Traffic

Cover image for Vol. 18 Issue 12

Edited By: Michael S. Marks, Trina A. Schroer, Robert G. Parton and Sharon A. Tooze

Online ISSN: 1600-0854

Recently Published Issues

See all

Virtual Issues

Advances in Cell Biology in China

Advances in Cell Biology in China
View this issue

Celebrating the Contributions of Ari Helenius

Celebrating the Contributions of Ari Helenius
View this issue

Virtual Issue Toolbox

Toolbox
View this issue

Chemical and Immunological Synapses"

Chemical and Immunological Synapses
View this issue

Recently Published Articles

  1. Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities

    Karen Y. Y. Fung, Gregory D. Fairn and Warren L. Lee

    Version of Record online: 21 NOV 2017 | DOI: 10.1111/tra.12533

    Thumbnail image of graphical abstract

    The permeability of macromolecules across continuous monolayers can occur by movement between cells, referred to as paracellular transport or leak, or through the cytoplasm of individual cells in vesicular carriers, by a process called transcytosis. In this review, we discuss the established transcytosis pathways in epithelial cells and the comparatively understudied processes in endothelial cells. Transcytosis of lipoproteins plays a critical role in the development of atherosclerosis and mucosal immunity. While a greater understanding of transcytosis will aid in the design of therapeutic compounds that exploit the uptake and delivery to target tissues.

  2. Journey to the centre of the cell: Virtual reality immersion into scientific data

    Angus P.R. Johnston, James Rae, Nicholas Ariotti, Benjamin Bailey, Andrew Lija, Robyn Webb, Charles Ferguson, Sheryl Maher, Thomas P. Davis, Richard I. Webb, John McGhee and Robert G. Parton

    Version of Record online: 21 NOV 2017 | DOI: 10.1111/tra.12538

    Thumbnail image of graphical abstract

    Visualization of microscopy data using virtual reality headsets has the potential to transform the way we understand, interact with and teach cell biology. In this study, we show how serial block-face SEM data can be used to build a three-dimensional (3D) virtual model of a cell that allows scientists, students and members of the public to explore and interact with a “real” cell.

  3. Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay

    Mahmoud Abdul Karim, Dieter Ronny Samyn, Sevan Mattie and Christopher Leonard Brett

    Accepted manuscript online: 14 NOV 2017 07:55AM EST | DOI: 10.1111/tra.12543

    Thumbnail image of graphical abstract
  4. You have full text access to this OnlineOpen article
    Retromer and the CIMPR – time for a trial separation?

    Matthew N.J. Seaman

    Accepted manuscript online: 14 NOV 2017 07:40AM EST | DOI: 10.1111/tra.12542

    Thumbnail image of graphical abstract

    Synopsis

    The cation-independent mannose 6-phosphate receptor (CIMPR) has long been regarded as the archetypal cargo protein for the retromer complex and its retrieval to the Golgi was thought to be mediated by the cargo-selective complex (CSC). But new data showing that the SNX-BAR dimer associates with the CIMPR has questioned this view. Here I discuss the recent findings in the context of several years of published data on retromer and propose a new model for retromer-mediated CIMPR retrieval.

  5. Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin α1

    Weili Zheng, Rui Wang, Xi Liu, Siyu Tian, Benqiang Yao, Ang Chen, Shikai Jin and Yong Li

    Version of Record online: 10 NOV 2017 | DOI: 10.1111/tra.12534

    Thumbnail image of graphical abstract

    The function of the histone acetyltransferase males-absent-on-the-first (MOF) is critical for many biological processes. However, the structural or functional mechanisms of the nucleocytoplasmic transport of MOF remain elusive. We identified novel importin α1-specific nuclear localization signals (NLSs) in the N-terminal of human MOF and revealed a unique binding mode of MOF, further emphasizing the diversity and specificity of the cargo-NLS-importin nuclear import system. Our structural studies will be of great importance in understanding the functional regulation of MOF in various biological processes.

SEARCH

SEARCH BY CITATION