Genes, Brain and Behavior

Cover image for Vol. 13 Issue 7

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/251 (Neurosciences)

Online ISSN: 1601-183X

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Introducing G2B REVIEWS

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This inaugural issue of G2B REVIEWS brings together contributions from nine of the leading laboratories in our field from around the world. Access the entire issue here for free! Read more

Recently Published Articles

  1. NMDA receptor deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities.

    Marija Milenkovic, Catharine A. Mielnik and Amy J. Ramsey

    Accepted manuscript online: 20 OCT 2014 01:16AM EST | DOI: 10.1111/gbb.12183

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    Male mice with reduced NMDA receptor levels show impairments in working memory and other behaviours at an earlier age than female mutant mice.

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    Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease

    A. Y. Chen, P. Wilburn, X. Hao and T. Tully

    Article first published online: 14 OCT 2014 | DOI: 10.1111/gbb.12172

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    Aged human α-synuclein A30P flies exhibited a distinct walking pattern and increased centrophobism, measured quantitatively using a high-speed camera and an automatic tracking system. This study provides an alternative paradigm for evaluating motor functions of Parkinson's fly model.

  3. Development and heritability of subcortical brain volumes at age 9 and 12

    Suzanne Swagerman, Rachel Brouwer, Eco de Geus, Hilleke Hulshoff Pol and Dorret Boomsma

    Accepted manuscript online: 14 OCT 2014 01:27AM EST | DOI: 10.1111/gbb.12182

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    In a longitudinal twin study on brain development between 9 and 12 years of age, we show increases in left and right hemisphere volumes of the thalamus, pallidum, hippocampus and amygdala , while volumes of the caudate, nucleus accumbens, and putamen (bilaterally in boys; right-sided only in girls) decreased. Our results show that heritability of all volumes is high from childhood onwards, genetic effects are similar for boys and girls, and we find no evidence for new genetic effects at age 12.

  4. Genetic architecture of subcortical brain regions: common and region-specific genetic contributions

    M. E. Rentería, N. K. Hansell, L. T. Strike, K. L. McMahon, G. I. de Zubicaray, I. B. Hickie, P. M. Thompson, N. G. Martin, S. E. Medland and M. J. Wright

    Article first published online: 7 OCT 2014 | DOI: 10.1111/gbb.12177

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    This multivariate twin study identifies a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In parallel, it also describes substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52).

  5. A case-control study of brain structure and behavioral characteristics in 47,XXX Syndrome

    Rhoshel K. Lenroot, Jonathan D. Blumenthal, Gregory L. Wallace, Liv S. Clasen, Nancy Raitano Lee and Jay N. Giedd

    Accepted manuscript online: 7 OCT 2014 02:33AM EST | DOI: 10.1111/gbb.12180

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    Differences in cortical thickness associated with an additional X chromosome in females.