© Federation of European Biochemical Societies
Edited By: Seamus Martin
Impact Factor: 3.986
ISI Journal Citation Reports © Ranking: 2013: 85/291 (Biochemistry & Molecular Biology)
Online ISSN: 1742-4658
Top cited FEBS Journal papers (two years from publication period April 2012 – September 2012)
Lipid metabolism in cancer
MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells
Te Liu, PhD, is an Associate Professor and Laboratory Director at the Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, China. The focus of his research group is on demonstrating the mechanisms that suppress the proliferation, tumorigenicity and multi-drug resistance of ovarian cancer-initiating (stem) cells via the epigenetic regulation of non-coding RNAs (microRNAs and lncRNAs). He has published more than 35 peer-reviewed articles as first or corresponding author.
Glycosaminoglycans: key players in cancer cell biology and treatment
Nikos Afratis, MSc, is a PhD student in the Department of Chemistry at the University of Patras. His previous research experience was gained at the Biotech Research & Innovation Centre, Copenhagen University. His research focuses on the biological roles of glycosaminoglycans and heparan sulfate proteoglycans in cancer cell biology. Nikos K. Karamanos is a Professor of Biochemistry at the University of Patras. His research activity is focused on biochemistry, biochemical analysis and matrix pathobiology and especially on how proteoglycans, glycosaminoglycans and metalloproteinases are implicated in tissue organization, pathogenesis and the progression of various disorders. He is also interested in the pharmacological targeting of signal transduction pathways regulating the expression and activity of matrix molecules.
The major facilitator superfamily (MFS) revisited
Milton Saier is Professor of Molecular Biology at the University of California at San Diego (UCSD). He studied biochemistry at UC Berkeley, conducted microbial genetics research at the Johns Hopkins University, and then took up his current position at UCSD. He has published six books and over 700 scientific studies. He directs research in two laboratories, one applying bioinformatic approaches, and one using molecular genetics. His research focuses on transmembrane molecular transport and the newly discovered phenomenon of directed mutation. He maintains the Transporter Classification Database (TCDB; www.tcdb.org).
Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells
Animal models of Parkinson’s disease
Fabio Blandini, MD, is a neurologist and biochemist. He is the Director of the Neurobiology Research area and Coordinator of the Center for Research in Neurodegenerative Diseases at the National Neurological Institute C. Mondino of Pavia, Italy. Marie-Therese Armentero is a molecular biologist, former Head of the Laboratory of Functional Neurochemistry of the Mondino Institute. During the past 15 years, they have dedicated their efforts to investigating biochemical and molecular mechanisms that are potentially involved in the pathogenesis and pathophysiology of Parkinson’s disease, through experimental PD models and studies conducted in patients.
Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist
Jiang XQ, as the Chairman of the Chinese Anti-Cancer Association Professional Committee of Biliary Tract Cancer Society, is a surgery Professor at the Second Military Medical University in China. Professor Jiang also heads a research group at the Eastern Hepatobiliary Hospital that is focusing on tumorigenesis mechanisms and clinical therapeutics against hepatobiliary carcinoma. Li Bin completed his PhD at the Second Military Medical University in China and is now a postdoctoral scholar at the Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy Sciences. His research focuses on hepatobiliary carcinoma epigenetics and metabonomics.
MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma
Disulfide bond formation network in the three biological kingdoms, bacteria, fungi and mammals
Kenji Inaba is a full professor of biochemistry and structural biology at the Institute of Multidisciplinary Research for Advanced Material, Tohoku University, Japan. Our group is focused on understanding the structural and mechanistic basis of the protein and redox homeostasis in cells. Our particular interest is the highly diverse protein disulfide bond formation and cleavage networks that have evolved in the mammalian endoplasmic reticulum.
Kynurenines: from the perspective of major psychiatric disorders
Dr Aye Mu Myint, MD, obtained a PhD in Neuroscience from the University of Maastricht, The Netherlands, and completed Habilitation in Experimental Psychiatry at Magdeburg University, Germany. She has worked as a visiting scientist at the Ludwig-Maximillian University Munich, Germany, since 2007, and also as a senior research scientist at Advanced Practical Diagnostics bvba (apDia), in Belgium, since 2006. She is also an Honorary Assistant Professor at the School for Mental Health and Neuroscience, Maastricht University. In 2003, she proposed the “neurodegeneration” hypothesis explaining the neurotoxic changes induced through the involvement of immune system imbalance and imbalance of the kynurenine metabolites beyond the activity of the tryptophan pathway. One of the leading scientists in the field of neuroscience and psychiatry, she is working on: major psychiatric disorders; links between depression and dementia; psychoneuroimmunology; the kynurenine pathway; and related neuroendocrinology in the clinical setting and in animal and in vitro models of depression, schizophrenia and neurodegenerative disease; and also antibodies and immunoassay developments through EU consortia. Outside the EU consortium, she collaborates with several universities including the University of New South Wales, Australia, and the Universities of Chicago, Illinois and John Hopkins in the USA.