Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3
Caiyue Li, Wenbo Ma, Shikui Yin, Xin Liang, Xiaodong Shu, Duanqing Pei, Terrance M Egan, Jufang Huang, Aihua Pan and Zhiyuan Li
Accepted manuscript online: 27 JAN 2016 10:06PM EST | DOI: 10.1111/tra.12379
The trafficking of ion channels to/from the plasma membrane is essential for the functionality of cells. We report the novel finding that the vesicular trafficking protein SNX11 promotes the trafficking of exogenous TRPV3 ion channel from the plasma membrane to lysosome for degradation via protein-protein interactions in HEK293T cells, and it also decreases the level of endogenous TRPV3 protein in human skin keratinocytes HaCaT cells, which leads to a change in the density of TRPV3 channels on the cell surface.