Genes, Brain and Behavior

Cover image for Vol. 14 Issue 7

Edited By: Andrew Holmes

Impact Factor: 3.661

ISI Journal Citation Reports © Ranking: 2014: 7/51 (Behavioral Sciences); 79/252 (Neurosciences)

Online ISSN: 1601-183X

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The new issue of G2B REVIEWS brings together a collection showcasing recent advances in stress-related research.  In the spirit of the journal, these FREE REVIEWS span the levels of genes, brain and behavior, and bridge the realms of basic research and clinical work.  Access the entire issue here for free!Read more

Recently Published Articles

  1. Family-based Genome Scan for Age at Onset of Late Onset Alzheimer's Disease in Whole Exome Sequencing Data

    Mohamad Saad, Zoran Brkanac and Ellen M Wijsman

    Accepted manuscript online: 3 SEP 2015 05:25AM EST | DOI: 10.1111/gbb.12250

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    In a dataset of whole exome-sequenced Alzheimer's Disease (AD) patients, we conducted single-marker and gene-based burden tests of Age At Onset (AAO) of AD for common and rare variants, respectively. We then performed a linkage analysis to add strength to our association signals. Moreover, we performed a gene-set enrichment analysis on the association signals to identify potential novel pathways associated with AAO. We found statistically significant association with AAO for seven genes (WRN, NTN4, LAMC3, SLC8A3, SLC19A3, MADD, and LRRK2) that have a plausible biological function related to AD. The identified genes are in pathways that are strong candidates for involvement in the development of AD pathology and may lead to a better understanding of AD pathogenesis. Finally, we obtained promising linkage regions in which several of association signals are located. Fig 2. Manhattan plot of the single marker test analysis that adjusts for APOE. The plot is based on all 39,993 tested SNPs. The horizontal blue line is the threshold we used to decide the most significant SNPs. The horizontal red line is the genome-wide significance threshold.

  2. DNA Methylation in Imprinted Genes IGF2 and GNASXL is Associated with Prenatal Maternal Stress

    Elise B Vangeel, Benedetta Izzi, Titia Hompes, Kristof Vansteelandt, Diether Lambrechts, Kathleen Freson and Stephan Claes

    Accepted manuscript online: 3 SEP 2015 04:49AM EST | DOI: 10.1111/gbb.12249

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    Maternal pregnancy-related anxiety is associated with fetal DNA methylation at the IGF2 DMR0

  3. Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype (pages 543–549)

    N. C. Mitchell, W. Koek and L. C. Daws

    Article first published online: 3 SEP 2015 | DOI: 10.1111/gbb.12238

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    Antidepressant-like response to desipramine is sensitive to age and serotonin transporter expression.

  4. Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear1 (pages 526–533)

    R. C. Hurt, J. C. Garrett, O. P. Keifer Jr., A. Linares, L. Couling, R. C. Speth, K. J. Ressler and P. J. Marvar

    Article first published online: 25 AUG 2015 | DOI: 10.1111/gbb.12235

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    Angiotensin II receptor type 1a (AT1aR) and corticotropin-releasing factor (CRF) co-localize in subsets of paraventricular nucleus (PVN) and central amygdala (CeA) neurons. Dense AT1aR and CRF expression is observed in the PVN and CeA of AT1aR-GFP (green fluorescent protein) mice.

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    A humanized version of Foxp2 does not affect ultrasonic vocalization in adult mice

    K. Hammerschmidt, C. Schreiweis, C. Minge, S. Pääbo, J. Fischer and W. Enard

    Article first published online: 25 AUG 2015 | DOI: 10.1111/gbb.12237

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    Male mice carrying the ‘humanized’ Foxp2 variant did not differ in structure or composition of their ultrasonic vocalizations from control littermates.