Genes, Brain and Behavior
© John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society
Edited By: Andrew Holmes
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Online ISSN: 1601-183X
Recently Published Articles
- NMDA receptor deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities.
Marija Milenkovic, Catharine A. Mielnik and Amy J. Ramsey
Accepted manuscript online: 20 OCT 2014 01:16AM EST | DOI: 10.1111/gbb.12183
Male mice with reduced NMDA receptor levels show impairments in working memory and other behaviours at an earlier age than female mutant mice.
- You have full text access to this OnlineOpen articleWalking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease
A. Y. Chen, P. Wilburn, X. Hao and T. Tully
Article first published online: 14 OCT 2014 | DOI: 10.1111/gbb.12172
Aged human α-synuclein A30P flies exhibited a distinct walking pattern and increased centrophobism, measured quantitatively using a high-speed camera and an automatic tracking system. This study provides an alternative paradigm for evaluating motor functions of Parkinson's fly model.
- Development and heritability of subcortical brain volumes at age 9 and 12
Suzanne Swagerman, Rachel Brouwer, Eco de Geus, Hilleke Hulshoff Pol and Dorret Boomsma
Accepted manuscript online: 14 OCT 2014 01:27AM EST | DOI: 10.1111/gbb.12182
In a longitudinal twin study on brain development between 9 and 12 years of age, we show increases in left and right hemisphere volumes of the thalamus, pallidum, hippocampus and amygdala , while volumes of the caudate, nucleus accumbens, and putamen (bilaterally in boys; right-sided only in girls) decreased. Our results show that heritability of all volumes is high from childhood onwards, genetic effects are similar for boys and girls, and we find no evidence for new genetic effects at age 12.
- Genetic architecture of subcortical brain regions: common and region-specific genetic contributions
M. E. Rentería, N. K. Hansell, L. T. Strike, K. L. McMahon, G. I. de Zubicaray, I. B. Hickie, P. M. Thompson, N. G. Martin, S. E. Medland and M. J. Wright
Article first published online: 7 OCT 2014 | DOI: 10.1111/gbb.12177
This multivariate twin study identifies a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In parallel, it also describes substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52).
- A case-control study of brain structure and behavioral characteristics in 47,XXX Syndrome
Rhoshel K. Lenroot, Jonathan D. Blumenthal, Gregory L. Wallace, Liv S. Clasen, Nancy Raitano Lee and Jay N. Giedd
Accepted manuscript online: 7 OCT 2014 02:33AM EST | DOI: 10.1111/gbb.12180