American Journal of Transplantation

Cover image for Vol. 14 Issue 12

Edited By: Allan D. Kirk

Impact Factor: 6.19

ISI Journal Citation Reports © Ranking: 2013: 1/26 (Transplantation); 2/204 (Surgery)

Online ISSN: 1600-6143

Images in Transplantation (CME)

  • An Unexpected Foreign Body in the Colon of a Heart Transplant Recipient

    An Unexpected Foreign Body in the Colon of a Heart Transplant Recipient

    Endoscopic view of the transverse colon. (A) The pacemaker wires fixed to the mucosa. (B) Removal of the wires. Arrow: the metallic tips at the end of the wires.

  • A 60-Year-Old Man With Necrotic Skin Lesions After Heart Transplantation

    A 60-Year-Old Man With Necrotic Skin Lesions After Heart Transplantation

    Photographs of the patient's left shoulder lesion (A) and chest lesion (B).

  • Right Homonymous Hemianopsia and Seizures in a Liver Transplant Recipient

    Right Homonymous Hemianopsia and Seizures in a Liver Transplant Recipient

    Neuroimaging. (A) Axial noncontrast computer tomography demonstrating hypodensity in the left occipital lobe. Note that the lesion does not precisely follow the vascular distribution of the posterior cerebral artery. (B) Axial diffusion-weighted magnetic resonance imaging (MRI) reveals hyperintensity in the left occipital lobe consistent with cytotoxic edema and recent infarct confirmed by corresponding hypointensity on the apparent diffusion coefficient map (C). (D) Axial T1-weighted, gadolinium enhanced MRI shows two confluent, rim-enhancing lesions abutting the occipital horn of the left lateral ventricle. There is associated midline shift and effacement of the ipsilateral hemispheric sulci.

  • Renal Failure in a Kidney Transplant Recipient—BK Virus Nephropathy or Rejection?

    Renal Failure in a Kidney Transplant Recipient—BK Virus Nephropathy or Rejection?

    The hematoxylin and eosin stain of transplant kidney biopsy done 3 years posttransplantation reveals moderate interstitial fibrosis and tubular atrophy with inflammatory infiltration. Serum creatinine was 2.5mg/dL and serum BK virus PCR was undetectable at <5000 copies/mL on the day of biopsy.

  • Bovine Pericardium Diaphragm Repair of Diaphragmatic Hernia After LVAD Explantation and Heart Transplantation

    Bovine Pericardium Diaphragm Repair of Diaphragmatic Hernia After LVAD Explantation and Heart Transplantation

    Chest X-ray showing the placement of the LVAD.

  • Emesis Following Laparoscopic Left Donor Nephrectomy

    Emesis Following Laparoscopic Left Donor Nephrectomy

    CT with oral contrast, sagittal view.

  • Hemorrhagic Shock One Month Following Uncomplicated Liver Transplantation

    Hemorrhagic Shock One Month Following Uncomplicated Liver Transplantation

    CT of the abdomen shows a collection in the porta hepatis/gallbladder fossa that represents a hematoma (labeled H). The reconstructed hepatic artery is redundant. The arrow represents an abnormality adjacent to the hepatic artery and the duodenum (labeled D).

  • Skin Nodule on the Ear of a Kidney–Pancreas Transplant Recipient

    Skin Nodule on the Ear of a Kidney–Pancreas Transplant Recipient
  • An Unexpected Foreign Body in the Colon of a Heart Transplant Recipient
  • A 60-Year-Old Man With Necrotic Skin Lesions After Heart Transplantation
  • Right Homonymous Hemianopsia and Seizures in a Liver Transplant Recipient
  • Renal Failure in a Kidney Transplant Recipient—BK Virus Nephropathy or Rejection?
  • Bovine Pericardium Diaphragm Repair of Diaphragmatic Hernia After LVAD Explantation and Heart Transplantation
  • Emesis Following Laparoscopic Left Donor Nephrectomy
  • Hemorrhagic Shock One Month Following Uncomplicated Liver Transplantation
  • Skin Nodule on the Ear of a Kidney–Pancreas Transplant Recipient

Recently Published Issues

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Current Issue Highlights

Regulatory T cells (Tregs), specifically CD4+ T cells that express FoxP3 and the high-affinity IL2 receptor CD25, have been increasingly recognized as providing critical balance to protective and alloreactive cytotoxic T cell responses. This has, in turn, spawned growing interest in harnessing Tregs as potential tools for the control of T cell–mediated allograft rejection, with many proposing that ex vivo expanded Tregs could be used therapeutically to induce tolerance. This month, Singh et al show, in a rigorous preclinical primate model, that sirolimus helps foster Treg persistence and function after ex vivo expansion and adoptive transfer. The work is an important step in designing a Treg-based clinical trial and a nice demonstration of cellular transfer techniques in primates. Cover design by Ken North, North Design Group.

Read the Editor's picks of the month:

Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half-Life and Phenotype After Adoptive Transfer
K. Singh, L. Stempora, R. D. Harvey, A. D. Kirk, C. P. Larsen, B. R. Blazar and L. S. Kean

Pharmacokinetics of Therapeutic Tregs
Q. Tang

Use of CTLA4Ig for Induction of Mixed Chimerism and Renal Allograft Tolerance in Nonhuman Primates
Y. Yamada, T. Ochiai, S. Boskovic, O. Nadazdin, T. Oura, D. Schoenfeld, K. Cappetta, R.-N. Smith, R. B. Colvin, J. C. Madsen, D. H. Sachs, G. Benichou, A. B. Cosimi and T. Kawai

Azithromycin and the Treatment of Lymphocytic Airway Inflammation After Lung Transplantation
R. Vos, S. E. Verleden, D. Ruttens, E. Vandermeulen, H. Bellon, A. Neyrinck, D. E. Van Raemdonck, J. Yserbyt, L. J. Dupont, E. K. Verbeken, E. Moelants, A. Mortier, P. Proost, D. Schols, B. Cox, G. M. Verleden and B. M. Vanaudenaerde

CLAD: Does the Emperor Have New Clothes?
A. R. Glanville

Randomized, Double-Blind Trial of Anidulafungin Versus Fluconazole for Prophylaxis of Invasive Fungal Infections in High-Risk Liver Transplant Recipients
D.J. Winston, A.P. Limaye, S. Pelletier, N. Safdar, M.I. Morris, K. Meneses, R.W. Busuttil and N. Singh

Revisiting Antifungal Prophylaxis in High-Risk Liver Transplant Recipients
S. Huprikar

Antifungal Prophylaxis in Liver Transplantation: A Systematic Review and Network Meta-Analysis
J. D. W. Evans, P. J. Morris and S. R. Knight

Bone Marrow–Derived Hematopoietic Stem and Progenitor Cells Infiltrate Allogeneic and Syngeneic Transplants
Z. Fan, K. Enjoji, J. C. Tigges, V. Toxavidis, V. Tchipashivili, W. Gong, T. B. Strom and M. Koulmanda

Watch the Latest Video in the AJT Video Library:

A Complete Treatment of Adult Living Donor Liver Transplantation: A Review of Surgical Technique and Current Challenges to Expand Indication of Patients
S.-G. Lee
Published online: October 2014


Dual adult-to-adult living donor liver transplantation using two left lobes.

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The AJT Report

Despite changes in the current liver allocation system, regional variation in transplant practices persists. This month, “The AJT Report” looks at how OPTN/UNOS is investigating ways to lessen that geographic disparity.

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AJT Report December 2014

News and Information

Get up to speed quickly with the latest in transplantation news from the American Journal of Transplantation newsroom.

In the Press


News

Frailty Increases Kidney Transplant Recipients' Risk of Dying Prematurely
Published on 10/30/14

Regardless of age, frailty is a strong risk factor for dying prematurely after a kidney transplant. The finding, which comes from a new study published in the American Journal of Transplantation, suggests that patients should be screened for frailty prior to kidney transplantation, and that those who are identified as frail should be closely monitored after the procedure.

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Virtual Issues

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Virtual issues are collections of articles on a particular subject, published in the American Journal of Transplantation. They are selected by a guest editor to provide a rapid overview of the activity in a particular aspect of transplantation.

The following virtual issues are available:

Viral Infections

Guest Editor: Dr. Emily Blumberg

Alloantibodies

Guest Editors: Drs. Howard M. Gebel and Robert A. Bray 

Costimulation Blockade

Guest Editor: Dr. Allan D. Kirk

Read more...

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