Genes, Brain and Behavior

Cover image for Vol. 13 Issue 6

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/251 (Neurosciences)

Online ISSN: 1601-183X

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Read G2B papers selected by the Editor in key thematic areas in our Virtual Issues, including our most recent one 'The molecular machinery of memory'.

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Recently Published Articles

  1. Increased behavioral responses to ethanol in Lmo3 knockout mice

    Antonia Savarese, Mimi E. Zou, Viktor Kharazia, Rajani Maiya and Amy W. Lasek

    Accepted manuscript online: 1 SEP 2014 04:25AM EST | DOI: 10.1111/gbb.12176

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    Increased binge-like ethanol consumption in Lmo3 null mice.

  2. Diazepam improves aspects of social behaviour and neuron activation in NMDA receptor-deficient mice

    C. A. Mielnik, W. Horsfall and A. J. Ramsey

    Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12155

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    NR1 knockdown mice displayed a reduction in social behaviour and a reduction in c-Fos immunoreactivity in the cingulate cortex and septal nuclei. Acute clozapine did not significantly alter sociability; however, diazepam treatment did increase sociability and neuronal activation in the lateral septal region. This study has identified the lateral septal region as a neural substrate of social behaviour and the GABA system as a potential therapeutic target for social dysfunction.

  3. Genome-wide screening for DNA variants associated with reading and language traits

    A. Gialluisi, D. F. Newbury, E. G. Wilcutt, R. K. Olson, J. C. DeFries, W. M. Brandler, B. F. Pennington, S. D. Smith, T. S. Scerri, N. H. Simpson, The SLI Consortium, M. Luciano, D. M. Evans, T. C. Bates, J. F. Stein, J. B. Talcott, A. P. Monaco, S. Paracchini, C. Francks and S. E. Fisher

    Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12158

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    Genome-wide association scan meta-analysis for reading and language ability.

  4. Loss of GluN2A-containing NMDA receptors impairs extra-dimensional set-shifting

    K. Marquardt, M. Saha, M. Mishina, J. W. Young and J. L. Brigman

    Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12156

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    The ability to flexibly adapt behavior is essential for an organisms survival in a complex environment. Although the mechanisms underlying behavioral flexibility have not yet been fully elucidated, the NMDA receptor shows strong potential as a mediator of the cortical plasticity required for these behaviors. Our study assessed the contribution of GluN2A-containing NMDA receptors to attentional set-shifting, a cross-species measure of behavioral flexibility. Testing global GluN2A knockout mice on this task, as well as a visual touch-screen discrimination reversal learning paradigm, we demonstrate that loss of GluN2A results in a significant and selective impairment on the extra-dimensional shift. Collectively, our data demonstrate a dissociable role for the GluN2A subunit in executive function, and to our knowledge this is the first study to examine the specific contribution of the GluN2A subunit to attentional set-shifting.

  5. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus

    D.-C. Cai, H. Fonteijn, T. Guadalupe, M. Zwiers, K. Wittfeld, A. Teumer, M. Hoogman, A. Arias-Vásquez, Y. Yang, J. Buitelaar, G. Fernández, H. G. Brunner, H. van Bokhoven, B. Franke, K. Hegenscheid, G. Homuth, S. E. Fisher, H. J. Grabe, C. Francks and P. Hagoort

    Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12157

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    A suggestive genetic variant rs72932726 close to gene DCBLD2 (3q12.1; P = 2.77 × 10-7) was found to be associated with the surface area of right Heschl's gyrus in a genome-wide association scan using 3054 healthy European-descent individuals. The same variant also showed association with other regions involved in speech processing. Some plausible candidate genes involved in the development of the nervous system (KALRN, COBLL1) and X-linked deafness (POU3F4) were associated with other morphological features of Heschl's gyrus.