Genes, Brain and Behavior

Cover image for Vol. 16 Issue 2

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrew Holmes

Impact Factor: 3.275

ISI Journal Citation Reports © Ranking: 2015: 8/51 (Behavioral Sciences); 93/256 (Neurosciences)

Online ISSN: 1601-183X


  1. 1 - 19
  1. Original Articles

    1. Role of the MT1 and MT2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice

      J. Liu, S. J. Clough and M. L. Dubocovich

      Version of Record online: 20 FEB 2017 | DOI: 10.1111/gbb.12369

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      Deletion of MT1 and/or MT2 melatonin receptor increases the prevalence of anxiety- and depression-like phenotypes in the C3H/HeN mice.

    2. Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice

      A. M. Colville, O. D. Iancu, D. L. Oberbeck, P. Darakjian, C. L. Zheng, N. A. R. Walter, C. A. Harrington, R. P. Searles, S. McWeeney and R. J. Hitzemann

      Version of Record online: 9 FEB 2017 | DOI: 10.1111/gbb.12367

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      Gene network analysis showed an effect of selection for ethanol preference on receptor signaling genes in the nucleus accumbens of heterogeneous stock-collaborative cross mice.

    3. Association of AKAP6 and MIR2113 with cognitive performance in a population-based sample of older adults

      S. J. Andrews, D. Das, K. J. Anstey and S. Easteal

      Version of Record online: 26 JAN 2017 | DOI: 10.1111/gbb.12368

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      Trajectories of cognitive performance for AKAP6 and MIR2113 genotypes.

    4. Standardized experiments in mutant mice reveal behavioural similarity on 129S5 and C57BL/6J backgrounds

      L. N. van de Lagemaat, L. E. Stanford, C. M. Pettit, D. J. Strathdee, K. E. Strathdee, K. A. Elsegood, D. G. Fricker, M. D. R. Croning, N. H. Komiyama and S. G. N. Grant

      Version of Record online: 20 JAN 2017 | DOI: 10.1111/gbb.12364

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      Comparison of effect sizes shows postsynaptic mutant behavioral phenotypes are similar between 129S5 and C57BL/6J mice.

    5. Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice

      Y. Zhou, M. Rubinstein, M. J. Low and M. J. Kreek

      Version of Record online: 17 JAN 2017 | DOI: 10.1111/gbb.12362

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      In this study, we provide genetic and pharmacological evidence that proopiomelanocortin (POMC) within the hypothalamus plays an essential role in alcohol drinking and relapse. Using site-specific transgenic mouse model and pharmacological validation experiments, we show that POMC expressed in the hypothalamic neurons (but not pituitary cells) plays an important role in the alcohol deprivation effect (the increase in alcohol intake after a period of abstinence), with impact on ‘binge’-like and escalation drinking. Medications targeting hypothalamic POMC by selective alteration of the region- and cell-specific POMC might have therapeutic efficacy.

    6. BDNF Val66Met polymorphism moderates the link between child maltreatment and reappraisal ability

      A. C. Miu, M. Cărnuţă, R. Vulturar, R. D. Szekely-Copîndean, M. I. Bîlc, A. Chiş, M. Cioară, K. C. Fernandez, A. Szentágotai-Tătar and J. J. Gross

      Version of Record online: 10 JAN 2017 | DOI: 10.1111/gbb.12366

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      BDNF Val66Met moderates the impact of child maltreatment on emotion regulation, fitting a differential susceptibility model.

    7. N/OFQ system in brain areas of nerve-injured mice: its role in different aspects of neuropathic pain

      M. Palmisano, D. Mercatelli, F. F. Caputi, D. Carretta, P. Romualdi and S. Candeletti

      Version of Record online: 10 JAN 2017 | DOI: 10.1111/gbb.12365

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      N/OFQ-NOP system supraspinal changes suggest its involvement in modulating sensory and emotional aspects of neuropathic pain.

    8. Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine

      C.-H. Yu, S.-C. Chu, P.-N. Chen, Y.-S. Hsieh and D.-Y. Kuo

      Version of Record online: 14 DEC 2016 | DOI: 10.1111/gbb.12360

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      We suggest that hypothalamic ghrelin signaling system, with the help of antioxidants, may participate in neuropeptide Y/cocaine- and amphetamine-regulated transcript-mediated appetite control in phenylpropanolamine-treated rats.

    9. Lessons from the canine Oxtr gene: populations, variants and functional aspects

      M. Bence, P. Marx, E. Szantai, E. Kubinyi, Z. Ronai and Z. Banlaki

      Version of Record online: 14 DEC 2016 | DOI: 10.1111/gbb.12356

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      Neighbor-joining tree supports the hypothesis that Oxtr variants could have been a selection target during canine domestication.

    10. The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder1

      E. Mallas, F. Carletti, C. A. Chaddock, S. Shergill, J. Woolley, M. M. Picchioni, C. McDonald, T. Toulopoulou, E. Kravariti, S. Kalidindi, E. Bramon, R. Murray, G. J. Barker and D. P. Prata

      Version of Record online: 29 NOV 2016 | DOI: 10.1111/gbb.12355

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      Psychosis risk variant for calcium-channel CACNA1C rs1006737 polymorphism is asociated with decreased microstructural white matter intergity in portions of the left middle occipital and parahippocampal gyri, right cerebelleum, left optic radiation and left inferior and superior temporal gyri, in schizophrenia patients.

  2. Reviews

    1. You have free access to this content
      Regulation of behaviour by the nuclear receptor TLX

      J. D. O'Leary, O. F. O'Leary, J. F. Cryan and Y. M. Nolan

      Version of Record online: 29 NOV 2016 | DOI: 10.1111/gbb.12357

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      The nuclear receptor Tlx regulates cognitive, motor, anxiety and aggressive behaviours.

  3. Original Articles

    1. Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression

      K. G. Sorwell, L. Renner, A. R. Weiss, M. Neuringer, S. G. Kohama and H. F. Urbanski

      Version of Record online: 24 NOV 2016 | DOI: 10.1111/gbb.12351

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      Correlation of cognitive performance with gene expression in the hippocampus and prefrontal cortex of aged female rhesus macaques.

    2. You have full text access to this OnlineOpen article
      Variants in the CNR1 gene predispose to headache with nausea in the presence of life stress

      G. Juhasz, E. Csepany, M. Magyar, A. E. Edes, N. Eszlari, G. Hullam, P. Antal, G. Kokonyei, I. M. Anderson, J. F. W. Deakin and G. Bagdy

      Version of Record online: 23 NOV 2016 | DOI: 10.1111/gbb.12352

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      CNR1 gene increases the risk of developing headache with nausea in life stress exposed subjects. Nausea maybe the result of the impaired endocannabinoid system driven top-down cortical control on important brainstem areas. A subgroup of migraine patients, who have frequent nausea associated with life stress triggered migraine attacks, may benefit from therapies that increase the endocannabinoid tone. rs806366 effect on headache with nausea.

    3. Inhibition of DNA methyltransferases regulates cocaine self-administration by rats: a genome-wide DNA methylation study

      M. Fonteneau, D. Filliol, P. Anglard, K. Befort, P. Romieu and J. Zwiller

      Version of Record online: 23 NOV 2016 | DOI: 10.1111/gbb.12354

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      DNA methyltransferase inhibitors enhance the reinforcing properties of cocaine; a methylome analysis shows underlying plasticity mechanisms.

    4. A new brain dopamine-deficient Drosophila and its pharmacological and genetic rescue

      K. Cichewicz, E. J. Garren, C. Adiele, Y. Aso, Z. Wang, M. Wu, S. Birman, G. M. Rubin and J. Hirsh

      Version of Record online: 23 NOV 2016 | DOI: 10.1111/gbb.12353

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      Dopamine (DA) is an essential neurotransmitter regulating locomotor activity and reward in humans. The DA deficiency in humans manifests as Parkinson's disease (PD), a condition caused by death of dopaminergic neurons. Here, we develop a model of brain DA deficiency in fruit flies that allows rescue with genetic methods or using PD drugs. To adequately assess the effects of neuron-selective rescue, we greatly improved upon DA immunohistochemistry detection to directly examine diffusion of release DA. With genetic rescue of DA synthesis limited to selected neurons innervating mushroom body and central complex, regions involved in regulating learning and locomotion, respectively, we found that DA does not diffuse to surrounding neurons, even with tightly intermingled neurons. This will allow precise manipulations in future studies. Furthermore, we show that tyrosine hydroxylase, the universally used marker of catecholamine neurons, is an imperfect marker of neuronal DA expression. Our new DA deficiency model will be useful in studying DA-modulated neuronal pathways, and the compensatory signaling mechanisms that can modulate the course of PD.

    5. Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

      J. B. Panksepp, E. D. Rodriguez and A. E. Ryabinin

      Version of Record online: 14 NOV 2016 | DOI: 10.1111/gbb.12346

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      Voluntary ethanol drinking is increased during social isolation independent of genotype and results in a changed circadian intake microstructure.

    6. High motivation for exercise is associated with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred mice

      M. C. Saul, P. Majdak, S. Perez, M. Reilly, T. Garland Jr and J. S. Rhodes

      Version of Record online: 7 NOV 2016 | DOI: 10.1111/gbb.12347

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      Figure 5C: Reciprocal relationships between the chromatin remodeling factor Baz1a, a histone H1 subunit H1f0, and a metabotropic serotonin receptor Htr1b is associated with high motivation for running.

    7. 5HT2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice

      D. A. Amodeo, E. Rivera, E. H. Cook Jr, J. A. Sweeney and M. E. Ragozzino

      Version of Record online: 21 OCT 2016 | DOI: 10.1111/gbb.12343

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      5HT2A receptor blockade rescues a reversal learning deficit when injected into the dorsomedial striatum in the BTBR mouse model of autism (e.g. Fig. 2).

    8. TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

      D. Stacey, R. Redlich, A. Büschel, N. Opel, D. Grotegerd, D. Zaremba, K. Dohm, C. Bürger, S. L. Meinert, K. Förster, J. Repple, C. Kaufmann, H. Kugel, W. Heindel, V. Arolt, U. Dannlowski and B. T. Baune

      Version of Record online: 4 OCT 2016 | DOI: 10.1111/gbb.12318

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      The findings of this study indicate a role for tumour necrosis factor receptor (TNFR) 1 in regulating striatal but not hippocampal morphology, as well as a complementary role for TNFR2 in hippocampal but not in striatal morphology.


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