Congenital Anomalies

Cover image for Vol. 56 Issue 4

Edited By: Yuji Nakajima

Impact Factor: 0.985

ISI Journal Citation Reports © Ranking: 2015: 91/120 (Pediatrics)

Online ISSN: 1741-4520

Virtual Issues


Virtual Issue: Cardiovascular Development and Defects

Congenital heart defect (CHD) is one of the most common birth defects affecting approximately 1% of newborn infants. Of these patients with CHD, 10-30% is diagnosed with severe defects, which require intensive care as well as surgical interventions during their infantile period. Some patients with genetic disorder are known to be associated with a specific spectrum of CHD. However, the etiologies behind all the CHD are largely unknown. In this issue, papers on cardiovascular malformations and development, which have been published in Congenital Anomalies since 2005, are selected. Case reports presenting patients with cardiovascular defects are also included. Accumulated knowledge of experimental as well as patient’s data on birth defects will discover the etiology, prevention and therapy of birth defects including CHD.

Yuji Nakajima
Editor-in-Chief of Congenital Anomalies

Review Articles

Formal genesis of the outflow tracts of the heart revisited: Previous works in the light of recent observations
Naomasa Okamoto, Naotaka Akimoto, Nobuto Hidaka, Shuneki Shoji and Hiroshi Sumida

Second lineage of heart forming region provides new understanding of conotruncal heart defects
Yuji Nakajima

Understanding heart development and congenital heart defects through developmental biology: A segmental approach
Masahide Sakabe, Hiroko Matsui, Hirokazu Sakata, Katsumi Ando, Toshiyuki Yamagishi and Yuji Nakajima

Original Articles

Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis
Atsuko Taki, Mayumi Abe, Motohiro Komaki, Kikuko Oku, Sachiko Iseki, Shuki Mizutani and Ikuo Morita

Chorangiosis and placental oxygenation
Kazunao Suzuki, Hiroaki Itoh, Satoshi Kimura, Kazuhiro Sugihara, Chizuko Yaguchi, Yukiko Kobayashi, Kyuya Hirai, Kinya Takeuchi, Motoi Sugimura andNaohiro Kanayama

Heart changes in 17-day-old fetuses of diabetic ICR (Institute of Cancer Research) mothers: Improvement with maternal immune stimulation
Juan Claudio Gutierrez, Mary Renee Prater, Theresa C. Hrubec, Bonnie J. Smith, Larry E. Freeman and Steven D. Holladay

Cardiovascular malformations induced by prenatal exposure to phenobarbital in rats
Hirokazu Okuda and Tetsuji Nagao

Morphological differences in cardiovascular anomalies induced by bis-diamine between Sprague–Dawley and Wistar rats
Hidetoshi Fujino, Masao Nakagawa, Setsuko Nishijima, Nobuhiko Okamoto, Takashi Hanato, Noriko Watanabe, Takeaki Shirai, Hiroshi Kamiya and Yoshihiro Takeuchi

Improved technique for fetal heart examination in developmental toxicity studies in rats
Hiroo Kanamori, Nobuyuki Seki, Takeshi Sugimoto and Yojiro Ooshima

Case Reports

Abnormal continuation of umbilical vein into extra-hepatic portal vein: Report of three cases
Sunil Jaiman and Hima Bindu Nalluri

Severe Peters Plus syndrome-like phenotype with anterior eye staphyloma and hypoplastic left heart syndrome: Proposal of a new syndrome
Reiko Shimizu Ryota Saito, Kenji Hoshino, Kiyoshi Ogawa, Takashi Negishi, Jiro Nishimura, Norimasa Mitsui, Makiko Osawa and Hirofumi Ohashi

Isolation of the left subclavian artery from the pulmonary artery in a patient with CHARGE association
Anneke P. Bech, Jeroen Op Den Akker and Pieter R. Matthijsse

Isolated levocardia: Prenatal diagnosis and management
Satoko Katsuya, Shigehito Yamada, Masayo Ukita, Hiromi Nishimura, Noriomi Matsumura, Ken Fukuhara, Yukiyasu Sato, Kohei Shiota and Ikuo Konishi

Clinical variability in a Japanese hereditary lymphedema type I family with an FLT4 mutation
Seiji Mizuno, Yasukazu Yamada, Kenichiro Yamada, Noriko Nomura and Nobuaki Wakamatsu

Refining chromosomal region critical for Down syndrome-related heart defects with a case of cryptic 21q22.2 duplication
Rika Kosaki, Kenjiro Kosaki, Kazushige Matsushima, Norimasa Mitsui, Naomichi Matsumoto and Hirofumi Ohashi

Acardiac acephalic twin gestation with transposition of great arteries in pump twin
Işık Üstüner, Erhan Şimşek, Korhan Kahraman, Bora Cengiz and Acar Koç

Virtual Issue: Developmental Anomalies in Embryo-Fetal Development Studie

The harmonized terminology of developmental anomalies in experimental animals, which was discussed by members of the International Federation of teratology Societies including North America, Europe and Japan, has been published. The historical control data for fetal anomalies in rats and rabbits were published by the project of the Japanese Teratology Society, Japanese Pharmaceutical Manufactures Association and others. In this issue, papers on terminology, historical control data, and methodology, which have been published in Congenital Anomalies since 1997, are selected. These papers are useful for research conducting Embryo-Fetal Development toxicity studies and data reviews of reproductive and developmental toxicity.

Yojiro Ooshima Member of Boards in Japanese Teratology Society

TERMINOLOGY

Terminology of developmental abnormalities in common laboratory mammals (Version 2)

Susan L. Makris, Howard M. Solomon, Ruth Clark, Kohei Shiota, Stephane Barbellion, Jochen Buschmann, Makoto Ema, Michio Fujiwara, Konstanze Grote, Keith P. Hazelden, Kok Wah Hew, Masao Horimoto, Yojiro Ooshima, Meg Parkinson and L. David Wise

Terminology of developmental abnormalities in common laboratory mammals (Japanese Version 1)

Masao HORIMOTO, Fumio ARIYUKI, Syunpei DAIDOHJI, Toshiyuki FUJII, Katsuhiro FUKUNISHI, Satoshi HANADA, Sunao IKEGAWA, Hiroyuki ISHII, Tatsuo INOUE, Takayuki IWASE, Masao MATSUURA, Toshiaki MATSUZAWA, Naoki NISHI, Yasutaka OHKUBO, Atsushi SANBUISSHO, Kiminori SEKIYA, Mizuno TANI, Hidemi TANIGUCHI, Yasuki YOKOMOTO, Jun-ichi YOSHIDA, Michihito TAKAHASHI and Mineo YASUDA

Terminology of developmental abnormalities in common laboratory mammals (Version 1)

L. David WISE, Sidney L. BECK, Diana BELTRAME, Bruce K. BEYER, Ibrahim CHAHOUD, Robert L. CLARK, Ruth CLARK, Alice M. DRUGA, Maureen H. FEUSTON, Pierre GUITTIN, Susan M. HENWOOD, Carole A. KIMMEL, Pia LINDSTROM, Anthony K. PALMER, Judith A. PETRERE, Howard M. SOLOMON, Mineo YASUDA and Raymond G. YORK

HISTORICAL CONTROL DATA

Historical Control Data Historical control data on developmental toxicity studies in rodents

Makoto Ema, Katsumi Endoh, Ryou Fukushima, Sakiko Fujii, Hiroaki Hara, Mutsuko Hirata-Koizumi, Akihiko Hirose, Hitoshi Hojo, Masao Horimoto, Nobuhito Hoshino, Yoshinori Hosokawa, Yukari Imai, Hiroshi Inada, Kunifumi Inawaka, Keiichi Itoh, Yoshihiro Katsumata, Hiroyuki Izumi, Hirohito Kato, Maki Maeda, Kiyoshi Matsumoto, Seiki Matsuo, Toshiki Matsuoka, Ikuo Matsuura, Hiroshi Mineshima, Yoji Miwa, Nao Nakano, Masato Naya, Hiroko Noyori, Takafumi Ohta, Harutaka Oku, Atsushi Ono, Tatsuya Shimizu, Kazuhiro Shimomura, Ikuro Takakura, Ryota Tanaka, Taishi Tateishi, Yuko Tominaga, Tohru Uesugi, Chizuru Urakawa, Kaoru Yabe, Akihito Yamashita, Toshiaki Yamauchi and Ryohei Yokoi

Stability of the reproductive variables and fetal malformations from control animals and animals treated with thalidomide in Kbl:JW rabbits over two decades

Yoshinori Kawamura, Kiyoshi Matsumoto and Keiichiro Sato

Historical control data on prenatal developmental toxicity studies in rabbits

Makoto Ema, Hiroaki Aoyama, Akihiro Arima, Yuzo Asano, Kazuhiro Chihara, Katsumi Endoh, Sakiko Fujii, Hiroaki Hara, Hashihiro Higuchi, Atsuko Hishikawa, Hitoshi Hojo, Masao Horimoto, Nobuhito Hoshino, Yoshinori Hosokawa, Hiroshi Inada, Ayumi Inoue, Keiichi Itoh, Hiroyuki Izumi, Maki Maeda, Kiyoshi Matsumoto, Seiki Matsuo, Ikuo Matsuura, Hiroshi Mineshima, Yoji Miwa, Hidenori Miyata, Yasumoto Mizoguchi, Nao Nakano, Masato Naya, Hanako Nishizawa, Ken-ichi Noritake, Hiroko Noyori, Takafumi Ohta, Harutaka Oku, Tatsuya Shimizu, Kazuhiro Shimomura, Kei Shiozawa, Ikuro Takakura, Ryota Tanaka, Tohru Uesugi, Kaoru Yabe, Toshiaki Yamauchi and Ryohei Yokoi

Differences in spontaneous fetal abnormalities among three outbred stocks of Wistar Hannover rats in Japan

Tetsuya Takeuchi, Hirokazu Okuda, Yoko Kasahara, Sugako Ushigome, Ikue Aihara and Shoji Fukushima

Characteristics of Kbl:Dutch rabbits in prenatal development in comparison with Kbl:New Zealand White rabbits

Ryo Kamata, Tetsuya Matsuoka, Yasumoto Mizoguchi, Ema Sano, Kotaro Serizawa, Toshikazu Ishikura and Yuzo Asano

Japan Pharmaceutical Manufacturers Association (JPMA) survey on background control data of developmental and reproductive toxicity studies in rats and rabbits

Toshio NAKATSUKA, Masao HORIMOTO, Minako ITO, Yoshio MATSUBARA, Masashi AKAIKE and Fumio ARIYUKI

METHODOLOGY

Investigation for methods of anesthesia and euthanasia for rat fetuses in developmental toxicity studies

Hirohito Kato, Momoko Dokai, Ryuichi Katagiri, Akihiro Arima and Yojiro Ooshima

Improved technique for fetal heart examination in developmental toxicity studies in rats

Hiroo Kanamori, Nobuyuki Seki, Takeshi Sugimoto and Yojiro Ooshima

Virtual Issue: Endocrine Disrupter

Since the last decade of the 20th century, much concern has been focused on the adverse effects of chemicals on endocrine activities, so-called the endocrine disrupter issue. Suspected endocrine disrupters on humans and/or wild life include both natural and man-made chemicals such as endogenous hormones and vitamins, phytoestrogens (alkyl-phenols of plant origin), pharmaceuticals, pesticides, synthesized chemicals for industrial use and environmental pollutants. Exposures to endocrine disrupters induce adverse outcomes in animals through receptor-mediated mechanisms and/or hormonal imbalances. Postulated adverse outcomes also diverge widely. However, one of the most serious concerns is the induction of reproductive and/or developmental toxicities. The present virtual issue consists of selected reviews and research papers on the endocrine disrupting effects of xenobiotics, which have been published in Congenital Anomalies since 2002.

Hiroaki Aoyama
Associate Editor for Congenital Anomalies

REVIEW ARTICLES

Necessity to establish new risk assessment and risk communication for human fetal exposure to multiple endocrine disruptors in Japan
Emiko Todaka and Chisato Mori

Developmental toxicity of estrogenic chemicals on rodents and other species
Taisen Iguchi, Hajime Watanabe, Yoshinao Katsu, Takeshi Mizutani, Shinichi Miyagawa, Atsuko Suzuki, Satomi Kohno, Kiyoaki Sone and Hideo Kato

Endocrine disruptor issues in Japan
Taisen Iguchi, Manabu Sumi and Shinsuke Tanabe

Roles of retinoic acid signaling in normal and abnormal development of the palate and tongue
Junko Okano, Jun Udagawa and Kohei Shiota

EPIDEMIOLOGY

Population-based case-control teratogenic study of hydroxyprogesterone treatment during pregnancy
István Dudás, János Gidai and Andrew E. Czeizel

REPRODUCTIVE AND/OR DEVELOPMENTAL TOXICITY STUDIES WITH EXPERIMENTAL ANIMALS

Alteration of androgen receptor immunoexpression by neonatal DES-treatment in mouse epididymis
Kaiya Takano, Masatoshi Komiyama, Naoji Toyota and Chisato Mori

Cleft lip and palate in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin: a morphological in vivo study
Tomohiro Yamada, Katsuaki Mishima, Kumiko Fujiwara, Hideto Imura and Toshio Sugahara

Two-generation reproduction toxicity study in rats with 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT)
Hitoshi Hojo Hiroaki Aoyama, Ken L. Takahashi, Naoko Shimizu, Masayuki Araki, Yoshio Takizawa, Koji Sakasai, Maki Kuwahara, Machiko Saka and Shoji Teramoto

Genome-wide screening of dioxin-responsive genes in fetal brain: bioinformatic and experimental approaches
Hideki Fujita, Hazuki Samejima, Noriyuki Kitagawa, Takayuki Mitsuhashi, Takanori Washio, Junzo Yonemoto, Masaru Tomita, Takao Takahashi and Kenjiro Kosaki

Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes
Hisayo Nishida, Shinichi Miyagawa, Daisuke Matsumaru, Yoshihiro Wada, Yoshihiko Satoh, Yukiko Ogino, Shinji Fukuda, Taisen Iguchi and Gen Yamada

Morphological and immunohistochemical studies on cleft palates induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice
Kumiko Fujiwara, Tomohiro Yamada, Katsuaki Mishima, Hideto Imura and Toshio Sugahara

Effects of in utero exposure to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) on somatic growth and endocrine status in rat offspring
Kenichi Kobayashi, Muneyuki Miyagawa, Rui-Sheng Wang, Megumi Suda, Soichiro Sekiguchi and Takeshi Honma

Early embryonic losses in mice induced by diethylstilbestrol
Tetsuji Nagao and Shinsuke Yoshimura

New method for detecting antiandrogenic effects through the measurement of external genitalia in rabbits
Kunifumi Inawaka, Noriyuki Kishimoto, Hashihiro Higuchi, Takayuki Okamoto and Satoshi Kawamura

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion
Hideto Imura, Tomohiro Yamada, Katsuaki Mishima, Kumiko Fujiwara, Harumi Kawaki, Azumi Hirata, Norio Sogawa, Takaaki Ueno and Toshio Sugahara

Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL/6J mice
Kenichi Kobayashi, Katsumi Ohtani, Hisayo Kubota and Muneyuki Miyagawa

Hypothyroidism caused by phenobarbital affects patterns of estrous cyclicity in rats
Yumei Li, Toshihiko Kumazawa, Tsukasa Ishiguro, Yuriko Kawakami, Hiromi Nishitani, Yoshiaki Tagawa and Yukiharu Matsumoto

Two-generation reproduction toxicity study in rats with methoxychlor
Hiroaki Aoyama, Hitoshi Hojo, Ken L. Takahashi, Naoko Shimizu-Endo, Masayuki Araki, Yukiko Takeuchi-Kashimoto, Machiko Saka and Shoji Teramoto

Exposure to ethinyl estradiol prenatally and/or after sexual maturity induces endometriotic and precancerous lesions in uteri and ovaries of mice
Eiji Koike, Yoshiko Yasuda, Mitsuru Shiota, Masao Shimaoka, Mitsuhiro Tsuritani, Hiroyoshi Konishi, Harufumi Yamasaki, Katsumi Okumoto and Hiroshi Hoshiai

Early to middle gestational exposure to diethylstilbestrol impairs the development of labyrinth zone in mouse placenta
Nao Kagawa, Yoshiaki Saito and Tetsuji Nagao

IN VITRO STUDIES

Effects of estrone on both embryonic and extra-embryonic regions in mouse embryos during pre-organogenesis in vitro
Yuji Kajiwara and Miki Imahori

In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment
Katsuhiko Warita, Tomoko Mitsuhashi, Ken-ichi Ohta, Shingo Suzuki, Nobuhiko Hoshi, Takanori Miki and Yoshiki Takeuchi

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