Genes, Brain and Behavior

Cover image for Vol. 14 Issue 7

Edited By: Andrew Holmes

Impact Factor: 3.661

ISI Journal Citation Reports © Ranking: 2014: 7/51 (Behavioral Sciences); 79/252 (Neurosciences)

Online ISSN: 1601-183X

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The new issue of G2B REVIEWS brings together a collection showcasing recent advances in stress-related research.  In the spirit of the journal, these FREE REVIEWS span the levels of genes, brain and behavior, and bridge the realms of basic research and clinical work.  Access the entire issue here for free!Read more

Recently Published Articles

  1. Plasticity-related genes in brain development and amygdala-dependent learning

    David E. Ehrlich and Sheena A. Josselyn

    Accepted manuscript online: 30 SEP 2015 02:47AM EST | DOI: 10.1111/gbb.12255

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    We review the pleiotropic functions in neural development and amygdala-dependent learning of canonical plasticity-related genes

  2. Developmental regulation of fear learning and anxiety behavior by endocannabinoids

    Tiffany T.-Y. Lee, Matthew N. Hill and Francis S. Lee

    Accepted manuscript online: 30 SEP 2015 02:47AM EST | DOI: 10.1111/gbb.12253

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    Major pathways of anandamide and 2-arachidonoylglycerol (2-AG) synthesis and degradation.

  3. Behavioral Phenotypes of Genetic Mouse Models of Autism

    Tatiana M. Kazdoba, Prescott T. Leach and Jacqueline N. Crawley

    Accepted manuscript online: 25 SEP 2015 03:16AM EST | DOI: 10.1111/gbb.12256

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    Review of behaviors in mouse models of autism with mutations in risk genes for synaptic and mTOR pathway proteins

  4. Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data

    M. Saad, Z. Brkanac and E. M. Wijsman

    Article first published online: 23 SEP 2015 | DOI: 10.1111/gbb.12250

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    In a dataset of whole exome-sequenced Alzheimer's disease (AD) patients, we conducted single-marker and gene-based burden tests of age at onset (AAO) of AD for common and rare variants, respectively. We then performed a linkage analysis to add strength to our association signals. Moreover, we performed a gene-set enrichment analysis on the association signals to identify potential novel pathways associated with AAO. We found statistically significant association with AAO for seven genes (WRN, NTN4, LAMC3, SLC8A3, SLC19A3, MADD and LRRK2) that have a plausible biological function related to AD. The identified genes are in pathways that are strong candidates for involvement in the development of AD pathology and may lead to a better understanding of AD pathogenesis. Finally, we obtained promising linkage regions in which several of association signals are located.

  5. DNA methylation in imprinted genes IGF2 and GNASXL is associated with prenatal maternal stress

    E. B. Vangeel, B. Izzi, T. Hompes, K. Vansteelandt, D. Lambrechts, K. Freson and S. Claes

    Article first published online: 23 SEP 2015 | DOI: 10.1111/gbb.12249

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    Maternal pregnancy-related anxiety is associated with fetal DNA methylation at the insulin-like growth factor 2 (IGF2) differentially methylated region (DMR0).