FEBS Journal

Cover image for Vol. 281 Issue 8

Edited By: Seamus Martin

Impact Factor: 4.25

ISI Journal Citation Reports © Ranking: 2012: 74/290 (Biochemistry & Molecular Biology)

Online ISSN: 1742-4658

Most Cited

Top cited FEBS Journal papers 2013 (two years from publication period April 2011 – September 2011)


MicroRNAs and epigenetics
Fumiaki Sato, Soken Tsuchiya, Stephen J. Meltzer and Kazuharu Shimizu 
FEBS Journal Volume 278, 1598–1609 (2011)


Fumiaki Sato, MD, PhD is currently an Associate Professor at the Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Japan. His current projects mainly focus on developing diagnostic algorithms using microRNA expression profile to predict the therapeutic response/resistance of breast cancer.

TNFR1-induced activation of the classical NF-kappa
Harald Wajant and Peter Scheurich
FEBS Journal, 278: 862–876 (2011)

 Harald Wajant
Harald Wajant is Professor and Head of the Division of Molecular Internal Medicine of the Department of Internal Medicine II of the University Hospital of Würzburg, Germany. He received his Ph.D. degree in biology from the University of Stuttgart in 1993 and was head of the Research group “TNF signaling” at the Institute of Cell Biology and Immunology, University of Stuttgart from 1994–2002. He joined the University Hospital of Wurzburg in 2003. His current research interests are the signaling mechanisms of TNF receptors and the development of TNF receptor-targeted therapeutic proteins.

Hyaluronan-CD44 interactions as potential targets for cancer therapy
Suniti Misra, Paraskevi Heldin, Vincent C. Hascall, Nikos K. Karamanos, Spyros S. Skandalis, Roger R. Markwald and Shibnath Ghatak
FEBS Journal, 278: 1429–1443 (2011)


Dr. Shibnath Ghatak and Dr. Suniti Misra are Assistant Professors, Department of Regenerative- Medicine and Cell-Biology, Medical University of South Carolina, USA. The research interests of Dr. Ghatak are COX-LOX and microRNA regulations of hyaluronan/CD44-interaction in cancer and in scleroderma. Dr. Misra's research focuses on colon-tumor specific delivery of shRNA/nanoparticle (recipient of NIH-RO3), and on the role of hyaluronan/CD44 in differentiation and survival of myo-fibroblasts in systemic and dermal sclerosis.
Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis
Nicole Tegtmeyer, Silja Wessler and Steffen Backert
FEBS Journal, 278: 1190–1202 (2011)
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
Zhe-Sheng Chen and Amit K. Tiwari
FEBS Journal, 278: 3226–3245 (2011) 
Zhe-Sheng Chen is a Professor in the College of Pharmacy and Health Sciences at St. John’s University, New York, US. His research is focused on understanding the biochemical basis of drug resistance as mediated by ATP-binding cassette transporters in health and diseases. Amit K. Tiwari is an Assistant Professor in the Department of Biomedical Sciences at Tuskegee University, AL, US and is involved in characterizing the drug resistance phenotype of novel anticancer drugs and research into the integration of signaling networks with systems biology leading to pharmacokinetic/pharmacodynamic development of novel anticancer drugs.
Flavogenomics - a genomic and structural view of flavin-dependent proteins
Peter Macheroux, Barbara Kappes and Steven E. Ealick
FEBS Journal, 278: 2625–2634 (2011)

Peter Macheroux is a Professor in the Institute of Biochemistry at the Graz University of Technology, Austria. His research interests revolve around cofactor-dependent enzymes with a focus on flavin-dependent enzymes. Steven Ealick is the William T. Miller Professor of Chemistry and Chemical Biology at Cornell University.  He is also Director of the Northeastern Collaborative Access Team at the Advanced Photon Source, Argonne National Laboratory.   

Natriuretic peptide metabolism, clearance and degradation
Lincoln R. Potter
FEBS Journal, 278: 1808–1817 (2011)
Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish
Amaury Herpin and Manfred Schartl
FEBS Journal, 278: 1010–1019 (2011)
Professor Manfred Schartl is Professor of Human Biochemistry and head of department at the University of Wuerzburg, Germany. His research interests are the molecular processes in organismic development and their malfunction in cancerogenesis, together with evolutionary questions focussing on sex determination and the impact of gene duplications for the evolution of genes and genomes. Amaury Herpin belongs to Professor Schartl’s group where he is currently studying molecular sex determination and gonad formation in the Medaka fish (Oryzias latipes) as a model organism.
Oxylipins in fungi
Florian Brodhun and Ivo Feussner
FEBS Journal, 278: 1047–1063 (2011)
Dr Florian Brodhun and Prof. Ivo Feussner belong to the Department for Plant Biochemistry of the Albrecht-von-Haller-Institute for Plant Sciences at the University of Göttingen, Germany. Dr. Florian Brodhun is focusing on various aspects of the molecular enzymology of lipid-modifying and thiamine-containing enzymes. Prof. Ivo Feussner is working on lipid peroxidation processes and on lipid metabolic pathways. Furthermore he is developing lipid profiling and metabolomic fingerprinting methods.
 α-enolase: a promising therapeutic and diagnostic tumor target
Michela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco Novelli
FEBS Journal, 278: 1064–1074 (2011)
Michela Capello, PhD, is a Post Doc at the MD Anderson Cancer Center. During her PhD at the University of Turin she focused her research on the proteomic profiling of tumor antigens in pancreatic cancer. Francesco Novelli is Associate Professor of Immunology at University of Turin Medical School, Department of Molecular Biotechnology and Health Sciences, his main research interests are early diagnosis and immunotherapies of pancreatic cancer.
Silintaphin-1-interaction with silicatein during structure-guiding bio-silica formation
Ute Schloßmacher, Matthias Wiens, Heinz C. Schröder, Xiaohong Wang, Klaus P. Jochum and Werner E. G. Müller
FEBS Journal, 278: 1145–1155 (2011)
Ms. Dr. Ute Schlossmacher is a postdoc with the University-Professor Dr. Werner E.G. Müller at the University Medical Center of the Johannes Gutenberg University Mainz, Germany (ERC Advanced Investigator Grant Research Group at Institute for Physiological Chemistry). The major research interests of the group include the enzymatic basis of biomineral formation in siliceous and calcareous sponges, as well as their bionic applications, especially in the fields of human bone reconstitution and osteoporosis.
Transcriptional and post-translational regulation of hyaluronan synthesis
Raija H. Tammi, Alberto G. Passi, Kirsi Rilla, Evgenia Karousou, Davide Vigetti, Katri Makkonen and Markku I. Tammi
FEBS Journal, 278: 1419–1428 (2011)
 Alberto Passi
Alberto Passi MD PhD is Professor of Biochemistry at the University of Insubria (Varese – Italy). He has focused his scientific interest on extracellular matrix metabolism and hyaluronan synthesis control in healthy and pathological conditions.