Genes, Brain and Behavior

Cover image for Vol. 15 Issue 8

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Andrew Holmes

Impact Factor: 3.275

ISI Journal Citation Reports © Ranking: 2015: 8/51 (Behavioral Sciences); 93/256 (Neurosciences)

Online ISSN: 1601-183X

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  1. Reviews

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      Alcohol-Dependent Molecular Adaptations of the NMDA Receptor System

      Nadege Morisot and Dorit Ron

      Accepted manuscript online: 1 DEC 2016 10:48AM EST | DOI: 10.1111/gbb.12363

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      This review focuses on findings in humans and rodents that support the implication of NMDAR signaling in the alcohol use disorders

  2. Original Articles

    1. Standardised experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

      Louie N. van de Lagemaat, Lianne E. Stanford, Charles Pettit, Douglas J. Strathdee, Karen E. Strathdee, Kathryn A. Elsegood, David G. Fricker, Mike D. R. Croning, Noboru H. Komiyama and Seth G. N. Grant

      Accepted manuscript online: 25 NOV 2016 05:40AM EST | DOI: 10.1111/gbb.12364

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      Comparison of effect sizes shows postsynaptic mutant behavioral phenotypes are similar between 129S5 and C57BL/6J mice.

    2. Hypothalamic-specific proopiomelanocortin-deficiency reduces alcohol drinking in male and female mice

      Yan Zhou, Marcelo Rubinstein, Malcolm J Low and Mary Jeanne Kreek

      Accepted manuscript online: 21 NOV 2016 09:25AM EST | DOI: 10.1111/gbb.12362

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      Here we provide genetic and pharmacological evidence that POMC within the hypothalamus plays an essential role in alcohol drinking and relapse. Using site-specific transgenic mouse model and pharmacological validation experiments, we show that POMC expressed in the hypothalamic neurons (but not pituitary cells) plays an important role in the alcohol deprivation effect (the increase in alcohol intake after a period of abstinence), with impact on “binge”-like and escalation drinking. Medications targeting hypothalamic POMC by selective alteration of the region- and cell- specific POMC might have therapeutic efficacy.

  3. Reviews

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      Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders

      Lauren Dobbs, Julia C. Lemos and Veronica A. Alvarez

      Accepted manuscript online: 17 NOV 2016 09:20AM EST | DOI: 10.1111/gbb.12361

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      This review discusses recent findings on the functional role of D2Rs and highlights the distinctive contributions of D2Rs expressed on specific neuronal subpopulations to the behavioral responses to stimulant drugs. A circuit-wide restructuring of local and long-range inhibitory connectivity within the basal ganglia is observed in response to manipulation of striatal D2R levels and is accompanied by multiple alterations in dopamine-dependent behaviors. These findings from animal models have deep clinical implications for SUD patients with low levels D2R availability where a similar restructuring of basal ganglia circuitry is expected to take place.

  4. Original Articles

    1. Lessons from the canine Oxtr gene: populations, variants and functional aspects

      Melinda Bence, Peter Marx, Eszter Szantai, Eniko Kubinyi, Zsolt Ronai and Zsofia Banlaki

      Accepted manuscript online: 11 NOV 2016 06:20AM EST | DOI: 10.1111/gbb.12356

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      Neighbor-joining tree supports the hypothesis that Oxtr variants could have been a selection target during canine domestication.

    2. Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine

      Ching-Han Yu, Shu-Chen Chu, Pei-Ni Chen, Yih-Shou Hsieh and Dong-Yih Kuo

      Accepted manuscript online: 8 NOV 2016 08:41AM EST | DOI: 10.1111/gbb.12360

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      We suggest that hypothalamic ghrelin signaling system, with the help of antioxidants, may participate in NPY/CART-mediated appetite control in PPA-treated rats.

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