Genes, Brain and Behavior

Cover image for Vol. 15 Issue 7

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Andrew Holmes

Impact Factor: 3.275

ISI Journal Citation Reports © Ranking: 2015: 8/51 (Behavioral Sciences); 93/256 (Neurosciences)

Online ISSN: 1601-183X


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  1. Reviews

    1. Reprogramming of mPFC transcriptome and function in alcohol dependence

      Markus Heilig, Estelle Barbier, Andrea Lynn Johnstone, Jenica Tapocik, Marcus W. Meinhardt, Simone Pfarr, Claes R. Wahlestedt and Wolfgang H. Sommer

      Accepted manuscript online: 22 SEP 2016 12:40PM EST | DOI: 10.1111/gbb.12344

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      Postdependent reprogramming of transcriptome responses in the mPFC affects local cue-responsive neuronal networks

  2. Original Articles

    1. 5HT2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice

      Dionisio A. Amodeo, Elaine Rivera, Edwin H. Cook Jr, John A. Sweeney and Michael E. Ragozzino

      Accepted manuscript online: 22 SEP 2016 10:50AM EST | DOI: 10.1111/gbb.12343

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      5HT2A receptor blockade rescues a reversal learning deficit when injected into the dorsomedial striatum in the BTBR mouse model ofautism (e.g. Figure 2)

    2. The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure

      Seungeun Yeo, Mary-Anne Enoch, Elena Gorodetsky, Longina Ahktar, Kornel Schuebel, Alec Roy and David Goldman

      Accepted manuscript online: 20 SEP 2016 09:55AM EST | DOI: 10.1111/gbb.12342

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      FKBP5 rs1360780 alleles show differential cis-action;genotype-childhood trauma together predict FKBP5 induction after GR stimulation

    3. Changes in Insulin-like Growth Factor Signaling Alter Phenotypes in Fragile X Mice

      Thomas L. Wise

      Accepted manuscript online: 19 SEP 2016 10:40AM EST | DOI: 10.1111/gbb.12340

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      Genetic changes in the levels of Igf signaling proteins alter several phenotypes in Fragile X mice.

    4. Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E

      Eric Villalón, Maria R. Jones, Christine Sibigtroth, Sammy J. Zino, Jeffrey M. Dale, Dan S. Landayan, Hailian Shen, DDW Cornelison and Michael L. Garcia

      Accepted manuscript online: 19 SEP 2016 08:00AM EST | DOI: 10.1111/gbb.12341

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      CMT2E pathology initiates in the muscle spindles altering the proprioceptive sensory system before affecting the motor system.

    5. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice

      Bin Wang, Yufang Zheng, Haixia Shi, Xiangdong Du, Yingying Zhang, Bin Wei, Man Luo, Hongyan Wang, Xiaohui Wu, Xiaodong Hua, Miao Sun and Xingshun Xu

      Accepted manuscript online: 13 SEP 2016 03:30AM EST | DOI: 10.1111/gbb.12339

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      Zfp462 deficiency causes anxiety-like behaviors

  3. Reviews

    1. Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice

      Katherine M. Holleran and Danny G. Winder

      Accepted manuscript online: 13 SEP 2016 03:30AM EST | DOI: 10.1111/gbb.12338

  4. Original Articles

    1. Thinking and Doing: The Effects of Dopamine and Oxytocin Genes and Executive Function on Mothering Behaviours

      Katherine T. Cost, Eva Unternaehrer, Andre Plamondon, Meir Steiner, Michael Meaney, Leslie Atkinson, James L. Kennedy, Alison S. Fleming and on behalf of the MAVAN Research Team

      Accepted manuscript online: 13 SEP 2016 03:26AM EST | DOI: 10.1111/gbb.12337

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      Oxytocin receptor genotype predicts enhanced cognitive decision-making, which mediates the relationship between oxytocin receptor genotype and both Positive Parenting and Physically Controlling Parenting.

  5. Reviews

    1. How contexts promote and prevent relapse to drug seeking

      Shaun Yon-Seng Khoo, Gabrielle D. Gibson, Asheeta A. Prasad and Gavan P. McNally

      Accepted manuscript online: 10 SEP 2016 01:35AM EST | DOI: 10.1111/gbb.12328

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      We review the behavioral and brain mechanisms enabling contexts to promote and prevent relapse to drug seeking. We emphasize that current understanding, although significant, defies explanations in terms of models at the level of brain structures and their connectivity. A key challenge is to recognise this complexity, understand how these circuits and channels are organized, as well as understand how different modes of activity of ensembles of neurons within them promote abstinence or relapse to drug seeking

  6. Original Articles


      Rolf W. Stottmann, Ashley Driver, Arnold Gutierrez, Matthew R. Skelton, Michael Muntifering, Christopher Stepien, Luke Knudson, Matthew Kofron, Charles V. Vorhees and Michael T. Williams

      Accepted manuscript online: 4 SEP 2016 10:00PM EST | DOI: 10.1111/gbb.12327

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      A missense mutation in tubulin beta, 2B leads to morphological changes in the hippocampus and cognitive deficits.

    2. Variation in Mothers’ Arginine Vasopressin Receptor 1a and Dopamine Receptor D4 Genes Predict Maternal Sensitivity via Social Cognition

      Esther M. Leerkes, Jinni Su, Susan Calkins, Vincent C. Henrich and Andrew Smolen

      Accepted manuscript online: 1 SEP 2016 03:55AM EST | DOI: 10.1111/gbb.12326

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      Mothers' AVPR1a and DRD4 are related to mothers’ compromised social cognition about their infants which in turn predicts less sensitive maternal behavior.

  7. Reviews

    1. Addiction, cognitive decline and therapy: Seeking ways to escape a vicious cycle

      Christina J. Perry and Andrew J. Lawrence

      Accepted manuscript online: 30 AUG 2016 03:01AM EST | DOI: 10.1111/gbb.12325

    2. Structural and functional plasticity of dendritic spines – root or result of behavior?

      Cassandra D. Gipson and M. Foster Olive

      Accepted manuscript online: 26 AUG 2016 03:00AM EST | DOI: 10.1111/gbb.12324

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      We review the complex interplay between dendritic spine morphology and its role in normal and abberrant behaviors.

  8. Original Articles

    1. RNA-Sequencing Profiles Hippocampal Gene Expression in a Validated Model of Cancer-Induced Depression

      Mina G. Nashed, Katja Linher-Melville, Benicio N. Frey and Gurmit Singh

      Accepted manuscript online: 26 AUG 2016 01:10AM EST | DOI: 10.1111/gbb.12323

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      Peripheral cancer induces distinct hippocampal transcriptional changes in a model of cancer-induced depression

    2. Altered gene expression in hippocampus and depressive-like behavior in young adult female mice by early protein malnutrition

      Laura M. Belluscio, Carolina D. Alberca, Nicolás Pregi and Eduardo T. Cánepa

      Accepted manuscript online: 24 AUG 2016 02:56AM EST | DOI: 10.1111/gbb.12322

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      Perinatal malnutrition causes altered gene expression and reduction in the number of neurons in female mice hippocampus

    3. TNF receptors (TNFR) 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults – Revision

      David Stacey, Ronny Redlich, Andreas Büschel, Nils Opel, Dominik Grotegerd, Dario Zaremba, Katharina Dohm, Christian Bürger, Susanne Meinert, Katharina Förster, Jonathan Repple, Carolin Kaufmann, Harald Kugel, Walter Heindel, Volker Arolt, Udo Dannlowski and Bernhard T Baune

      Accepted manuscript online: 16 AUG 2016 04:00AM EST | DOI: 10.1111/gbb.12318

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      The findings of the present study indicate a role for tumour necrosis factor receptor (TNFR) 1 in regulating striatal but not hippocampal morphology, as well as a complementary role for TNFR2 in hippocampal but not striatal morphology.


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