Cover image for Vol. 18 Issue 6

Edited By: Michael S. Marks, Trina A. Schroer, Robert G. Parton and Sharon A. Tooze

Online ISSN: 1600-0854

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Recently Published Articles

  1. Pharmacologically increasing microtubule acetylation corrects stress-exacerbated effects of organophosphates on neurons

    Anand N. Rao, Ankita Patil, Zachary D. Brodnik, Liang Qiang, Rodrigo A. España, Kimberly A. Sullivan, Mark M. Black and Peter W. Baas

    Version of Record online: 25 MAY 2017 | DOI: 10.1111/tra.12489

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    An organophosphate surrogate for sarin elicits negative effects on microtubule stability, organelle transport and dopamine release from cultured neurons. The effects are exacerbated by hormone treatment that mimics physical stress, and correctable by treatment with tubacin, which increases microtubule acetylation. The results suggest a potential mechanistic basis as well as a potential therapy for neuropathology of Gulf War Illness.

  2. The outer membrane vesicles: Secretion system type zero

    Andrea Guerrero-Mandujano, Cecilia Hernández-Cortez, Jose Antonio Ibarra and Graciela Castro-Escarpulli

    Version of Record online: 23 MAY 2017 | DOI: 10.1111/tra.12488

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  3. Spatial-specific functions in retrograde neuronal signalling

    Eitan Erez Zahavi, Roy Maimon and Eran Perlson

    Version of Record online: 18 MAY 2017 | DOI: 10.1111/tra.12487

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    Zahavi et al review mechanisms of axonal retrograde signalling in neurons, focusing on selected neurotrophic, injury and guidance cues that have site-specific signalling and functional roles. Increasing evidence demonstrates a common concept in various extracellular signalling, in which their signal and cellular outcome are directly regulated by their localization along the length of the polarized neuron. The authors describe and discuss the known molecular events that can regulate the specificity of these signalers along the neuron and point at standing questions and possible translational implications of these spatial aspects.

  4. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease

    Georg F. Vogel, Andreas R. Janecke, Iris M. Krainer, Karin Gutleben, Barbara Witting, Sally G. Mitton, Sahar Mansour, Antje Ballauff, Joseph T. Roland, Amy C. Engevik, Ernest Cutz, Thomas Müller, James R. Goldenring, Lukas A. Huber and Michael W. Hess

    Version of Record online: 17 MAY 2017 | DOI: 10.1111/tra.12486

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