise, that might be perceived as influencing an author's objectivity is considered a potential source of conflict of interest. These must be disclosed when directly relevant or indirectly related to the work that the authors describe in their manuscript. Potential sources of conflict of interest include but are not limited to patent or stock ownership, membership of a company board of directors, membership of an advisory board or committee for a company, and consultancy for or receipt of speaker's fees from a company. The existence of a conflict of interest does not preclude publication in this journal.

If the authors have no conflict of interest to declare, they must also state this at submission. It is the responsibility of the corresponding author to review this policy with all authors and to collectively list in the cover letter to the Editor, in the manuscript (in the footnotes, or Conflict of Interest or Acknowledgements section), and in the online submission system ALL pertinent commercial and other relationships.

Note to NIH Grantees: Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance.  This accepted version will be made publicly available 12 months after publication.  For further information, see

A submitted manuscript must be an original contribution not previously published (except as an abstract or a preliminary report), must not be under consideration for publication elsewhere, and, if accepted, must not be published elsewhere in similar form, in any language, without the consent of Wiley-Blackwell. Each person listed as an author is expected to have participated in the study to a significant extent. Although the editors and referees make every effort to ensure the validity of published manuscripts, the final responsibility rests with the authors, not with the Journal, its editors, or the publisher. All manuscripts must be submitted on-line through the journal’s Web site at See submission instructions under 'On-line manuscript submission.'

Patient anonymity and informed consent: It is the author’s responsibility to ensure that a patient’s anonymity be carefully protected and to verify that any experimental investigation with human subjects reported in the manuscript was performed with informed consent and following all the guidelines for experimental investigation with human subjects required by the institution(s) with which all the authors are affiliated. Authors should mask patients' eyes and remove patients' names from figures unless they obtain written consent from the patients and submit written consent with the manuscript.

Research ethics. You will be asked during online submission to confirm that your study has been approved by relevant bodies (e.g. institutional review boards, research ethics committees) and that appropriate consent was obtained for studies involving human or animal participants.

Permissions: Authors must submit written permission from the copyright owner (usually the publisher) to use direct quotations, tables, or illustrations that have appeared in copyrighted form elsewhere, along with complete details about the source. Any permissions fees that might be required by the copyright owner are the responsibility of the authors requesting use of the borrowed material, not the responsibility of Wiley-Blackwell.

Publication Charges

Manuscripts accepted for publication in Alcoholism: Clinical and Experimental Research will be assessed a publication charge of $60.00 (U.S.) per page to cover, in part, the cost of publication. Editorial consideration of a manuscript is in no way related to the author’s ability to assume the page charge, but it is expected that this charge will be paid by the author’s research funds that supported the research. Requests for waiver of page charges will be considered at the time of acceptance, if rationale can be provided.


OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see:

Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website here.

Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of this license:

Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

Manuscript Submission

On-line manuscript submission: All manuscripts must be submitted on-line through the journal's Web site at First-time users: Please click the Register button from the menu and enter the requested information. On successful registration, you will be sent an e-mail indicating your user name and password. Print a copy of this information for future reference. Note: If you have received an e-mail from us with an assigned user ID and password, or if you are a repeat user, do not register again; just log in. Once you have an assigned ID and password, you do not need to re-register, even if your status changes (that is, author, reviewer, or editor). Authors: Please click the log-in button from the menu at the top of the page and log into the system as an Author. Submit your manuscript according to the author instructions. You will be able to track the progress of your manuscript through the system. If you experience any problems, please contact Mary Newcomb,, or by calling (317) 375-0819. You may also contact Lisa Daitch, Associate Managing Editor,, or by calling (925) 915-0271. Requests for help and other questions will be addressed in the order received.

Authors who submit a manuscript do so with the understanding that if it is accepted for publication, copyright in the article, including the right to reproduce the article in all forms and media, shall be assigned exclusively to the Research Society on Alcoholism.

Articles, editorials, letters to the editor, and other text material in the journal Alcoholism: Clinical and Experimental Research represent the opinions of the authors and do not reflect the opinions of the Research Society on Alcoholism, the International Society for Biomedical Research on Alcoholism, the publisher, or the institution with which the author is affiliated, unless the contrary is clearly specified. All papers are subject to peer review by a Review Editor (member of the Board of Review Editors, the Editor, and the Associate Editors) and one or two referees. Authors may suggest up to four, and disqualify two, potential referees.

Types of Papers

The following types of articles may be submitted for publication in the journal.

Manuscripts exceeding the word and reference limitations will be returned without review.

-Original Research articles are not to exceed 5000 words (excluding title page, abstract, references, tables, and figures.) References are not to exceed 50.

-Commentaries are not to exceed 2500 words (excluding title page, abstract, references, tables and figures) and 20 references.

-Critical Review articles are not to exceed 5000 words (excluding title page, abstract, references, tables, and figures.) References are unlimited. Please use the following guidelines for critical reviews:

1) Provide a concise introduction whose content would be difficult to derive from the field without reading the entire literature. This is particularly important because the audience is multidisciplinary.

2) Do not include new data in the submission. The inclusion of unpublished data in the manuscript will result in the article being reviewed as an Original Research Article.

3) Focus critically upon a set of findings and methodologies and define the criteria for inclusion/exclusion. The focus should generally be a subpart of a larger area. For example, a review of alcohol’s actions on the liver would be so expansive as to be impossible to manage given the limitations of space. However, a critical review of oxidative stress on liver function could be reviewed comprehensively.

4) Include at least one figure that provides an overarching perspective on the topic being reviewed. Include tables to augment descriptions in text.

5) Provide insightful discussion of the conclusions from a review of the evidence and suggestions for future directions for research.

6) Explain the significance of the area of research to a multidisciplinary audience.

Critical reviews should be comprehensive and, thus, there is no limit on the number of references cited. The review length can vary, but because of the journal’s page limitations, authors should limit their reviews to 5,000 words of text. As with other full-length articles in ACER, the review should include a structured abstract, which should be modified as appropriate for a review, rather than a data-based article. All accompanying information should be supplied as required by the journal, including the names of potential peer reviewers.

All critical reviews (invited or unsolicited) will be peer reviewed. If upon review, major revisions are deemed necessary, the revised manuscript should be submitted within two months of receipt of the reviews; the comparable duration for minor revisions is one month.

All contributions should be submitted through our online system at

Please indicate that the manuscript is to be considered as a Critical Review and whether it was invited or not.

A cover letter signed by the corresponding author must accompany the manuscript. The letter should state that "all authors have read and approved the manuscript for submission to Alcoholism: Clinical and Experimental Research; have made a substantial contribution to the conception, design, gathering, analysis and/or interpretation of data and a contribution to the writing and intellectual content of the article; and acknowledge that they have exercised due care in ensuring the integrity of the work." Further, the letter should state that "none of the original material contained in the manuscript has been submitted for consideration nor will any of it be published elsewhere except in abstract form in connection with scientific meetings." Only submissions accompanied by a signed cover letter containing all of these elements will be assigned for peer review.

Clinical Trials All clinical trials to be reported in the journal must adhere to the principles of the Consolidated Standards of Reporting Trials (CONSORT), as embodied in the CONSORT Checklist ( and the CONSORT Flow Diagram ( For a clinical trial to be reviewed for publication in ACER, both the completed checklist and diagram must accompany the manuscript at the time of its initial submission.

 Preparation of Manuscript

Please ensure that all text (including abstract, body of manuscript, figure legends, and references) is submitted as double-spaced type in Word Document Format. We also require all text to be line-numbered. Manuscripts that do not adhere to the following instructions will be returned to the corresponding author for technical revision before undergoing peer review.

Title page:

The title page should include:

  • The complete manuscript title
  • The full names of all authors, their highest academic degrees, and affiliations
  • Name and address for correspondence, including fax number, telephone number, and e-mail address
  • All sources of support, including pharmaceutical and industry support, that require acknowledgement

Manuscripts that do not adhere to the following instructions will be returned to the corresponding author for technical revision before undergoing peer review.

Structured abstract and key words: The article should be briefly summarized or abstracted in a short paragraph (approximately 300 words) at the beginning of the text on a separate page. It should contain 4 elements labeled: Background, Methods, Results, and Conclusions. At the end of the paragraph, provide no more than 5 key words or phrases.

Search Engine Optimization: Driving usage and readership is critically important to raising the visibility of your published research. One of the key factors in sustaining long-term usage is through search engine optimization (SEO). Below is a list of suggested ways of maximizing your SEO.

1. Make sure your article title is SEO-friendly. It should be descriptive, and it must include a key phrase from your topic. Key words should appear within the title’s first 65 characters.
2. Provide up to five key words or phrases in the keyword field.
3. Be sure your key words and phrases appear in your abstract several times, but don’t go overboard or the search engine may kick you out.
4. When referencing authors, be consistent. Use their names as they generally appear in past online publications.
5. When appropriate, use your key words in article section headings.

Remember: They can’t read it if they can’t find it!

For more detailed information on SEO, including helpful examples, go to

Text: Organize the manuscript into four main headings: Introduction, Materials and Methods, Results, and Discussion. Define abbreviations at first mention in text and in each table and figure. If a brand name is cited, supply the manufacturer's name and address (city and state/country).
Abbreviations: For a list of standard abbreviations, consult the Council of Biology Editors Style Guide (available from the Council of Science Editors, 9650 Rockville Pike, Bethesda, MD 20814) or other standard sources. Write out the full term for each abbreviation at its first use unless it is a standard unit of measure.

References: The authors are responsible for the accuracy and completeness of information contained in the references. The journal uses Harvard Style for Referencing.


Cite references in the text by name and year in parentheses. Several publications by the same author or group should be listed in chronological order; those that appeared in the same year should be distinguished by a,b,c, etc. Where there are two authors, both should be named, but with three or more only the first author's name plus "et al." should be given.

-Reference List

The list of references should only include works that are cited in the text and have been published or accepted for publication. Personal communications and unpublished works should only be mentioned in the text. Do not use footnotes or endnotes as a substitute for a reference list. Reference list entries should be alphabetized by the last names of the first author of each work. References should be compiled (double-spaced) at the end of the article in alphabetical order. Identify multiple authors published in the same year with an a,b,c, etc. after the year. In-text citations should be listed by author name(s) and year of publication in parentheses.

Journal article, list all authors
1. Aragon CMG, Spivak K, Amit Z (1991a) Effect of 3-amino-1,2,4-triazole on ethanol-induced narcosis, lethality and hypothermia in rats. Pharmacol Biochem Behav 39:55-59.
Aragon CMG, Stotland LM, Amit Z (1991b) Studies on ethanol-brain catalase
interaction: evidence for central ethanol oxidation. Alcohol Clin Exp Res 15:165-169.

Book chapter
2. Holtzman SG (1990) Discriminative stimulus effects of drugs: relationship to potential for abuse, in Modern Methods in Pharmacology, Vol. 6, Testing and Evaluation of Drugs of Abuse (Adler M, Cowan A eds), pp 193-210. Wiley-Liss, New York.

Entire book
3. Julien RM (1985) A Primer of Drug Action. 4th ed. WH Freeman, New York.

4. Epi Info [computer program]. Version 6. Atlanta, GA: Centers for Disease Control and Prevention; 1994.

Online journals
5. Friedman SA. Preeclampsia: a review of the role of prostaglandins. Obstet Gynecol [serial online]. January 1988;71:22-37. Available from: BRS Information Technologies, McLean, VA. Accessed December 15, 1990.

6. CANCERNET-PDQ [database online]. Bethesda, MD: National Cancer Institute; 1996. Updated March 29, 1996.

World Wide Web
7. Gostin LO. Drug use and HIV/AIDS [JAMA HIV/AIDS Web site]. June 1, 1996. Available at: Accessed June 26, 1997.

Tables: Create tables using the table creating and editing feature of your word processing software (eg, Word). Do not use Excel or comparable spreadsheet programs. Each table should include the table title, appropriate column heads, and explanatory legends (including definitions of any abbreviations used). Tables should be self-explanatory and should supplement, rather than duplicate, the material in the text. Cite tables consecutively in the text, and number them in that order. Tables may be submitted at the end of the manuscript text file. Table legends should appear on a separate page, labeled 'Table Legends'.

Figures: There are three preferred formats for digital artwork submission: Encapsulated PostScript (EPS), Portable Document Format (PDF), and Tagged Image Format (TIFF). We suggest that line art be saved as EPS files. Alternately, these may be saved as PDF files at 600 dots per inch (dpi) or better at final size. Tone art, or photographic images, should be saved as TIFF files with a resolution of 300 dpi at final size. For combination figures, or artwork that contains both photographs and labeling, we recommend saving figures as EPS files, or as PDF files with a resolution of 600 dpi or better at final size. More detailed information on the submission of electronic artwork can be found at:

Please mark your figures in such a way that ensures legibility when printed as color OR black & white pages.

Each figure should be submitted individually - one figure per file.

Figure legends: Include legends for all figures. They should be brief and specific, and they should appear on a separate manuscript page after the references. Use scale markers in the image for electron micrographs, and indicate the type of stain used.

Supporting Information: If you have supporting information that you would like to link to your submission, please read the following instructions:

Style: Pattern manuscript style after the American Medical Association Manual of Style (10th edition). Stedman’s Medical Dictionary (28th edition) and Merriam Webster’s Collegiate Dictionary (11th edition) should be used as standard references. Refer to drugs and therapeutic agents by their accepted generic or chemical names, and do not abbreviate them. Use code numbers only when a generic name is not yet available. In that case, supply the chemical name and a figure giving the chemical structure of the drug. Capitalize the trade names of drugs and place them in parentheses after the generic names. To comply with trademark law, include the name and location (city and state in USA; city and country outside USA) of the manufacturer of any drug, supply, or equipment mentioned in the manuscript. Use the metric system to express units of measure and degrees Celsius to express temperatures. Please submit all text (including abstract, figures, legends, and references) as double-spaced.

Manuscript Revisions

All manuscript revisions should be submitted online within three months following the editor's decision. If this is not enough time in which to make your revisions, please contact the Editorial Office for an extension. If you do not request an extension and your revisions are not submitted within three months, your manuscript will be withdrawn by the editorial office. At that point, any further work by you will be considered as a new submission.

After Acceptance

Author Services: Author Services enables authors to track their article – once it has been accepted – through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The author will receive an e-mail with a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Page proofs and corrections: Corresponding authors will receive electronic page proofs to check the copyedited and typeset article before publication. Portable document format (PDF) files of the typeset pages and support documents (eg, reprint order form) will be sent to the corresponding author by e-mail. Complete instructions will be provided with the e-mail for downloading and printing the files and for faxing the corrected page proofs to the publisher. It is the author’s responsibility to ensure that there are no errors in the proofs. Changes that have been made to conform to journal style will stand if they do not alter the authors' meaning. Only the most critical changes to the accuracy of the content will be made. Changes that are stylistic or are a reworking of previously accepted material will be disallowed. The publisher reserves the right to deny any changes that do not affect the accuracy of the content. Authors may be charged for alterations to the proofs beyond those required to correct errors or to answer queries. Proofs must be checked carefully and corrections faxed within 24 to 48 hours of receipt, as requested in the cover letter accompanying the page proofs.

Offprints: Free access to the final PDF offprint of your article will be available via Wiley-Blackwell's Author Services. Please register to access your article PDF offprint and enjoy the many other benefits the service offers. Visit to register.

If you wish to order reprints from this journal please click on the following link:

NEW: Pre-acceptance English-language editing

Authors for whom English is a second language may choose to have their manuscript professionally edited before submission or during the review process. Authors wishing to pursue a professional English-language editing service should make contact and arrange payment with the editing service of their choice. For more details regarding the recommended services, please refer to