Genetic architecture of subcortical brain regions: common and region-specific genetic contributions
M. E. Rentería, N. K. Hansell, L. T. Strike, K. L. McMahon, G. I. de Zubicaray, I. B. Hickie, P. M. Thompson, N. G. Martin, S. E. Medland and M. J. Wright
Article first published online: 7 OCT 2014 | DOI: 10.1111/gbb.12177
This multivariate twin study identifies a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In parallel, it also describes substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52).