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Journal of Cellular and Molecular Medicine

All articles accepted from 12 September 2012 are published under the terms of the Creative Commons Attribution License.   Articles accepted before this date were published under the agreement as stated in the final article.

Cover image for Vol. 18 Issue 12

Edited By: L.M. Popescu

Impact Factor: 3.698

ISI Journal Citation Reports © Ranking: 2013: 27/122 (Medicine Research & Experimental); 80/185 (Cell Biology)

Online ISSN: 1582-4934

Author Guidelines

Please note that Journal of Cellular and Molecular Medicine will be joining the Wiley Open Access publishing program of fully open access journals published by Wiley from January 2013. For further information visit the Wiley Open Access website.
Manuscripts submitted after 12 September 2012 and accepted for publication will be published as open access articles, immediately free to read, download and share. Authors or their funder will be required to pay an Article Publication Charge upon acceptance.

Manuscript Submissions
Authors should submit complete manuscripts (with separate figure files) to the JCMM ScholarOne Manuscripts website, at:

Please follow the instructions given at this site, noting that all information entered during the submission process related to the manuscript should also be included in, and be identical to, the final submitted version of the manuscript. The corresponding author must complete all the mandatory fields in the submission process, but preliminary data can be stored if additional information needs to be obtained - for example, the e-mail addresses of all the named authors (who will all be informed of the submission process). Should authors encounter difficulties they may contact the Wiley-Blackwell support desk in the USA (Tel.: +1 434 817 2040 ext. 167,

Submission is considered on the conditions that papers are previously unpublished, and are not offered simultaneously elsewhere; that all authors have read and approved the content, and all authors have also declared all competing interests; and that the work complies with Ethical Policies of the journal, and has been conducted under internationally accepted ethical standards after relevant ethical review. It is highly recommended you read this policy and complete any necessary documentation prior to your submission

Authors are encouraged to supply the names of potential referees, and/or of referees that they do not wish to review their paper.
Authors of Invited Reviews should supply the name of the Guest Editor who invited them to write.

Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. English-language editing will (a) improve grammar, spelling and punctuation, (b) improve clarity and resolve any ambiguity caused by poor phrasing, and (c) improve word choice and ensure that the tone of the language is appropriate for an academic journal. A list of independent suppliers of editing services can be found at All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.

You will be prompted to sign the Open Access Agreement electronically after manuscript review and acceptance. We have introduced a convenient new process for signing your Open Access Agreement electronically (eOAA) that will save you considerable time and effort. The author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper. You may preview the copyright terms and conditions here.

Categories of manuscripts

Original Articles (research papers) - up to 15 printed pages.
Reviews - up to 10 printed pages.
Review Series - up to 10 printed pages and no more than 120 references.
Short Communications, Images in Cellular/Molecular Medicine, Editorial Forewords, Commentaries, Points of View, Letters to the Editor - up to 2 printed pages.
Medical Hypotheses, Retro-views of significant ideas and discoveries.

Research Ethics
If the research described involves human subjects or experimental animals, the authors must give details in the manuscript of the approval obtained for the protocol from the Ethics Committee of the institution in which the research was undertaken. Experiments on live vertebrates or higher invertebrates must be demonstrated to be ethically acceptable and in accordance with institutional and national guidelines or regulations for the use and welfare of laboratory animals.
If the manuscript reports medical research involving human subjects, authors must include a statement confirming that informed consent was obtained from all subjects, and that the research was carried out according to the World Medical Association Declaration of Helsinki. Any form of registration that may identify a patient must be excluded from the content of the paper. When clinical images of patients are submitted it is the responsibility of the authors to obtain, prior to submission, full informed consent by the patient for the use of the photographs, and to ensure that full anonymity is preserved.

Publication Ethics
Journal of Cellular and Molecular Medicine is a member of the Committee on Publication Ethics and subscribes to its recommendations (Committee on Publication Ethics [COPE]: guidelines on good publication practice, The policy of Wiley-Blackwell and of JCMM on the major ethical principles of academic publishing are described in our Best Practice Guidelines on Publication Ethics: (Graf C, Wager E, Bowman A, et al., Int J Clin Pract 2007; 61 [suppl 152]: 126). The Editors reserve the right to reject a paper on ethical grounds. All authors are responsible for adhering to guidelines on good publication practice.

All authors must fulfill the following criteria: 1. Substantial contributions to research design, or the acquisition, analysis or interpretation of data; 2. Drafting the paper or revising it critically; and 3. Approval of the submitted and final versions.

Conflicts of interest
The authors are responsible for recognizing and disclosing financial and other conflicts of interest related to their study or to the subject of their paper. The authors must acknowledge in the manuscript all financial support for the research work and other financial or personal connections to the work. A conflict of interest statement must be included in every manuscript, as a separate section after the Acknowledgements (if any) and before the References. In the absence of conflicts of interest, the authors must include the statement: “The authors confirm that there are no conflicts of interest.”

Manuscript format
Manuscripts should be typewritten in A4 page format (210x297 mm), with double spacing, margins of 25 mm, and page numbering. Times New Roman font, 12-point size, is required. As a guide, a research article of about 3500 words, plus figures and tables, will take up approximately 10 pages. The text of research manuscripts should be arranged in the following sections: Title page, Abstract and Keywords, Introduction, Materials and Methods, Results, Discussion, Acknowledgements, Conflict of Interest Statement, References, Tables, Figure Legends and Figures. Headings for subdivisions of the text should be clearly identified using a different font type (e.g. bold, underlined). All materials should comply with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals, prepared by the International Committee of Medical Journal Editors ( Within the main document, figure and table legends, and references, all words of Latin origin (e.g. versus, vs., in vitro, in vivo, ex vivo, in situ, de novo, et al., etc.) must be italicised.

Title page
This should carry the following information: the title of the article (concise and informative, not longer than 80-100 characters, including spaces and punctuation), authors’ names and their respective institutional affiliations, department(s) and institution(s) to which the work should be attributed to. To facilitate accurate exports to indexing sites (e.g. PubMed), authors with multi-part surnames (e.g. van der Waals, da Vinci, Ramón y Cajal) are advised to underline all parts of their surname in the author listing at the beginning of their manuscript. Each affiliation should be numbered accordingly. The author responsible for correspondence should be marked by an asterisk, and their full address, telephone/fax numbers, and e-mail address must be indicated. All Reviews must include a bulleted list of all headings and sub-headings present in the review. This should be placed before the abstract.

Abstract and keywords
An abstract must accompany each paper and should not exceed 250 words. The abstract should follow the title page, and the authors need to be careful that it reflects the content of the article accurately. The abstract must clearly provide the background for the study and should state the study's objectives, methods used, main results, and principal conclusions. It should be easily understood without reference to the text. No other references are allowed. If necessary, include only few important values. Avoid reporting detailed statistics and using abbreviations. Following the abstract, a list of 3-10 keywords is essential for indexing purposes.  In addition, please add for Reviews, a list of the main topics.

Units of measurement, nomenclature and abbreviations
Quantities of, and symbols for, physical units should be expressed in accordance with the recommendations of the International System of Units (Système International d'Unités), i.e.: SI units. Alternative or non-SI units may be used, but these must be defined at their first occurrence in the text.

Chemical and biochemical nomenclature should follow the Recommendations of the IUPAC-IUB Commission on Nomenclature. Enzymes, when first mentioned, should be written in full, followed by the IUB Enzyme Commission number. Approved names may be used and details may be obtained from the latest edition of Enzyme Nomenclature. For the expression of catalytic activity, use the International Federation of Clinical Chemistry methods for the measurement of catalytic concentration of enzymes. The producer should be specified for chemicals. Chemical structure must be specified, if laboratory code numbers are used. For drugs, use international non-proprietary (generic) names.

Use standard abbreviations. Any non-standard abbreviations (to be avoided if possible) should be explained in the text the first time they are used. Avoid the use of abbreviations in the title.

Clinical trials (if applicable)
Clinical trials should be registered and the authors must state the registration number and name of the trial registry. If this is not available, please provide an explanation.

This section, placed after the Discussion, should specify any contributions that need acknowledgment but do not justify authorship, such as acknowledging technical help. It must also list all governmental, industrial, charitable, philanthropic and/or personal sources of funding used for the studies described in the manuscript. Attribution of these funding sources is preferred, as in these examples:
- This work was supported by a grant from the National Institutes of Health, USA (DKxxxx to AB).
- This work was supported by the Crohn’s and Colitis Foundation of Canada (grant to AB and CD).
- This work was supported by a grant from "...." Inc. (to AB) and equipment was donated by "...." Inc.
- EF received a graduate studentship award from the University of ".....".
The authors must also indicate their specific contributions to the work described in the manuscript. Some examples include: Performed the research; Designed the research study; Contributed essential reagents or tools; Analyzed the data; Wrote the paper.
An author may list more than one contribution, and more than one author may have contributed to the same element of the work. E.g. AB performed the research, AB and CD analyzed the data and wrote the paper, EF contributed the knockout mice for the study and GH designed the research study and wrote the paper.

References should be numbered consecutively in the order in which they are first mentioned in the text. Identify references in text, tables, and legends by Arabic numerals in square brackets (e.g. [1], [2-6], etc.). The reference list is a separate section at the end of the manuscript. All references must be up-to-date. Type each reference single-spaced, with one line space between references. For papers published online ahead of print (Epub), the digital object identifier (DOI) must be provided.

Use exactly the reference style and format as shown below. Each reference should contain names and initials of the allowed number of authors. In the case of more than 3 authors, "et al." should end the authors list after the first 3 names. In the case of 4 authors, all the names must appear in the list. In the case of 3 or fewer authors, all the names must appear in the authors list.

The titles of journals (font style italic) should be abbreviated according to Index Medicus. Inaccurate referencing may delay publication.
N.B. Reference citations must be according to the Uniform Requirements for Manuscripts Submitted to Biomedical Journals, as stated by the International Committee of Medical Journal Editors.

(a) Standard journal article
Halpern SD, Ubel PA, Caplan AL. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002; 347: 284-7.
(b) Epub article
Yang X, Cai WB, Xu Z, et al. High efficacy and minimal peptide required for the anti-angiogenic and anti-hepatocarcinoma activities of plasminogen K5. J Cell Mol Med. 2009. DOI: 10.1111/j.1582-4934.2009.01004.x
(c) Books and Monographs
Murray PR, Rosenthal KS, Kobayashi GS, et al. Medical microbiology. 4th ed. St. Louis: Mosby; 2002.
(d) Chapter in a book
Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill; 2002. p. 93-113.

References in Articles
We recommend the use of a tool such as Reference Manager for reference management and formatting.
Reference Manager reference styles can be searched for here:

Avoid footnotes. When essential, they are indicated in the text by symbols, typed at the foot of the appropriate page, e.g. the address of the author for correspondence (*), on the title page, or explanatory notes for tables.

Include tables in the main manuscript file, starting on a separate page. Use the table function of a word processor rather than tab and space, and do not submit tables as figure files/images. Number tables consecutively with Arabic numerals and give each a short, descriptive heading. Give each column a short or abbreviated heading. Place explanatory matter in footnotes to the table, not in the heading. Explain in the footnotes all non-standard abbreviations used in the table. Omit internal horizontal and vertical lines. If data from another published or unpublished source are used, obtain permission and acknowledge fully. Tables should be self-explanatory and understandable without reference to the text of the article.

Figure Legends
Each figure should have a legend containing sufficient information to make the figure intelligible without reference to the text. When symbols, arrows, numbers or letters are used to identify parts of the illustrations, explain each one in the legend. Figure legends should be included in the main manuscript file for upload, in double-spaced text on a separate page, with Arabic numbers corresponding to the illustrations.

Please submit vector graphics (e.g. line artwork) in Encapsulated Postscript Format (EPS), and bitmap files (e.g. half-tones) in Tagged Image File Format (TIFF). Detailed guidance on preparing digital illustrations is available via Wiley-Blackwell Author Services at Letters, numbers and symbols should be clear and even throughout, and of sufficient size so that when reduced for publication the item will still be legible; titles and detailed explanations should be included in the legends, not in the illustrations themselves. Cite each figure in the text in consecutive order.

If you wish to use a figure that has been previously published, you must acknowledge the original source and submit written permission from the copyright holder to reproduce the material. . Please go to to get permission.

Supporting Information
Supporting Information can be a useful way for an author to include important but ancillary information with the online version of an article. Examples of Supporting Information include additional tables, data sets, figures, movie files, audio clips, 3D structures, and other related nonessential multimedia files. Supporting Information should be cited within the article text, and a descriptive legend should be included. It is published as supplied by the author, and a proof is not made available prior ro publication; for these reasons, authors should provide any Supporting Information in the desired final format.

For further information on the recommended files types and requirements for submission, please visit:

An electronic version of the revised manuscript must be provided. Accepted manuscripts will be published from the Word file (not PDF) wherever practicable and therefore revised versions must be provided in this form. This reduces typesetting errors and speeds up publication. Authors must ensure that all sections of their paper, excluding figures, are presented in a single file, and that all files and figure and table ordering are updated to incorporate all revisions. Two versions of the main manuscript file should be supplied, one with the revisions marked using “Track Changes”, and one with all changes accepted.

Files should be formatted double-spaced with no hyphenation and automatic word-wrap (no hard returns within paragraphs). Please type your text consistently, e.g. take care to distinguish between '1' (one) and 'l' (lower-case L) and '0' (zero) and 'O' (capital O), etc.

Tables should be created using the table editor function of word processing software. Do not use graphics software to create tables.

In-line equations should be typed as text were possible. Graphics programs and 'equation editors' can also be used, and the output will be used were possible but displayed equations may occasionally be re-keyed by our typesetters.

Please submit digital versions of your figures, as EPS and TIFF format files only. Please note that your paper will go through production more quickly if the figures do not have to be relabelled or redrawn. Please ensure that your electronic artwork is prepared such that, after reduction to fit across one or two columns or two-thirds width (80mm, 169mm or 110mm respectively) as required, all lettering will be clear and easy to read, i.e. no labels should be too large or too small. Avoid using tints if possible; if they are essential to the understanding of the figure, try to make them coarse. No artwork for publication should be incorporated into the final accepted text files.
Full guidance on submission of artwork is available at


Article Publication Charge
Manuscripts submitted after 12 September 2012 and accepted for publication will be published as open access articles, immediately free to read, download and share. You or your funder will be required to pay an Article Publication Charge on acceptance.

Open Access Agreement
The Corresponding Author will be prompted to sign the Open Access Agreement electronically after acceptance.

The corresponding author will receive an email alert containing a link to a web site. A working e-mail address must therefore be provided for the corresponding author. The proof can be downloaded as a PDF (portable document format) file from this site. Acrobat Reader will be required in order to read this file. This software can be downloaded (free of charge) from the following web site:
This will enable the file to be opened, read on screen and printed out in order for any corrections to be added. Further instructions will be sent with the proof. Hard copy proofs will be posted if no e-mail address is available. Excessive changes made by the author in the proofs, excluding typesetting errors, will be charged separately.

Free access to the final PDF offprint of an article will be available via Author Services only. Authors are therefore recommended to sign up for Author Services to access their article PDF offprint and enjoy the many other benefits the service offers.

Author Services
Wiley-Blackwell's Author Services enables authors to track accepted articles through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The corresponding author will receive an e-mail with a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Author Material Archive Policy
Please note that unless specifically requested otherwise, Wiley-Blackwell will dispose of all hardcopy or electronic material submitted, two months after publication. If you require the return of any material submitted, please inform the editorial office or production editor as soon as possible.