FEMS Yeast Research

Erg11 mutations in Candida albicans

This study shows that all Erg11 point mutations in C. albicans that resulted in amino acid substitutions conferred resistance to azoles, particularly FLZ and VOR. The findings are clinically relevant, as these point mutations were originally derived from clinical isolates. These mutations could potentially be used to identify resistant strains, to adjust treatments accordingly, and for the rational design of new drugs less prone to resistance.

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Effect of oxygen conditions on methanol metabolism

In this article the authors provide evidence that methanol metabolism and peroxisome morphology in C. boidinii are coordinated by induction of methanol-metabolizing enzymes whose induction level was affected by oxygen conditions, and that a key factor for its induction is the mitochondrial respiratory chain.

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Organelles and Cells

This virtual issue was compiled for ISSY2013 "Cell Surface and Organelles in Yeasts: from Basics to Applications".

This issue will be freely available during the conference and through until the end of June.

Metabolic footprinting in Chardonnay fermentations

Hyung Ah Kang (Editor): “This is an excellent case study in applying cutting edge technology to the oldest yeast biotechnological process”

The authors reveal the metabolic footprints and fermentation profiles of commercial wine yeast strains in Chardonnay. Group of strains with related phenotypes were found and these similarities can be linked to genomic similarities, providing insight into the diversity of this unique class of industrial strains.

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Thematic issues previously published in FEMS Yeast Research include:

Metabolic engineering, synthetic biology and systems biology
March 2012

Yeasts as a model for human diseases
December 2010