Cover image for Vol. 16 Issue 12

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Michael S. Marks, Trina A. Schroer, Tom H. Stevens, Sharon A. Tooze

Online ISSN: 1600-0854


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  1. Original Articles

    1. The aPKC/Par3/Par6 Polarity Complex and Membrane Order Are Functionally Interdependent in Epithelia During Vertebrate Organogenesis

      Ahmed Abu-Siniyeh, Dylan M. Owen, Carola Benzing, Silke Rinkwitz, Thomas S. Becker, Arindam Majumdar and Katharina Gaus

      Article first published online: 23 NOV 2015 | DOI: 10.1111/tra.12339

      The differential distribution of lipids between apical and basolateral membranes is necessary for many epithelial cell functions, but how membrane organization integrated within the polarity network poorly understood. Here we quantified and manipulated membrane order in the gut, kidney and liver ductal epithelia in developing zebrafish larvae with Laurdan 2-photon microscopy and found a reciprocal relationship between membrane order and the apical-basal distribution of polarity proteins.

    2. HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis

      Anna Albecka, Romain F. Laine, Anne F.J. Janssen, Clemens F. Kaminski and Colin M. Crump

      Article first published online: 6 NOV 2015 | DOI: 10.1111/tra.12340

      Thumbnail image of graphical abstract

      Our results demonstrate that transport of herpes simplex virus-1 glycoproteins to the plasma membrane prior to endocytosis is the major route by which these envelope proteins are localized to cytoplasmic virus assembly compartments. We show that this process requires dynamin and that internalization of glycoprotein complexes can employ clathrin-dependent and/or -independent pathways.


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