The C-terminal tails of heterotrimeric kinesin-2 motor subunits directly bind to α-tubulin1: Possible implications for cilia-specific tubulin entry
Mukul Girotra, Shalini Srivastava, Anuttama Kulkarni, Ayan Barbora, Kratika Bobra, Debnath Ghosal, Pavithra Devan, Amol Aher, Akanksha Jain, Dulal Panda and Krishanu Ray
Version of Record online: 5 JAN 2017 | DOI: 10.1111/tra.12461
Tubulin entry into the cilia and flagella is essential for their growth. The article by Girotra et al suggests that the tail domains of heterotrimeric kinesin-2 motor subunits can selectively bind certain α-tubulin1 isotypes and regulate the entry of tubulin into cilia. The conjecture is supported by extensive binding studies in vitro and tissue-cultured cells using recombinant tail fragments of both Drosophila and mouse orthologues, as well as genetic analysis in Drosophila.