FEMS Immunology & Medical Microbiology

The human respiratory tract pathogen Chlamydia pneumoniae AR39 is naturally infected by the bacteriophage ϕCPAR39. To study the growth of the phage, antibodies were generated to VP1 and used to investigate the ϕCPAR39 infection. Using immunofluorescence laser confocal microscopy and two-dimensional gel electrophoresis, we investigated the ϕCPAR39 infection of C. pneumoniae AR39. It was observed that ϕCPAR39 infection differentially suppressed the C. pneumoniae protein synthesis as the polymorphic membrane protein 10 and the secreted chlamydial protein Cpn0796 was hardly xpressed while the secreted chlamydial protein Cpaf was expressed, but not secreted. The inclusion membrane protein, IncA, was demonstrated to surround the phage-infected abnormal reticulate bodies (RB) as well as being located in the inclusion membrane. READ MORE

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The papers featured include new insights into the diagnosis of fastidious bacterial endocarditis, bartonella species infecting rodents and bartonella quintana in head louse nits.

Click on the links below to view thematic issues published in FEMS Immunology & Medical Microbiology:

Rickettsia and other intracellular bacteria
March 2012

Biofilms
August 2010

Neglected Tropical Diseases
February 2010

Chlamydia
March 2009

Pathogenesis and Host Response in Helicobacter Infections
July 2007

Campylobacter
February 2007