FEBS Journal

Cover image for Vol. 281 Issue 15

Edited By: Seamus Martin

Impact Factor: 3.986

ISI Journal Citation Reports © Ranking: 2013: 85/291 (Biochemistry & Molecular Biology)

Online ISSN: 1742-4658

Most Cited

Top cited FEBS Journal papers (two years from publication period October 2011 – March 2012)


Membrane and surface interactions of Alzheimer's A beta peptide - insights into the mechanism of cytotoxicity
Thomas L. Williams and Louise C. Serpell 
FEBS Journal, 278: 3905-3917 (2011)

WilliamsThomasSerpellLouiseLouise Serpell is Professor of Biochemistry at the University of Sussex in Brighton, UK where she has run a research group focusing on the structure and function of amyloidogenic proteins for over ten years. Dr. Thomas Williams is a Postdoctoral Scholar at Case Western Reserve University, Cleveland, USA. His research focuses on protein aggregation in Alzheimer's and Prion disease, and the development of therapeutics against these diseases.


Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
Haider Raza
FEBS Journal, 278: 4243–4251 (2011)

HaiderRazaHaider Raza is Professor and Chair in the Department of Biochemistry at the College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates. Dr Raza completed his PhD in India and Post-Doc training in the USA. He has been invited on many occasions to the Karolinska Institute, Stockholm, Sweden; FDA, USA; and several other places in the USA and Europe as a visiting scientist. His research interest is in mitochondrial dysfunction, oxidative stress and drug metabolism. He has published more than 80 peer reviewed articles.


Antimicrobial peptides important in innate immunity
Andreas Cederlund, Gudmundur H. Gudmundsson and Birgitta Agerberth
FEBS Journal, 278: 3942–3951 (2011)


Protein alpha-N-acetylation studied by N-terminomics
Petra Van Damme, Thomas Arnesen and Kris Gevaert
FEBS Journal, 278: 3822–3834 (2011)

GevaertKris Gevaert, PhD, is a Full Professor in Functional Proteomics at Ghent University (Belgium), and heads the Functional Proteomics group of the VIB Department of Medical Protein Research and the VIB Proteomics Expertise Centre. His group has developed several approaches for targeted analysis of protein modifications by mass spectrometry, amongst other N-terminomics approaches to study N-terminal protein modifications.


Composition and function of cytochrome c biogenesis System II
Jörg Simon and Lars Hederstedt
FEBS Journal, 278: 4179–4188 (2011)

HederstedtLars Hederstedt is a Professor of Microbiology at Lund University, Lund, Sweden. From the University of Stockholm, he received a basic training in chemistry and molecular genetics and from the Karolinska Institutet an MD in bacteriology. His research field is physiology of gram-positive bacteria. Past and present research comprises heme and heme-protein biosynthesis, respiratory enzymes and endospore cortex biogenesis.


A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
John E. Weldon and Ira Pastan
FEBS Journal, 278: 4683–4700 (2011)

PastanWeldonJohn E. Weldon, PhD, is an Assistant Professor in the Department of Biological Sciences at Towson University, MD USA. His research interests include immunoconjugate engineering, Pseudomonas exotoxin A, and the diphthamide residue of elongation factor 2. Dr Ira Pastan established the Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD, USA in 1970 and is currently Co-Chief of the Laboratory. He is developing a new therapy for cancer by making fusion proteins composed of the Fv portion of monoclonal antibodies directed at receptor proteins on cancer cells fused to a genetically modified form of Pseudomonas exotoxin A. Three of these recombinant immunotoxins are being tested in humans with various forms of cancer.

Actin as target for modification by bacterial protein toxins
Klaus Aktories, Alexander E. Lang, Carsten Schwan and Hans G. Mannherz
FEBS Journal, 278: 4526–4543 (2011)

MannherzAktoriesKlaus Aktories is Professor and Director at the Institute of Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg, Germany. The main interests of his group in Freiburg are bacterial protein toxins, which target the actin cytoskeleton and/or GTPases by ADP-ribosylation, glucosylation or deamidation. Hans Georg Mannherz is Professor Emeritus at the Department of Anatomy and Molecular Embryology, Ruhr-University, Bochum, Germany. His main research topics are actin and actin binding proteins.

Epsilon toxin: a fascinating pore-forming toxin
Michel R. Popoff
FEBS Journal, 278: 4602–4615 (2011)

PopoffMichel R. Popoff is head of the research unit ‘Anaerobic Bacteria and Toxins’ and of the National Reference Centre for Anaerobic Bacteria and Botulism at the Pasteur Institute, Paris. His scientific interests are focused on clostridial toxins.


TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Robert H. Baloh
FEBS Journal, 278: 3539–3549 (2011)

BalohRobert H. Baloh, MD, PhD earned his bachelor’s degree at Brown University, his doctorate in neuroscience and medical degree at Washington University, and completed his neurology residency at Harvard Medical School. He is currently an Associate Professor of Neurology at Cedars-Sinai Medical Center and the University of California, Los Angeles. Dr. Baloh's lab studies the molecular mechanisms of neurodegeneration, with a focus on motor neuron disease and inherited neuropathies.


Mechanisms for ATP-dependent chromatin remodelling: the means to the end
Andrew Flaus and Tom Owen-Hughes
FEBS Journal, 278: 3579–3595 (2011)

Cytochrome c biogenesis System I
Julie M. Stevens, Despoina A. I. Mavridou, Rebecca Hamer, Paraskevi Kritsiligkou, Alan D. Goddard and Stuart J. Ferguson
FEBS Journal, 278: 4170–4178 (2011)

Julie_StevensStuart_FergusonStuart Ferguson is Professor of Biochemistry at the University of Oxford and William R. Miller Fellow of St Edmund Hall, Oxford. He has research interests in bioenergetics, specifically bacterial respiration and metalloproteins. He received the Keilin Medal of the Biochemical Society in 2001 and co-authors the widely read book ‘Bioenergetics’. Julie Stevens received her BSc(Hons) and PhD at the University of the Witwatersrand, South Africa. She is currently at the University of Oxford researching periplasmic post-translational modification pathways and hemoprotein assembly.

Fumarase: a paradigm of dual targeting and dual localized functions
Ohad Yogev, Adi Amaati and Ophry Pines
FEBS Journal, 278: 4230–4242 (2011)

PinesOphry Pines is Professor of Molecular Biology in the Department of Microbiology and Molecular Genetics at the Faculty of Medicine of the Hebrew University of Jerusalem, Israel. He joined this Faculty in 1987 and served as Head of Molecular Biology until 2007. From 2013, he is the Harry and Helen L. Brenner Chair in Molecular Biology. Research interests include targeting, translocation across membranes, folding and subcellular distribution of proteins in eukaryotic cells in health and disease.