Cover image for Vol. 18 Issue 5

Edited By: Michael S. Marks, Trina A. Schroer, Robert G. Parton and Sharon A. Tooze

Online ISSN: 1600-0854

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Recently Published Articles

  1. The Outer Membrane Vesicles: Secretion System Type zero

    Andrea Guerrero-Mandujano, Cecilia Hernández-Cortez, J. Antonio Ibarra and Graciela Castro-Escarpulli

    Accepted manuscript online: 19 APR 2017 01:21AM EST | DOI: 10.1111/tra.12488


    Membrane vesicle (MV) secretion is widely distributed in all domains of life. MVs carry nucleic acids, proteins or both. In this minireview Andrade-Guerrero et al. revisit the state of the art MV secretion in bacteria, focusing in outer membrane vesicles (OMVs), and support the previously proposed idea of naming this as the type zero secretion system.

  2. Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with Microvillus Inclusion Disease

    Georg F. Vogel, Andreas R. Janecke, Iris M. Krainer, Karin Gutleben, Barbara Witting, Sally G. Mitton, Sahar Mansour, Antje Ballauff, Joseph T. Roland, Amy C. Engevik, Ernest Cutz, Thomas Müller, James R. Goldenring, Lukas A. Huber and Michael W. Hess

    Accepted manuscript online: 13 APR 2017 09:03AM EST | DOI: 10.1111/tra.12486

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    Graphical Abstract

  3. HIV infection is influenced by dynamin at 3 independent points in the viral life cycle

    Anupriya Aggarwal, Tina L. Hitchen, Lars Ootes, Samantha McAllery, Andrew Wong, Khanh Nguyen, Adam McCluskey, Phillip J. Robinson and Stuart G. Turville

    Version of Record online: 11 APR 2017 | DOI: 10.1111/tra.12481

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    The concept that HIV endocytosis is the rate limiting step for HIV fusion in primary resting and activated CD4 T cell subsets has become controversial. Although dynamin plays a key role in endocytosis, modulation of its activity has led to both supportive and contradictory evidence for its role in HIV fusion. Through chemical dissection of dynamin action in the HIV life cycle of primary resting and activated CD4 T cells, we reveal that dynamin plays a role at 3 discrete stages: cell cycle related HIV transcription, the HIV fusion site and the HIV fusion reaction.

  4. Spatial-Specific Functions in Retrograde Neuronal Signalling

    Eitan Erez Zahavi, Roy Maimon and Eran Perlson

    Accepted manuscript online: 10 APR 2017 01:15AM EST | DOI: 10.1111/tra.12487

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    Zahavi et al. review mechanisms of axonal retrograde signalling in neurons, focusing on selected neurotrophic, injury and guidance cues that have site-specific signalling and functional roles. Increasing evidence demonstrates a common concept in various extracellular signalling, in which their signal and cellular outcome are directly regulated by their localization along the length of the polarized neuron. The authors describe and discuss the known molecular events that can regulate the specificity of these signalers along the neuron and point at standing questions and possible translational implications of these spatial aspects.

  5. Enzyme reversal to explore the function of yeast E3 ubiquitin-ligases

    Chris MacDonald, Stanley Winistorfer, R. Marshall Pope, Michael E. Wright and Robert C. Piper

    Accepted manuscript online: 6 APR 2017 12:05AM EST | DOI: 10.1111/tra.12485

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    Graphical abstract

    MacDonaldet al. describe a library of ‘anti-ligase’ reagents that antagonize the activity of endogenous E3 ubiquitin ligases, perturbing their function and stabilizing endogenous substrate levels. The library was used to identify E3 ligases required for vacuolar sorting from the biosynthetic and endocytic pathways.