Genes, Brain and Behavior

Cover image for Vol. 13 Issue 6

Edited By: Andrew Holmes

Impact Factor: 3.597

ISI Journal Citation Reports © Ranking: 2012: 10/49 (Behavioral Sciences); 84/252 (Neurosciences)

Online ISSN: 1601-183X

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Read G2B papers selected by the Editor in key thematic areas in our Virtual Issues, including our most recent one 'The molecular machinery of memory'.

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Recently Published Articles

  1. Genome-wide screening for DNA variants associated with reading and language traits

    Alessandro Gialluisi, Dianne F. Newbury, Erik G. Wilcutt, Richard K. Olson, John C. DeFries, William M. Brandler, Bruce F. Pennington, Shelley D. Smith, Thomas S. Scerri, Nuala H. Simpson, The SLI Consortium, Michelle Luciano, David M. Evans, Timothy C. Bates, John F. Stein, Joel B. Talcott, Anthony P. Monaco, Silvia Paracchini, Clyde Francks and Simon E. Fisher

    Accepted manuscript online: 28 JUL 2014 05:30AM EST | DOI: 10.1111/gbb.12158

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    Genome-wide association scan meta-analysis for reading and language ability

  2. Loss of GluN2A-Containing NMDA Receptors Impairs Extra-dimensional Set-Shifting

    Kristin Marquardt, Monica Saha, Masayoshi Mishina, Jared W Young and Jonathan L Brigman

    Accepted manuscript online: 24 JUL 2014 06:09AM EST | DOI: 10.1111/gbb.12156

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    The ability to flexibly adapt behavior is essential for an organisms survival in a complex environment. Although the mechanisms underlying behavioral flexibility have not yet been fully elucidated, the NMDA receptor shows strong potential as a mediator of the cortical plasticity required for these behaviors. Our study assessed the contribution of GluN2A-containing NMDA receptors to attentional set-shifting, a cross-species measure of behavioral flexibility. Testing global GluN2A knockout mice on this task, as well as a visual touch-screen discrimination reversal learning paradigm, we demonstrate that loss of GluN2A results in a significant and selective impairment on the extra-dimensional shift. Collectively, our data demonstrate a dissociable role for the GluN2A subunit in executive function, and to our knowledge this is the first study to examine the specific contribution of the GluN2A subunit to attentional set-shifting.

  3. SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality

    M. Laplana, J. L. Royo, L. F. García, A. Aluja, J. L. Gomez-Skarmeta and J. Fibla

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12154

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    A CNV mapping to gene SIRPB1 was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner.

  4. Food deprivation and nicotine correct akinesia and freezing in Na+-leak current channel (NALCN)-deficient strains of Caenorhabditis elegans

    K. Bonnett, R. Zweig, E. J. Aamodt and D. S. Dwyer

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12153

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    Nicotine and food deprivation correct abnormal movement (akinesia and freezing) in NALCN-deficient C. elegans.

  5. CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control

    D. E. Evans, D. A. MacQueen, K. G. Jentink, J. Y. Park, H.-Y. Lin and D. J. Drobes

    Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12151

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    Nicotine deprivation reduces P3a amplitude among minor allele carriers at rs588765, rs17408276 and rs3829787.