Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice
Alexandre M. Colville, Ovidiu D. Iancu, Denesa L. Oberbeck, Priscila Darakjian, Christina L. Zheng, Nicole A. R. Walter, Christina A. Harrington, Robert P. Searles, Shannon McWeeney and Robert J. Hitzemann
Accepted manuscript online: 6 JAN 2017 12:30AM EST | DOI: 10.1111/gbb.12367
Multidimensional scaling (MDS) plots of genome-wide differences between High (magenta) and Low (turquoise) ethanol preferring selected lines compared with the founding strains (B6=red, AJ=brown, 129=purple, NOD=black, NZO=orange, CAST=dark green, PWK=green, blue=WSB) of the HS-CC founder stock. This figure illustrates strong genetic divergence between High and Low preferring lines, in part due to incorporation of wild-derived alleles in the low line. Additionally, it is notable the WSB/Eij strain appears most genetically similar to the high preferring line.