Genes, Brain and Behavior

Cover image for Vol. 13 Issue 6

Edited By: Andrew Holmes

Impact Factor: 3.597

ISI Journal Citation Reports © Ranking: 2012: 10/49 (Behavioral Sciences); 84/252 (Neurosciences)

Online ISSN: 1601-183X

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Read G2B papers selected by the Editor in key thematic areas in our Virtual Issues, including our most recent one 'The molecular machinery of memory'.

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Recently Published Articles

  1. SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality

    M. Laplana, J. L. Royo, L. F. García, A. Aluja, J. L. Gomez-Skarmeta and J. Fibla

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12154

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    A CNV mapping to gene SIRPB1 was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner.

  2. Food deprivation and nicotine correct akinesia and freezing in Na+-leak current channel (NALCN)-deficient strains of Caenorhabditis elegans

    K. Bonnett, R. Zweig, E. J. Aamodt and D. S. Dwyer

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12153

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    Nicotine and food deprivation correct abnormal movement (akinesia and freezing) in NALCN-deficient C. elegans.

  3. CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control

    D. E. Evans, D. A. MacQueen, K. G. Jentink, J. Y. Park, H.-Y. Lin and D. J. Drobes

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12151

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    Nicotine deprivation reduces P3a amplitude among minor allele carriers at rs588765, rs17408276 and rs3829787.

  4. Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation

    X. Li, D. Baker-Andresen, Q. Zhao, V. Marshall and T. W. Bredy

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12150

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    Methyl CpG binding domain Ultra-Sequencing (MBD Ultra-Seq) is a robust method for detecting DNA methylation in neurons derived from discrete brain regions of individual animals. We demonstrate the value of this method by characterizing differences in 5-methylcytosine (5mC) in neurons and non-neurons of the ventromedial prefrontal cortex of individual adult C57BL/6 mice, using as little as 50 ng of genomic DNA per sample. This protocol will facilitate the detection of experience-dependent changes in DNA methylation in a variety of behavioural paradigms and help identify aberrant experience-induced DNA methylation that may underlie risk and resiliency to neuropsychiatric disease.

  5. Do individually ventilated cage systems generate a problem for genetic mouse model research?

    W. Logge, J. Kingham and T. Karl

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12149

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    Nrg1 mutant mice of IVC housing do not show impairments in prepulse inhibition, which is characteristic for FILTER-housed mutants.