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Cover image for Vol. 18 Issue 6

Edited By: Michael S. Marks, Trina A. Schroer, Robert G. Parton and Sharon A. Tooze

Online ISSN: 1600-0854

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Recently Published Articles

  1. The outer membrane vesicles: Secretion system type zero

    Andrea Guerrero-Mandujano, Cecilia Hernández-Cortez, Jose Antonio Ibarra and Graciela Castro-Escarpulli

    Version of Record online: 23 MAY 2017 | DOI: 10.1111/tra.12488

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  2. Spatial-specific functions in retrograde neuronal signalling

    Eitan Erez Zahavi, Roy Maimon and Eran Perlson

    Version of Record online: 18 MAY 2017 | DOI: 10.1111/tra.12487

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    Zahavi et al review mechanisms of axonal retrograde signalling in neurons, focusing on selected neurotrophic, injury and guidance cues that have site-specific signalling and functional roles. Increasing evidence demonstrates a common concept in various extracellular signalling, in which their signal and cellular outcome are directly regulated by their localization along the length of the polarized neuron. The authors describe and discuss the known molecular events that can regulate the specificity of these signalers along the neuron and point at standing questions and possible translational implications of these spatial aspects.

  3. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease

    Georg F. Vogel, Andreas R. Janecke, Iris M. Krainer, Karin Gutleben, Barbara Witting, Sally G. Mitton, Sahar Mansour, Antje Ballauff, Joseph T. Roland, Amy C. Engevik, Ernest Cutz, Thomas Müller, James R. Goldenring, Lukas A. Huber and Michael W. Hess

    Version of Record online: 17 MAY 2017 | DOI: 10.1111/tra.12486

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  4. Endocytic Activity of HIV-1 Vpu: Phosphoserine-dependent Interactions with Clathrin Adaptors

    Charlotte A. Stoneham, Rajendra Singh, Xiaofei Jia, Yong Xiong and John Guatelli

    Accepted manuscript online: 14 MAY 2017 11:35PM EST | DOI: 10.1111/tra.12495

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    SYNOPSIS STATEMENT

    The endosomal coat proteins clathrin and the heterotetrameric clathrin adaptors are cofactors for the immunomodulatory activities of the HIV-1 accessory protein Vpu. Here we show that Vpu interacts with clathrin adaptors in a multifaceted manner: the Vpu cytoplasmic domain binds directly to basic patches on the μ subunit, as well as to a hemi-complex formed by the large, specific (α or γ) and σ subunits. Both interactions are regulated by phosphorylation of serines in the Vpu cytoplasmic domain.

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