Genes, Brain and Behavior

Cover image for Vol. 14 Issue 3

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/252 (Neurosciences)

Online ISSN: 1601-183X

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The new issue of G2B REVIEWS brings together a collection showcasing recent advances in stress-related research.  In the spirit of the journal, these FREE REVIEWS span the levels of genes, brain and behavior, and bridge the realms of basic research and clinical work.  Access the entire issue here for free!Read more

Recently Published Articles

  1. SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice

    Stephen B. McHugh, Christopher Barkus, Joao Lima, Lucas R. Glover, Trevor Sharp and David M. Bannerman

    Accepted manuscript online: 30 MAR 2015 08:46AM EST | DOI: 10.1111/gbb.12215

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    Mice that over-express the serotonin transporter exhibit reduced fear to aversive cues with uncertain outcomes.

  2. Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains (pages 271–280)

    T. Wiltshire, R. B. Ervin, H. Duan, M. A. Bogue, W. C. Zamboni, S. Cook, W. Chung, F. Zou and L. M. Tarantino

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gbb.12209

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    Inbred strains vary widely in locomotor activation, rearing and average velocity in response to a single dose of 20 mg/kg cocaine.

  3. White matter microstructure in bipolar disorder is influenced by the serotonin transporter gene polymorphism 5-HTTLPR (pages 238–250)

    F. Benedetti, I. Bollettini, S. Poletti, C. Locatelli, C. Lorenzi, A. Pirovano, E. Smeraldi and C. Colombo

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gbb.12206

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    White matter microstructure in bipolar disorder is influenced by a serotonin transporter gene polymorphism

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    Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice (pages 260–270)

    S. Gellhaar, D. Marcellino, M. B. Abrams and D. Galter

    Article first published online: 27 MAR 2015 | DOI: 10.1111/gbb.12210

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    Chronic L-DOPA treatment induces a high dyskinesia score in 24-week-old MitoPark mice, a genetic model of Parkinson's disease.

  5. Expression of freezing and fear-potentiated startle during sustained fear in mice (pages 281–291)

    T. Daldrup, J. Remmes, J. Lesting, S. Gaburro, M. Fendt, P. Meuth, V. Kloke, H.-C. Pape and T. Seidenbecher

    Article first published online: 25 MAR 2015 | DOI: 10.1111/gbb.12211

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    This study describes a novel training protocol to assess phasic/sustained fear in freely behaving mice, using freezing and/or fear-potentiated startle as measures of fear. Findings are that (1) a motion sensitive platform enables measurement of startle responses in freely behaving mice, (2) absence or presence of startle stimuli during retrieval as well as unpredictability of a given threat determine phasic/sustained fear response profiles and(3) both freezing and startle responses indicate phasic/sustained components of fear, with sustained freezing reflecting unpredictability of conditioned stimulus (CS)/unconditioned stimulus (US) pairings.