Genes, Brain and Behavior

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Edited By: Andrew Holmes

Impact Factor: 3.275

ISI Journal Citation Reports © Ranking: 2015: 8/51 (Behavioral Sciences); 93/256 (Neurosciences)

Online ISSN: 1601-183X

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The focus of the new 2017 issue of G2B REVIEWS is Drug Addiction. Drug addictions are serious medical conditions that have genetic and neurobiological correlates that remain elusive, but which are subject of intense investigation. This issue of G2B REVIEWS presents a dozen articles on the latest breakthroughs in drug addiction from some of the leaders in the field. Access the entire issue for free: click here

Recently Published Articles

  1. Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

    L. N. van de Lagemaat, L. E. Stanford, C. M. Pettit, D. J. Strathdee, K. E. Strathdee, K. A. Elsegood, D. G. Fricker, M. D. R. Croning, N. H. Komiyama and S. G. N. Grant

    Version of Record online: 20 JAN 2017 | DOI: 10.1111/gbb.12364

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    Comparison of effect sizes shows postsynaptic mutant behavioral phenotypes are similar between 129S5 and C57BL/6J mice.

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    Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders (pages 56–70)

    L. K. Dobbs, J. C. Lemos and V. A. Alvarez

    Version of Record online: 18 JAN 2017 | DOI: 10.1111/gbb.12361

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    This review discusses recent findings on the functional role of D2Rs and highlights the distinctive contributions of D2Rs expressed on specific neuronal subpopulations to the behavioral responses to stimulant drugs. A circuit-wide restructuring of local and long-range inhibitory connectivity within the basal ganglia is observed in response to manipulation of striatal D2R levels and is accompanied by multiple alterations in dopamine- dependent behaviors. These findings from animal models have deep clinical implications for SUD patients with low levels D2R availability where a similar restructuring of basal ganglia circuitry is expected to take place.

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    Alcohol-dependent molecular adaptations of the NMDA receptor system (pages 139–148)

    N. Morisot and D. Ron

    Version of Record online: 18 JAN 2017 | DOI: 10.1111/gbb.12363

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    This review focuses on findings in humans and rodents that support the implication of N-methyl-d-aspartate receptor signaling in the alcohol use disorders.

  4. Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice

    Y. Zhou, M. Rubinstein, M. J. Low and M. J. Kreek

    Version of Record online: 17 JAN 2017 | DOI: 10.1111/gbb.12362

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    In this study, we provide genetic and pharmacological evidence that proopiomelanocortin (POMC) within the hypothalamus plays an essential role in alcohol drinking and relapse. Using site-specific transgenic mouse model and pharmacological validation experiments, we show that POMC expressed in the hypothalamic neurons (but not pituitary cells) plays an important role in the alcohol deprivation effect (the increase in alcohol intake after a period of abstinence), with impact on ‘binge’-like and escalation drinking. Medications targeting hypothalamic POMC by selective alteration of the region- and cell-specific POMC might have therapeutic efficacy.