Genes, Brain and Behavior

Cover image for Vol. 14 Issue 1

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/252 (Neurosciences)

Online ISSN: 1601-183X

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Introducing G2B REVIEWS

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This inaugural issue of G2B REVIEWS brings together contributions from nine of the leading laboratories in our field from around the world. Access the entire issue here for free! Read more

Recently Published Articles

  1. Aggression is Associated with Aerobic Glycolysis in the Honey Bee Brain

    Sriram Chandrasekaran, Clare C. Rittschof, Danijel Djukovic, Haiwei Gu, Daniel Raftery, Nathan D. Price and Gene E. Robinson

    Accepted manuscript online: 30 JAN 2015 05:03AM EST | DOI: 10.1111/gbb.12201

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    Relative levels of central metabolism metabolites and genes in the aggressive brain. Metabolites are listed in circles and genes are in rectangles. Metabolites in white were not measured. Dark green and dark red colors represent changes in metabolites and mRNA that were statistically significant (a decrease or increase, respectively) according to gene expression and metabolite data from honeybees treated with alarm pheromone versus control. Light green and light red colors represent a non-significant decrease or increase, respectively. Protein complexes in the oxidative phosphorylation pathway, which are composed of variable numbers of protein subunits, are drawn as cartoons that represent the physical shapes of the complexes. Complexes are colored green to represent the general down regulation of the transcripts that encode protein constituents. Circles with black and dotted borders were compounds that were indistinguishable from one another in the metabolomics analysis. Abbreviations: Glucose – GLC, Pyruvate – PYR, Oxaloacetate – OAA, Citrate – CIT, Alpha-ketoglutarate - AKG, succinate – SUC, Fumarate – FUM, Malate – MAL, Succinyl-COA - SCA, Glutamate – GLU, Glutamine – GLN, Lactate – LAC, Alanine – ALA, Glucose 6 phosphate - G6P, Fructose 6 phosphate - F6P, Fructose 1,6 bis phosphate – FBP, Glyceraldehyde 3 Phosphate – GADP, Dihydroxyacetone Phosphate – DHAP, 1,3 bisphosphoglycerate - 1,3BPG, 3 phosphoglycerate - 3PG, 2 phosphoglycerate - 2PG, Phosphoenolpyruvate – PEP.

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    Integrated circuits and molecular components for stress and feeding: implications for eating disorders (pages 85–97)

    J. A. Hardaway, N. A. Crowley, C. M. Bulik and T. L. Kash

    Article first published online: 28 JAN 2015 | DOI: 10.1111/gbb.12185

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    Eating disorders are complex brain disorders that afflict millions of individuals worldwide. The etiology of these diseases is not fully understood, but a growing body of literature suggests that stress and anxiety may play a critical role in their development. Though a considerable body of research and societal emphasis has been placed on prevention and intervention of both stress-related behaviors and eating disorders (EDs), the combination of the two has only recently come to the forefront of scientific and clinical aims. This review will briefly highlight major EDs and relevant background, discuss rodent models of feeding and EDs and global behavioral work, explore the circuitry of feeding behaviors and how stress manipulations may shift specific aspects of this circuit, and identify some overlapping stress and feeding-related molecular systems.

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    The GAD65 knock out mouse – a model for GABAergic processes in fear- and stress-induced psychopathology (pages 37–45)

    Iris Müller, Gürsel Çalışkan and Oliver Stork

    Article first published online: 28 JAN 2015 | DOI: 10.1111/gbb.12188

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    GAD65 is involved in anxiety. Here we review characteristics of the GAD65 knock out mouse and highlight its relevance for psychiatric research.

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    Epigenetics and memory: causes, consequences and treatments for post-traumatic stress disorder and addiction (pages 73–84)

    C. L. Pizzimenti and K. M. Lattal

    Article first published online: 28 JAN 2015 | DOI: 10.1111/gbb.12187

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    Overlapping behavioral, neurobiological and epigenetic mechanisms control the extinction of learned fear and drug-seeking responses.

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    Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions (pages 4–21)

    D. A. Hamilton and J. L. Brigman

    Article first published online: 28 JAN 2015 | DOI: 10.1111/gbb.12191

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    Reversal learning, inhibitory learning and extradimensional set shifting have been extensively used to investigate the frontocortical bases of behavioral flexibility. This article reviews the current literature linking behavioral flexibility in these tasks to distinct subregions of frontal cortex in rats and mice.