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Cover image for Vol. 19 Issue 1

Edited By: Michael S. Marks, Trina A. Schroer, Robert G. Parton and Sharon A. Tooze

Online ISSN: 1600-0854

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Advances in Cell Biology in China

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Celebrating the Contributions of Ari Helenius

Celebrating the Contributions of Ari Helenius
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Chemical and Immunological Synapses"

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Recently Published Articles

  1. Rab35 GTPase and Cancer: Linking membrane trafficking to tumorigenesis

    Ronan Shaughnessy and Arnaud Echard

    Accepted manuscript online: 4 JAN 2018 05:05AM EST | DOI: 10.1111/tra.12546

    Thumbnail image of graphical abstract

    Rab35 is a small GTPase that was recently reported to possess oncogenic activating mutations in human tumors. Conversely, Rab35 depletion inverts apico-basal cell polarity and promotes cell migration. In the present review we describe how Rab35’s known functions in membrane trafficking, signaling, cell division and cell migration could explain its role in tumorigenesis.

  2. Dysregulation of Rab5-Mediated Endocytic Pathways in Alzheimer's Disease

    Wei Xu, Fang Fang, Jianqing Ding and Chengbiao Wu

    Accepted manuscript online: 3 JAN 2018 07:55AM EST | DOI: 10.1111/tra.12547

    Thumbnail image of graphical abstract

    Dysregulation of the endo-lysosomal system has emerged as one of the early cellular pathologies for Alzheimer's disease (AD). Rab5 is a small GTPase that plays a critical role in mediating internalization and endocytic trafficking. Recent studies have demonstrated Rab5 is hyper-activated and Rab5+ early endosomes are found to be abnormally enlarged in post-mortem brain of AD patients and in mouse models of AD. In the review, we will summarize recent research findings linking Rab5 dysfunction to AD pathogenesis.

  3. Ergosterol is mainly located in the cytoplasmic leaflet of the yeast plasma membrane

    Lukasz M. Solanko, David P. Sullivan, Yves Y. Sere, Maria Szomek, Anita Lunding, Katarzyna A. Solanko, Azra Pizovic, Lyubomir D. Stanchev, Thomas Günther Pomorski, Anant K. Menon and Daniel Wüstner

    Accepted manuscript online: 28 DEC 2017 01:37AM EST | DOI: 10.1111/tra.12545

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    Synopsis

    The transbilayer distribution of sterols in the plasma membrane (PM) is highly debated. Exploiting yeast cells in which ergosterol is entirely replaced with closely related fluorescent dehydroergosterol (DHE), we show that PM sterols reside primarily (~80%) in the inner leaflet of the yeast PM. Maintenance of this pronounced asymmetry does not require metabolic energy but is weakened upon sphingolipid depletion and loss of PM phospholipid asymmetry.

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    V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase (pages 58–82)

    Sanja Perkovska, Catherine Méjean, Mohammed Akli Ayoub, Juan Li, Floriane Hemery, Maithé Corbani, Nadine Laguette, Maria-Angeles Ventura, Hélène Orcel, Thierry Durroux, Bernard Mouillac and Christiane Mendre

    Version of Record online: 21 DEC 2017 | DOI: 10.1111/tra.12535

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    Molecular mechanisms of the vasopressin receptor V1b subtype (V1bR) trafficking and function were investigated. Both β-arrestin-1 and 2 play a fundamental role in internalization and recycling of V1bR with rapid and transient V1bR-arrestin interaction via V1bR C-terminus in a phosphorylation-independent manner. In parallel, V1bR MAP kinase activation is dependent on arrestins and Src-kinase but not on G-proteins. Interestingly, Src kinase interacts with V1bR at the plasma membrane at basal state and dissociates when receptor internalization occurs.

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    Retromer and the cation-independent mannose 6-phosphate receptor—Time for a trial separation?

    Matthew N. J. Seaman

    Version of Record online: 21 DEC 2017 | DOI: 10.1111/tra.12542

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    The cation-independent mannose 6-phosphate receptor (CIMPR) has long been regarded as the archetypal cargo protein for the retromer complex and its retrieval to the Golgi was thought to be mediated by the cargo-selective complex. But new data showing that the SNX-BAR dimer associates with the CIMPR have questioned this view. Here, I discuss the recent findings in the context of several years of published data on retromer and propose a new model for retromer-mediated CIMPR retrieval.

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