Genes, Brain and Behavior

Cover image for Vol. 13 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/251 (Neurosciences)

Online ISSN: 1601-183X

VIEW

  1. 1 - 15
  1. Original Articles

    1. Diazepam improves aspects of social behaviour and neuron activation in NMDA receptor-deficient mice

      C. A. Mielnik, W. Horsfall and A. J. Ramsey

      Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12155

      Thumbnail image of graphical abstract

      NR1 knockdown mice displayed a reduction in social behaviour and a reduction in c-Fos immunoreactivity in the cingulate cortex and septal nuclei. Acute clozapine did not significantly alter sociability; however, diazepam treatment did increase sociability and neuronal activation in the lateral septal region. This study has identified the lateral septal region as a neural substrate of social behaviour and the GABA system as a potential therapeutic target for social dysfunction.

    2. Genome-wide screening for DNA variants associated with reading and language traits

      A. Gialluisi, D. F. Newbury, E. G. Wilcutt, R. K. Olson, J. C. DeFries, W. M. Brandler, B. F. Pennington, S. D. Smith, T. S. Scerri, N. H. Simpson, The SLI Consortium, M. Luciano, D. M. Evans, T. C. Bates, J. F. Stein, J. B. Talcott, A. P. Monaco, S. Paracchini, C. Francks and S. E. Fisher

      Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12158

      Thumbnail image of graphical abstract

      Genome-wide association scan meta-analysis for reading and language ability.

    3. Loss of GluN2A-containing NMDA receptors impairs extra-dimensional set-shifting

      K. Marquardt, M. Saha, M. Mishina, J. W. Young and J. L. Brigman

      Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12156

      Thumbnail image of graphical abstract

      The ability to flexibly adapt behavior is essential for an organisms survival in a complex environment. Although the mechanisms underlying behavioral flexibility have not yet been fully elucidated, the NMDA receptor shows strong potential as a mediator of the cortical plasticity required for these behaviors. Our study assessed the contribution of GluN2A-containing NMDA receptors to attentional set-shifting, a cross-species measure of behavioral flexibility. Testing global GluN2A knockout mice on this task, as well as a visual touch-screen discrimination reversal learning paradigm, we demonstrate that loss of GluN2A results in a significant and selective impairment on the extra-dimensional shift. Collectively, our data demonstrate a dissociable role for the GluN2A subunit in executive function, and to our knowledge this is the first study to examine the specific contribution of the GluN2A subunit to attentional set-shifting.

    4. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus

      D.-C. Cai, H. Fonteijn, T. Guadalupe, M. Zwiers, K. Wittfeld, A. Teumer, M. Hoogman, A. Arias-Vásquez, Y. Yang, J. Buitelaar, G. Fernández, H. G. Brunner, H. van Bokhoven, B. Franke, K. Hegenscheid, G. Homuth, S. E. Fisher, H. J. Grabe, C. Francks and P. Hagoort

      Article first published online: 29 AUG 2014 | DOI: 10.1111/gbb.12157

      Thumbnail image of graphical abstract

      A suggestive genetic variant rs72932726 close to gene DCBLD2 (3q12.1; P = 2.77 × 10-7) was found to be associated with the surface area of right Heschl's gyrus in a genome-wide association scan using 3054 healthy European-descent individuals. The same variant also showed association with other regions involved in speech processing. Some plausible candidate genes involved in the development of the nervous system (KALRN, COBLL1) and X-linked deafness (POU3F4) were associated with other morphological features of Heschl's gyrus.

    5. Behavioral characterization of striatal-enriched protein tyrosine phosphatase (STEP) knockout mice

      S. J. Sukoff Rizzo, S. M. Lotarski, P. Stolyar, T. McNally, C. Arturi, M. Roos, J. E. Finley, V. Reinhart and T. A. Lanz

      Article first published online: 28 AUG 2014 | DOI: 10.1111/gbb.12169

      Thumbnail image of graphical abstract

      Hypersensitivity of STEP KO mice to acute challenge with MK-801. Dose responses curves of MK-801 on locomotor activity as measured by distance traveled in an open field in STEP WT (a), HET (b), and KO (c) mice. Data are presented as group mean ± SEM per timepoint. Comparative analysis across dose levels for 0.056 mg/kg (d), 0.10 mg/kg (e) and 0.178 mg/kg (f) revealed hypersensitivity of KO mice for a dose of MK-801 that was ineffective in HET and WT littermate controls (n = 7–8 per dose per genotype).

    6. Sex-specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy

      T. Chachua, C. Goletiani, G. Maglakelidze, G. Sidyelyeva, M. Daniel, E. Morris, J. Miller, E. Shang, D. J. Wolgemuth, D. A. Greenberg, J. Velíšková and L. Velíšek

      Article first published online: 28 AUG 2014 | DOI: 10.1111/gbb.12160

      Thumbnail image of graphical abstract

      Brd2 haploinsufficiency in mouse model of juvenile myoclonic epilepsy results in sex-specific behavioral traits.

    7. Brain serotonin determines maternal behavior and offspring survival

      M. Angoa-Pérez, M. J. Kane, C. E. Sykes, S. A. Perrine, M. W. Church and D. M. Kuhn

      Article first published online: 27 AUG 2014 | DOI: 10.1111/gbb.12159

      Thumbnail image of graphical abstract

      Litters born to TPH2−/− dams show decreased survival, increased cannibalism and reduced body weight that is rescued by cross-fostering.

    8. You have full text access to this OnlineOpen article
      GWAS-based pathway analysis differentiates between fluid and crystallized intelligence

      A. Christoforou, T. Espeseth, G. Davies, C. P. D. Fernandes, S. Giddaluru, M. Mattheisen, A. Tenesa, S. E. Harris, D. C. Liewald, A. Payton, W. Ollier, M. Horan, N. Pendleton, P. Haggarty, S. Djurovic, S. Herms, P. Hoffman, S. Cichon, J. M. Starr, A. Lundervold, I. Reinvang, V. M. Steen, I. J. Deary and S. Le Hellard

      Article first published online: 8 AUG 2014 | DOI: 10.1111/gbb.12152

      Thumbnail image of graphical abstract

      GWAS-based pathway analysis differentiates between fluid and crystallized intelligence ( gF and gC).

    9. SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality

      M. Laplana, J. L. Royo, L. F. García, A. Aluja, J. L. Gomez-Skarmeta and J. Fibla

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12154

      Thumbnail image of graphical abstract

      A CNV mapping to gene SIRPB1 was significantly associated with impulsive-disinhibited personality scores in a dose-dependent manner.

    10. Food deprivation and nicotine correct akinesia and freezing in Na+-leak current channel (NALCN)-deficient strains of Caenorhabditis elegans

      K. Bonnett, R. Zweig, E. J. Aamodt and D. S. Dwyer

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12153

      Thumbnail image of graphical abstract

      Nicotine and food deprivation correct abnormal movement (akinesia and freezing) in NALCN-deficient C. elegans.

    11. CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control

      D. E. Evans, D. A. MacQueen, K. G. Jentink, J. Y. Park, H.-Y. Lin and D. J. Drobes

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12151

      Thumbnail image of graphical abstract

      Nicotine deprivation reduces P3a amplitude among minor allele carriers at rs588765, rs17408276 and rs3829787.

  2. Techniques

    1. Methyl CpG Binding Domain Ultra-Sequencing: a novel method for identifying inter-individual and cell-type-specific variation in DNA methylation

      X. Li, D. Baker-Andresen, Q. Zhao, V. Marshall and T. W. Bredy

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12150

      Thumbnail image of graphical abstract

      Methyl CpG binding domain Ultra-Sequencing (MBD Ultra-Seq) is a robust method for detecting DNA methylation in neurons derived from discrete brain regions of individual animals. We demonstrate the value of this method by characterizing differences in 5-methylcytosine (5mC) in neurons and non-neurons of the ventromedial prefrontal cortex of individual adult C57BL/6 mice, using as little as 50 ng of genomic DNA per sample. This protocol will facilitate the detection of experience-dependent changes in DNA methylation in a variety of behavioural paradigms and help identify aberrant experience-induced DNA methylation that may underlie risk and resiliency to neuropsychiatric disease.

  3. Original Articles

    1. Do individually ventilated cage systems generate a problem for genetic mouse model research?

      W. Logge, J. Kingham and T. Karl

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12149

      Thumbnail image of graphical abstract

      Nrg1 mutant mice of IVC housing do not show impairments in prepulse inhibition, which is characteristic for FILTER-housed mutants.

    2. Association between the oxytocin receptor (OXTR) gene and children's social cognition at 18 months

      M. Wade, T. J. Hoffmann, K. Wigg and J. M. Jenkins

      Article first published online: 23 JUL 2014 | DOI: 10.1111/gbb.12148

      Thumbnail image of graphical abstract

      Variability in the oxytocin receptor (OXTR) gene is associated with social cognition at 18 months, the earliest known association in human children to date.

    3. Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study

      L. J. van der Knaap, J. M. Schaefer, I. H. A. Franken, F. C. Verhulst, F. V. A. van Oort and H. Riese

      Article first published online: 24 JUN 2014 | DOI: 10.1111/gbb.12147

      Thumbnail image of graphical abstract

      Higher rates of COMT promoter methylation were associated with non-daily smoking in adolescents.

VIEW

  1. 1 - 15

SEARCH

SEARCH BY CITATION