© Federation of European Biochemical Societies
Edited By: Richard Perham
Impact Factor: 4.25
ISI Journal Citation Reports © Ranking: 2012: 74/290 (Biochemistry & Molecular Biology)
Online ISSN: 1742-4658
Top cited FEBS Journal papers 2013 (two years from publication period October 2010 – March 2011)
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Chrisostomi Gialeli, Achilleas D. Theocharis and Nikos K. Karamanos
FEBS Journal 277, 16–27, January 2011
Chrisostomi Gialeli, M.Sc., is a Ph.D. student at the University of Patras, Dept. of Chemistry, and her research focuses on tumor microenvironment interactions that affect cancer cell functional properties and expression of matrix macromolecules. Professor Nikos Karamanos research focuses on matrix macromolecules and especially on their implications for tissue organization, pathogenesis and progression of various disorders, as well as pharmacological targeting of growth factor receptors and signal transduction pathways mediating the expression of matrix effectors.
Efficient and targeted delivery of siRNA in vivo
Min Suk Shim and Young Jik Kwon
FEBS Journal 277, 4814–4827, December 2010
Dr. Young Jik Kwon is an associate professor at the University of California, Irvine, and currently oversees research at the BioTherapeutics Engineering Laboratory (BioTEL). His current projects mainly focus on gene therapy, drug delivery, cancer-targeted therapeutics, combined molecular imaging and therapy, and cancer vaccines.
Regulation of matrix metalloproteinase activity in health and disease
Elin Hadler-Olsen, Bodil Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen and Jan-Olof Winberg
FEBS Journal 278, 28–45, January 2011
Elin Hadler-Olsen is an Associate Professor and Jan-Olof Winberg is a Professor at the Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Norway. Hadler-Olsen’s research interests are the role of proteolytic enzymes like matrix metalloproteases (MMPs) in health and disease. Winberg’s research interests include biochemical and kinetic characterization of enzymes belonging to the short-chain dehydrogenase/reductase (SDR) superfamily and the MMP family, as well as the role of MMP and SDR enzymes in health and disease.
Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
Achilleas D. Theocharis, Spyridon S. Skandalis, George N. Tzanakakis and Nikos K. Karamanos
FEBS Journal 277, 3904–3923, October 2010
Achilleas Theocharis is Assistant Professor of Biochemistry & Molecular Biology in the Department of Chemistry at the University of Patras, Greece. His current research focuses on the role of proteoglycans, glycosaminoglycans and matrix metalloproteinases in the pathogenesis of various disorders. Nikos Karamanos, Professor of Biochemistry at the University of Patras, has extensive experience in the areas of matrix pathobiochemistry, cell signaling, pharmacological targeting, preclinical evaluation of drugs at cell level, and development of bioanalytical methods and cytotoxicity.
Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis
Feifan Zhou, Ying Yang and Da Xing
FEBS Journal 278, 403–413, February 2011
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans
Renato V. Iozzo and Liliana Schaefer
FEBS Journal 277, 3864–3875, October 2010
Renato V. Iozzo, M.D., Ph.D. (Honoris Causa) is a Professor of Pathology and Cell Biology, and Professor of Biochemistry and Molecular Biology at Thomas Jefferson University, Philadelphia, PA USA. He is the Editor-In-Chief of Matrix Biology. His research focuses on the roles of proteoglycans in cancer biology and tumor angiogenesis
Liliana Schaefer, M.D., is a Professor of Nephropharmacology at the Goethe University in Frankfurt/Main. She is a Senior Editor of the journal Matrix Biology and presides over the German Society for Matrix Biology. Her research focuses on the role of soluble proteoglycans as danger signals in inflammation, cancer, and fibrosis.
Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity
FEBS Journal 277, 4602–4613, November 2010
Massimo Stefani was born in Pisa and graduated in Biological Sciences at the University of Florence. From 1981 he was researcher at the Department of Biochemistry at the University of Florence. In 1990, he became full professor of Biochemistry at the University of Siena and, in 1993, a full professor of Biochemistry at the University of Florence.
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis
Uri Barash, Victoria Cohen-Kaplan, Ilana Dowek, Ralph D. Sanderson, Neta Ilan, Israel Vlodavsky
FEBS Journal 277, 3890–3903, October 2010
Israel Vlodavsky is Professor at the Cancer and Vascular Biology Research Center at the Technion (Israel Institute of Technology) in Haifa. His research interests include the control of cell proliferation and differentiation by the extracellular matrix and the role of heparanase in cancer, inflammation and kidney dysfunction. He has received prestigious awards for his work and has authored or co-authored more than 400 research articles, reviews and book chapters.
Proteoglycans in health and disease: the multiple roles of syndecan shedding
Tina Manon-Jensen, Yoshifumi Itoh and John R. Couchman
FEBS Journal 277, 3876–3889, October 2010
John Couchman is a Professor in the Department of Biomedical Sciences at the University of Copenhagen. His research interests include cell adhesion and signaling, with particular emphasis on the syndecan transmembrane proteoglycan receptors. In addition to structure/function studies, the role of syndecans in tumor progression is also being investigated.
A structural overview of the PDI family of proteins
Guennadi Kozlov, Pekka Määttänen, David Y. Thomas and Kalle Gehring
FEBS Journal 277, 3924–3936, October 2010
Dr. Guennadi Kozlov is a research associate in the Department of Biochemistry at McGill University, Montreal, Canada. One of his research interests focuses on studying chaperones and folding catalysts that assist in folding protein substrates in the endoplasmic reticulum.
The heat shock factor family and adaptation to proteotoxic stress
Mitsuaki Fujimoto and Akira Nakai
FEBS Journal 277, 4112–4125, October 2010
Akira Nakai is a Professor of Biochemistry and Molecular Biology at Yamaguchi University School of Medicine, Japan. He graduated in medicine and completed his doctorate at Tottori University, followed by post-doctoral research at Northwestern University, USA. His research interest is in understanding the molecular mechanisms and patho-physiological roles of the heat shock response, which regulates cellular proteostasis and is tightly related to protein misfolding diseases.