Genes, Brain and Behavior

Cover image for Vol. 14 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Andrew Holmes

Impact Factor: 3.505

ISI Journal Citation Reports © Ranking: 2013: 10/49 (Behavioral Sciences); 93/252 (Neurosciences)

Online ISSN: 1601-183X

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  1. Original Articles

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      SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice

      S. B. McHugh, C. Barkus, J. Lima, L. R. Glover, T. Sharp and D. M. Bannerman

      Article first published online: 17 APR 2015 | DOI: 10.1111/gbb.12215

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      Mice that over-express the serotonin transporter exhibit reduced fear to aversive cues with uncertain outcomes.

    2. You have full text access to this OnlineOpen article
      The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains

      J. D. Eicher, C. M. Stein, F. Deng, A. A. Ciesla, N. R. Powers, R. Boada, S. D. Smith, B. F. Pennington, S. K. Iyengar, B. A. Lewis and J. R. Gruen

      Article first published online: 8 APR 2015 | DOI: 10.1111/gbb.12214

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      Variation in 3′ untranslated region of DCDC2 associated with phonology in children with speech sound disorder.

    3. You have full text access to this OnlineOpen article
      Pathway analysis of genome-wide association datasets of personality traits

      H.-N. Kim, B.-H. Kim, J. Cho, S. Ryu, H. Shin, J. Sung, C. Shin, N. H. Cho, Y. A. Sung, B.-O. Choi and H.-L. Kim

      Article first published online: 1 APR 2015 | DOI: 10.1111/gbb.12212

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      Here we report the first pathway analysis of all five personality traits. Our results illustrate biological understanding and novel genetic associations to personality using GWA datasets. These pathway analyses for personality implicate several gene sets involved in neuronal cell adhesion, neuronal ion channel functioning and synaptic transmission. The most notable finding is the significant convergence on key molecules in these pathways which have been broadly implicated in psychiatric disorders, including schizophrenia and bipolar disorders. By understanding the relationship between personality and psychiatric disorders, it might be possible to identify individuals at risk for developing the diseases as well as to provide behavioral intervention. Our results provide an opportunity to look at how genetic architecture regulates the formation and maintenance of personality.

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      Lack of replication for the myosin-18B association with mathematical ability in independent cohorts

      K. A. Pettigrew, S. F. Fajutrao Valles, K. Moll, K. Northstone, S. Ring, C. Pennell, C. Wang, R. Leavett, M. E. Hayiou-Thomas, P. Thompson, N. H. Simpson, S. E. Fisher, The SLI Consortium, A. J. O. Whitehouse, M. J. Snowling, D. F. Newbury and S. Paracchini

      Article first published online: 1 APR 2015 | DOI: 10.1111/gbb.12213

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      We could not replicate the association of the myosin-18B gene with mathematical ability.

    5. Human-directed social behaviour in dogs shows significant heritability

      M. E. Persson, L. S. V. Roth, M. Johnsson, D. Wright and P. Jensen

      Article first published online: 24 MAR 2015 | DOI: 10.1111/gbb.12194

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      During a problem solving task, females beagle dogs displayed more human-directed contact seeking behaviours than males

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