Journal of Thrombosis and Haemostasis

Cover image for Vol. 14 Issue 11

Edited By: Pieter Reitsma and Frits Rosendaal

Impact Factor: 5.565

ISI Journal Citation Reports © Ranking: 2015: 6/63 (Peripheral Vascular Disease); 10/70 (Hematology)

Online ISSN: 1538-7836

Author Guidelines


JTH welcomes fundamental and clinical manuscripts in the broad field of thrombosis and hemostasis.

These include basic manuscripts on blood coagulation and fibrinolysis, proteins and reactions, blood platelets, and the interaction of all these components with other biological systems such as, but not limited to, the vessel wall, blood cells, and invading organisms. Clinical manuscripts can cover a wide variety of topics including venous thrombosis and arterial disease, plus hemophilia and other bleeding disorders, as well as platelet diseases. The subject area of clinical manuscripts can range from etiology to diagnostics, prognosis, prevention, and treatment.

The editors will evaluate submitted manuscripts on soundness of methods, originality, insights into mechanisms and foreseeable impact on patient care.

Contributions can have the following formats: Original article, Brief report, Commentary, Review, Forum, Case report, and Letter to the editor.

Reviews and commentaries, that deal with an article in the same issue, are mostly solicited by the editors in chief. The Forum category is for commentaries on publications in other journals or general viewpoints. Original manuscripts are expected to present an in depth study of a particular subject. Studies that are definitive can also be published in a brief format. Please note that the bar for Brief reports is quite high with respect to originality and impact. JTH rarely publishes Case reports, and only those that give new and deep insight qualify. Letters to the editor are meant solely for discussion of recently published JTH articles.

Please submit online at

Manuscripts must be accompanied by a covering letter stating that the submission is:

  • original work not previously published in any substantial part;
  • not under consideration of publication elsewhere; and
  • submitted to Journal of Thrombosis and Haemostasis (JTH)™ for consideration of publication.

In addition, submissions must include a statement that the manuscript has been read and approved for submission to JTH™ by all qualified authors and a statement of actual or potential conflict of interest capable of influencing judgment on the part of any author. A conflict of interest disclaimer will be included with the published article. All financial relations with any commercial biomedical company over the last five years (income, honorarium, consulting fee, license fees, stock ownership) should be declared for all authors. Conflict of Interest forms are mandatory upon submission of a manuscript and a completed form is required from each author. These should be uploaded with all other manuscript files at the submission stage. Blank forms can be down loaded from the homepage, For further information on conflicts of interest, please see the guidelines of the International Committee of Medical Journal Editors

Upon submitting, you will be prompted to select the type of submission (e.g. Original Article, Review) and the section heading to which the manuscript should be assigned. The sections are: Review Articles; Original Articles and Brief Reports (Clinical Haemostasis and Thrombosis, Cardiovascular Medicine, Coagulation, Fibrinolysis, Platelets and Vascular Biology); Letters to the Editor; Case Reports and Recommendations and Guidelines.

Manuscripts should have: a wide margin, double spacing, and numbered pages beginning with the title page. The title of the paper, name and address, with the affiliation of each author, and the name of the institution where the work has been carried out should appear on the title page, as should the name and full postal address (with phone/fax numbers and e-mail address) of the corresponding author only. The corresponding author (only one is permitted) is responsible for reading the proofs and communicating with the other authors, and for informing the JTH™ Editorial Office of any change in details until the paper is published. Wiley-Blackwell reserves the right to contact another author if the corresponding author is not available to check proofs.

Authors must adhere to acceptable use of American English and syntax; only abbreviations and symbols that are generally accepted should be used and the title should be devoid of abbreviations. Unfamiliar abbreviations should be used as little as necessary and must be defined when first used. The Editors reserve the right to make corrections, both literary and technical, to the papers. Please note that unless specifically requested, Wiley-Blackwell will dispose of all electronic material submitted 2 months after publication.

Editorial policies and practices
The Journal of Thrombosis and Haemostasis follows the International Committee of Medical Journal Editors Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals

Authors of all accepted manuscripts are required to assign copyright of their papers to the International Society on Thrombosis and Haemostasis. Your article cannot be published until the publisher has received the appropriate signed license agreement. Once your article has been received by Wiley for production the corresponding author will receive an email from Wiley’s Author Services system which will ask them to log in and will present them with the appropriate license for completion.

Authors may wish to take advantage of the OnlineOpen service. OnlineOpen is available to authors who wish to make their article available to non-subscribers upon publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see Any authors wishing to send their paper to OnlineOpen will be required to complete the payment form available from our website at which can be done at any stage of the evaluation process or after acceptance.

Prior to acceptance there is no requirement to inform the Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their merit.

What to submit
Text files are submitted in Word format, and figures in TIFF or EPS format. Images embedded in Word documents or in PPT format cannot be used. RRF and PDF originals are not recommended due to potential conversion errors in the system. Please note that if the proper program extension is not in the filename, it must be added by the author before uploading the file; e.g. filename: Antithrombin should be renamed Antithrombin.doc; Figure1 should be renamed Figure1.eps or Figure1.tiff, etc. Without the extension, the files will not be recognized by the system and therefore may not convert properly: this will cause delays in reviewing the submission. Authors must state on the cover page of the manuscript (under the title and affiliation) the word count of the abstract and the word count of the text separately.

If your manuscript reports a randomized clinical trial you must complete a CONSORT checklist and the trial must be registered. If an observational study is reported a STROBE checklist should be completed. Meta-analyses should be reported according to the PRISMA guidelines. If your manuscript contains a prediction model, please complete a TRIPOD checklist.

Types of Articles

Review Articles. Review articles will generally be solicited, but unsolicited reviews on timely subjects will be considered. Review articles should be fewer than 5000 words (for the body of the text) with an unstructured abstract of up to 250 words. No more than three authors, 100 references and eight tables or figures are permitted.

Original Articles. It is important that the word count for Original Articles be kept to 4000 words for the main body of the text with up to 75 references, no more than eight tables or figures and a maximum of 12 authors. A structured abstract of up to 250 words is also required. Only in exceptional circumstances are more than 12 authors considered - see Authorship Details below for further information. Supporting information may be added for online publication (see below).

Letters to the Editors. This is a correspondence category only. Letters should not exceed 1500 words for the main body of the text with up to 10 references, no more than one table or figure and a maximum of six authors.

Case Reports. These should be kept to 1500 words with no more than 20 references and up to one table or figure. An unstructured abstract of up to 150 words should also be included and no more than six authors are permitted. Supporting information may be added for online publication (see below).

Brief Reports. These follow a similar format as an Original Article in that they should be structured and have an abstract of up to 250 words, but the Results and Discussion sections in the main body of the text should be combined. The word count for Brief Reports should be kept to 2000 words for the main body of the text, with up to 30 references and no more than four tables or figures. A maximum of 12 authors are allowed but no supporting information is permitted.

Recommendations and Guidelines. These include SSC recommendations originating from an SSC subcommittee and ISTH guidance papers which have gone through the Guidelines and Guidance Committee process. SSC recommendations are brief reports which must not exceed 1500 words for the main body of the text and can have up to two tables or figures and no more than 30 references. The authors must be limited to seven. The cover letter accompanying the manuscript must be undersigned by both the corresponding author and the Subcommittee Chairman. Additional supporting information may be submitted for publication on the JTH™ web site (see below). Manuscripts must be submitted with clear identification as SSC Communications. The Subcommittee Chairman will be responsible for determining the appropriate authors. Manuscripts submitted will be sent by JTH™ to the SSC Chairman-Elect, who acts as Associate Editor of JTH™, for review and decision. Communications regarding the progress of SSC manuscripts should be directed to the JTH™ Editorial Office.

ISTH guidance papers must not exceed 3000 words for the main body of the text or 2500 words if one table or figure is included. The number of authors is limited to seven and no more than 30 references are allowed. Papers need to be undersigned by the Guidelines and Guidance Committee and will be dealt with by the assigned guidance Associate Editor, Marcel Levi.

Please visit the ISTH official website for further information on submitting official communications of the SSC ( and guidance papers (

It is possible to submit papers under the Recommendations and Guidelines heading which are not official SSC communications, in which case the instructions for original papers apply. All contributions for Recommendations and Guidelines will undergo external review.

Forums. Papers in this category can be up to 1500 words and must include an abstract of approximately 150 words. No more than three authors, 20 references and one table or figure is permitted.

Commentaries. These should be limited to 1500 words and have no more than three authors, 20 references and one table or figure.

Manuscript Format

Title. In addition to the full title, authors should provide a short version (running head), not more than 50 characters long, including spaces. Please do not use abbreviations.

Authorship Details. The Editors require that an Addendum be included in all papers except review articles and invited letters to the editor where the role of each author in the study is specified. The Addendum should be placed at the end of the Discussion section, before the Acknowledgements, and names should be given as initial(s) only followed by surnames (e.g. P. H. Reitsma). Authorship implies a substantial contribution to concept and design, analysis and/or interpretation of data; critical writing or revising the intellectual content; and final approval of the version to be published. The order of the authors must be agreed upon before submission of the manuscript and any changes in the order can only be made after explicit consent of each of the authors. JTH™ does not allow the use of dual authorship. If more than twelve authors meet criteria for authorship of an original article (or three authors for a review article), please contact the Editors in Chief to obtain approval before completing the submission of your manuscript. Give author names as initial(s) only followed by surnames, which should be clearly linked to the respective addresses, if more than one, by use of the following symbols: *, †, ‡, §, ¶) which, for more than six addresses, may be doubled as follows: **, ††, ‡‡, §§, ¶¶, etc.

If a study group is given in the author list ('for the XX Study Group'), please provide an appendix listing the contributors, all of whom must complete a conflict of interest form because they are considered authors. If you do not wish contributors to be considered as authors, please do not include a study group in the author list but you can still list the contributors in an appendix.
Technical assistance should be acknowledged in a separate paragraph. For more information on what constitutes an author, please refer to ICMJE

For revised articles, any changes in the number and order of authors can only be made after explicit consent from each of the authors. Such changes must be communicated to the Editors in Chief prior to resubmission, accompanied by a letter confirming each author's consent to the proposed amendments. The Editors reserve the right to refuse requests for authorship changes.

Essentials. JTH now publishes summary points on all original articles, brief reports and case reports in order to provide a synopsis of the research. Please provide four bullet points of no more than 98 characters each, including spaces, under the heading ‘Essentials’. The bullet points should be categorized as follows: one for background, one for setting and two for results/significance/conclusion (please do not include these subheadings). This section should immediately precede the abstract.

If abbreviations are used, please write the term in full with the abbreviation in brackets in the first instance, for example, ‘deep vein thrombosis (DVT)’.

Summary. Original Articles, Brief Reports, and Review Articles should include an abstract with a maximum of 250 words. In the case of Original Articles and Brief Reports, it should be structured under the following headings: Background, Objectives, Patients/Methods, Results and Conclusions. Case Reports should include an unstructured abstract of up to 150 words. Other manuscript submissions should not include an abstract. Please note that P-values are not permitted in the summary.

Keywords. Provide five keywords in alphabetical order following the Summary. These keywords must be taken from the Medical Subject Headings List and should be searchable by the exact term (

Potential Reviewers. It is mandatory that you provide 4 potential preferred reviewers for all submissions.

Main Text. Give generic names of drugs. Full names of substances with abbreviations must be given at first mention; thereafter, use the abbreviation. Symbols should be inserted as per the instructions on the submission site. Any studies that require informed consent and approval by an Ethics Committee based on either the Declaration of Helsinki or local laws should seek consent and approval, and report on it in the article. Similarly, in case animal experiments are reported, approval by the local animal welfare committee should be mentioned.

Headings. Only three levels of headings are used in JTH™ (the third being a run-on heading, where the text follows on the same line). Work must be rewritten if any part of it contains more than three types of heading in succession.

References. Only papers closely related to the author’s work should be referenced; exhaustive lists should be avoided. Authors should preferably refer to original work, not to reviews. Verify all references for completeness and accuracy, and format references as a plain, unstructured list. References should appear as a numbered list at the end of the manuscript and with numbers in square brackets [1], [3–5] in the text. References are a modified version of Vancouver style, omitting issue numbers and with the first 20 authors named. References to personal communications, unpublished data, and manuscripts either ‘in preparation’ or ‘submitted for publication’ should be inserted, if essential, in the text only and not listed in the references. Publications ‘in press’ should be updated as soon as possible. For further examples, see the ‘Uniform Requirements for Manuscripts Submitted to Biomedical Journals’ at

We recommend the use of a tool such as EndNote or Reference Manager for reference management and formatting.

EndNote reference styles can be searched for here: Reference Manager reference styles can be searched for here:

Tables. Tables should be kept to a minimum and contain only essential data and should be cited in the text. Verify information for accuracy and consistency with the manuscript’s text. Each table should be given an Arabic number. The title (legend) of the table should contain only minimal text. Any other information, such as definitions of abbreviations, probability statistics, etc., should be in the table footnote; if symbols are necessary, they should be the same as given for the authors’ details above. Headings and columns should be laid out clearly; avoid use of sub-headings. Avoid wordy, over-full tables. Any blank cells should have a dash. Tables should be submitted in an editable file format, not in image format (e.g., not as a PDF, JPEG, etc.).

Supporting Information. It is possible to submit supporting information for Original Articles, Recommendations and Guidelines, Review Articles and Case Reports, but not for Letters to the Editor or Brief Reports. Supporting information, which should be limited to data sets or additional figures or tables, will not be published in the print edition of the journal but will be viewable in the online edition. Please note that additional descriptions of methods should not be submitted as supporting information; these should be in the main body of the text. For meta-analyses and Recommendations and Guidelines, the Supporting Information may contain text and references. There is no maximal length for Supporting information.

Supporting information must be submitted to the journal with the rest of the article. Any such material that is submitted after acceptance of the main article will be referred to the Editor for approval and this may delay publication. Supporting information will be published exactly as supplied and it is the author's responsibility to ensure that the material is logically laid out, adequately described, and is in a format that is likely to be accessible to readers. It is recommended that text and graphics be supplied in PDF format, data tables in native file formats such as Excel, and animations and other moving images or sound files in common Internet standard formats such as AVI, MPG, WAV, QuickTime, animated GIF or Flash.

Detailed information on our guidelines on Supporting information is available at

The only appendices that will be published in the print journal are lists of study group participants. Please list only the city, state and country for each participant.

A legend should be provided for each illustration. Photomicrographs should state the original magnification. Legends should provide sufficient information to allow the reader comprehension without reference to the text, and should be grouped at the end of the manuscript. Illustrations should be referred to in the text as ‘Figs’ and be given Arabic numbers. The final width of the figures will be either 82, 114 or 173 mm. Lines should be of sufficient thickness to stand reduction (at least 4 mm wide for a 50% reduction), and letters should be a minimum of 9 pt Arial or an equivalent size.

Digital Images
Images submitted to JTH™ must exactly represent the original data. Figures that are compiled into multi-figure panels should be kept individually and be available upon request. Manipulation of images should be kept to an absolute minimum, and if the quality of an image is too poor to clearly support the conclusion, the experiment should be repeated.
Collecting images: If multiple images are compared to one another, each image has to be collected in the same manner. Any processing should be applied uniformly to all images. If differences in collection/processing are necessary, these need to be described in the legend.
Brightness and Contrast: If the brightness or contrast of an image needs minor adjustment, adjustments must be applied to the entire image and must not obscure or eliminate any information. Always note any adjustment in the legend.
Cloning Tools: Images should not be airbrushed to remove blemishes. Do not use cloning tools to manipulate any aspect of an image
Gels/Blots: All gels should contain a positive and a negative control, and a set of molecular weight markers. For Western blots, control panels (e.g. β-actin, GAPDH, etc.) should come from a stripped and re-probed membrane of the experimental blot that is shown. If this is not possible, the control blots should be derived from the same samples and this should be indicated in the figure legend.
Cropping: Conservative cropping of gels and blots is allowed to improve clarity and conciseness if the following points are observed:

- important bands must be retained
- at least several band widths should be retained above and below the cropped band
- cropping must be noted in the legend
- band(s) of interest must be clearly labeled
- molecular weight marker positions should be shown in all gels/blots

Splicing: Occasionally, images are spliced to rearrange the order of samples for the sake of presentation, such as those in a Western blot. If splicing of data from a single experiment is necessary, draw contrasting (black or white) lines to indicate where the images were joined and state the manipulation in the legend. It would be preferable to re-run the gel so that the order is correct. Images from different experiments should not be spliced to form a new single image.

Color Illustrations
It is the policy of JTH™ for authors to pay the full cost for the reproduction of their colour artwork ($450 per page). Therefore, please note that if there is colour artwork in your manuscript when it is accepted for publication, Wiley-Blackwell requires you to complete and return a colour work agreement form before your paper can be published. This form will be despatched to you via email along with your proofs.

In the event that an author is not able to cover the costs of reproducing colour figures in colour in the printed version of the journal, JTH™ offers authors the opportunity to reproduce colour figures in colour for free in the online version of the article (but they will still appear in black and white in the print version). If an author wishes to take advantage of this free colour-on-the-web service, they should liaise with the Editorial Office to ensure that the appropriate documentation is completed for the Publisher.

Electronic Artwork
Please read the information on the Publisher's web site at Line artwork (such as graphs) should be submitted as EPS files or TIFF files with a minimum resolution of 800 dpi. Other artwork (such as photographs) should be submitted as a minimum 300 dpi TIFF file. Information on creating EPS files from Microsoft Windows, Powerpoint, Excel and Apple Mac is available from the Wiley-Blackwell website.

Note: To ensure font consistency across all papers, figures containing text will be re-keyed during typesetting. Authors should review the text within figures for accuracy during the proofing stage.

Pre-print publication via Accepted Articles
The accepted manuscript will appear online within 10 days of acceptance on the Wiley-Blackwell service Accepted Articles. Once the article is fully corrected (print-ready) it will be published online. All preprint published articles can be referenced using the DOI number provided.

Accepted Articles is the Publisher's service whereby peer reviewed, accepted articles are published online as and when they are ready, prior to their ultimate inclusion in a print or online issue and without having been copy-edited. This service has been designed to ensure the earliest possible circulation of research papers immediately after acceptance. Readers should note that articles published within Accepted Articles have been fully refereed, but have not been through the copy-editing and proof correction process. Wiley-Blackwell cannot be held responsible for errors or consequences arising from the use of information contained in these articles; nor do the views and opinions expressed necessarily reflect those of Wiley-Blackwell. Accepted Articles papers appear in PDF-only format, without the accompanying full-text HTML.

The corresponding author will receive an e-mail alert containing a link to an online proofing website. A working e-mail address must therefore be provided for the corresponding author. The PDF proof can be viewed and annotated online. The author will only be able to annotate the file using Acrobat Reader 8.0 or later. The latest version can be downloaded free of charge at the following address:

Further instructions will be sent with the proof. Excessive changes made by the author in the proofs, excluding typesetting errors, will be charged separately. Wiley-Blackwell reserves the right to contact another author if the corresponding author is not available to check proofs.

The Production Editor will require approval from the Editors for any significant changes to content, title etc made by the author at the proof stage, and the authors are requested to make such changes explicit.

Note: To ensure font consistency across all papers, figures containing text will be re-keyed during typesetting. Authors should review the text within figures for accuracy during the proofing stage.

Offprints (with covers or without) can be ordered from a website that accompanies the proof alert email.

Online production tracking is now available for your article through Wiley-Blackwell’s Author Services.
Author Services enables authors to track their article – once it has been accepted – through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The author will receive an e-mail with a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Copyright and photocopying
© 2010 International Society on Thrombosis and Haemostasis. All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means without the prior permission in writing from the copyright holder. Authorization to photocopy items for internal and personal use is granted by the copyright holder for libraries and other users registered with their local Reproduction Rights Organisation (RRO), e.g. Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923, USA (, provided the appropriate fee is paid directly to the RRO. This consent does not extend to other kinds of copying such as copying for general distribution for advertising or promotional purposes, for creating new collective works or for resale. Special requests should be addressed to Wiley-Blackwell at:

The Publisher, the International Society on Thrombosis and Haemostasis and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher, the International Society on Thrombosis and Haemostasis and Editors, neither does the publication of advertisements constitute any endorsement by the Publisher, the International Society on Thrombosis and Haemostasis and Editors of the products advertised.

Journal of Thrombosis and Haemostasis (JTH)™ Appeals procedure
Please do not resubmit papers which have previously been rejected. If an author feels that their paper has been handled unsatisfactorily during the editorial process, an appeals procedure is in place. The author should write to the Editor in Chief responsible for the manuscript, outlining the concerns. The Editor in Chief will review the submission, investigate the grievance, and provide a response, generally within one week. In all cases, the Editors’ decision is final. The Editorial Offices will endeavour to keep authors informed about the progress of their appeal and to provide a timely response to any correspondence.