Genes, Brain and Behavior

Cover image for Vol. 13 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/251 (Neurosciences)

Online ISSN: 1601-183X

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  1. Original Articles

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      Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease

      A. Y. Chen, P. Wilburn, X. Hao and T. Tully

      Article first published online: 14 OCT 2014 | DOI: 10.1111/gbb.12172

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      Aged human α-synuclein A30P flies exhibited a distinct walking pattern and increased centrophobism, measured quantitatively using a high-speed camera and an automatic tracking system. This study provides an alternative paradigm for evaluating motor functions of Parkinson's fly model.

    2. Genetic architecture of subcortical brain regions: common and region-specific genetic contributions

      M. E. Rentería, N. K. Hansell, L. T. Strike, K. L. McMahon, G. I. de Zubicaray, I. B. Hickie, P. M. Thompson, N. G. Martin, S. E. Medland and M. J. Wright

      Article first published online: 7 OCT 2014 | DOI: 10.1111/gbb.12177

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      This multivariate twin study identifies a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In parallel, it also describes substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52).

    3. Genetics of gene expression characterizes response to selective breeding for alcohol preference

      P. L. Hoffman, L. M. Saba, S. Flink, N. J. Grahame, K. Kechris and B. Tabakoff

      Article first published online: 29 SEP 2014 | DOI: 10.1111/gbb.12175

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      Genetics of gene expression can be used to identify genomic regions fixed during artificial selection. Priority genes with expression difference from selective breeding for alcohol preference.

    4. Increased behavioral responses to ethanol in Lmo3 knockout mice

      A. Savarese, M. E. Zou, V. Kharazia, R. Maiya and A. W. Lasek

      Article first published online: 24 SEP 2014 | DOI: 10.1111/gbb.12176

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      Increased binge-like ethanol consumption in Lmo3 null mice.

    5. Central dopamine action modulates neuropeptide-controlled appetite via the hypothalamic PI3K/NF-κB-dependent mechanism

      Y.-S. Hsieh, P.-N. Chen, C.-H. Yu and D.-Y. Kuo

      Article first published online: 19 SEP 2014 | DOI: 10.1111/gbb.12174

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      Dopamine–PI3K–NF-κB signaling in the hypothalamus plays functional roles in the modulation of NPY and POMC neurotransmissions and in the control of AMPH-evoked appetite suppression.

    6. Fear-related behaviors in Lurcher mutant mice exposed to a predator

      T. Lorivel, V. Roy and P. Hilber

      Article first published online: 19 SEP 2014 | DOI: 10.1111/gbb.12173

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      Cerebellar Lurcher mutants facing a predator exhibited an exaggerated fear-related response when compared with control mice (legend in the article).

    7. Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal

      L. C. Kruse, N. A. R. Walter and K. J. Buck

      Article first published online: 17 SEP 2014 | DOI: 10.1111/gbb.12171

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      Reduced Mpdz expression in the caudolateral substantia nigra pars reticulata enhances alcohol withdrawal severity in mice.

    8. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability

      D. T. Truong, A. Che, A. R. Rendall, C. E. Szalkowski, J. J. LoTurco, A. M. Galaburda and R. Holly Fitch

      Article first published online: 3 SEP 2014 | DOI: 10.1111/gbb.12170

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      Dcdc2 mutant mice show impaired working and reference memory performance on a 4/8 radial arm water maze.

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