Virtual Issue Ion Channels and Transporters

August 2010

Papers Selected by Hermona Soreq and Ferdinand Hucho

Front cover: Figure 1 from I K Pajeva et al. (2009) FEBS J 276: 7016-36 and Figure 2 from E C Crowley and R Callaghan (2010) FEBS J 277: 530-539

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Introduction

Among the molecules that are pivotal for neuronal function are some of the most prominent membrane proteins: the ion channels and transporters. In this Virtual Issue we have brought together papers covering not only classical ion channels like voltage-dependent potassium channels and G-protein activated potassium channels, including some channel-specific toxins, but also representatives of the large family of Transient Receptor Potential (TRP) channels. We also extended the focus to intracellular interaction partners, following recent evidence that the interaction of channels with proteins of the cytoskeleton plays a major role in signal transduction.

Because of the abundance and variety of representatives of the other group of neuronal membrane proteins presented in this issue, the transporters, we have focussed on one subgroup: the multidrug resistance transporters. Although they are not exclusively neuronal, we feel that they are of special interest for neuropharmacologists.

This Virtual Issue gives an overview of the sort of cutting-edge work published in FEBS Journal on ion channels and transporters.

Ion Channels

Reviews:

• Submembraneous microtubule cytoskeleton: biochemical and functional interplay of TRP channels with the cytoskeleton
  Chandan Goswami, Tim Hucho
  FEBS Journal Volume 275, Issue 19, October 2008, Pages: 4684-99
  

• Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton
  Xing-Zhen Chen, Qiang Li, Yuliang Wu, Genqing Liang, Carlos J. Lara, Horacio F. Cantiello
  FEBS Journal Volume 275, Issue 19, October 2008, Pages: 4675-83
  

Regular articles:

• An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel
  Zhiguang Yuchi, Victor P. T. Pau, Bridget X. Lu, Murray Junop, Daniel S. C. Yang
  FEBS Journal Volume 276, Issue 21, November 2009, Pages: 6236-46

• Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase
  Carmen Müllner, Bibiane Steinecker, Astrid Gorischek, Wolfgang Schreibmayer
  FEBS Journal Volume 276, Issue 21, November 2009, Pages: 6218-26

• The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials
  Stefanie Bunse, Silviu Locovei, Matthias Schmidt, Feng Qiu, Georg Zoidl, Gerhard Dahl, Rolf Dermietzel
  FEBS Journal Volume 276, Issue 21, November 2009, Pages: 6258-70

• YidC is required for the assembly of the MscL homopentameric pore
  Ovidiu I. Pop, Zora Soprova, Gregory Koningstein, Dirk-Jan Scheffers, Peter van Ulsen, David Wickström, Jan-Willem de Gier, Joen Luirink
  FEBS Journal Volume 276, Issue 17, September 2009, Pages: 4891-99

• GCN4 enhances the stability of the pore domain of potassium channel KcsA
  Zhiguang Yuchi, Victor P. T. Pau, Daniel S. C. Yang
  FEBS Journal Volume 275, Issue 24, December 2008, Pages: 6228-36

• KCNE4 can co-associate with the I_Ks (KCNQ1-KCNE1) channel complex
  Lauren J. Manderfield, Alfred L. George Jr
  FEBS Journal Volume 275, Issue 6, March 2008, Pages: 1336-49

Toxins

Review:

• Marine toxins and the cytoskeleton: a new view of palytoxin toxicity
  M. Carmen Louzao, Isabel R. Ares, Eva Cagide
  FEBS Journal Volume 275, Issue 24, December 2008, Pages: 6067-74
  
  

Regular articles:

• The Janus-faced atracotoxins are specific blockers of invertebrate K_Ca channels
  Simon J. Gunning, Francesco Maggio, Monique J. Windley, Stella M. Valenzuela, Glenn F. King, Graham M. Nicholson
  FEBS Journal Volume 275, Issue 16, August 2008, Pages: 4045-59

• Voltage-gated sodium channel isoform-specific effects of pompilidotoxins
  Emanuele Schiavon, Marijke Stevens, André J. Zaharenko, Katsuhiro Konno, Jan Tytgat, Enzo Wanke
  FEBS Journal Volume 277, Issue 4, February 2010, Pages: 918-30
  
  

Multidrug Resistance Transporters

Reviews, Minireview Series (MRS):

• Multidrug efflux pumps: the big issues
  Richard Callaghan
  FEBS Journal Volume 277, Issue 3, February 2010, Pages: 529

• Multidrug efflux pumps: drug binding – gates or cavity?
  Emily Crowley, Richard Callaghan
  FEBS Journal Volume 277, Issue 3, February 2010, Pages: 530-39

• Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps-first come, first served?
  Robert Ernst, Petra Kueppers, Jan Stindt, Karl Kuchler, Lutz Schmitt
  FEBS Journal Volume 277, Issue 3, February 2010, Pages: 540-49

• Multidrug efflux pumps: the structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues
  Ian D. Kerr, Peter M. Jones, Anthony M. George
  FEBS Journal Volume 277, Issue 3, February 2010, Pages: 550-63
  
  

Regular articles:

• The four and a half LIM domain protein 2 interacts with and regulates the HERG channel
  Jijin Lin, Shuguang Lin, Xiyong Yu, Patrick C. Choy, Xiuzhang Shen, Chunyu Deng, Sujuan Kuang, Jun Wu
  FEBS Journal Volume 275, Issue 18, September 2008, Pages: 4531-39
  

• Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein
  Ilza K. Pajeva, Christoph Globisch, Michael Wiese
  FEBS Journal Volume 276, Issue 23, December 2009, Pages: 7016-26

• Functional role of the linker region in purified human P-glycoprotein
  Tomomi Sato, Atsushi Kodan, Yasuhisa Kimura, Kazumitsu Ueda, Toru Nakatsu, Hiroaki Kato
  FEBS Journal Volume 276, Issue 13, July 2009, Pages: 3504-16

• Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains
  Thomas Stockner, Sjoerd J. de Vries, Alexandre M. J. J. Bonvin, Gerhard F. Ecker, Peter Chiba
  FEBS Journal Volume 276, Issue 4, February 2009, Pages: 964-72

• Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
  Christopher A. McDevitt, Emily Crowley, Gemma Hobbs, Kate J. Starr, Ian D. Kerr, Richard Callaghan
  FEBS Journal Volume 275, Issue 17, September 2008, Pages: 4354-62

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